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Conserved domains on  [gi|1907155395|ref|XP_036019857|]
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toll-like receptor 4 isoform X1 [Mus musculus]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
464-605 6.62e-33

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 123.20  E-value: 6.62e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395  464 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 543
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907155395  544 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 605
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
139-372 8.42e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 8.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 139 DLPFLKSLTLTMNKGSISFKKvalpsLSYLDLSRNALSfsgccsysDLGTN-----SLRHLDLSFNGAIIMSANFMGLEE 213
Cdd:COG4886    94 DLTNLTELDLSGNEELSNLTN-----LESLDLSGNQLT--------DLPEElanltNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 214 LQHLDFQHSTLKRVTEfsAFLSLEKLLYLDISytNTKI-DFDGIFLGLTSLNTLKMAGNSFKDntLSNVFANTTNLTFLD 292
Cdd:COG4886   161 LKSLDLSNNQLTDLPE--ELGNLTNLKELDLS--NNQItDLPEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLD 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 293 LSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLDSSHynQLYSLSTLDCSFNRIETSKgiLQHFPKSLAFFNLTNNSVAC 372
Cdd:COG4886   235 LSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLL 308
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
464-605 6.62e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 123.20  E-value: 6.62e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395  464 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 543
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907155395  544 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 605
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 467-606 3.04e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 113.61  E-value: 3.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 467 FVIYSS----QNEDWVRNELVKNLeeGVPRFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 542
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 543 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNPLGRHIFWRRLKN 603
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 1907155395 604 ALL 606
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
139-372 8.42e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 8.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 139 DLPFLKSLTLTMNKGSISFKKvalpsLSYLDLSRNALSfsgccsysDLGTN-----SLRHLDLSFNGAIIMSANFMGLEE 213
Cdd:COG4886    94 DLTNLTELDLSGNEELSNLTN-----LESLDLSGNQLT--------DLPEElanltNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 214 LQHLDFQHSTLKRVTEfsAFLSLEKLLYLDISytNTKI-DFDGIFLGLTSLNTLKMAGNSFKDntLSNVFANTTNLTFLD 292
Cdd:COG4886   161 LKSLDLSNNQLTDLPE--ELGNLTNLKELDLS--NNQItDLPEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLD 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 293 LSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLDSSHynQLYSLSTLDCSFNRIETSKgiLQHFPKSLAFFNLTNNSVAC 372
Cdd:COG4886   235 LSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLL 308
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 161-347 1.74e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 161 ALPSLSYLDLSRNALSFSGCCSYSDLGTN-SLRHLDLSFNGaiimsanfmglEELQHLDFQHSTLKRVTEfsaflSLEKL 239
Cdd:cd00116    79 KGCGLQELDLSDNALGPDGCGVLESLLRSsSLQELKLNNNG-----------LGDRGLRLLAKGLKDLPP-----ALEKL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 240 LYLDISYTNTK-IDFDGIFLGLTSLNTLKMAGNSFKDN---TLSNVFANTTNLTFLDLSKCQLE-----QISwGVFDTLH 310
Cdd:cd00116   143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1907155395 311 RLQLLNMSHNNL-----LFLDSSHYNQLYSLSTLDCSFNRIE 347
Cdd:cd00116   222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 140-248 2.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 140 LPFLKSLTLTMNK--GSISFKKVALPSLSYLDLSRNalSFSGCCSYSdLGTNSLRHLDLS---FNGAIIMSanFMGLEEL 214
Cdd:PLN00113  427 LPLVYFLDISNNNlqGRINSRKWDMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDLSrnqFSGAVPRK--LGSLSEL 501

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907155395 215 QHLDFQHSTLKRV--TEFSaflSLEKLLYLDISYTN 248
Cdd:PLN00113  502 MQLKLSENKLSGEipDELS---SCKKLVSLDLSHNQ 534
LRR_8 pfam13855
Leucine rich repeat;
286-346 3.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907155395 286 TNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRI 346
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
464-605 6.62e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 123.20  E-value: 6.62e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395  464 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 543
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907155395  544 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 605
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 467-606 3.04e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 113.61  E-value: 3.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 467 FVIYSS----QNEDWVRNELVKNLeeGVPRFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 542
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 543 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNPLGRHIFWRRLKN 603
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 1907155395 604 ALL 606
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
139-372 8.42e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 8.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 139 DLPFLKSLTLTMNKGSISFKKvalpsLSYLDLSRNALSfsgccsysDLGTN-----SLRHLDLSFNGAIIMSANFMGLEE 213
Cdd:COG4886    94 DLTNLTELDLSGNEELSNLTN-----LESLDLSGNQLT--------DLPEElanltNLKELDLSNNQLTDLPEPLGNLTN 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 214 LQHLDFQHSTLKRVTEfsAFLSLEKLLYLDISytNTKI-DFDGIFLGLTSLNTLKMAGNSFKDntLSNVFANTTNLTFLD 292
Cdd:COG4886   161 LKSLDLSNNQLTDLPE--ELGNLTNLKELDLS--NNQItDLPEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLD 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 293 LSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLDSSHynQLYSLSTLDCSFNRIETSKgiLQHFPKSLAFFNLTNNSVAC 372
Cdd:COG4886   235 LSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLL 308
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 467-562 6.35e-12

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 62.72  E-value: 6.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 467 FVIYSSQNEDWVRnELVKNLEE-GvprFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAq 545
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAaG---YRVWLDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75

                          90
                  ....*....|....*..
gi 1907155395 546 tWQFLSSRSGIIFIVLE 562
Cdd:pfam13676  76 -LADPEGRKRLIPVRLE 91
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
139-392 2.17e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 139 DLPFLKSLTLTMNK-GSISFKKVALPSLSYLDLSRNALSfsgccsysDLGTN-----SLRHLDLSFNGAIIMSANFMGLE 212
Cdd:COG4886   111 NLTNLESLDLSGNQlTDLPEELANLTNLKELDLSNNQLT--------DLPEPlgnltNLKSLDLSNNQLTDLPEELGNLT 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 213 ELQHLDFQHStlkRVTEFSAFLS-LEKLLYLDISYTNTKiDFDGIFLGLTSLNTLKMAGNSFKDntLSNvFANTTNLTFL 291
Cdd:COG4886   183 NLKELDLSNN---QITDLPEPLGnLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTD--LPE-LGNLTNLEEL 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 292 DLSKCQLEQISwgVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVA 371
Cdd:COG4886   256 DLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                         250       260
                  ....*....|....*....|.
gi 1907155395 372 CICEHQKFLQWVKEQKQFLVN 392
Cdd:COG4886   334 LVTLTTLALSLSLLALLTLLL 354
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-371 2.03e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 2.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 123 QSLSIIRCQLKQFPTL--DLPFLKSLTLTMNK-GSISFKKVALPSLSYLDLSRNALSfsgccsysDLGTN-----SLRHL 194
Cdd:COG4886   116 ESLDLSGNQLTDLPEElaNLTNLKELDLSNNQlTDLPEPLGNLTNLKSLDLSNNQLT--------DLPEElgnltNLKEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 195 DLSFNGAIIMSANFMGLEELQHLDFQHStlkRVTEFSAFLS-LEKLLYLDISYTN-TKIDFdgiFLGLTSLNTLKMAGNS 272
Cdd:COG4886   188 DLSNNQITDLPEPLGNLTNLEELDLSGN---QLTDLPEPLAnLTNLETLDLSNNQlTDLPE---LGNLTNLEELDLSNNQ 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 273 FKDNTLSnvfANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGI 352
Cdd:COG4886   262 LTDLPPL---ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                         250
                  ....*....|....*....
gi 1907155395 353 LQHFPKSLAFFNLTNNSVA 371
Cdd:COG4886   339 TLALSLSLLALLTLLLLLN 357
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 161-347 1.74e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 161 ALPSLSYLDLSRNALSFSGCCSYSDLGTN-SLRHLDLSFNGaiimsanfmglEELQHLDFQHSTLKRVTEfsaflSLEKL 239
Cdd:cd00116    79 KGCGLQELDLSDNALGPDGCGVLESLLRSsSLQELKLNNNG-----------LGDRGLRLLAKGLKDLPP-----ALEKL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 240 LYLDISYTNTK-IDFDGIFLGLTSLNTLKMAGNSFKDN---TLSNVFANTTNLTFLDLSKCQLE-----QISwGVFDTLH 310
Cdd:cd00116   143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1907155395 311 RLQLLNMSHNNL-----LFLDSSHYNQLYSLSTLDCSFNRIE 347
Cdd:cd00116   222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 140-248 2.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 140 LPFLKSLTLTMNK--GSISFKKVALPSLSYLDLSRNalSFSGCCSYSdLGTNSLRHLDLS---FNGAIIMSanFMGLEEL 214
Cdd:PLN00113  427 LPLVYFLDISNNNlqGRINSRKWDMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDLSrnqFSGAVPRK--LGSLSEL 501

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907155395 215 QHLDFQHSTLKRV--TEFSaflSLEKLLYLDISYTN 248
Cdd:PLN00113  502 MQLKLSENKLSGEipDELS---SCKKLVSLDLSHNQ 534
LRR_8 pfam13855
Leucine rich repeat;
286-346 3.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907155395 286 TNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRI 346
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-368 1.19e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 222 STLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNsfkdntlsNVFANTTNLTFLDLSKCQLEQI 301
Cdd:COG4886    57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155395 302 SWGVFDtLHRLQLLNMSHNNLLFLDSShYNQLYSLSTLDCSFNRIETSKGILQHFPKsLAFFNLTNN 368
Cdd:COG4886   129 PEELAN-LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNN 192
LRR_8 pfam13855
Leucine rich repeat;
282-322 6.02e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 6.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907155395 282 FANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNL 322
Cdd:pfam13855  21 FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 214-346 5.32e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 214 LQHLDFQHSTLKRVTEFSAFLSLEKLlYLDisytNTKI----DFDGiflgLTSLNTLKMAGNS--------FKDNTLSNV 281
Cdd:cd21340    48 LTHLYLQNNQIEKIENLENLVNLKKL-YLG----GNRIsvveGLEN----LTNLEELHIENQRlppgekltFDPRSLAAL 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907155395 282 fANTtnLTFLDLSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLD--SSHYNQLYSLSTLDCSFNRI 346
Cdd:cd21340   119 -SNS--LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 286-323 6.89e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 6.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907155395 286 TNLTFLDLSKCQLEQISWgvFDTLHRLQLLNMSHNNLL 323
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKI 36
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 216-371 7.44e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 216 HLDFQHSTLKRVTEFSAFLSLeKLLYLdisYTN--TKIDFDGIFLGLTSL-----NTLKMAG-NSFK--------DNTLS 279
Cdd:cd21340     6 HLYLNDKNITKIDNLSLCKNL-KVLYL---YDNkiTKIENLEFLTNLTHLylqnnQIEKIENlENLVnlkklylgGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 280 NV--FANTTNLTFLDLSKCQL---EQISWG---VFDTLHRLQLLNMSHNNLLFLDSSHYnqLYSLSTLDCSFNRIETSKG 351
Cdd:cd21340    82 VVegLENLTNLEELHIENQRLppgEKLTFDprsLAALSNSLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLEE 159

                         170       180
                  ....*....|....*....|..
gi 1907155395 352 ILQHFPK--SLAFFNLTNNSVA 371
Cdd:cd21340   160 LLDLLSSwpSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 143-322 7.76e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 143 LKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSgccSYSDLGT-NSLRHLDLSFN---GAIIMS-ANFMGLEELQhL 217
Cdd:PLN00113  120 LRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGE---IPNDIGSfSSLKVLDLGGNvlvGKIPNSlTNLTSLEFLT-L 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907155395 218 DFQHSTLKRVTEFSAFLSLeKLLYLdiSYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNvFANTTNLTFLDLSKCQ 297
Cdd:PLN00113  196 ASNQLVGQIPRELGQMKSL-KWIYL--GYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSS-LGNLKNLQYLFLYQNK 271

                         170       180
                  ....*....|....*....|....*.
gi 1907155395 298 LE-QISWGVFDtLHRLQLLNMSHNNL 322
Cdd:PLN00113  272 LSgPIPPSIFS-LQKLISLDLSDNSL 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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