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Conserved domains on  [gi|1907149073|ref|XP_036018797|]
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potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1 [Mus musculus]

Protein Classification

cyclic nucleotide-gated ion channel( domain architecture ID 13328258)

cyclic nucleotide-gated ion channel is a nonselective channel that is opened by the direct binding of cyclic nucleotides, cAMP and cGMP

CATH:  2.60.120.10
Gene Ontology:  GO:0016020|GO:0030551|GO:0005216|GO:0006811|GO:0022832
PubMed:  12087135|17601606
SCOP:  4000272
TCDB:  1.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 189-297 2.14e-26

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


:

Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 103.56  E-value: 2.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 189 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRGRR 263
Cdd:cd00038     1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREqivgfLGPGDLFGELALLGNGPR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907149073 264 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF 297
Cdd:cd00038    81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 347-535 5.01e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  347 RGLAPGTGARLSGKPVLWEPlvhaPLQAAAVTSNVAIALTHQRGPLPLSPDSPATllarsarrsagsPASPLVPvraGPL 426
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRR----RAARPTVGSLTSLADPPPPPPTPEPAPHALV------------SATPLPP---GPA 2726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  427 LARGPWASTSRLPAPPAR----TLHASLSRTGRSQVSLLGP-------PPGGGARRL-GPRGRPLSASQPSLPQRATGDG 494
Cdd:PHA03247  2727 AARQASPALPAAPAPPAVpagpATPGGPARPARPPTTAGPPapappaaPAAGPPRRLtRPAVASLSESRESLPSPWDPAD 2806

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907149073  495 SPRRKGSGSERLPPSgllAKPPGTVQPPRSSVP-EPVTPRGP 535
Cdd:PHA03247  2807 PPAAVLAPAAALPPA---ASPAGPLPPPTSAQPtAPPPPPGP 2845
PLN03192 super family cl33658
Voltage-dependent potassium channel; Provisional
 10-278 8.69e-07

Voltage-dependent potassium channel; Provisional


The actual alignment was detected with superfamily member PLN03192:

Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.79  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  10 VRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVS--MNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVW 87
Cdd:PLN03192  200 IRCARLLSVTLFLVHCAGCLYYLIADRYPHQGKTWIGavIPNFRETSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEMI 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  88 LTMLSMIVGATCYAMFIGHATALIqsLDSSRR--QYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILG 165
Cdd:PLN03192  280 FIIFYMLFNLGLTAYLIGNMTNLV--VEGTRRtmEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAESLNQQQLID 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 166 ELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR 245
Cdd:PLN03192  358 QLPKSICKSICQHLFLPVVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIDSEGEKER 437

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1907149073 246 ----LTDGSYFGEICLLTRGRRTASVRADTYCRLYSL 278
Cdd:PLN03192  438 vvgtLGCGDIFGEVGALCCRPQSFTFRTKTLSQLLRL 474
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 189-297 2.14e-26

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 103.56  E-value: 2.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 189 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRGRR 263
Cdd:cd00038     1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREqivgfLGPGDLFGELALLGNGPR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907149073 264 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF 297
Cdd:cd00038    81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 189-298 6.77e-19

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 82.45  E-value: 6.77e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  189 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRR 263
Cdd:smart00100   1 LFKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGeeqivGTLGPGDFFGELALLTNSRR 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907149073  264 TASVRADTY--CRLYSLSVDHFNAVLEEFPMMRRAFE 298
Cdd:smart00100  81 AASAAAVALelATLLRIDFRDFLQLLPELPQLLLELL 117
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 190-321 1.29e-18

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 84.27  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 190 FAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLT-----DGSYFGEICLLTRGRRT 264
Cdd:COG0664     1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQIlgflgPGDFFGELSLLGGEPSP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907149073 265 ASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSE 321
Cdd:COG0664    81 ATAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAE 137
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 207-289 5.54e-17

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 76.11  E-value: 5.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 207 FEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD 281
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGreqilAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPRE 80


                  ....*...
gi 1907149073 282 HFNAVLEE 289
Cdd:pfam00027  81 DFLELLER 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
 347-535 5.01e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  347 RGLAPGTGARLSGKPVLWEPlvhaPLQAAAVTSNVAIALTHQRGPLPLSPDSPATllarsarrsagsPASPLVPvraGPL 426
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRR----RAARPTVGSLTSLADPPPPPPTPEPAPHALV------------SATPLPP---GPA 2726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  427 LARGPWASTSRLPAPPAR----TLHASLSRTGRSQVSLLGP-------PPGGGARRL-GPRGRPLSASQPSLPQRATGDG 494
Cdd:PHA03247  2727 AARQASPALPAAPAPPAVpagpATPGGPARPARPPTTAGPPapappaaPAAGPPRRLtRPAVASLSESRESLPSPWDPAD 2806

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907149073  495 SPRRKGSGSERLPPSgllAKPPGTVQPPRSSVP-EPVTPRGP 535
Cdd:PHA03247  2807 PPAAVLAPAAALPPA---ASPAGPLPPPTSAQPtAPPPPPGP 2845
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 10-278 8.69e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.79  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  10 VRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVS--MNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVW 87
Cdd:PLN03192  200 IRCARLLSVTLFLVHCAGCLYYLIADRYPHQGKTWIGavIPNFRETSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEMI 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  88 LTMLSMIVGATCYAMFIGHATALIqsLDSSRR--QYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILG 165
Cdd:PLN03192  280 FIIFYMLFNLGLTAYLIGNMTNLV--VEGTRRtmEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAESLNQQQLID 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 166 ELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR 245
Cdd:PLN03192  358 QLPKSICKSICQHLFLPVVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIDSEGEKER 437

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1907149073 246 ----LTDGSYFGEICLLTRGRRTASVRADTYCRLYSL 278
Cdd:PLN03192  438 vvgtLGCGDIFGEVGALCCRPQSFTFRTKTLSQLLRL 474
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
216-311 9.28e-04

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 40.74  E-value: 9.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 216 VVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRG-RRTASVRADTYCRLYSLSVDHFNAVLEE 289
Cdd:PRK11753   31 LIHAGEKAETLYYIVKGSVAVLIKDEEGkemilSYLNQGDFIGELGLFEEGqERSAWVRAKTACEVAEISYKKFRQLIQV 110

                          90       100
                  ....*....|....*....|..
gi 1907149073 290 FPMMRRAFETVAMDRLRRIGKK 311
Cdd:PRK11753  111 NPDILMALSAQMARRLQNTSRK 132
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 189-297 2.14e-26

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 103.56  E-value: 2.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 189 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRGRR 263
Cdd:cd00038     1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREqivgfLGPGDLFGELALLGNGPR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907149073 264 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF 297
Cdd:cd00038    81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 189-298 6.77e-19

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 82.45  E-value: 6.77e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  189 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRR 263
Cdd:smart00100   1 LFKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGeeqivGTLGPGDFFGELALLTNSRR 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907149073  264 TASVRADTY--CRLYSLSVDHFNAVLEEFPMMRRAFE 298
Cdd:smart00100  81 AASAAAVALelATLLRIDFRDFLQLLPELPQLLLELL 117
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 190-321 1.29e-18

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 84.27  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 190 FAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLT-----DGSYFGEICLLTRGRRT 264
Cdd:COG0664     1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQIlgflgPGDFFGELSLLGGEPSP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907149073 265 ASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSE 321
Cdd:COG0664    81 ATAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAE 137
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 207-289 5.54e-17

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 76.11  E-value: 5.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 207 FEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD 281
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGreqilAVLGPGDFFGELALLGGEPRSATVVALTDSELLVIPRE 80


                  ....*...
gi 1907149073 282 HFNAVLEE 289
Cdd:pfam00027  81 DFLELLER 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
 347-535 5.01e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  347 RGLAPGTGARLSGKPVLWEPlvhaPLQAAAVTSNVAIALTHQRGPLPLSPDSPATllarsarrsagsPASPLVPvraGPL 426
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRR----RAARPTVGSLTSLADPPPPPPTPEPAPHALV------------SATPLPP---GPA 2726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  427 LARGPWASTSRLPAPPAR----TLHASLSRTGRSQVSLLGP-------PPGGGARRL-GPRGRPLSASQPSLPQRATGDG 494
Cdd:PHA03247  2727 AARQASPALPAAPAPPAVpagpATPGGPARPARPPTTAGPPapappaaPAAGPPRRLtRPAVASLSESRESLPSPWDPAD 2806

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907149073  495 SPRRKGSGSERLPPSgllAKPPGTVQPPRSSVP-EPVTPRGP 535
Cdd:PHA03247  2807 PPAAVLAPAAALPPA---ASPAGPLPPPTSAQPtAPPPPPGP 2845
PHA03247 PHA03247
large tegument protein UL36; Provisional
 366-533 5.70e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 5.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  366 PLVHAPLQAAAVTSNVAIALTHQRGPLPLSPdSPATLLARSARRSAGSPASPLVP----VRAGPLLARGPWASTSRLPAP 441
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP-PPTSAQPTAPPPPPGPPPPSLPLggsvAPGGDVRRRPPSRSPAAKPAA 2877

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  442 PARTLHASLSRTGRSQVSLLGP-PPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPP----------SG 510
Cdd:PHA03247  2878 PARPPVRRLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdpagagepSG 2957

                          170       180
                   ....*....|....*....|....*....
gi 1907149073  511 LLAKP------PGTVQPPRSSVPEPVTPR 533
Cdd:PHA03247  2958 AVPQPwlgalvPGRVAVPRFRVPQPAPSR 2986
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 10-278 8.69e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.79  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  10 VRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVS--MNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVW 87
Cdd:PLN03192  200 IRCARLLSVTLFLVHCAGCLYYLIADRYPHQGKTWIGavIPNFRETSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEMI 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  88 LTMLSMIVGATCYAMFIGHATALIqsLDSSRR--QYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILG 165
Cdd:PLN03192  280 FIIFYMLFNLGLTAYLIGNMTNLV--VEGTRRtmEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAESLNQQQLID 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 166 ELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR 245
Cdd:PLN03192  358 QLPKSICKSICQHLFLPVVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEIIDSEGEKER 437

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1907149073 246 ----LTDGSYFGEICLLTRGRRTASVRADTYCRLYSL 278
Cdd:PLN03192  438 vvgtLGCGDIFGEVGALCCRPQSFTFRTKTLSQLLRL 474
PHA03247 PHA03247
large tegument protein UL36; Provisional
 349-536 5.16e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 5.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  349 LAPGTGARLSGKPVLwePLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPAtllarSARRSAGSPASPLVPVRAGPLLA 428
Cdd:PHA03247  2721 LPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA-----PPAAPAAGPPRRLTRPAVASLSE 2793

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  429 RGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLGPrGRPLSASQPSLPQratgDGSPRRKGSGSERLPP 508
Cdd:PHA03247  2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPL----GGSVAPGGDVRRRPPS 2868

                          170       180
                   ....*....|....*....|....*...
gi 1907149073  509 SGLLAKPPGTVQPPRSSVPEPVTPRGPQ 536
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLARPAVSRSTE 2896
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 347-536 2.82e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 347 RGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAialthQRGPLPLSPDSPATllaRSARRSAGSPASPLVPVRAGPL 426
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAP-----APAGAAAAPAEASA---APAPGVAAPEHHPKHVAVPDAS 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 427 LARGPWASTSRLPAPPARTlhASLSRTGRSQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERL 506
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPP--PAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907149073 507 PPSGLLakPPGTVQPPRSSVPEPVTPRGPQ 536
Cdd:PRK07764  742 PPEPDD--PPDPAGAPAQPPPPPAPAPAAA 769
PHA03247 PHA03247
large tegument protein UL36; Provisional
 350-536 8.18e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 8.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  350 APGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSA----GSPASPLVP----V 421
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAlppaASPAGPLPPptsaQ 2835

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  422 RAGPLLARGPWASTsrLPAPPARTLHASLSRTGRSQvsllgPPPGGGARRLGPRGRPLSA---SQPSLPQRATGDGSPRR 498
Cdd:PHA03247  2836 PTAPPPPPGPPPPS--LPLGGSVAPGGDVRRRPPSR-----SPAAKPAAPARPPVRRLARpavSRSTESFALPPDQPERP 2908

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1907149073  499 KGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQ 536
Cdd:PHA03247  2909 PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
347-539 1.13e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 347 RGLA--PGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPV--- 421
Cdd:PRK12323  359 RMLAfrPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAarq 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 422 --RAGPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLGPRGRPLSASQP-SLPQRATGDGSPRR 498
Cdd:PRK12323  439 asARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPpEFASPAPAQPDAAP 518

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907149073 499 KGSGSERLPPSGLL----AKPPGTVQPPRSSVPEPVTPRGPQISA 539
Cdd:PRK12323  519 AGWVAESIPDPATAdpddAFETLAPAPAAAPAPRAAAATEPVVAP 563
PHA03247 PHA03247
large tegument protein UL36; Provisional
 366-535 1.47e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  366 PLVHAPLQAAAVTSnvaiALTHQRGPLPLSPdspaTLLARSARRSA-GSPASPLVPVrAGPLLARGPWASTSRLPAPPAR 444
Cdd:PHA03247  2554 PLPPAAPPAAPDRS----VPPPRPAPRPSEP----AVTSRARRPDApPQSARPRAPV-DDRGDPRGPAPPSPLPPDTHAP 2624

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  445 TLHASLSRTGRSQvsllgpPPGGGARRLGPRGRPLSASQP---SLPQRATGDGSPRRKGSGSERLPPSGL---------L 512
Cdd:PHA03247  2625 DPPPPSPSPAANE------PDPHPPPTVPPPERPRDDPAPgrvSRPRRARRLGRAAQASSPPQRPRRRAArptvgsltsL 2698

                          170       180
                   ....*....|....*....|...
gi 1907149073  513 AKPPGTVQPPRSSvPEPVTPRGP 535
Cdd:PHA03247  2699 ADPPPPPPTPEPA-PHALVSATP 2720
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 389-541 2.56e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 2.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  389 RGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPARTLhASLSRTGRSQVSLLGPPPGGG 468
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPL-SSPEETARAPSSPPAEPPPST 197

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907149073  469 ARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISANM 541
Cdd:PHA03307   198 PPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIW 270
PHA03378 PHA03378
EBNA-3B; Provisional
 388-539 2.72e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 388 QRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPaRTLHASLSRTGRSQVSLLGPPPGG 467
Cdd:PHA03378  622 RQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQP-SPTGANTMLPIQWAPGTMQPPPRA 700

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907149073 468 GARRLGPRGRPlSASQPslPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISA 539
Cdd:PHA03378  701 PTPMRPPAAPP-GRAQR--PAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAA 769
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
321-535 5.01e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.91  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 321 EPSPGSSGGVMEQHLVQhdrdMARGVRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPA 400
Cdd:PRK07003  359 EPAVTGGGAPGGGVPAR----VAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPA 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 401 TLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRL-------PAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLG 473
Cdd:PRK07003  435 TADRGDDAADGDAPVPAKANARASADSRCDERDAQPPAdsgsasaPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPA 514

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 474 PRGR-----PLSASQPSLPQRATGDGSPRRKGSG----------------SERLPPSGLLAKPPG------TVQPPRSSV 526
Cdd:PRK07003  515 AASRedapaAAAPPAPEARPPTPAAAAPAARAGGaaaaldvlrnagmrvsSDRGARAAAAAKPAAapaaapKPAAPRVAV 594


                  ....*....
gi 1907149073 527 PEPvTPRGP 535
Cdd:PRK07003  595 QVP-TPRAR 602
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 361-539 5.71e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  361 PVLWEPLVHAPLQAAAVTSNVAIALT-HQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLP 439
Cdd:PHA03307    35 LLSGSQGQLVSDSAELAAVTVVAGAAaCDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSP 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  440 APPARTlhaslsrtgrsQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTV 519
Cdd:PHA03307   115 DPPPPT-----------PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETA 183

                          170       180
                   ....*....|....*....|
gi 1907149073  520 QPPrSSVPEPVTPRGPQISA 539
Cdd:PHA03307   184 RAP-SSPPAEPPPSTPPAAA 202
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
216-311 9.28e-04

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 40.74  E-value: 9.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 216 VVREGSVGRKMYFIQHGLLSVLARGARD-----TRLTDGSYFGEICLLTRG-RRTASVRADTYCRLYSLSVDHFNAVLEE 289
Cdd:PRK11753   31 LIHAGEKAETLYYIVKGSVAVLIKDEEGkemilSYLNQGDFIGELGLFEEGqERSAWVRAKTACEVAEISYKKFRQLIQV 110

                          90       100
                  ....*....|....*....|..
gi 1907149073 290 FPMMRRAFETVAMDRLRRIGKK 311
Cdd:PRK11753  111 NPDILMALSAQMARRLQNTSRK 132
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 383-539 1.49e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 383 IALtHQRGPLPLSPDSPA----TLLARSARRSAGSPASPLVPVRAGPllargpwastsrlpAPPARTLHASLSRTGRSQV 458
Cdd:PRK14951  336 ICL-HGRAELGLAPDEYAaltmVLLRLLAFKPAAAAEAAAPAEKKTP--------------ARPEAAAPAAAPVAQAAAA 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 459 SLLGPPPGGGARrlgPRGRPLSASQPSLPQR--ATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQ 536
Cdd:PRK14951  401 PAPAAAPAAAAS---APAAPPAAAPPAPVAApaAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAP 477


                  ...
gi 1907149073 537 ISA 539
Cdd:PRK14951  478 APA 480
PHA03247 PHA03247
large tegument protein UL36; Provisional
 365-535 1.61e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  365 EPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRL--PAPP 442
Cdd:PHA03247  2625 DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  443 ARTLHASlsrtGRSQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKG-----SGSER-LPPSGLLAKPP 516
Cdd:PHA03247  2705 PPTPEPA----PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArppttAGPPApAPPAAPAAGPP 2780

                          170
                   ....*....|....*....
gi 1907149073  517 GTVQPPRSSVPEPVTPRGP 535
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLP 2799
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 392-541 1.68e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 392 LPLSPDSPATLLARSARRSAGSPAsplvpvrAGPLLARGPWASTSRLPAPPArtlhaslsrtgrsqvsllGPPPGGGARR 471
Cdd:PRK07764  364 LPSASDDERGLLARLERLERRLGV-------AGGAGAPAAAAPSAAAAAPAA------------------APAPAAAAPA 418

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 472 LGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISANM 541
Cdd:PRK07764  419 AAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAP 488
PHA03378 PHA03378
EBNA-3B; Provisional
 347-534 2.02e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 347 RGLAPGTGARLSGkPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASP--LVPVRAG 424
Cdd:PHA03378  612 QSHIPETSAPRQW-PMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGAntMLPIQWA 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 425 PLLARGPWASTSRLPAPPARTLHASLSRTGRSQVsllgPPPGGGARRLGPrgrPLSASQPSLPQRATGDGSPRRKGSGSE 504
Cdd:PHA03378  691 PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRA----RPPAAAPGRARP---PAAAPGRARPPAAAPGRARPPAAAPGR 763

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907149073 505 RLPPSGLLAKPpgTVQPPRSSVPEPVT-PRG 534
Cdd:PHA03378  764 ARPPAAAPGAP--TPQPPPQAPPAPQQrPRG 792
PHA03378 PHA03378
EBNA-3B; Provisional
 316-536 2.07e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 316 QRKRSEPSPG-SSGGVMEQHLVQHDRDMARGVRGLAPGTGARLSGKPVLWEPLVH-APLQAAAVTSNVAIALTHQRGPLP 393
Cdd:PHA03378  594 QTPWPVPHPSqTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFpTPHQPPQVEITPYKPTWTQIGHIP 673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 394 L--SPDSPATLLARSARRSAGSPA----SPLVPVRAGPLLARGPWASTSRLPAPPARTLHAslsRTGRSQVSLLGPPPGG 467
Cdd:PHA03378  674 YqpSPTGANTMLPIQWAPGTMQPPprapTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRA---RPPAAAPGRARPPAAA 750

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907149073 468 GARRLGPRGRPLSASQPslpQRATGDGSPRRkgsgserlPPSGllakPPGTVQPPRSSvPEPVTPrgPQ 536
Cdd:PHA03378  751 PGRARPPAAAPGRARPP---AAAPGAPTPQP--------PPQA----PPAPQQRPRGA-PTPQPP--PQ 801
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
324-535 2.21e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 324 PGSSGGvmeqhlvqhDRDMARGVRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLL 403
Cdd:PRK12323  365 PGQSGG---------GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 404 ARSA------RRSAGSPASPLVPVRAGPllargPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGggaRRLGPRGR 477
Cdd:PRK12323  436 ARQAsargpgGAPAPAPAPAAAPAAAAR-----PAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW---EELPPEFA 507

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907149073 478 PLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGP 535
Cdd:PRK12323  508 SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP 565
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
387-539 2.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073 387 HQRGPLPLSPDSPA----TLLARSARRSAGS--PASPlVPVRAGPLLARGPWASTSRlPAPPARTlHASLSRTGRSQVSL 460
Cdd:PRK12323  338 LGRSELALAPDEYAgftmTLLRMLAFRPGQSggGAGP-ATAAAAPVAQPAPAAAAPA-AAAPAPA-APPAAPAAAPAAAA 414

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907149073 461 LGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPrrkgsgSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISA 539
Cdd:PRK12323  415 AARAVAAAPARRSPAPEALAAARQASARGPGGAPAP------APAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAA 487
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 391-536 3.65e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  391 PLPLSPDSPATLLARSARRSAGSPASPLVPVR------AGPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPP 464
Cdd:PHA03307   212 PISASASSPAPAPGRSAADDAGASSSDSSSSEssgcgwGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP 291

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907149073  465 PGGGARRL--GPRGRPLSASQPSL----PQRATGDGSPRRKGSGSE-RLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQ 536
Cdd:PHA03307   292 RERSPSPSpsSPGSGPAPSSPRASssssSSRESSSSSTSSSSESSRgAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 366-536 8.94e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.00  E-value: 8.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  366 PLV-HAPLQAAAVTSNVAIALTHQRGPlPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLlARGPWASTSRLPAPPAR 444
Cdd:PHA03307   735 PLVrYSPRRARARASAWDITDALFSNP-SLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAA-FRRPGRLRRSGPAADAA 812

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907149073  445 TLHASLSRTGRSQVSLLGPPPGGgARRLGPRGRPLSASQ-------PSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPG 517
Cdd:PHA03307   813 SRTASKRKSRSHTPDGGSESSGP-ARPPGAAARPPPARSsesskskPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKA 891

                          170
                   ....*....|....*....
gi 1907149073  518 TVQPPRSSVPEPVTPRGPQ 536
Cdd:PHA03307   892 AAAAPPAGAPAPRPRPAPR 910
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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