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Conserved domains on  [gi|1907068392|ref|XP_036019905|]
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nonsense-mediated mRNA decay factor SMG7 isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EST1_DNA_bind super family cl26538
Est1 DNA/RNA binding domain; Est1 is a protein which recruits or activates telomerase at the ...
 1-95 5.19e-11

Est1 DNA/RNA binding domain; Est1 is a protein which recruits or activates telomerase at the site of polymerization. This is the DNA/RNA binding domain of EST1.


The actual alignment was detected with superfamily member pfam10373:

Pssm-ID: 431239  Cd Length: 279  Bit Score: 64.36  E-value: 5.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068392   1 MSFLGILCKCPLQNDSQES---NNAYPLPAVKVSMDWLRLRPRVFQ-----EAVVDERQYIWPWLIS--LLNSFHPREDD 70
Cdd:pfam10373 177 FTLFGLLLEEVNTLEALKSftpVATRYLPALRVYLCWLKSNPSVLEfedkdEKLVDSLSDLWNELLSstLLNSSFDVEKR 256

                          90       100
                  ....*....|....*....|....*
gi 1907068392  71 LSNTnaTPLPEEFELQGFLALRPSF 95
Cdd:pfam10373 257 PKRD--YLLEEDVELKGFSPLGYRL 279
 
Name Accession Description Interval E-value
EST1_DNA_bind pfam10373
Est1 DNA/RNA binding domain; Est1 is a protein which recruits or activates telomerase at the ...
 1-95 5.19e-11

Est1 DNA/RNA binding domain; Est1 is a protein which recruits or activates telomerase at the site of polymerization. This is the DNA/RNA binding domain of EST1.


Pssm-ID: 431239  Cd Length: 279  Bit Score: 64.36  E-value: 5.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068392   1 MSFLGILCKCPLQNDSQES---NNAYPLPAVKVSMDWLRLRPRVFQ-----EAVVDERQYIWPWLIS--LLNSFHPREDD 70
Cdd:pfam10373 177 FTLFGLLLEEVNTLEALKSftpVATRYLPALRVYLCWLKSNPSVLEfedkdEKLVDSLSDLWNELLSstLLNSSFDVEKR 256

                          90       100
                  ....*....|....*....|....*
gi 1907068392  71 LSNTnaTPLPEEFELQGFLALRPSF 95
Cdd:pfam10373 257 PKRD--YLLEEDVELKGFSPLGYRL 279
 
Name Accession Description Interval E-value
EST1_DNA_bind pfam10373
Est1 DNA/RNA binding domain; Est1 is a protein which recruits or activates telomerase at the ...
 1-95 5.19e-11

Est1 DNA/RNA binding domain; Est1 is a protein which recruits or activates telomerase at the site of polymerization. This is the DNA/RNA binding domain of EST1.


Pssm-ID: 431239  Cd Length: 279  Bit Score: 64.36  E-value: 5.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068392   1 MSFLGILCKCPLQNDSQES---NNAYPLPAVKVSMDWLRLRPRVFQ-----EAVVDERQYIWPWLIS--LLNSFHPREDD 70
Cdd:pfam10373 177 FTLFGLLLEEVNTLEALKSftpVATRYLPALRVYLCWLKSNPSVLEfedkdEKLVDSLSDLWNELLSstLLNSSFDVEKR 256

                          90       100
                  ....*....|....*....|....*
gi 1907068392  71 LSNTnaTPLPEEFELQGFLALRPSF 95
Cdd:pfam10373 257 PKRD--YLLEEDVELKGFSPLGYRL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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