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Conserved domains on  [gi|1907125829|ref|XP_036016646|]
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endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COPIIcoated_ERV super family cl06835
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 1-126 6.75e-37

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


The actual alignment was detected with superfamily member pfam07970:

Pssm-ID: 462327  Cd Length: 225  Bit Score: 125.80  E-value: 6.75e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125829   1 MTHTIHKLSFGDTLQVQNVhgafNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQRYSYQYTV------ANKEYVAY 74
Cdd:pfam07970 100 FSHTIHHLSFGPDIPGEKV----NPLDGTKVQTDTGNYMFQYFLKVVPTRYEFLDGKKIETNQYSVtsherpLTGGRDEH 175

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907125829  75 SHTGriIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILD 126
Cdd:pfam07970 176 GRGG--LPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAIIGGVFTVASLID 225
 
Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 1-126 6.75e-37

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


Pssm-ID: 462327  Cd Length: 225  Bit Score: 125.80  E-value: 6.75e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125829   1 MTHTIHKLSFGDTLQVQNVhgafNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQRYSYQYTV------ANKEYVAY 74
Cdd:pfam07970 100 FSHTIHHLSFGPDIPGEKV----NPLDGTKVQTDTGNYMFQYFLKVVPTRYEFLDGKKIETNQYSVtsherpLTGGRDEH 175

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907125829  75 SHTGriIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILD 126
Cdd:pfam07970 176 GRGG--LPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAIIGGVFTVASLID 225
 
Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 1-126 6.75e-37

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


Pssm-ID: 462327  Cd Length: 225  Bit Score: 125.80  E-value: 6.75e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125829   1 MTHTIHKLSFGDTLQVQNVhgafNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQRYSYQYTV------ANKEYVAY 74
Cdd:pfam07970 100 FSHTIHHLSFGPDIPGEKV----NPLDGTKVQTDTGNYMFQYFLKVVPTRYEFLDGKKIETNQYSVtsherpLTGGRDEH 175

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907125829  75 SHTGriIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILD 126
Cdd:pfam07970 176 GRGG--LPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAIIGGVFTVASLID 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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