rRNA N6-adenosine-methyltransferase METTL5 isoform X4 [Mus musculus]
METTL5 family protein( domain architecture ID 10006292)
METTL5 family protein similar to Homo sapiens methyltransferase-like protein 5 that is a catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA
List of domain hits
Name | Accession | Description | Interval | E-value | |||
COG2263 | COG2263 | Predicted RNA methylase [General function prediction only]; |
7-130 | 3.16e-46 | |||
Predicted RNA methylase [General function prediction only]; : Pssm-ID: 441864 [Multi-domain] Cd Length: 199 Bit Score: 148.51 E-value: 3.16e-46
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Name | Accession | Description | Interval | E-value | |||
COG2263 | COG2263 | Predicted RNA methylase [General function prediction only]; |
7-130 | 3.16e-46 | |||
Predicted RNA methylase [General function prediction only]; Pssm-ID: 441864 [Multi-domain] Cd Length: 199 Bit Score: 148.51 E-value: 3.16e-46
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prmA | PRK00517 | 50S ribosomal protein L11 methyltransferase; |
49-126 | 3.04e-13 | |||
50S ribosomal protein L11 methyltransferase; Pssm-ID: 234786 [Multi-domain] Cd Length: 250 Bit Score: 64.40 E-value: 3.04e-13
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MTS | pfam05175 | Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ... |
46-129 | 5.18e-13 | |||
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases. Pssm-ID: 428349 [Multi-domain] Cd Length: 170 Bit Score: 62.61 E-value: 5.18e-13
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AdoMet_MTases | cd02440 | S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
55-129 | 2.15e-11 | |||
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.). Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 56.67 E-value: 2.15e-11
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Name | Accession | Description | Interval | E-value | |||
COG2263 | COG2263 | Predicted RNA methylase [General function prediction only]; |
7-130 | 3.16e-46 | |||
Predicted RNA methylase [General function prediction only]; Pssm-ID: 441864 [Multi-domain] Cd Length: 199 Bit Score: 148.51 E-value: 3.16e-46
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RsmC | COG2813 | 16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
55-136 | 5.57e-17 | |||
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 73.30 E-value: 5.57e-17
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PrmA | COG2264 | Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis]; |
49-95 | 2.27e-13 | |||
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441865 [Multi-domain] Cd Length: 284 Bit Score: 65.19 E-value: 2.27e-13
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prmA | PRK00517 | 50S ribosomal protein L11 methyltransferase; |
49-126 | 3.04e-13 | |||
50S ribosomal protein L11 methyltransferase; Pssm-ID: 234786 [Multi-domain] Cd Length: 250 Bit Score: 64.40 E-value: 3.04e-13
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MTS | pfam05175 | Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ... |
46-129 | 5.18e-13 | |||
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases. Pssm-ID: 428349 [Multi-domain] Cd Length: 170 Bit Score: 62.61 E-value: 5.18e-13
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TrmN6 | COG4123 | tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
55-129 | 3.31e-12 | |||
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 61.31 E-value: 3.31e-12
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AdoMet_MTases | cd02440 | S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
55-129 | 2.15e-11 | |||
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.). Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 56.67 E-value: 2.15e-11
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PrmA | pfam06325 | Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ... |
51-126 | 3.23e-11 | |||
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences. Pssm-ID: 428888 [Multi-domain] Cd Length: 294 Bit Score: 59.20 E-value: 3.23e-11
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Methyltransf_25 | pfam13649 | Methyltransferase domain; This family appears to be a methyltransferase domain. |
55-126 | 9.14e-11 | |||
Methyltransferase domain; This family appears to be a methyltransferase domain. Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 54.88 E-value: 9.14e-11
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PRK09328 | PRK09328 | N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional |
51-128 | 3.13e-10 | |||
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional Pssm-ID: 236467 [Multi-domain] Cd Length: 275 Bit Score: 56.32 E-value: 3.13e-10
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UbiG | COG2227 | 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
51-126 | 1.38e-09 | |||
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 52.33 E-value: 1.38e-09
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HemK | COG2890 | Methylase of polypeptide chain release factors [Translation, ribosomal structure and ... |
48-128 | 1.66e-09 | |||
Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Pssm-ID: 442135 [Multi-domain] Cd Length: 282 Bit Score: 54.39 E-value: 1.66e-09
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SmtA | COG0500 | SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
55-126 | 1.25e-08 | |||
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]; Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 51.07 E-value: 1.25e-08
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PRK14968 | PRK14968 | putative methyltransferase; Provisional |
49-129 | 6.09e-08 | |||
putative methyltransferase; Provisional Pssm-ID: 237872 [Multi-domain] Cd Length: 188 Bit Score: 49.13 E-value: 6.09e-08
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Methyltransf_31 | pfam13847 | Methyltransferase domain; This family appears to have methyltransferase activity. |
51-126 | 1.31e-07 | |||
Methyltransferase domain; This family appears to have methyltransferase activity. Pssm-ID: 463998 [Multi-domain] Cd Length: 150 Bit Score: 47.80 E-value: 1.31e-07
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UbiE | COG2226 | Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
51-126 | 1.37e-07 | |||
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 47.68 E-value: 1.37e-07
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TrmA | COG2265 | tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ... |
48-128 | 2.07e-07 | |||
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 441866 [Multi-domain] Cd Length: 377 Bit Score: 48.63 E-value: 2.07e-07
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Nnt1 | COG3897 | Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ... |
47-95 | 1.59e-06 | |||
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443104 [Multi-domain] Cd Length: 216 Bit Score: 45.65 E-value: 1.59e-06
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COG4076 | COG4076 | Predicted RNA methylase [General function prediction only]; |
51-124 | 5.21e-06 | |||
Predicted RNA methylase [General function prediction only]; Pssm-ID: 443253 [Multi-domain] Cd Length: 230 Bit Score: 44.26 E-value: 5.21e-06
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CobL | COG2242 | Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ... |
57-106 | 4.30e-05 | |||
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 441843 [Multi-domain] Cd Length: 403 Bit Score: 41.69 E-value: 4.30e-05
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cbiT | PRK00377 | cobalt-precorrin-6Y C(15)-methyltransferase; Provisional |
55-121 | 4.83e-05 | |||
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional Pssm-ID: 234740 Cd Length: 198 Bit Score: 41.32 E-value: 4.83e-05
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rsmC | PRK09489 | 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC; |
55-129 | 5.17e-05 | |||
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC; Pssm-ID: 181902 [Multi-domain] Cd Length: 342 Bit Score: 41.46 E-value: 5.17e-05
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UPF0020 | pfam01170 | Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ... |
30-130 | 7.34e-05 | |||
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains. Pssm-ID: 395932 [Multi-domain] Cd Length: 184 Bit Score: 40.42 E-value: 7.34e-05
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Methyltransf_12 | pfam08242 | Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
57-126 | 1.09e-04 | |||
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 38.89 E-value: 1.09e-04
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COG4976 | COG4976 | Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
10-126 | 1.48e-04 | |||
Predicted methyltransferase, contains TPR repeat [General function prediction only]; Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 39.60 E-value: 1.48e-04
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PRK14967 | PRK14967 | putative methyltransferase; Provisional |
55-129 | 2.40e-04 | |||
putative methyltransferase; Provisional Pssm-ID: 184931 [Multi-domain] Cd Length: 223 Bit Score: 39.27 E-value: 2.40e-04
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PRK15128 | PRK15128 | 23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI; |
50-128 | 2.71e-04 | |||
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI; Pssm-ID: 185082 [Multi-domain] Cd Length: 396 Bit Score: 39.43 E-value: 2.71e-04
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Cfa | COG2230 | Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
55-108 | 4.05e-04 | |||
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism]; Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 38.37 E-value: 4.05e-04
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Dcm | COG0270 | DNA-cytosine methylase [Replication, recombination and repair]; |
55-103 | 4.16e-04 | |||
DNA-cytosine methylase [Replication, recombination and repair]; Pssm-ID: 440040 [Multi-domain] Cd Length: 277 Bit Score: 38.64 E-value: 4.16e-04
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RlmL | COG0116 | 23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ... |
78-130 | 4.99e-04 | |||
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification Pssm-ID: 439886 [Multi-domain] Cd Length: 369 Bit Score: 38.54 E-value: 4.99e-04
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HsdM | COG0286 | Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]; |
79-135 | 6.66e-04 | |||
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]; Pssm-ID: 440055 [Multi-domain] Cd Length: 243 Bit Score: 38.24 E-value: 6.66e-04
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Cyt_C5_DNA_methylase | cd00315 | Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ... |
55-128 | 2.15e-03 | |||
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability. Pssm-ID: 238192 [Multi-domain] Cd Length: 275 Bit Score: 36.83 E-value: 2.15e-03
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TRM1 | COG1867 | tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ... |
51-131 | 3.15e-03 | |||
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 441472 Cd Length: 383 Bit Score: 36.39 E-value: 3.15e-03
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DNA_methylase | pfam00145 | C-5 cytosine-specific DNA methylase; |
55-105 | 5.16e-03 | |||
C-5 cytosine-specific DNA methylase; Pssm-ID: 395093 [Multi-domain] Cd Length: 324 Bit Score: 35.75 E-value: 5.16e-03
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PRK07580 | PRK07580 | Mg-protoporphyrin IX methyl transferase; Validated |
47-124 | 5.39e-03 | |||
Mg-protoporphyrin IX methyl transferase; Validated Pssm-ID: 236059 [Multi-domain] Cd Length: 230 Bit Score: 35.58 E-value: 5.39e-03
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Tam | COG4106 | Trans-aconitate methyltransferase [Energy production and conversion]; |
55-126 | 5.66e-03 | |||
Trans-aconitate methyltransferase [Energy production and conversion]; Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 34.41 E-value: 5.66e-03
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Blast search parameters | ||||
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