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Conserved domains on  [gi|1907156290|ref|XP_036020067|]
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nibrin isoform X2 [Mus musculus]

Protein Classification

BRCT domain-containing protein( domain architecture ID 13026988)

BRCT (BRCA1 C-terminus) domain-containing protein may interact with DNA, and participate in DNA-damage checkpoint or DNA-repair pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
104-212 3.68e-33

Second BRCT domain on Nijmegen syndrome breakage protein;


:

Pssm-ID: 465151  Cd Length: 118  Bit Score: 123.17  E-value: 3.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156290 104 ERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQ-------------SFFSAPGTCVVDVGITNTqliis 170
Cdd:pfam16508   2 ERKTLFEGKTFVFLDQKQFERLSPPITNGGGKALLYEVEPGETTpddfvryvknvgsELLTGKGVVVVRFRPKKS----- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1907156290 171 hSQKKWIHLIMDTLQRN-GLRPIPEAEIGLAVIFMTTENYCNP 212
Cdd:pfam16508  77 -SNEEWIASFENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 10-71 6.18e-27

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


:

Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 103.84  E-value: 6.18e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156290  10 SGKTVLNQAILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKAV 71
Cdd:cd17741    13 EEKKKLKQIIAKLGGKVVNEWTEECTHLVMSKIKVTVKVICALISGKPIVTPEYLDALLEAI 74
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 568-628 4.43e-23

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


:

Pssm-ID: 462531  Cd Length: 62  Bit Score: 92.75  E-value: 4.43e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907156290 568 KNFKKFKKATFPGAGKLPHIIGGSDLVGHHARKNTELEEWLKQEMEVSRKggpHTRDCTLA 628
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQ---SAREESLA 58
 
Name Accession Description Interval E-value
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
104-212 3.68e-33

Second BRCT domain on Nijmegen syndrome breakage protein;


Pssm-ID: 465151  Cd Length: 118  Bit Score: 123.17  E-value: 3.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156290 104 ERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQ-------------SFFSAPGTCVVDVGITNTqliis 170
Cdd:pfam16508   2 ERKTLFEGKTFVFLDQKQFERLSPPITNGGGKALLYEVEPGETTpddfvryvknvgsELLTGKGVVVVRFRPKKS----- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1907156290 171 hSQKKWIHLIMDTLQRN-GLRPIPEAEIGLAVIFMTTENYCNP 212
Cdd:pfam16508  77 -SNEEWIASFENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 10-71 6.18e-27

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 103.84  E-value: 6.18e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156290  10 SGKTVLNQAILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKAV 71
Cdd:cd17741    13 EEKKKLKQIIAKLGGKVVNEWTEECTHLVMSKIKVTVKVICALISGKPIVTPEYLDALLEAI 74
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 568-628 4.43e-23

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


Pssm-ID: 462531  Cd Length: 62  Bit Score: 92.75  E-value: 4.43e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907156290 568 KNFKKFKKATFPGAGKLPHIIGGSDLVGHHARKNTELEEWLKQEMEVSRKggpHTRDCTLA 628
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQ---SAREESLA 58
 
Name Accession Description Interval E-value
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
104-212 3.68e-33

Second BRCT domain on Nijmegen syndrome breakage protein;


Pssm-ID: 465151  Cd Length: 118  Bit Score: 123.17  E-value: 3.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156290 104 ERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQ-------------SFFSAPGTCVVDVGITNTqliis 170
Cdd:pfam16508   2 ERKTLFEGKTFVFLDQKQFERLSPPITNGGGKALLYEVEPGETTpddfvryvknvgsELLTGKGVVVVRFRPKKS----- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1907156290 171 hSQKKWIHLIMDTLQRN-GLRPIPEAEIGLAVIFMTTENYCNP 212
Cdd:pfam16508  77 -SNEEWIASFENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 10-71 6.18e-27

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 103.84  E-value: 6.18e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156290  10 SGKTVLNQAILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKAV 71
Cdd:cd17741    13 EEKKKLKQIIAKLGGKVVNEWTEECTHLVMSKIKVTVKVICALISGKPIVTPEYLDALLEAI 74
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 568-628 4.43e-23

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


Pssm-ID: 462531  Cd Length: 62  Bit Score: 92.75  E-value: 4.43e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907156290 568 KNFKKFKKATFPGAGKLPHIIGGSDLVGHHARKNTELEEWLKQEMEVSRKggpHTRDCTLA 628
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQ---SAREESLA 58
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
 19-63 8.28e-08

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 49.54  E-value: 8.28e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907156290  19 ILQLGGLTANNWtEECTHLVMSAVKVTIKTICALICGRPIIKPEY 63
Cdd:cd17744    18 IKKLGGSVVDSV-EDCTHLVTDKVRRTVKFLCALARGIPIVSPDW 61
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 8-64 1.35e-07

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 48.90  E-value: 1.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156290   8 YVSG-----KTVLNQAILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYF 64
Cdd:cd00027     4 CFSGlddeeREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWL 65
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 15-70 8.22e-06

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 44.15  E-value: 8.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907156290  15 LNQAILQLGGLTANNwTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKA 70
Cdd:cd17712    17 LTKKVTILGGEVVES-PQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQ 71
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 15-70 2.37e-05

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 42.55  E-value: 2.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907156290  15 LNQAILQLGG--LTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKA 70
Cdd:cd17738    17 LISIIEKLGGkvLDSDEFDPKCTHLICGKPSRSEKFLAACAAGKWILHPSYIEASAKA 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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