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Conserved domains on  [gi|1907115597|ref|XP_036015621|]
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tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RsmB super family cl33775
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
118-156 8.45e-10

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


The actual alignment was detected with superfamily member COG0144:

Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 56.55  E-value: 8.45e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907115597 118 AASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYPG 156
Cdd:COG0144   236 EASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNK 274
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
118-156 8.45e-10

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 56.55  E-value: 8.45e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907115597 118 AASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYPG 156
Cdd:COG0144   236 EASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNK 274
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
119-147 8.62e-07

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 47.86  E-value: 8.62e-07
                          10        20
                  ....*....|....*....|....*....
gi 1907115597 119 ASLLPVLALELRDGEAVLDLCAAPGGKSV 147
Cdd:PRK14902  238 SSMLVAPALDPKGGDTVLDACAAPGGKTT 266
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
124-151 2.44e-05

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 42.80  E-value: 2.44e-05
                          10        20
                  ....*....|....*....|....*...
gi 1907115597 124 VLALELRDGEAVLDLCAAPGGKSVALLQ 151
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAE 28
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
117-161 1.28e-04

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 41.39  E-value: 1.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907115597 117 NAASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYPGTVCSV 161
Cdd:TIGR00563 224 DASAQWVATWLAPQNEETILDACAAPGGKTTHILELAPQAQVVAL 268
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
118-156 8.45e-10

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 56.55  E-value: 8.45e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907115597 118 AASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYPG 156
Cdd:COG0144   236 EASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNK 274
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
119-147 8.62e-07

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 47.86  E-value: 8.62e-07
                          10        20
                  ....*....|....*....|....*....
gi 1907115597 119 ASLLPVLALELRDGEAVLDLCAAPGGKSV 147
Cdd:PRK14902  238 SSMLVAPALDPKGGDTVLDACAAPGGKTT 266
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
118-153 1.90e-06

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 46.72  E-value: 1.90e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907115597 118 AASLLpvlalELRDGEAVLDLCAAPGGKSVALLQCA 153
Cdd:PRK10901  236 AATLL-----APQNGERVLDACAAPGGKTAHILELA 266
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
124-151 2.44e-05

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 42.80  E-value: 2.44e-05
                          10        20
                  ....*....|....*....|....*...
gi 1907115597 124 VLALELRDGEAVLDLCAAPGGKSVALLQ 151
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAE 28
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
117-149 2.55e-05

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 43.51  E-value: 2.55e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907115597 117 NAASLLPVLALELRDGEAVLDLCAAPGGKSVAL 149
Cdd:PRK14904  236 NPTQALACLLLNPQPGSTVLDLCAAPGGKSTFM 268
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
117-161 1.28e-04

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 41.39  E-value: 1.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907115597 117 NAASLLPVLALELRDGEAVLDLCAAPGGKSVALLQCAYPGTVCSV 161
Cdd:TIGR00563 224 DASAQWVATWLAPQNEETILDACAAPGGKTTHILELAPQAQVVAL 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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