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Conserved domains on  [gi|1907118834|ref|XP_036015923|]
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type 2 lactosamine alpha-2,3-sialyltransferase isoform X4 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 114-319 3.41e-137

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23984:

Pssm-ID: 480271  Cd Length: 206  Bit Score: 387.18  E-value: 3.41e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 114 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 194 LRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907118834 274 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDI 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 3.41e-137

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 387.18  E-value: 3.41e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 114 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 194 LRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907118834 274 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDI 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-323 5.58e-71

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 220.94  E-value: 5.58e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 109 EFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSD-------SSHYDPN 181
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 182 TTAVLVVFKPQDLRWLVEILLGKKINT----QGFWKTPALKLiyKQYQIRILDPYITSEAAFQMLRFPRVfpkdqKPKHP 257
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907118834 258 TTGIIAITMAFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDIIKKK 323
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEG 255
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 3.41e-137

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 387.18  E-value: 3.41e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 114 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 194 LRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 273
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907118834 274 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDI 319
Cdd:cd23984   161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 114-319 1.61e-110

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 319.62  E-value: 1.61e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 114 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 193
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 194 LRWLVEILLGKKINTQ-GFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPrvFPKDQKPKHPTTGIIAITMAFHICS 272
Cdd:cd23967    81 LLWLQAVIKGKKPNGKgGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLP--MNGKQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1907118834 273 EVHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDI 319
Cdd:cd23967   159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 114-316 2.82e-81

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 245.34  E-value: 2.82e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 114 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSS-HYDPNTTAVLVVFKPQ 192
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGiENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 193 DLRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRvfpKDQKPKHPTTGIIAITMAFHICS 272
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPG---QRKKKQKPTTGLLAITLALHLCD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907118834 273 EVHLAGFKY-NFYSPNSPLHYYGNATMSLMkQNAYHNLTAEQLFL 316
Cdd:cd23982   158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSM-ANSGHNLNAEAQAI 201
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-323 5.58e-71

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 220.94  E-value: 5.58e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 109 EFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSD-------SSHYDPN 181
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 182 TTAVLVVFKPQDLRWLVEILLGKKINT----QGFWKTPALKLiyKQYQIRILDPYITSEAAFQMLRFPRVfpkdqKPKHP 257
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907118834 258 TTGIIAITMAFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDIIKKK 323
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEG 255
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 114-316 1.27e-69

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 215.76  E-value: 1.27e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 114 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQD 193
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 194 LRWLVEILLGKKI---NTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFP----RVFPKDQkpKHPTTGIIAITM 266
Cdd:cd23983    81 FAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPepqsRLWGWDK--NVPTLGVTAVVL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907118834 267 AFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFL 316
Cdd:cd23983   159 ATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFL 208
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 115-316 1.57e-67

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 210.55  E-value: 1.57e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 115 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQDL 194
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 195 RWLVEILLGKKIN-TQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSE 273
Cdd:cd23981    82 KWLKYIVYKEKVSaSDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907118834 274 VHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFL 316
Cdd:cd23981   162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFL 204
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 118-319 3.84e-38

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 134.41  E-value: 3.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 118 CVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRL-------FYPESVFSDSSHYDPNTTAVLVVF- 189
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVlnskwagFYLRGPRCGCHPLPLEEEVVLILSr 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 190 -KPQDLRWLVEILLGKKiNTQGFWKTPALKLIykQYQIRILDpyitseaafqmlrFPRVFPkDQKPKHPTTGIIAITMAF 268
Cdd:cd19952    81 aAAADFKRLKRRKKRHD-NAVLLLTDPAPDLL--SYVRKRLE-------------KLGLKS-FFGGNAPSSGLLAVLLAL 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907118834 269 HICSEVHLAGF-KYNFYSPNSPLHYYGNATMSLMkqNAYHNLTAEQLFLNDI 319
Cdd:cd19952   144 QLCDSVDLYGFgVDSGHAPKVPYHYYDLVEAEEG--TAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 105-322 6.41e-37

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 133.56  E-value: 6.41e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 105 DLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVfsdsSHYDPNTTA 184
Cdd:cd23966    67 NPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 185 VLVVFKPQDLRWLVEILLGKKInTQGFWKTPAlKLIYKQYQIRILDPyitseaAFqmlrFPRVFPK--DQKPKHPTTGII 262
Cdd:cd23966   143 VLVPFKVLDLQWLISALTTGEI-TRTYTPVKR-FIKADKDKVLVINP------AF----IKYVHDNwtEHHGRYPSTGFL 210

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907118834 263 AITMAFHICSEVHLAGF---KYNFYSpnsplHYY-GNATMSLMKQNAYHNLTAEqlflNDIIKK 322
Cdd:cd23966   211 ALIFALHICDEVSVFGFgadSKGNWH-----HYWeKNRSAGAFRKTGVHDADFE----SDIIKK 265
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 81-312 2.45e-36

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 132.38  E-value: 2.45e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834  81 FPLPYGIKTFE-TYFSSALSKLQSCDLFDEF----DRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEE 155
Cdd:cd23964    43 YKLPFGWGGLNrEVVERLLRNLNLTSSRYMFvlrgGRPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 156 EVGTRTTFRLFYPESVF-SDSSHY--DPNTTAVLVVFKPQDLRWLVEILLGKKINTQ---GFWKTPALKLIYKQYQIRIL 229
Cdd:cd23964   123 DVGTKTSFYTFFPESLHnSLLKHVpqDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGcdkGKRPPPLFGPKLNATNVRLL 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 230 DPYITSEAAFQMLRFPRVFpkdqkpkHPTTGIIAITMAFHICSEVHLAGFKYNfysPNSPLHYYGNATMSLMKQNAYHNL 309
Cdd:cd23964   203 HPDFIRYLFNRWLNSSTSY-------RPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVFYANHDF 272


                  ...
gi 1907118834 310 TAE 312
Cdd:cd23964   273 TNE 275
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 105-308 2.25e-28

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 111.13  E-value: 2.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 105 DLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVfsdsSHYDPNTTA 184
Cdd:cd23980    71 DPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESF----RELAQNVSM 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 185 VLVVFKPQDLRWLVEILLGKKINtQGFWKTPAlKLIYKQYQIRILDPyitseaAFQMLRFPRVFpkDQKPKHPTTGIIAI 264
Cdd:cd23980   147 ILVPFKTLDLEWVISATTTGTIS-HTYVPVPR-KIKVKKEKILIYHP------AFIKYVFDRWL--QGHGRYPSTGILSV 216

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907118834 265 TMAFHICSEVHLAGFKYNfySPNSPLHYY-GNATMSLMKQNAYHN 308
Cdd:cd23980   217 IFSLHVCDEVDLYGFGAD--SKGNWHHYWeNNPSAGAFRKTGVHD 259
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 115-294 1.38e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 104.63  E-value: 1.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 115 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLF-YP--ESVFSDSSHYDPNTTA-VLVVFk 190
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVsHSslPRLLRNAILLLAGTRApTVVVF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 191 pqdlrWLVEIllgkKINTQGFWKTPALKLIYKQYqiRILDPYITSEAafQMLRFPRVFPKDQ-KPKHPT-----TGIIAI 264
Cdd:cd23965    80 -----WGPET----KMNKDGAGKYNLLRSLSKKY--PDVEFYSLTPE--KMDYADELFEKETgKSRIKSgtwlsTGWFTM 146

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907118834 265 TMAFHICSEVHLAGFKYNFY---SPNS--PLHYYG 294
Cdd:cd23965   147 LLALDVCDEIKVYGMVPENYcreHPNSkvPYHYYE 181
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 99-329 3.30e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 102.34  E-value: 3.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834  99 SKLQSCDLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV--FSDSS 176
Cdd:cd23963    47 SLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILkrRYNSL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 177 HYDPNTTAVLvvfkpQDLRWLVE-ILLGKKINTQgfWKTPALKLIYKQYQIRILDPYItseaAFQMLRFPRVFPK----D 251
Cdd:cd23963   127 KKNRDRDKFL-----NRLKEYNGsILWYPKFSFK--SSTNLLLKAARALKKNGLNLTV----VYSNPEHFLAVQKfwkrR 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 252 QKPKHPTTGIIAITMAFHICSEVHLAGF-KYNFYSPNSPL--HYYGNATMSlmKQNAYHNLTAEQLFLNDiIKKKMVINL 328
Cdd:cd23963   196 GLEKRPSTGLYLVSLALTFCDEIHLYGFwPFPTDPNGRPVpyHYYDDLSPS--TKNKVHNMPEEFKLLRE-LHKKGVLKL 272


                  .
gi 1907118834 329 T 329
Cdd:cd23963   273 H 273
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 107-279 2.45e-23

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 97.25  E-value: 2.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 107 FDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESvfsdSSHYDPNTTAVL 186
Cdd:cd23979    72 YRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPES----AKNLPANVSFVL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 187 VVFKPQDLRWLVEILLGKKINtqgFWKTPALKLI-YKQYQIRILDPyitseaAFqmlrFPRVFPK--DQKPKHPTTGIIA 263
Cdd:cd23979   148 VPFKTLDLLWITSALSTGQIR---FTYAPVKQFLrVDKDKVQIYNP------AF----FKYIHDRwtEHHGRYPSTGMLV 214

                         170
                  ....*....|....*.
gi 1907118834 264 ITMAFHICSEVHLAGF 279
Cdd:cd23979   215 LFFALHVCDEVNVYGF 230
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 116-315 5.84e-23

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 95.80  E-value: 5.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 116 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNttavlvvfkpqDLR 195
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQILSKPEFNFLTD-----------PLY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 196 WLVEILLGKKINTQG----FWKTPALKLI--YKQYQIR-------ILDPyitseaafqmlRFP--------RVFPKDQKP 254
Cdd:cd23968   115 RNVTLLVWDPSSYNVnlekWYKKPDFDFFpnYIKYRRRhpeepfyLIDP-----------RFLwrlwdilqEYTPEKIKP 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907118834 255 KHPTTGIIAITMAFHICSEVHLagfkYNFYSPN--SPL-HYYGNATMSLMKQNAYHNLTAEQLF 315
Cdd:cd23968   184 NPPSSGFIGIVLMLHLCDWVDV----YEYVPSVrqTDRcHYYDVEKDLACTLGAWHPLAAEKLL 243
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 115-293 1.42e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 87.50  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 115 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHY----------DPNTTA 184
Cdd:cd23973    83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILqkrgfknipqDKDIKY 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 185 VLVVFKPQDLRWLVEILLGKKINTQGFWKTPALKLIYKQYQiriLDPYITSEAAFqmLRFPR---VFPKDQKPKH----- 256
Cdd:cd23973   163 ILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYFSGDFT---EDKYLVLHPDF--LRYVKnrfLRSKTLKGKYwaiyr 237

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1907118834 257 PTTGIIAITMAFHICSEVHLAGFKYNFYSpNSPLHYY 293
Cdd:cd23973   238 PTTGAFLLLTALHLCDTVSAYGFITEDYR-KYPDHYY 273
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 114-322 8.15e-17

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.98  E-value: 8.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 114 PCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLF------YPESVFSDSSHYdpnTTAVLV 187
Cdd:cd23985    44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLInsqlvtTEKHKFLKDSLY---NEGILI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 188 VFKPQDLrwlveillgkKINTQGFWKTPALKLI--YKQYqiRILDPyitsEAAFQMLRfPRV-----------FPKDQKP 254
Cdd:cd23985   121 VWDPAPY----------HSDIPEWYKNPDYNFFenYKTY--RRLNP----NQPFYILH-PQMqwelwdiiqenSPEEIQP 183

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907118834 255 KHPTTGIIAITMAFHICSEVHLagfkYNFYSPNSP---LHYYGNATMSLMKQNAYHNLtaeqLFLNDIIKK 322
Cdd:cd23985   184 NPPSSGMLGIILMMTLCDQVDV----YEFLPSKRKtdvCHYYQKFFDRACTMGAYHPL----LYEKNLVKH 246
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 116-316 1.14e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 75.89  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 116 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPesvfSDSSHYDPNttavlvVFKPQDLR 195
Cdd:cd23970    69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP----SILEKYYNN------LLTIQDRN 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 196 WLVEIL--LGKKIntqgFWkTPALKLIYKQYQIRILDPYItseaaFQMLRFPRV---FP-------------KDQKPKHP 257
Cdd:cd23970   139 NFFLSLkkLDGAI----LW-IPAFFFHTSATVTRTLVDFF-----VEHRGQLKVqlaWPgnimqhvnrywktKHLSPKRL 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907118834 258 TTGIIAITMAFHICSEVHLAGF-KYNFYSPNSPL--HYYGN-ATMSLMKQNAYHNLTAEQLFL 316
Cdd:cd23970   209 STGILMYTLASAICEEIHLYGFwPFGFDPTGTPLpyHYYDKkGTKFTTKWQESHQLPAEFVLL 271
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 116-312 1.23e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 75.53  E-value: 1.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 116 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPeSVFSDSSHYDPNTTavlvvfkpqDLR 195
Cdd:cd23969    65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNP-SVIPHAYGDLVNAT---------DKE 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 196 WLVEILlgKKINTQGFWkTPALKLIYKQYQIRILDPYI--------TSEAAFQMLRFPRVFPKDQK--PKHPTTGIIAIT 265
Cdd:cd23969   135 KFVERL--RQLGDSILW-IPAFVSKGGEEHVQWTNEIIlkhklnvkTAYPPLRLNHAIRGYWLTTKfrIKRPSTGLLMYT 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907118834 266 MAFHICSEVHLAGFkYNF----YSPNSPLHYYGNATMSLmkQNAYHNLTAE 312
Cdd:cd23969   212 LATRFCDEIHLYGF-YPFsedgNGRAVKYHYYDNRKYLT--TARPHKMPEE 259
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 96-300 3.56e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 74.79  E-value: 3.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834  96 SALSKLQSCD---LFDEFDR----VPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYP 168
Cdd:cd23974    58 DALNLLNSSAngqMFDWWDRpngrSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFST 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 169 ESVFSDSSHYD-------PNTTAVLVVFKPQDLR--WLVEILLGKKINTQGFWKTPALKLIY----KQYQIRILDPYITS 235
Cdd:cd23974   138 NTLMNSLRAYAgvgfngpPQSKETRYIFLPDHDRdyLLVKAALTHTPIDRGRDKSKRPSKYFgkdvTAEKFKIYHPDFIR 217

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907118834 236 EAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSEVHLAGF---KYNFYSPN------SPLHYYGNATMSL 300
Cdd:cd23974   218 YLRNRFLWSPILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSDHyydktyHKVVFYANHDLRL 291
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 49-300 4.65e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 74.47  E-value: 4.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834  49 PAFANLLRFPqlYPFLCRADFIKVAAMSGTNNFPLPYGIKTF-ETYFSSALSKL---QSCDLFDEFDRVP-CKRCVVVGN 123
Cdd:cd23972    13 PHFRGLFNFD--IPVLLWGQHFTPALWDRLSQRKVPYGWKGLsHQVVASTLSLLndsANAKLFFPRDTPGkCIRCAVVGN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 124 GGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLF----YPESVFSDSSH---YDPNTTAVLVVFKPQDLRW 196
Cdd:cd23972    91 GGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFtvntMKNSLISYWNLgftRTPQGQDLQYIFIPSDIRD 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 197 LVEI---LLGKKIN---------TQGFWKTPA---LKLIYKQYQIRILDPYITSEaaFQMLRFPRVFpkdqkpkHPTTGI 261
Cdd:cd23972   171 YVMLrsaILGVPVPegldkgdrpHKYFGPEASakkFKLLHPDFISYLTDRFLKSK--LLNTHYGHLY-------MPSTGA 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907118834 262 IAITMAFHICSEVHLAGF---KYNFYSPN------SPLHYYGNATMSL 300
Cdd:cd23972   242 LMLLTALHTCDQVSAYGFitsNYWKFSDHyyerkkKPLVFYANHDMLL 289
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 116-296 1.14e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 73.06  E-value: 1.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 116 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPE----------------------SVFS 173
Cdd:cd23988    65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafggfrnesdrekfvhrlSMLN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 174 DSSHYDPnttAVLVVFKPQDLRWLVEILLGKKINTQGFWktPALKLIYKqyqirILDPYITSEAAFqmlrfprvfpkdqk 253
Cdd:cd23988   145 DSVLWIP---AFMVKGGEKHVEWVNALILKNKLKVRTAY--PSLRLIHA-----VRGYWLTNKVNI-------------- 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907118834 254 pKHPTTGIIAITMAFHICSEVHLAGF------------KYNFYSpNSPLHYYGNA 296
Cdd:cd23988   201 -KRPSTGLLMYTLATRFCDEIHLYGFwpfpkdangnpvKYHYYD-DLKYRYFSNA 253
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 116-316 1.34e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.56  E-value: 1.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 116 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFR------LFYPESVFSDSSHYdpnTTAVLVVF 189
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRiinsqiLTNPNHHFIDSSLY---KDVILVAW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 190 KPQDLrwlveillgkKINTQGFWKTPALKLI--YKQYQIR-------ILDPYITseaaFQMLRFPRVFPKDQ-KPKHPTT 259
Cdd:cd23986   127 DPAPY----------SANLHKWYKKPDYNLFtpYVQYRKRnpnqpfyILHPKFI----WQLWDIIQENTQEKiQPNPPSS 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907118834 260 GIIAITMAFHICSEVHLagfkYNF---YSPNSPLHY---YGNATMSLmkqNAYHNLTAEQLFL 316
Cdd:cd23986   193 GFIGILIMMSMCREVHV----YEYipsVRQTDLCHYherYYDAACTL---GAYHPLLYEKLLI 248
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 115-293 4.85e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 70.27  E-value: 4.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 115 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSdsshydpnttavlVVFKPQDL 194
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYR-------------VLRRPQEF 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 195 RWL----VEILLGKKINTQGFWKTPALKLIYKQYQI-RILDPYITSEAafQMLRFPRVFP----KDQKPKHP--TTGIIA 263
Cdd:cd23978    68 LNRtpetTLIFWGPPNKMQKDGKSNLFRIIQRASMTfPNMSAFVVSPR--RMRQFDDLFRgetgRDRKKSHSwlSTGWFT 145

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1907118834 264 ITMAFHICSEVHLAGF-KYNFYSPNS-----PLHYY 293
Cdd:cd23978   146 MVIAVELCDNVHVYGMvPPNYCSKRPtpkkmPYHYY 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 115-293 9.83e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 69.58  E-value: 9.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 115 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV---FSDSSHY--DPNTTaVLVVF 189
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVpllLKNPDYFfkETNET-IYVIW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 190 KP-----QDLRWLVEILLGKKINtqgfwktpalklIYKQYQIrildpYITSEAafQMLRFPRVFPKD------QKPKHPT 258
Cdd:cd23975    80 GPfrnmrKDGKGIVYNMLKKAVE------------SYPQAKI-----YVTTEK--RMSYCDTVFKKEtgkdrvQSGSYLS 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1907118834 259 TGIIAITMAFHICSEVHLAGFKYNFYSPNS-----PLHYY 293
Cdd:cd23975   141 TGWFTLILAMDACYGIHVYGMINDTYCKTEgyrkvPYHYY 180
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 116-312 1.87e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 69.58  E-value: 1.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 116 KRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV---FSD------------------ 174
Cdd:cd23987    65 KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqraFEDlvnetwkekflqrlqsln 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 175 -SSHYDPnttAVLVVFKPQDLRWLVEILLGKKINTQGFWktPALKLIYKqyqirILDPYITSEAAFqmlrfprvfpkdqk 253
Cdd:cd23987   145 gSILWIP---AFMAKGGEERVEWVNDLILKHHINVRTAY--PSLRLLHA-----VRGYWLTNKVHI-------------- 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907118834 254 pKHPTTGIIAITMAFHICSEVHLAGFKYNFYSPN-SPL--HYYGNATMSLMKQNAYHNLTAE 312
Cdd:cd23987   201 -KRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNqNPVkyHYYDSLKYGYTSQASPHTMPLE 261
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 115-326 2.61e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 65.27  E-value: 2.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 115 CKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESV---FSDSSHY-DPNTTAVLVVFK 190
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVpllLRNQGYFfQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 191 PqdLRWLVEILLGKKINTqgfwkTPALKLIYKQYQIRILdpyiTSEaafQMLRFPRVFpKDQKPKHP-------TTGIIA 263
Cdd:cd23977    81 P--ERNMDRDGGGKTYRA-----LLTLAKMYPHLQVYTL----TEE---KMAYCDGVF-QNETGKNRmksgsflSTGWFT 145

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907118834 264 ITMAFHICSEVHLAGFKYNFY-----SPNSPLHYY-----GNATMSLMKQNAY---HNLTAEQLFLNDIIKKKMVI 326
Cdd:cd23977   146 MILALELCEEILVYGMVSDSYcrnknHSSVPYHYYekgrlDECRMYLVHERAPrggHRFITEKAIFSRWAKRKKIR 221
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 110-295 1.54e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 57.65  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 110 FDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPvLGHEEEVGTRTTF-------------------RLF---- 166
Cdd:cd23971    59 FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNLvtanpsilrekfhnlkkrrRPFverm 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 167 --YPESV-----FSDSSHYDPNTTAVLVV-----------FKPQDLRWLVEillgkkintqgFWKTpalkliykqyqiri 228
Cdd:cd23971   138 kvYGNALlllpaFSYTSNTEPSLRALYTLedfgspqkvlfFNPEYLRNLSR-----------YWKS-------------- 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 229 ldpyitseaafQMLRFPRvfpkdqkpkhPTTGIIAITMAFHICSEVHLAGF-KYNFYSPNSPL--HYYGN 295
Cdd:cd23971   193 -----------KGLKARR----------LSTGLMLVSAALELCENVHLYGFwPFSTDLDGNPIshHYYDN 241
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 110-295 2.77e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 54.07  E-value: 2.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 110 FDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLG-HEEEVGTRTTFRLFYPeSVFSDSSH---------YD 179
Cdd:cd23990    59 YSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINP-SIITERFHklekwrrpfYE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 180 -----PNTTAVLVVF---KPQDLRWLVEILLgkkintQGFWKTPALKLIYKQYQIRIldpyitseAAFQMLRFPRVfpkd 251
Cdd:cd23990   138 vlqvyENASVVLPAFyntRNTDVSIRVKYVL------DDFESQQAVYYFHPQYLLNV--------SRFWLRQGVRA---- 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907118834 252 qkpKHPTTGIIAITMAFHICSEVHLAGFkYNFysPNSPL------HYYGN 295
Cdd:cd23990   200 ---KRISSGLMLVTAALELCEEVHLYGF-WAF--PMNPSgifithHYYDN 243
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 110-161 7.49e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 52.83  E-value: 7.49e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907118834 110 FDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHE-EEVGTRT 161
Cdd:cd23991    59 FRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKT 111
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 112-316 1.41e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 52.14  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 112 RVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVL-GHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFK 190
Cdd:cd23989    60 QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMK 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 191 PQDLRWLVEILLGKKINTQ-GFWKTPALKLIYKQYQIRILDPyitseaafQMLRFPRVF--PKDQKPKHPTTGIIAITMA 267
Cdd:cd23989   140 VYGRSYIYMPAFSMKTGTDpSLRVYYTLADVGANQTVLFANP--------NFLRNVGKFwkSKGVHAKRLSTGLFLVSAA 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907118834 268 FHICSEVHLAGF-KYNFYSPNSPL--HYYGNatmsLMKQNAYHNLTAEQLFL 316
Cdd:cd23989   212 LGLCEEVTIYGFwPFSVDLDERTIshHYYDN----VLPDSGFHAMPEEFLQL 259
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 112-293 2.94e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 50.64  E-value: 2.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 112 RVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVfsdsshydpnttavlvvfkP 191
Cdd:cd23976    12 KMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI-------------------Q 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907118834 192 QDLRWLVEILLGKKINTQGFW------KTPALKLIYKQYQI--RI---LDPYITSEAafQMLRFPRVFP----KDQKPKH 256
Cdd:cd23976    73 RILRNRNELLNVSQGTVFIFWgpsnymRRDGKGLVYNNLQLmnQIlpkLKVYTITRH--KMLQFDELFKretgKDRKISN 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907118834 257 P--TTGIIAITMAFHICSEVHLAG-----FKYNFYSPNSPLHYY 293
Cdd:cd23976   151 TwlSTGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYY 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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