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Conserved domains on  [gi|1907121721|ref|XP_036016137|]
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ankyrin repeat domain-containing protein 12 isoform X4 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13791050)

ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
173-291 7.70e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 7.70e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  173 RQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 252
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907121721  253 TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
PTZ00121 super family cl31754
MAEBL; Provisional
382-1165 6.84e-08

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 58.23  E-value: 6.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  382 KEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDE--EGLQNRKISTACSVAESSHPDMQAKKE-- 457
Cdd:PTZ00121  1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAEda 1163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  458 --YEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNFRKSFSPKDDTSLHLFHISTG 535
Cdd:PTZ00121  1164 rkAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK 1243
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  536 KSPK-HSCGLSEKQTPLKQEHTKACISPGSSEMSLQPDLTRYDNAEPESSNVKSYKHKEKNKQQKDFHIEFGEKSNAKIK 614
Cdd:PTZ00121  1244 KAEEeRNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  615 DEDHNPAFENSDCTLKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFDRefwkenffKSDE 694
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--------KADE 1395
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  695 TEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKVKDPKEEKDSVSTEKEAECC 774
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  775 SVGVSVSQEAAGLH--SSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTD 852
Cdd:PTZ00121  1476 KKKAEEAKKADEAKkkAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE 1555
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  853 RVREKDKLysHQTERCHKDSEKLKNTVRKTDDRER-------------NREKADRKHDREKPERERYLAENKEKHLEKRK 919
Cdd:PTZ00121  1556 ELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKaeearieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  920 QSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNvtnlKHLQEERKSSTGDSSGKTQHEKALSLKERARD----EPLKT 995
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEakkaEELKK 1709
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  996 PDGKEKDKKDIDRyKERDKRKDKAQlntliRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1075
Cdd:PTZ00121  1710 KEAEEKKKAEELK-KAEEENKIKAE-----EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721 1076 WHRKHKEKIKQKEKERLRNrTCLELKVKDKEKTKHAPTESKSKELTRSRSSELTDVY------SKEKQSKDVGSNRSQSV 1149
Cdd:PTZ00121  1784 ELDEEDEKRRMEVDKKIKD-IFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKnmqleeADAFEKHKFNKNNENGE 1862
                          810
                   ....*....|....*.
gi 1907121721 1150 DNRNVLNLGKPSYISE 1165
Cdd:PTZ00121  1863 DGNKEADFNKEKDLKE 1878
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
173-291 7.70e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 7.70e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  173 RQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 252
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907121721  253 TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
189-277 1.41e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.95  E-value: 1.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  189 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIaAGADVNTQGlDDDTPLHDSASSGHRDIVK 268
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78

                   ....*....
gi 1907121721  269 LLLRHGGNP 277
Cdd:pfam12796   79 LLLEKGADI 87
PHA03095 PHA03095
ankyrin-like protein; Provisional
178-290 1.37e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 1.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLHM---AAIRGDVKQVKELISLGANVNVKDFAGWTPLH-EACNVGYYDVAKILIAAGADVNTQGLDDDT 253
Cdd:PHA03095    40 VNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907121721  254 PLHDSASSG--HRDIVKLLLRHGGNPFQANKHGERPVDV 290
Cdd:PHA03095   120 PLHVYLSGFniNPKVIRLLLRKGADVNALDLYGMTPLAV 158
PTZ00121 PTZ00121
MAEBL; Provisional
382-1165 6.84e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 58.23  E-value: 6.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  382 KEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDE--EGLQNRKISTACSVAESSHPDMQAKKE-- 457
Cdd:PTZ00121  1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAEda 1163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  458 --YEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNFRKSFSPKDDTSLHLFHISTG 535
Cdd:PTZ00121  1164 rkAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK 1243
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  536 KSPK-HSCGLSEKQTPLKQEHTKACISPGSSEMSLQPDLTRYDNAEPESSNVKSYKHKEKNKQQKDFHIEFGEKSNAKIK 614
Cdd:PTZ00121  1244 KAEEeRNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  615 DEDHNPAFENSDCTLKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFDRefwkenffKSDE 694
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--------KADE 1395
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  695 TEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKVKDPKEEKDSVSTEKEAECC 774
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  775 SVGVSVSQEAAGLH--SSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTD 852
Cdd:PTZ00121  1476 KKKAEEAKKADEAKkkAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE 1555
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  853 RVREKDKLysHQTERCHKDSEKLKNTVRKTDDRER-------------NREKADRKHDREKPERERYLAENKEKHLEKRK 919
Cdd:PTZ00121  1556 ELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKaeearieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  920 QSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNvtnlKHLQEERKSSTGDSSGKTQHEKALSLKERARD----EPLKT 995
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEakkaEELKK 1709
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  996 PDGKEKDKKDIDRyKERDKRKDKAQlntliRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1075
Cdd:PTZ00121  1710 KEAEEKKKAEELK-KAEEENKIKAE-----EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721 1076 WHRKHKEKIKQKEKERLRNrTCLELKVKDKEKTKHAPTESKSKELTRSRSSELTDVY------SKEKQSKDVGSNRSQSV 1149
Cdd:PTZ00121  1784 ELDEEDEKRRMEVDKKIKD-IFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKnmqleeADAFEKHKFNKNNENGE 1862
                          810
                   ....*....|....*.
gi 1907121721 1150 DNRNVLNLGKPSYISE 1165
Cdd:PTZ00121  1863 DGNKEADFNKEKDLKE 1878
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
667-1177 9.95e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.13  E-value: 9.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  667 NKDNAKELQRSIEFDREFWKENFFKSDETEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKEN 746
Cdd:pfam02463  215 LKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKE 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  747 EKSLREEKVkdpKEEKDSVSTEKEaeccsvgVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERK 826
Cdd:pfam02463  295 EEELKSELL---KLERRKVDDEEK-------LKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKL 364
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  827 FSEKEKKIKHEHKSEREKLDFSDCTDRVREKDKLYSHQTERCHKDSEKLKNTVRKTDDRERNREKADRK---HDREKPER 903
Cdd:pfam02463  365 QEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEeeeESIELKQG 444
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  904 ERYLAENKEKHLEKRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKHLQEERKSSTGDSSGKTQHEKALS 983
Cdd:pfam02463  445 KLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI 524
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  984 LKERARDEPLKTPDGKEKDKKDIDRYKERDKRKDKAqlntLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFE 1063
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEV----EERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEID 600
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721 1064 RMLSLKDLEieqwhrKHKEKIKQKEKERLRNRTCLELKVKDKEKTKHAPTESKS---KELTRSRSSELTDVYSKEKQSKD 1140
Cdd:pfam02463  601 PILNLAQLD------KATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLrkgVSLEEGLAEKSEVKASLSELTKE 674
                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1907121721 1141 VGSNRSQSVDNRNVLNLGKPSYISESGSNRSPRSEGE 1177
Cdd:pfam02463  675 LLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
185-256 1.11e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  185 GETPLHMAAIRGDVKQVKELISLGANVNV--------------KDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLD 250
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgpknLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                   ....*.
gi 1907121721  251 DDTPLH 256
Cdd:cd22192    169 GNTVLH 174
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
218-245 2.82e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 2.82e-05
                            10        20
                    ....*....|....*....|....*...
gi 1907121721   218 GWTPLHEACNVGYYDVAKILIAAGADVN 245
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
841-965 1.24e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 43.75  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  841 EREKL-DFSDCTDRVREKDKLySHQTERCHKDSEKLKNTvRKTDDRERNREKADRKHDREKPERERYLAENKEK-HLEKR 918
Cdd:TIGR01622    6 ERERLrDSSSAGDRDRRRDKG-RERSRDRSRDRERSRSR-RRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRrRGDSY 83
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1907121721  919 KQSDSSEYSKSEKVRTKDRDREGEKKEKlRDKESVNVTNLKHLQEER 965
Cdd:TIGR01622   84 RRRRDDRRSRREKPRARDGTPEPLTEDE-RDRRTVFVQQLAARARER 129
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
173-291 7.70e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 7.70e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  173 RQKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 252
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGE 187
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907121721  253 TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:COG0666    188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
174-291 1.36e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 1.36e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  174 QKDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDT 253
Cdd:COG0666     76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1907121721  254 PLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
178-311 9.82e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 9.82e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHD 257
Cdd:COG0666    146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907121721  258 SASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSGDDE 311
Cdd:COG0666    226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
175-291 5.77e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.49  E-value: 5.77e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  175 KDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTP 254
Cdd:COG0666     44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907121721  255 LHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:COG0666    124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
Ank_2 pfam12796
Ankyrin repeats (3 copies);
189-277 1.41e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.95  E-value: 1.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  189 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIaAGADVNTQGlDDDTPLHDSASSGHRDIVK 268
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78

                   ....*....
gi 1907121721  269 LLLRHGGNP 277
Cdd:pfam12796   79 LLLEKGADI 87
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
178-286 1.49e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.25  E-value: 1.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHD 257
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
                           90       100
                   ....*....|....*....|....*....
gi 1907121721  258 SASSGHRDIVKLLLRHGGNPFQANKHGER 286
Cdd:COG0666    259 AAAAGAALIVKLLLLALLLLAAALLDLLT 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
178-290 1.37e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.99  E-value: 1.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLHM---AAIRGDVKQVKELISLGANVNVKDFAGWTPLH-EACNVGYYDVAKILIAAGADVNTQGLDDDT 253
Cdd:PHA03095    40 VNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907121721  254 PLHDSASSG--HRDIVKLLLRHGGNPFQANKHGERPVDV 290
Cdd:PHA03095   120 PLHVYLSGFniNPKVIRLLLRKGADVNALDLYGMTPLAV 158
Ank_2 pfam12796
Ankyrin repeats (3 copies);
178-247 2.71e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 2.71e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQVKELISlGANVNVKDFaGWTPLHEACNVGYYDVAKILIAAGADVNTQ 247
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
177-291 4.65e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 80.01  E-value: 4.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  177 KINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLH 256
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907121721  257 DSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
120-276 5.77e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 79.71  E-value: 5.77e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  120 STPVSILFGYPLSERKQM---ALLMQMTARDNSPDSTPSHPSQATPAQKKTPSS-----SSRQKDkINKRNERGETPLHM 191
Cdd:PHA03100    69 STPLHYLSNIKYNLTDVKeivKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSiveylLDNGAN-VNIKNSDGENLLHL 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  192 AAIRGDVK------------------QVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDT 253
Cdd:PHA03100   148 YLESNKIDlkilkllidkgvdinaknRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
                          170       180
                   ....*....|....*....|...
gi 1907121721  254 PLHDSASSGHRDIVKLLLRHGGN 276
Cdd:PHA03100   228 PLHIAILNNNKEIFKLLLNNGPS 250
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
116-284 8.41e-13

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 73.78  E-value: 8.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  116 GTKKSTPVSILFgyplserKQMALLMQMTARDNSPDSTpshpSQATPAQKKTPSSSSRQKDKINkrnergETPLHMAAIR 195
Cdd:PTZ00322    23 GSRKRRAKPISF-------ERMAAIQEEIARIDTHLEA----LEATENKDATPDHNLTTEEVID------PVVAHMLTVE 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  196 -------GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVK 268
Cdd:PTZ00322    86 lcqlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165
                          170
                   ....*....|....*.
gi 1907121721  269 LLLRHGGNPFQANKHG 284
Cdd:PTZ00322   166 LLSRHSQCHFELGANA 181
PHA02876 PHA02876
ankyrin repeat protein; Provisional
152-276 9.67e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 73.56  E-value: 9.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  152 STPSHPSQATPAQKK-TPSSSSRQKDkINKRNERGETPLHMAAIRG-DVKQVKELISLGANVNVKDFAGWTPLHEACNVG 229
Cdd:PHA02876   274 NTPLHHASQAPSLSRlVPKLLERGAD-VNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLD 352
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907121721  230 YY-DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGN 276
Cdd:PHA02876   353 RNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
175-291 7.28e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 7.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  175 KDKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTP 254
Cdd:COG0666     11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907121721  255 LHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:COG0666     91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA 127
PHA02874 PHA02874
ankyrin repeat protein; Provisional
178-291 8.30e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.53  E-value: 8.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEAcnVGYYDVAKILIAAGADVNTQGLDDDTPLHD 257
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA--IIHNRSAIELLINNASINDQDIDGSTPLHH 260
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907121721  258 SAS-SGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:PHA02874   261 AINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA02878 PHA02878
ankyrin repeat protein; Provisional
178-274 2.09e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.29  E-value: 2.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNE-RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLH 256
Cdd:PHA02878   160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239
                           90
                   ....*....|....*....
gi 1907121721  257 DSASS-GHRDIVKLLLRHG 274
Cdd:PHA02878   240 ISVGYcKDYDILKLLLEHG 258
PHA02878 PHA02878
ankyrin repeat protein; Provisional
146-291 3.28e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.90  E-value: 3.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  146 RDNSPDSTPSHPSQATPAQKKTPSSSSRQKdKINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 225
Cdd:PHA02878   163 KDRHKGNTALHYATENKDQRLTELLLSYGA-NVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  226 cnVGY---YDVAKILIAAGADVNTQG-LDDDTPLHDSASSghRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:PHA02878   242 --VGYckdYDILKLLLEHGVDVNAKSyILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
186-273 3.31e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 3.31e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  186 ETPLHMAAIRGDVKQVKELISLGANVN---VKDfaGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSG 262
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLGKFADdvfYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146
                           90
                   ....*....|.
gi 1907121721  263 HRDIVKLLLRH 273
Cdd:PHA02875   147 DIKGIELLIDH 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
178-287 1.25e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLH--MAAIRGDVKQVKELISLGANVNVKDFAGWTPLH-----EACNVgyyDVAKILIAAGADVNTQGLD 250
Cdd:PHA03095   110 VNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvllksRNANV---ELLRLLIDAGADVYAVDDR 186
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907121721  251 DDTPLHDSASSGHRD--IVKLLLRHGGNPFQANKHGERP 287
Cdd:PHA03095   187 FRSLLHHHLQSFKPRarIVRELIRAGCDPAATDMLGNTP 225
PHA03095 PHA03095
ankyrin-like protein; Provisional
197-276 1.59e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.73  E-value: 1.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  197 DVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKI---LIAAGADVNTQGLDDDTPLHDSASSGHR-DIVKLLLR 272
Cdd:PHA03095    26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIK 105

                   ....
gi 1907121721  273 HGGN 276
Cdd:PHA03095   106 AGAD 109
Ank_4 pfam13637
Ankyrin repeats (many copies);
187-238 1.63e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907121721  187 TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI 238
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
218-271 2.12e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 2.12e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907121721  218 GWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLL 271
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
177-246 2.22e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.99  E-value: 2.22e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  177 KINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNT 246
Cdd:PHA03100   184 PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02878 PHA02878
ankyrin repeat protein; Provisional
197-291 1.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.89  E-value: 1.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  197 DVKQVKELISLGANVNVKD-FAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGG 275
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225
                           90
                   ....*....|....*.
gi 1907121721  276 NPFQANKHGERPVDVA 291
Cdd:PHA02878   226 STDARDKCGNTPLHIS 241
PTZ00121 PTZ00121
MAEBL; Provisional
382-1165 6.84e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 58.23  E-value: 6.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  382 KEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDE--EGLQNRKISTACSVAESSHPDMQAKKE-- 457
Cdd:PTZ00121  1084 KEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAEda 1163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  458 --YEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNFRKSFSPKDDTSLHLFHISTG 535
Cdd:PTZ00121  1164 rkAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK 1243
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  536 KSPK-HSCGLSEKQTPLKQEHTKACISPGSSEMSLQPDLTRYDNAEPESSNVKSYKHKEKNKQQKDFHIEFGEKSNAKIK 614
Cdd:PTZ00121  1244 KAEEeRNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  615 DEDHNPAFENSDCTLKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFDRefwkenffKSDE 694
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--------KADE 1395
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  695 TEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKVKDPKEEKDSVSTEKEAECC 774
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  775 SVGVSVSQEAAGLH--SSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTD 852
Cdd:PTZ00121  1476 KKKAEEAKKADEAKkkAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE 1555
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  853 RVREKDKLysHQTERCHKDSEKLKNTVRKTDDRER-------------NREKADRKHDREKPERERYLAENKEKHLEKRK 919
Cdd:PTZ00121  1556 ELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKaeearieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  920 QSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNvtnlKHLQEERKSSTGDSSGKTQHEKALSLKERARD----EPLKT 995
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEakkaEELKK 1709
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  996 PDGKEKDKKDIDRyKERDKRKDKAQlntliRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQ 1075
Cdd:PTZ00121  1710 KEAEEKKKAEELK-KAEEENKIKAE-----EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721 1076 WHRKHKEKIKQKEKERLRNrTCLELKVKDKEKTKHAPTESKSKELTRSRSSELTDVY------SKEKQSKDVGSNRSQSV 1149
Cdd:PTZ00121  1784 ELDEEDEKRRMEVDKKIKD-IFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKnmqleeADAFEKHKFNKNNENGE 1862
                          810
                   ....*....|....*.
gi 1907121721 1150 DNRNVLNLGKPSYISE 1165
Cdd:PTZ00121  1863 DGNKEADFNKEKDLKE 1878
PHA02875 PHA02875
ankyrin repeat protein; Provisional
187-276 1.88e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  187 TPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHR-D 265
Cdd:PHA02875   137 SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiD 216
                           90
                   ....*....|.
gi 1907121721  266 IVKLLLRHGGN 276
Cdd:PHA02875   217 IVRLFIKRGAD 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
177-255 3.05e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 3.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907121721  177 KINKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPL 255
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_5 pfam13857
Ankyrin repeats (many copies);
178-225 3.53e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 3.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 225
Cdd:pfam13857    9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
189-252 5.04e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.87  E-value: 5.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907121721  189 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDD 252
Cdd:PLN03192   626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
PHA02876 PHA02876
ankyrin repeat protein; Provisional
118-275 6.77e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 6.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  118 KKSTPVSILF--GYplsERKQMALLMQMTARDNSPDS---TPSHPSQATPAQKKTPSSSSRQKDKINKRNERGETPLHMA 192
Cdd:PHA02876   306 KGETPLYLMAknGY---DTENIRTLIMLGADVNAADRlyiTPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYA 382
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  193 AIRGDV----------------------------------KQVKELISLGANVNVKDFAGWTPLHEAC-NVGYYDVAKIL 237
Cdd:PHA02876   383 AVRNNVviintlldygadiealsqkigtalhfalcgtnpyMSVKTLIDRGANVNSKNKDLSTPLHYACkKNCKLDVIEML 462
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1907121721  238 IAAGADVNTQGLDDDTPLhdSASSGHRDIVKLLLRHGG 275
Cdd:PHA02876   463 LDNGADVNAINIQNQYPL--LIALEYHGIVNILLHYGA 498
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
184-285 1.13e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.72  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  184 RGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL--IAAGADVNT--------------- 246
Cdd:PLN03192   557 KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAagdllctaakrndlt 636
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907121721  247 -------QGLDDDTPLHDSASS-------GHRDIVKLLLRHGGNPFQANKHGE 285
Cdd:PLN03192   637 amkellkQGLNVDSEDHQGATAlqvamaeDHVDMVRLLIMNGADVDKANTDDD 689
PTZ00121 PTZ00121
MAEBL; Provisional
368-1006 1.48e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 1.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  368 EEISKMIDDRHI---LRKEQRRENESEAERSGLFAKQEKTFYSKSFKTKKQKPSRVLCSSTESSDEEGL---QNRKISTA 441
Cdd:PTZ00121  1215 EEARKAEDAKKAeavKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELkkaEEKKKADE 1294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  442 CSVAESSHPDMQAKKEYEYKQKGKVKRKLKNQNKNKENQELKQEKEGKENSRIATLTVNTALDCSEKYREEGNfrksfsp 521
Cdd:PTZ00121  1295 AKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAE------- 1367
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  522 kddtslhlfhistgkspkhscgLSEKQTplKQEHTKACISPGSSEMSLQPDLTRyDNAEPESSNVKSYKHKEKNKQQKDf 601
Cdd:PTZ00121  1368 ----------------------AAEKKK--EEAKKKADAAKKKAEEKKKADEAK-KKAEEDKKKADELKKAAAAKKKAD- 1421
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  602 hiEFGEKSNAKIKDEDHNPAFENSdctlKKMDKEGKTLKKHKLKHKEKDKEKHKKEVEGEKEKYKNKDNAKELQRSIEFD 681
Cdd:PTZ00121  1422 --EAKKKAEEKKKADEAKKKAEEA----KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEA 1495
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  682 REFWKENFFKSDETE--DLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLREEKvkdPK 759
Cdd:PTZ00121  1496 KKKADEAKKAAEAKKkaDEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK---KA 1572
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  760 EEKDSVSTEKEAECCSVGVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDrrfQTKEKEldrNERKFSEKEKKIKHEHK 839
Cdd:PTZ00121  1573 EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE---ELKKAE---EEKKKVEQLKKKEAEEK 1646
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  840 SEREKLdfsdctDRVREKDKLYSHQTERCHKDSEKLKNTVRKTDDRERNREKADRKHDREKPERE---RYLAENKEKHLE 916
Cdd:PTZ00121  1647 KKAEEL------KKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEelkKKEAEEKKKAEE 1720
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  917 KRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKHLQEERksstgdsSGKTQHEKALSLKERARDEPLKTP 996
Cdd:PTZ00121  1721 LKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKK-------AEEIRKEKEAVIEEELDEEDEKRR 1793
                          650
                   ....*....|
gi 1907121721  997 DGKEKDKKDI 1006
Cdd:PTZ00121  1794 MEVDKKIKDI 1803
PHA02859 PHA02859
ankyrin repeat protein; Provisional
178-284 1.54e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 50.97  E-value: 1.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQ--VKELISLGANVNVKdfagwTPLHEACNVGYY---------DVAKILIAAGADVNT 246
Cdd:PHA02859    44 VNDCNDLYETPIFSCLEKDKVNVeiLKFLIENGADVNFK-----TRDNNLSALHHYlsfnknvepEILKILIDSGSSITE 118
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907121721  247 QGLDDDTPLHDSAS--SGHRDIVKLLLRHGGNPFQANKHG 284
Cdd:PHA02859   119 EDEDGKNLLHMYMCnfNVRINVIKLLIDSGVSFLNKDFDN 158
Ank_5 pfam13857
Ankyrin repeats (many copies);
237-291 2.34e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 2.34e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907121721  237 LIAAG-ADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
187-276 3.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 3.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  187 TPLHMA--AIRGDVkqVKELISLGANVNVKDFAGWTPLHEACNVGYY-----DVAKILIAAGADVNTQGLDDDTPLHDSA 259
Cdd:PHA03100    37 LPLYLAkeARNIDV--VKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAI 114
                           90
                   ....*....|....*....
gi 1907121721  260 S--SGHRDIVKLLLRHGGN 276
Cdd:PHA03100   115 SkkSNSYSIVEYLLDNGAN 133
PHA02875 PHA02875
ankyrin repeat protein; Provisional
183-291 4.49e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.53  E-value: 4.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  183 ERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSG 262
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179
                           90       100
                   ....*....|....*....|....*....
gi 1907121721  263 HRDIVKLLLRHGGNPfqaNKHGERPvDVA 291
Cdd:PHA02875   180 DIAICKMLLDSGANI---DYFGKNG-CVA 204
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
184-215 5.33e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.97  E-value: 5.33e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907121721  184 RGETPLHMAAIR-GDVKQVKELISLGANVNVKD 215
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
667-1177 9.95e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.13  E-value: 9.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  667 NKDNAKELQRSIEFDREFWKENFFKSDETEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKEN 746
Cdd:pfam02463  215 LKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKE 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  747 EKSLREEKVkdpKEEKDSVSTEKEaeccsvgVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERK 826
Cdd:pfam02463  295 EEELKSELL---KLERRKVDDEEK-------LKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKL 364
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  827 FSEKEKKIKHEHKSEREKLDFSDCTDRVREKDKLYSHQTERCHKDSEKLKNTVRKTDDRERNREKADRK---HDREKPER 903
Cdd:pfam02463  365 QEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEeeeESIELKQG 444
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  904 ERYLAENKEKHLEKRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKHLQEERKSSTGDSSGKTQHEKALS 983
Cdd:pfam02463  445 KLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI 524
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  984 LKERARDEPLKTPDGKEKDKKDIDRYKERDKRKDKAqlntLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFE 1063
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEV----EERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEID 600
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721 1064 RMLSLKDLEieqwhrKHKEKIKQKEKERLRNRTCLELKVKDKEKTKHAPTESKS---KELTRSRSSELTDVYSKEKQSKD 1140
Cdd:pfam02463  601 PILNLAQLD------KATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLrkgVSLEEGLAEKSEVKASLSELTKE 674
                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1907121721 1141 VGSNRSQSVDNRNVLNLGKPSYISESGSNRSPRSEGE 1177
Cdd:pfam02463  675 LLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
185-256 1.11e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.40  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  185 GETPLHMAAIRGDVKQVKELISLGANVNV--------------KDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLD 250
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgpknLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                   ....*.
gi 1907121721  251 DDTPLH 256
Cdd:cd22192    169 GNTVLH 174
PHA02874 PHA02874
ankyrin repeat protein; Provisional
201-288 1.17e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 1.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  201 VKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQA 280
Cdd:PHA02874   107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                   ....*...
gi 1907121721  281 NKHGERPV 288
Cdd:PHA02874   187 DNNGESPL 194
PHA02876 PHA02876
ankyrin repeat protein; Provisional
165-276 1.27e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.45  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  165 KKTPSSSSRQKDKINKRNErgetplHMAAIRGDVKQ-----VKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIA 239
Cdd:PHA02876   126 KEAISGNDIHYDKINESIE------YMKLIKERIQQdelliAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLS 199
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907121721  240 AGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGN 276
Cdd:PHA02876   200 YGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN 236
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
234-291 1.37e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 1.37e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907121721  234 AKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
218-245 1.38e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.43  E-value: 1.38e-05
                           10        20
                   ....*....|....*....|....*....
gi 1907121721  218 GWTPLHEAC-NVGYYDVAKILIAAGADVN 245
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
181-272 1.46e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  181 RNERGETPLHMAAIRGDVK--QVKELISLGANVNVKDFAGWTPLHEAcnvGYYD---VAKILIAAGADVNTQGLDDDTPL 255
Cdd:PHA03095   218 TDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYA---AVFNnprACRRLIALGADINAVSSDGNTPL 294
                           90
                   ....*....|....*..
gi 1907121721  256 HDSASSGHRDIVKLLLR 272
Cdd:PHA03095   295 SLMVRNNNGRAVRAALA 311
PHA03095 PHA03095
ankyrin-like protein; Provisional
178-225 2.51e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 2.51e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 225
Cdd:PHA03095   250 INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLM 297
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
218-245 2.82e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 2.82e-05
                            10        20
                    ....*....|....*....|....*...
gi 1907121721   218 GWTPLHEACNVGYYDVAKILIAAGADVN 245
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
209-256 4.03e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 4.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907121721  209 ANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLH 256
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
250-277 4.25e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.25e-05
                            10        20
                    ....*....|....*....|....*...
gi 1907121721   250 DDDTPLHDSASSGHRDIVKLLLRHGGNP 277
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
184-213 4.42e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.42e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907121721   184 RGETPLHMAAIRGDVKQVKELISLGANVNV 213
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02798 PHA02798
ankyrin-like protein; Provisional
198-284 1.03e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 47.14  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  198 VKQVKELISLGANVNVKDFAGWTPLheaC----NVGYY----DVAKILIAAGADVNTQGLDDDTPLHDSASSGH---RDI 266
Cdd:PHA02798    51 TDIVKLFINLGANVNGLDNEYSTPL---CtilsNIKDYkhmlDIVKILIENGADINKKNSDGETPLYCLLSNGYinnLEI 127
                           90
                   ....*....|....*...
gi 1907121721  267 VKLLLRHGGNPFQANKHG 284
Cdd:PHA02798   128 LLFMIENGADTTLLDKDG 145
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
749-1047 1.14e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.43  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  749 SLREEKVKDPKEEKDSVSTEKEAECCSVgvsvsQEAAGLHSSEKEMDAE---------KQERHTKEREKSDRRFQTKEKE 819
Cdd:pfam17380  285 SERQQQEKFEKMEQERLRQEKEEKAREV-----ERRRKLEEAEKARQAEmdrqaaiyaEQERMAMERERELERIRQEERK 359
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  820 LDRNERKFSEKEKKIKHEHKSEREKLDFSDCTDRVRE------KDKLYSHQTERCHKDSEKLKNTVRKTDDRERNR---- 889
Cdd:pfam17380  360 RELERIRQEEIAMEISRMRELERLQMERQQKNERVRQeleaarKVKILEEERQRKIQQQKVEMEQIRAEQEEARQRevrr 439
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  890 --EKADRKHDR---EKPERERYLAENKEKHLEKRKQSDSSEYSKSEKVRTKDRDR---------------EGEKKEKLRD 949
Cdd:pfam17380  440 leEERAREMERvrlEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRkilekeleerkqamiEEERKRKLLE 519
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  950 KESVNVTNLKHLQEERKSSTGDSSGKTQHEKALSLKERAR--DEPLKTPDGKEKDKKDIDRYKERDKRKDKAQLNTLIrl 1027
Cdd:pfam17380  520 KEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRkaTEERSRLEAMEREREMMRQIVESEKARAEYEATTPI-- 597
                          330       340
                   ....*....|....*....|
gi 1907121721 1028 ksetEKLKPKLSPASKDTRP 1047
Cdd:pfam17380  598 ----TTIKPIYRPRISEYQP 613
PHA03095 PHA03095
ankyrin-like protein; Provisional
181-277 1.54e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 1.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  181 RNERGETPLHMAA--IRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKI--LIAAGADVNTQGLDDDTPLH 256
Cdd:PHA03095   183 VDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLH 262
                           90       100
                   ....*....|....*....|.
gi 1907121721  257 DSASSGHRDIVKLLLRHGGNP 277
Cdd:PHA03095   263 YAAVFNNPRACRRLIALGADI 283
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
250-282 1.98e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 1.98e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907121721  250 DDDTPLHDSA-SSGHRDIVKLLLRHGGNPFQANK 282
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
192-270 2.63e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 2.63e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907121721  192 AAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLL 270
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-215 2.85e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 2.85e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907121721  176 DKINKRN-ERGETPLHMAAIRGDVKQVKELISLGANVNVKD 215
Cdd:pfam12796   51 EHADVNLkDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
184-213 3.99e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 3.99e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907121721  184 RGETPLHMAAIRGDVKQVKELISLGANVNV 213
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
218-246 4.28e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.16  E-value: 4.28e-04
                           10        20
                   ....*....|....*....|....*....
gi 1907121721  218 GWTPLHEACNVGYYDVAKILIAAGADVNT 246
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
782-1064 7.38e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 44.73  E-value: 7.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  782 QEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFSEKEKKIKHEHKSEREKLDFSDCTDRVREKDKly 861
Cdd:pfam17380  281 QKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEER-- 358
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  862 SHQTERCHKDS-----------EKLKNTVRKTDDRERNREKADRKHDREKPERERYLAENKEKHLEKRKQsdsSEYSKSE 930
Cdd:pfam17380  359 KRELERIRQEEiameisrmrelERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAE---QEEARQR 435
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  931 KVRTKDRDREGEkKEKLRDKE---SVNVTNLKHLQEERKSStgdssgKTQHEKALSLKERARDEPLKTPDGKEKDKKDID 1007
Cdd:pfam17380  436 EVRRLEEERARE-MERVRLEEqerQQQVERLRQQEEERKRK------KLELEKEKRDRKRAEEQRRKILEKELEERKQAM 508
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907121721 1008 RYKERDKRKDKAQLNTLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDLMQTSFER 1064
Cdd:pfam17380  509 IEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEER 565
PHA02874 PHA02874
ankyrin repeat protein; Provisional
178-291 1.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  178 INKRNERGETPLhMAAIR-GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILI------------------ 238
Cdd:PHA02874    28 INISVDETTTPL-IDAIRsGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdngvdtsilpipciekdm 106
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907121721  239 -----AAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 291
Cdd:PHA02874   107 iktilDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIA 164
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
841-965 1.24e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 43.75  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  841 EREKL-DFSDCTDRVREKDKLySHQTERCHKDSEKLKNTvRKTDDRERNREKADRKHDREKPERERYLAENKEK-HLEKR 918
Cdd:TIGR01622    6 ERERLrDSSSAGDRDRRRDKG-RERSRDRSRDRERSRSR-RRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRrRGDSY 83
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1907121721  919 KQSDSSEYSKSEKVRTKDRDREGEKKEKlRDKESVNVTNLKHLQEER 965
Cdd:TIGR01622   84 RRRRDDRRSRREKPRARDGTPEPLTEDE-RDRRTVFVQQLAARARER 129
Ank_4 pfam13637
Ankyrin repeats (many copies);
178-205 1.37e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 1.37e-03
                           10        20
                   ....*....|....*....|....*...
gi 1907121721  178 INKRNERGETPLHMAAIRGDVKQVKELI 205
Cdd:pfam13637   27 INAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
185-277 2.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 2.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  185 GETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD-DTPLHDSASSGH 263
Cdd:PHA02875    35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKK 114
                           90
                   ....*....|....
gi 1907121721  264 RDIVKLLLRHGGNP 277
Cdd:PHA02875   115 LDIMKLLIARGADP 128
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
672-1057 3.68e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 42.65  E-value: 3.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  672 KELQRSIEFDREFWKENFFKSDETEDLFLTMEHESIIEKKTKMEKNMKDDRSAKEKHVSKERNFKEEREKTKKENEKSLR 751
Cdd:pfam02463  632 TELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  752 EEKVKDPKEE-KDSVSTEKEAEccsvgVSVSQEAAGLHSSEKEMDAEKQERHTKEREKSDRRFQTKEKELDRNERKFsek 830
Cdd:pfam02463  712 LKKLKLEAEElLADRVQEAQDK-----INEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKT--- 783
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  831 ekKIKHEHKSEREKLDFSDCTDRVREKDKLYSHQTErchkdseklkntvrKTDDRERNREKADRKHDREKPERERYLAEN 910
Cdd:pfam02463  784 --EKLKVEEEKEEKLKAQEEELRALEEELKEEAELL--------------EEEQLLIEQEEKIKEEELEELALELKEEQK 847
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907121721  911 KEKHLEKRKQSDSSEYSKSEKVRTKDRDREGEKKEKLRDKESVNVTNLKH-LQEERKSSTGDSSGKTQHEKALSLKERAR 989
Cdd:pfam02463  848 LEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEeKKELEEESQKLNLLEEKENEIEERIKEEA 927
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907121721  990 DEPLKTPDGKEKDKKDIDRYKERDKRKDKAQLNTLIRLKSETEKLKPKLSPASKDTRPKEKRLVNDDL 1057
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDEL 995
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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