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Conserved domains on  [gi|1907150391|ref|XP_036018969|]
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amphoterin-induced protein 1 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12267147)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 5.11e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 5.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  66 LDLSHNNLSRLRAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSDLQALEVLLLYNNH 145
Cdd:COG4886   118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 146 IVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
LRRNT super family cl02423
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 34-63 9.78e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


The actual alignment was detected with superfamily member smart00013:

Pssm-ID: 413314 [Multi-domain]  Cd Length: 33  Bit Score: 33.45  E-value: 9.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907150391   34 CPANCLCASNILSCSKQQLPNVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 5.11e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 5.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  66 LDLSHNNLSRLRAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSDLQALEVLLLYNNH 145
Cdd:COG4886   118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 146 IVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-213 1.09e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  30 SVVSCPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLraewtPTRL-TNLHSLLLSHNHLNFISSEafvp 108
Cdd:PRK15370  210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLpSALQSLDLFHNKISCLPEN---- 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 109 VPN-LRYLDLSSNHLHTLDE---------FLFSD-LQALEVLLLYNNHIVVVDRNAFEDM-----AQLQKLYLSQNQISR 172
Cdd:PRK15370  281 LPEeLRYLSVYDNSIRTLPAhlpsgithlNVQSNsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITV 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907150391 173 FPVELIkdgnklPKLMLLDLSSNKLKKLPltdlQKLPAWVK 213
Cdd:PRK15370  361 LPETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
LRR_8 pfam13855
Leucine rich repeat;
110-170 2.72e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.72e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907150391 110 PNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-238 1.37e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  83 TRLTNLHsllLSHNHLNFIssEAFVPVPNLRYLDLSSNHLHTLDEFLFsdLQALEVLLLYNNHIVVVDRnaFEDMAQLQK 162
Cdd:cd21340     2 KRITHLY---LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 163 LYLSQNQISRF---------------------PVELIKDGNKL----PKLMLLDLSSNKLKKlpLTDLQKLPAWVKngLY 217
Cdd:cd21340    73 LYLGGNRISVVeglenltnleelhienqrlppGEKLTFDPRSLaalsNSLRVLNISGNNIDS--LEPLAPLRNLEQ--LD 148

                         170       180
                  ....*....|....*....|.
gi 1907150391 218 LHNNPLECDCKLYQLFSHWQY 238
Cdd:cd21340   149 ASNNQISDLEELLDLLSSWPS 169
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-63 9.78e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 33.45  E-value: 9.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907150391   34 CPANCLCASNILSCSKQQLPNVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 5.11e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 5.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  66 LDLSHNNLSRLRAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSDLQALEVLLLYNNH 145
Cdd:COG4886   118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 146 IVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-235 8.48e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 8.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  44 ILSCSKQQLPNVPQSLPSYTAL--LDLSHNNLSRLRAEWTPtrLTNLHSLLLSHNHLNFISsEAFVPVPNLRYLDLSSNH 121
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 122 LHTLDEFLfSDLQALEVLLLYNNHIVVVDrnAFEDMAQLQKLYLSQNQISRFPVELikdgnKLPKLMLLDLSSNKLKKLP 201
Cdd:COG4886   217 LTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA-----NLTNLKTLDLSNNQLTDLK 288

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1907150391 202 LTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSH 235
Cdd:COG4886   289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-224 9.07e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 9.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  43 NILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFIsSEAFVPVPNLRYLDLSSNHL 122
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 123 HTLDEFLfSDLQALEVLLLYNNHIVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP- 201
Cdd:COG4886   149 TDLPEPL-GNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPL----GNLTNLEELDLSGNQLTDLPe 222

                         170       180
                  ....*....|....*....|....
gi 1907150391 202 -LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886   223 pLANLTNL-----ETLDLSNNQLT 241
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-213 1.09e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  30 SVVSCPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLraewtPTRL-TNLHSLLLSHNHLNFISSEafvp 108
Cdd:PRK15370  210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLpSALQSLDLFHNKISCLPEN---- 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 109 VPN-LRYLDLSSNHLHTLDE---------FLFSD-LQALEVLLLYNNHIVVVDRNAFEDM-----AQLQKLYLSQNQISR 172
Cdd:PRK15370  281 LPEeLRYLSVYDNSIRTLPAhlpsgithlNVQSNsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITV 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907150391 173 FPVELIkdgnklPKLMLLDLSSNKLKKLPltdlQKLPAWVK 213
Cdd:PRK15370  361 LPETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-247 3.47e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 3.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  45 LSCSKQQLPNVPQSLPSYTAL--LDLSHNNLSRLRAEWTptRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHL 122
Cdd:COG4886   164 LDLSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 123 HTLDEFlfSDLQALEVLLLYNNHIVVVDRNAfeDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPL 202
Cdd:COG4886   241 TDLPEL--GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1907150391 203 TDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDF 247
Cdd:COG4886   317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR_8 pfam13855
Leucine rich repeat;
110-170 2.72e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.72e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907150391 110 PNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 2.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 2.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907150391  86 TNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
66-122 1.39e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 1.39e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907150391  66 LDLSHNNLSRLRAEWtPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGA-FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
136-197 1.56e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907150391 136 LEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDgnkLPKLMLLDLSSNKL 197
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG---LPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-238 1.37e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  83 TRLTNLHsllLSHNHLNFIssEAFVPVPNLRYLDLSSNHLHTLDEFLFsdLQALEVLLLYNNHIVVVDRnaFEDMAQLQK 162
Cdd:cd21340     2 KRITHLY---LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 163 LYLSQNQISRF---------------------PVELIKDGNKL----PKLMLLDLSSNKLKKlpLTDLQKLPAWVKngLY 217
Cdd:cd21340    73 LYLGGNRISVVeglenltnleelhienqrlppGEKLTFDPRSLaalsNSLRVLNISGNNIDS--LEPLAPLRNLEQ--LD 148

                         170       180
                  ....*....|....*....|.
gi 1907150391 218 LHNNPLECDCKLYQLFSHWQY 238
Cdd:cd21340   149 ASNNQISDLEELLDLLSSWPS 169
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-197 2.82e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  66 LDLSHNNLSRLRAEWTPTRL---TNLHSLLLSHNHLNFISSEAFVP----VPNLRYLDLSSNHLHTLD-EFLFSDLQA-- 135
Cdd:COG5238   269 LYLSGNQIGAEGAIALAKALqgnTTLTSLDLSVNRIGDEGAIALAEglqgNKTLHTLNLAYNGIGAQGaIALAKALQEnt 348

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907150391 136 -LEVLLLYNNHI----VVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKL 197
Cdd:COG5238   349 tLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLI 415
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 64-198 2.11e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  64 ALLDLSHNNLS----RLRAEWTPTRLTNLHSLLLSHNHLNFISSE----AFVPVPNLRYLDLSSNHLH-----TLDEFLf 130
Cdd:cd00116   111 QELKLNNNGLGdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGdagirALAEGL- 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907150391 131 SDLQALEVLLLYNNHI----VVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLP--KLMLLDLSSNKLK 198
Cdd:cd00116   190 KANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPniSLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
159-223 6.59e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 6.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907150391 159 QLQKLYLSQNQISRFPVELIKDgnkLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKngLYLHNNPL 223
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRY--LDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
23-214 1.87e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.76  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  23 EVARAGRSVVSCPANCLCASN-ILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLraewtPTRLTNLHSLLLSHNHLnfi 101
Cdd:PRK15387  183 EESRGRAAVVQKMRACLNNGNaVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSL-----PALPPELRTLEVSGNQL--- 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391 102 SSEAFVPvPNLRYLDLSSN---HLHTLDE-----FLFSD-LQALEVLLLYNNHIVVVDrNAFEDM----AQLQKLYLSQN 168
Cdd:PRK15387  255 TSLPVLP-PGLLELSIFSNpltHLPALPSglcklWIFGNqLTSLPVLPPGLQELSVSD-NQLASLpalpSELCKLWAYNN 332

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1907150391 169 QISRFPVelikdgnkLPK-LMLLDLSSNKLKKLPLTDLQKLPAWVKN 214
Cdd:PRK15387  333 QLTSLPT--------LPSgLQELSVSDNQLASLPTLPSELYKLWAYN 371
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-174 5.60e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150391  66 LDLSHNNLSRLRAEwtpTRLTNLHSLLLSHNHLNfiSSEAFVPVPN--------LRYLDLSSNHLHTLDEflFSDLQALE 137
Cdd:cd21340    73 LYLGGNRISVVEGL---ENLTNLEELHIENQRLP--PGEKLTFDPRslaalsnsLRVLNISGNNIDSLEP--LAPLRNLE 145

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907150391 138 VLLLYNNHIVVVDR--NAFEDMAQLQKLYLSQNQISRFP 174
Cdd:cd21340   146 QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-63 9.78e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 33.45  E-value: 9.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907150391   34 CPANCLCASNILSCSKQQLPNVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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