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Conserved domains on  [gi|1907126448|ref|XP_036016708|]
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zinc finger protein 946 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 37-74 2.18e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.18e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907126448  37 FKDVAVEFSQEEWECLDCAQRALYMDVMLENYNNLFFV 74
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-545 3.03e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 262 KPYKCNECIKSFTQKSSLKRHQRIHTGEKPYKCS--ECNKCFSHKYILIIHQKIHTGEKPYKCNA-CGKCFTLKGELRIH 338
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 339 QRIHTGEKPYKCSECDKSFTQKGQLIIHQRIHTGEKPYKCSEC----------------------DKCFIKKYSLVTHQR 396
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 397 MHTGENPYKCSECDKCFTLKSGLRIHERIHTGEKPYKCSECDKSFIKKIYLRIHQSVHigeKLYKCSECDKCFMH----- 471
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPRSslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 472 KCSLSSHQRLHTGE-----KPYKCSICDKCFTSKGYLGSHQR--IHTGE--KPYQCSE--CDKCFTHKGSLKRHERIHTG 540
Cdd:COG5048   269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348


                  ....*
gi 1907126448 541 VKLYK 545
Cdd:COG5048   349 ISPAK 353
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 37-74 2.18e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.18e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907126448  37 FKDVAVEFSQEEWECLDCAQRALYMDVMLENYNNLFFV 74
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
37-76 9.04e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 9.04e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907126448   37 FKDVAVEFSQEEWECLDCAQRALYMDVMLENYNNLFFVVF 76
Cdd:smart00349   3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-73 1.77e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.77e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907126448  35 LRFKDVAVEFSQEEWECLDCAQRALYMDVMLENYNNLFF 73
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-545 3.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 262 KPYKCNECIKSFTQKSSLKRHQRIHTGEKPYKCS--ECNKCFSHKYILIIHQKIHTGEKPYKCNA-CGKCFTLKGELRIH 338
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 339 QRIHTGEKPYKCSECDKSFTQKGQLIIHQRIHTGEKPYKCSEC----------------------DKCFIKKYSLVTHQR 396
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 397 MHTGENPYKCSECDKCFTLKSGLRIHERIHTGEKPYKCSECDKSFIKKIYLRIHQSVHigeKLYKCSECDKCFMH----- 471
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPRSslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 472 KCSLSSHQRLHTGE-----KPYKCSICDKCFTSKGYLGSHQR--IHTGE--KPYQCSE--CDKCFTHKGSLKRHERIHTG 540
Cdd:COG5048   269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348


                  ....*
gi 1907126448 541 VKLYK 545
Cdd:COG5048   349 ISPAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 3.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907126448 334 ELRIHQRIHTGEKPYKCSECDKSFTQ 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 290-342 2.70e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907126448 290 KPYkCSECNKCFSHKYILIIHQKIHTgekpYKCNACGKCFTLKGELRIH-QRIH 342
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 37-74 2.18e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.18e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907126448  37 FKDVAVEFSQEEWECLDCAQRALYMDVMLENYNNLFFV 74
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
37-76 9.04e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 9.04e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907126448   37 FKDVAVEFSQEEWECLDCAQRALYMDVMLENYNNLFFVVF 76
Cdd:smart00349   3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-73 1.77e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.77e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907126448  35 LRFKDVAVEFSQEEWECLDCAQRALYMDVMLENYNNLFF 73
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-545 3.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 262 KPYKCNECIKSFTQKSSLKRHQRIHTGEKPYKCS--ECNKCFSHKYILIIHQKIHTGEKPYKCNA-CGKCFTLKGELRIH 338
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 339 QRIHTGEKPYKCSECDKSFTQKGQLIIHQRIHTGEKPYKCSEC----------------------DKCFIKKYSLVTHQR 396
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 397 MHTGENPYKCSECDKCFTLKSGLRIHERIHTGEKPYKCSECDKSFIKKIYLRIHQSVHigeKLYKCSECDKCFMH----- 471
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPRSslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 472 KCSLSSHQRLHTGE-----KPYKCSICDKCFTSKGYLGSHQR--IHTGE--KPYQCSE--CDKCFTHKGSLKRHERIHTG 540
Cdd:COG5048   269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348


                  ....*
gi 1907126448 541 VKLYK 545
Cdd:COG5048   349 ISPAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-407 2.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 262 KPYKCNECIKSFTQKSSLKRHQR--IHTGE--KPYKCSE--CNKCFSHKYILIIHQKIHTGEKPYKCNACGKCFT----L 331
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKfsplL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 332 KGELRIHQRIHTGEKPYKCSECDKSFTQKG-------QLIIHQRIHTGEKPYKCSECDKCFIKKYSLVTHQRMHTGENPY 404
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNfkrdsnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ...
gi 1907126448 405 KCS 407
Cdd:COG5048   448 LCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-519 1.04e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 267 NECIKSFTQKSSLKRHQRIHTGEKPYKCSECNKCFSHKYILIIHQKIHTGEKPYKCNACGKCFTLKGELRIHQRIHTGEK 346
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 347 PYKCSECDKSFTQKGQLIIHQRIHTGE-------KPYKCSECDKCFIKKYSLVTHQRM--HTGEN--PYKCSE--CDKCF 413
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPYslCGKLF 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 414 TLKSGLRIHERIHTGEKPYKC--SECDKSFIKKIYLRIHQSV--HIGEKLYKCSECDkcfMHKC----------SLSSHQ 479
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETL---SNSCirnfkrdsnlSLHIIT 410

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1907126448 480 RLHTGEKPYKCSICDKCFTSKGYLGSHQRIHTGEKPYQCS 519
Cdd:COG5048   411 HLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-495 8.75e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 249 SDLRIHQPVHTRGKPYKCNECIKSFTQKSSLKRHQRIHTGEKPYKCSECNKCFSHKYILIIHQKIHTGEKPYKCNACGKC 328
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 329 FTLKGELRIHQRIHTGE-------KPYKCSECDKSFTQKGQLIIHQR--IHTGE--KPYKCSE--CDKCFIKKYSLVTHQ 395
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 396 RMHTGENPYKC--SECDKCFTLKSGLRIHERI--HTGEKPYKCSECDKSFI-------KKIYLRIHQSVHIGEKLYKCSE 464
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCirnfkrdSNLSLHIITHLSFRPYNCKNPP 423

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1907126448 465 CDKCFMHKCSLSSHQRLHTGEKPYKCSICDK 495
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 3.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907126448 334 ELRIHQRIHTGEKPYKCSECDKSFTQ 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-303 4.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907126448 278 SLKRHQRIHTGEKPYKCSECNKCFSH 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-441 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|...
gi 1907126448 419 LRIHERIHTGEKPYKCSECDKSF 441
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 290-342 2.70e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907126448 290 KPYkCSECNKCFSHKYILIIHQKIHTgekpYKCNACGKCFTLKGELRIH-QRIH 342
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-327 3.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 206 KPYKCSECEECFTQLCDLKSHQR--NHIGEKL----CKSSEHDNCFALKSDLRIHQPVHTRGKPYKC------------- 266
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpfsCPYSLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126448 267 ------------------------NECIKSFTQKSSLKRHQRIHTGEKP--YKCSECNKCFSHKYILIIHQKIHTGEKPY 320
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*..
gi 1907126448 321 KCNACGK 327
Cdd:COG5048   448 LCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-499 3.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907126448 474 SLSSHQRLHTGEKPYKCSICDKCFTS 499
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-527 4.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.16e-03
                          10        20
                  ....*....|....*....|...
gi 1907126448 505 SHQRIHTGEKPYQCSECDKCFTH 527
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-385 9.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.41e-03
                          10        20
                  ....*....|....*....|
gi 1907126448 366 HQRIHTGEKPYKCSECDKCF 385
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
390-414 9.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.70e-03
                          10        20
                  ....*....|....*....|....*
gi 1907126448 390 SLVTHQRMHTGENPYKCSECDKCFT 414
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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