NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907124229|ref|XP_036016474|]
View 

zinc finger protein 52 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-536 1.19e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 105 KPYQCGHCRKYFSTTSSLSIHQRIHTGEKPYKCN--ICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLlvQLSALKSHQ 182
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 183 RRHTGEKPYKCQQCD-RSFAHCASLRWHQKIHSPEIHYECKE--------CGKSCFELSHLKRHcrIHTAEKPYRYEVCD 253
Cdd:COG5048   110 LSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvNTPQSNSLHPPLPA--NSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 254 TSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLrtyqrvhtgkRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKC 333
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS----------SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 334 KDCDKSFLrissvrirqkihagerryrckeCGRSFTWFSNLRVHQRVHTGER-PYRCKECGKSFTTGSNLRVHQ--KIHT 410
Cdd:COG5048   258 SESPRSSL----------------------PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 411 GE--KPYKC--KDCDISFLWISNLRTHQKIHTGEKPYKC--QECNKSFTRCS------YLRDHQKIHTGEKLYKCKDCDI 478
Cdd:COG5048   316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSNSCI 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907124229 479 SFMW---ISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISF 536
Cdd:COG5048   396 RNFKrdsNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
569-594 1.06e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 569 NLRTHQKIHTGEKPYKCQECNKSFTR 594
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-564 3.77e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.77e-03
                          10        20
                  ....*....|....*....|....
gi 1907124229 541 SLRRHQKIHTGEKPYKCKDCDISF 564
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-536 1.19e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 105 KPYQCGHCRKYFSTTSSLSIHQRIHTGEKPYKCN--ICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLlvQLSALKSHQ 182
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 183 RRHTGEKPYKCQQCD-RSFAHCASLRWHQKIHSPEIHYECKE--------CGKSCFELSHLKRHcrIHTAEKPYRYEVCD 253
Cdd:COG5048   110 LSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvNTPQSNSLHPPLPA--NSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 254 TSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLrtyqrvhtgkRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKC 333
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS----------SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 334 KDCDKSFLrissvrirqkihagerryrckeCGRSFTWFSNLRVHQRVHTGER-PYRCKECGKSFTTGSNLRVHQ--KIHT 410
Cdd:COG5048   258 SESPRSSL----------------------PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 411 GE--KPYKC--KDCDISFLWISNLRTHQKIHTGEKPYKC--QECNKSFTRCS------YLRDHQKIHTGEKLYKCKDCDI 478
Cdd:COG5048   316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSNSCI 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907124229 479 SFMW---ISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISF 536
Cdd:COG5048   396 RNFKrdsNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-202 7.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 177 ALKSHQRRHTGEKPYKCQQCDRSFAH 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
569-594 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 569 NLRTHQKIHTGEKPYKCQECNKSFTR 594
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 361-409 1.78e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907124229 361 CKECGRSFTWFSNLRVHQRVHTgerpYRCKECGKSFTTGSNLRVH-QKIH 409
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-564 3.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.77e-03
                          10        20
                  ....*....|....*....|....
gi 1907124229 541 SLRRHQKIHTGEKPYKCKDCDISF 564
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-536 1.19e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 105 KPYQCGHCRKYFSTTSSLSIHQRIHTGEKPYKCN--ICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLlvQLSALKSHQ 182
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 183 RRHTGEKPYKCQQCD-RSFAHCASLRWHQKIHSPEIHYECKE--------CGKSCFELSHLKRHcrIHTAEKPYRYEVCD 253
Cdd:COG5048   110 LSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvNTPQSNSLHPPLPA--NSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 254 TSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLrtyqrvhtgkRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKC 333
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS----------SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 334 KDCDKSFLrissvrirqkihagerryrckeCGRSFTWFSNLRVHQRVHTGER-PYRCKECGKSFTTGSNLRVHQ--KIHT 410
Cdd:COG5048   258 SESPRSSL----------------------PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 411 GE--KPYKC--KDCDISFLWISNLRTHQKIHTGEKPYKC--QECNKSFTRCS------YLRDHQKIHTGEKLYKCKDCDI 478
Cdd:COG5048   316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSNSCI 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907124229 479 SFMW---ISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISF 536
Cdd:COG5048   396 RNFKrdsNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
243-634 4.97e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 243 AEKPYRYEVCDTSITVNSTLKTHHKIHTREKPY--RYRECDKSITKCSYLRTYQRVHTGKRPYRCteCDKFFTKHSNLRQ 320
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 321 HQKIHTGEKPPKCKDCDKSFLRISSVRIRQKIHAGERRYRCKECGRSFTWFSNLRVHQRVHTgerPYRCKECGKSFTTGS 400
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 401 NLRVHQKIHTGEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECNKSFTRCSYLRDHQKIHTGEKLYKCKDCDISF 480
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 481 MWISSLRRHQKIHTGE-------KPYKCRGCEKSFTQCSTLRDHQ--KIHTGE--KPYKC--KDCGISFLWISSLRRHQK 547
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 548 IHTGEKPYKCKDC----DISFLWISNLRTHQKIHTGEKPYKCQE-----CNKSFTRCSYLRVHQRTHSGEKLYKCEN--C 616
Cdd:COG5048   345 LHTSISPAKEKLLnsssKFSPLLNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNppC 424

                         410
                  ....*....|....*...
gi 1907124229 617 DVSFMWISNLRRHQKIHT 634
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-621 1.06e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 189 KPYKCQQCDRSFAHCASLRWHQKIHSPEIHYEC--KECGKSCFELSHLKRHCRIHTAEKPYRyeVCDTSITVNSTL---K 263
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL--NSKSLPLSNSKAsssS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 264 THHKIHTREKPYRYRECDKSITKCSYLRTYQRVHTGKRPYRCTEC--DKFFTKHSNLRQHQKIHTGEKPPKCKDcdksfl 341
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNTPQSNSLHPPLPANSLSKDPSSN------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 342 riSSVRIRQKIHAGERRYRCKECGRSFTWFSNLRVHQRVHTGERPYRCKECGKSFTTGSNLRVHQKIHTGEKPYKCKDCD 421
Cdd:COG5048   184 --LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 422 ISFLWISNLRTHQKIHTGE-------KPYKCQECNKSFTRCSYLRDHQ--KIHTGEKLYKC----KDCDISFMWISSLRR 488
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFscpySLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 489 HQKIHTGEKPYKC--RGCEKSFTQCSTLRDHQKI--HTGEKPYKCKDCGISFLWISSLRRHqkihtgekpykckdcdisf 564
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS------------------- 402

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907124229 565 lwISNLRTHQKIHTGEKPYKCQECNKSFTRCSYLRVHQRTHSGEKLYKCENCDVSFM 621
Cdd:COG5048   403 --NLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-202 7.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 177 ALKSHQRRHTGEKPYKCQQCDRSFAH 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-510 9.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 485 SLRRHQKIHTGEKPYKCRGCEKSFTQ 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-454 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 429 NLRTHQKIHTGEKPYKCQECNKSFTR 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
569-594 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 569 NLRTHQKIHTGEKPYKCQECNKSFTR 594
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-398 1.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 373 NLRVHQRVHTGERPYRCKECGKSFTT 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 361-409 1.78e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907124229 361 CKECGRSFTWFSNLRVHQRVHTgerpYRCKECGKSFTTGSNLRVH-QKIH 409
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 98-214 3.62e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229  98 ETVDMEEKPYQCGHCRKYFSTTSSLSIH---QRIHT-GEKPYKCNI--CGKSFNQWSSLKtdqtlhtakkpYKCKEG--G 169
Cdd:COG5189   309 EMIDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLK-----------YHMLHGhqN 377

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907124229 170 KLLVQLSALKSHQRRHTGEKPYKCQQCDRSFAHCASLRWHQKiHS 214
Cdd:COG5189   378 QKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
121-146 3.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124229 121 SLSIHQRIHTGEKPYKCNICGKSFNQ 146
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-564 3.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.77e-03
                          10        20
                  ....*....|....*....|....
gi 1907124229 541 SLRRHQKIHTGEKPYKCKDCDISF 564
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 439-519 5.53e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124229 439 GEKPYKCQ--ECNKSFTRCSYLRDHQKI-HTGEKLYKCKDCDisfmwisslrRHQKIHTGEKPYKCRGCEKSFTQCSTLR 515
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPE----------KMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....
gi 1907124229 516 DHQK 519
Cdd:COG5189   416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-424 8.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....
gi 1907124229 401 NLRVHQKIHTGEKPYKCKDCDISF 424
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH