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Conserved domains on  [gi|1907143724|ref|XP_036018541|]
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rRNA N6-adenosine-methyltransferase METTL5 isoform X3 [Mus musculus]

Protein Classification

METTL5 family protein( domain architecture ID 10006292)

METTL5 family protein similar to Homo sapiens methyltransferase-like protein 5 that is a catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-174 5.39e-56

Predicted RNA methylase [General function prediction only];


:

Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 174.71  E-value: 5.39e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724   7 KELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDA 86
Cdd:COG2263     2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  87 LEIFNKNVEEFElTNVDMIQCDVYSLSNrmSKLFDTVIMNPPFGTkNNKGTDMAFLKTALGMARtAVYSLHKSSTSIFKR 166
Cdd:COG2263    81 LEIARENAERLG-VRVDFIRADVTRIPL--GGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155


                  ....*...
gi 1907143724 167 KLLNGKSR 174
Cdd:COG2263   156 RFAADRGG 163
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-174 5.39e-56

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 174.71  E-value: 5.39e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724   7 KELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDA 86
Cdd:COG2263     2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  87 LEIFNKNVEEFElTNVDMIQCDVYSLSNrmSKLFDTVIMNPPFGTkNNKGTDMAFLKTALGMARtAVYSLHKSSTSIFKR 166
Cdd:COG2263    81 LEIARENAERLG-VRVDFIRADVTRIPL--GGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155


                  ....*...
gi 1907143724 167 KLLNGKSR 174
Cdd:COG2263   156 RFAADRGG 163
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-145 2.05e-13

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 64.53  E-value: 2.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  46 TYDDIENKAVADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVYslSNRMSKLFDTVI 124
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKESPDAELtMVDINARALESARENLAANGLENGEVVASDVY--SGVEDGKFDLII 103

                          90       100
                  ....*....|....*....|...
gi 1907143724 125 MNPPF--GTKNNKGTDMAFLKTA 145
Cdd:pfam05175 104 SNPPFhaGLATTYNVAQRFIADA 126
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
49-126 6.10e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 64.40  E-value: 6.10e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907143724  49 DIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNveeFELTNVDMiqcDVYSLSNrmSKLFDTVIMN 126
Cdd:PRK00517  117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAAREN---AELNGVEL---NVYLPQG--DLKADVIVAN 186
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-129 3.33e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.05  E-value: 3.33e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKLFDTVIMNPPF 129
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-174 5.39e-56

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 174.71  E-value: 5.39e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724   7 KELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDA 86
Cdd:COG2263     2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  87 LEIFNKNVEEFElTNVDMIQCDVYSLSNrmSKLFDTVIMNPPFGTkNNKGTDMAFLKTALGMARtAVYSLHKSSTSIFKR 166
Cdd:COG2263    81 LEIARENAERLG-VRVDFIRADVTRIPL--GGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155


                  ....*...
gi 1907143724 167 KLLNGKSR 174
Cdd:COG2263   156 RFAADRGG 163
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 55-146 4.08e-18

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 77.15  E-value: 4.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVYslSNRMSKLFDTVIMNPPF--GT 131
Cdd:COG2813    53 VLDLGCGYGVIGLALAKRNPEARVtLVDVNARAVELARANAAANGLENVEVLWSDGL--SGVPDGSFDLILSNPPFhaGR 130

                          90
                  ....*....|....*
gi 1907143724 132 KNNKGTDMAFLKTAL 146
Cdd:COG2813   131 AVDKEVAHALIADAA 145
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-145 2.05e-13

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 64.53  E-value: 2.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  46 TYDDIENKAVADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVYslSNRMSKLFDTVI 124
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKESPDAELtMVDINARALESARENLAANGLENGEVVASDVY--SGVEDGKFDLII 103

                          90       100
                  ....*....|....*....|...
gi 1907143724 125 MNPPF--GTKNNKGTDMAFLKTA 145
Cdd:pfam05175 104 SNPPFhaGLATTYNVAQRFIADA 126
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
49-95 5.38e-13

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 65.19  E-value: 5.38e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907143724  49 DIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE 95
Cdd:COG2264   146 LKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVDIDPVAVEAARENAE 192
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
49-126 6.10e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 64.40  E-value: 6.10e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907143724  49 DIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNveeFELTNVDMiqcDVYSLSNrmSKLFDTVIMN 126
Cdd:PRK00517  117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAAREN---AELNGVEL---NVYLPQG--DLKADVIVAN 186
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 55-129 7.54e-12

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 61.31  E-value: 7.54e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907143724  55 VADLGCGCGVLSIG-AAMLGAGLCVGFDIDEDALEIFNKNVEEFELTN-VDMIQCDVYSLSNRM-SKLFDTVIMNPPF 129
Cdd:COG4123    41 VLDLGTGTGVIALMlAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELpPGSFDLVVSNPPY 118
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-129 3.33e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.05  E-value: 3.33e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKLFDTVIMNPPF 129
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 51-126 7.27e-11

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 59.20  E-value: 7.27e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907143724  51 ENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNveeFELTNVDMiQCDVYSLSNRMSKLFDTVIMN 126
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKEN---AELNGVEA-RLEVYLPGDLPKEKADVVVAN 232
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-126 1.90e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.88  E-value: 1.90e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELtNVDMIQCDVYSLSNRMSKlFDTVIMN 126
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFPDGS-FDLVVSS 70
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 51-128 6.83e-10

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 56.32  E-value: 6.83e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907143724  51 ENKAVADLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQCDVysLSNRMSKLFDTVIMNPP 128
Cdd:PRK09328  108 EPLRVLDLGTGSGAIALALAKERPDAEVtAVDISPEALAVARRNAKHGLGARVEFLQGDW--FEPLPGGRFDLIVSNPP 184
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 51-126 2.80e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.33  E-value: 2.80e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907143724  51 ENKAVADLGCGCGVLSIGAAMLGAgLCVGFDIDEDALEIFNKNVEEFeltNVDMIQCDVYSLSNRMSKlFDTVIMN 126
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGS-FDLVICS 94
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 48-128 3.57e-09

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 54.39  E-value: 3.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  48 DDIENKAVADLGCGCGVLSIG-AAMLGAGLCVGFDIDEDALEIFNKNVEEFELTN-VDMIQCDVYS-LSNRMSklFDTVI 124
Cdd:COG2890   109 PAGAPPRVLDLGTGSGAIALAlAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEpLPGDGR--FDLIV 186


                  ....
gi 1907143724 125 MNPP 128
Cdd:COG2890   187 SNPP 190
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 55-126 2.52e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.07  E-value: 2.52e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKLFDTVIMN 126
Cdd:COG0500    30 VLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPLPAESFDLVVAF 101
PRK14968 PRK14968
putative methyltransferase; Provisional
 49-129 6.31e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 49.90  E-value: 6.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  49 DIENKAVADLGCGCGVLSIGAAMLGAGLcVGFDIDEDALEIFNKNVEEFELTN--VDMIQCDVysLSNRMSKLFDTVIMN 126
Cdd:PRK14968   21 DKKGDRVLEVGTGSGIVAIVAAKNGKKV-VGVDINPYAVECAKCNAKLNNIRNngVEVIRSDL--FEPFRGDKFDVILFN 97


                  ...
gi 1907143724 127 PPF 129
Cdd:PRK14968   98 PPY 100
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 51-126 1.11e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.57  E-value: 1.11e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907143724  51 ENKAVADLGCGCGVLSIGAAMLGAGLC--VGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKL-FDTVIMN 126
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAevVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEDDkFDVVISN 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 51-126 2.60e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 2.60e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907143724  51 ENKAVADLGCGCGVLSIGAAMLGAgLCVGFDIDEDALEIFNKNVEEFELtNVDMIQCDVYSL---SNRmsklFDTVIMN 126
Cdd:COG2226    22 PGARVLDLGCGTGRLALALAERGA-RVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLpfpDGS----FDLVISS 94
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 48-128 4.31e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 48.63  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  48 DDIENKAVADLGCGCGVLSIGAAmLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKL--FDTVIM 125
Cdd:COG2265   230 DLTGGERVLDLYCGVGTFALPLA-RRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLWGgrPDVVVL 308


                  ...
gi 1907143724 126 NPP 128
Cdd:COG2265   309 DPP 311
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 47-95 3.02e-06

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 45.65  E-value: 3.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907143724  47 YDDIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE 95
Cdd:COG3897    66 HPEVAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRLNAA 114
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
51-124 9.74e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 44.26  E-value: 9.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907143724  51 ENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELT-NVDMIQCDVYSLsnRMSKLFDTVI 124
Cdd:COG4076    35 PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINADATDL--DLPEKADVII 107
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
55-151 4.40e-05

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 42.62  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  55 VADLGCGCGVLsigAAMLGAG-------LCvgfDIDEDALEIFNKNVEEFELTNvDMIQCDVYS-LSNRmsklFDTVIMN 126
Cdd:PRK09489  200 VLDVGCGAGVL---SAVLARHspkirltLS---DVSAAALESSRATLAANGLEG-EVFASNVFSdIKGR----FDMIISN 268

                          90       100
                  ....*....|....*....|....*
gi 1907143724 127 PPFgtknNKGtdmafLKTALGMART 151
Cdd:PRK09489  269 PPF----HDG-----IQTSLDAAQT 284
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 57-106 8.28e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 41.69  E-value: 8.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907143724  57 DLGCGCGVLSIGAAMLGAGLCV-GFDIDEDALEIFNKNVEEFELTNVDMIQ 106
Cdd:COG2242   253 DIGAGSGSVSIEAARLAPGGRVyAIERDPERAALIRANARRFGVPNVEVVE 303
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 55-121 1.06e-04

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 40.94  E-value: 1.06e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  55 VADLGCGCGVLSIGAAML-GAGLCV-GFDIDEDALEIFNKNVEEF-ELTNVDMIQCDVYSLSNRMSKLFD 121
Cdd:PRK00377   44 ILDIGCGTGSVTVEASLLvGETGKVyAVDKDEKAINLTRRNAEKFgVLNNIVLIKGEAPEILFTINEKFD 113
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 30-130 1.27e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 40.42  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  30 PTRPHIAACMLYTIHNTYDDienkAVADLGCGCGVLSIGAAMLGA------------GLCVGFDIDEDALEIFNKNVEEF 97
Cdd:pfam01170  11 PLKETLAAAMVNLAGWKPGD----PLLDPMCGSGTILIEAALMGAniapgkfdarvrAPLYGSDIDRRMVQGARLNAENA 86

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907143724  98 ELTN-VDMIQCDVYSLSnRMSKLFDTVIMNPPFG 130
Cdd:pfam01170  87 GVGDlIEFVQADAADLP-LLEGSVDVIVTNPPYG 119
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-126 1.98e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.89  E-value: 1.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907143724  57 DLGCGCGVLSIGAAMLGAGL-CVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKLFDTVIMN 126
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLeYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVAS 72
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
10-126 3.18e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 39.60  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  10 ESRLQEVDGFEKPKLLLEQyptrphiaacmlytIHNTYDDIENKAVADLGCGCGVLsiGAAMLGAGLCV-GFDIDEDALE 88
Cdd:COG4976    19 DAALVEDLGYEAPALLAEE--------------LLARLPPGPFGRVLDLGCGTGLL--GEALRPRGYRLtGVDLSEEMLA 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907143724  89 IFNKNVEEFELTNVDMiqCDVYSLSNRmsklFDTVIMN 126
Cdd:COG4976    83 KAREKGVYDRLLVADL--ADLAEPDGR----FDLIVAA 114
PRK14967 PRK14967
putative methyltransferase; Provisional
 55-129 4.20e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.27  E-value: 4.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTnVDMIQCDVYSLSNRMSklFDTVIMNPPF 129
Cdd:PRK14967   40 VLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVD-VDVRRGDWARAVEFRP--FDVVVSNPPY 111
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
50-128 5.03e-04

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 39.43  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  50 IENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVE--EFELTNVDMIQCDVYSLSNRM---SKLFDTVI 124
Cdd:PRK15128  219 VENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVElnKLDLSKAEFVRDDVFKLLRTYrdrGEKFDVIV 298


                  ....
gi 1907143724 125 MNPP 128
Cdd:PRK15128  299 MDPP 302
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 55-108 6.70e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.37  E-value: 6.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTN-VDMIQCD 108
Cdd:COG2230    55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLAD 109
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
55-103 7.43e-04

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 38.64  E-value: 7.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVD 103
Cdd:COG0270     6 VIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVIEGD 54
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 78-130 9.17e-04

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 38.54  E-value: 9.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907143724  78 VGFDIDEDALEIFNKNVEEFELTN-VDMIQCDVYSLSNRMSKlfDTVIMNPPFG 130
Cdd:COG0116   254 FGSDIDPRAIEAARENAERAGVADlIEFEQADFRDLEPPAEP--GLIITNPPYG 305
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
79-136 1.25e-03

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 37.86  E-value: 1.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907143724  79 GFDIDEDALEI--FN---KNVEEFELTNVDmiqcdvySLSNRMSKL--FDTVIMNPPFGTKNNKG 136
Cdd:COG0286    80 GQEINPTTYRLakMNlllHGIGDPNIELGD-------TLSNDGDELekFDVVLANPPFGGKWKKE 137
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 55-128 3.49e-03

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 36.83  E-value: 3.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNveeFeltNVDMIQCDVYSLSNRMSKL-FDTVIMNPP 128
Cdd:cd00315     3 VIDLFAGIGGFRLGLEKAGFEIVAANEIDKSAAETYEAN---F---PNKLIEGDITKIDEKDFIPdIDLLTGGFP 71
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 51-131 5.60e-03

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 36.39  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907143724  51 ENKAVADLGCGCGVLSIGAAmLGAGLCVGF-DIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKLFDTVIMNpPF 129
Cdd:COG1867    57 REISYLDALAASGIRGLRYA-LEVGIKVTLnDIDPEAVELIRENLELNGLEDVEVYNRDANALLHELGRRFDVVDLD-PF 134


                  ..
gi 1907143724 130 GT 131
Cdd:COG1867   135 GS 136
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
55-105 8.29e-03

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 35.75  E-value: 8.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907143724  55 VADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKN-----------VEEFELTNVDMI 105
Cdd:pfam00145   3 FIDLFAGIGGFRLGLEQAGFECVAANEIDKSAAKTYEANfpkvpigditlIDIKDIPDIDIL 64
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
55-126 8.47e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 34.41  E-value: 8.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907143724  55 VADLGCGCGVLSIG-AAMLGAGLCVGFDIDEDALEIFNKNveefeLTNVDMIQCDVYSLsnRMSKLFDTVIMN 126
Cdd:COG4106     5 VLDLGCGTGRLTALlAERFPGARVTGVDLSPEMLARARAR-----LPNVRFVVADLRDL--DPPEPFDLVVSN 70
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 47-124 8.99e-03

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 35.58  E-value: 8.99e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907143724  47 YDDIENKAVADLGCGCGVLSIGAAMLGAGLcVGFDIDEDALEIFNKNV-EEFELTNVDMIQCDVYSLSNRmsklFDTVI 124
Cdd:PRK07580   59 DGDLTGLRILDAGCGVGSLSIPLARRGAKV-VASDISPQMVEEARERApEAGLAGNITFEVGDLESLLGR----FDTVV 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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