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Conserved domains on  [gi|1907069387|ref|XP_036021599|]
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uncharacterized protein C8orf34 homolog isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5586 super family cl39317
Family of unknown function (DUF5586); This is a family of unknown function found in chordata.
 6-366 0e+00

Family of unknown function (DUF5586); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17824:

Pssm-ID: 465522  Cd Length: 402  Bit Score: 530.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387   6 QTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGNQGQLQRALSGSAALWAESeSSEPKGTRRDFRSYD 85
Cdd:pfam17824   1 QTRIQAYLEKNKIGPLFEELMTKLITETPDHPIPFLIDHLQTKQGSPGQLQRTLSGSAALWAES-SKESKGTRRDFRSYE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387  86 KPWQMNAKKPKKSKSDLAVSNISPPSPDSKS-------------------------------------------CIAISD 122
Cdd:pfam17824  80 KPWQIHPKKPKKSKSDLAVSNISPPSPESKSlprsiehpkwdwrtkpqsrdfdelnhilqeskklgkalenlsrSIAISD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 123 ELDKETLAFNSsLLRPRVIGEWIGRAENDADPLAAEMLQPPVPRSKNDSWESEDSSSsPAGSLKMEPKTKGLKQQQQQHK 202
Cdd:pfam17824 160 ELDKETVTYNS-VLRPRVVGEWVGREEEDADPLAAEMLQPPVPRAKTEQWESEDGSS-PAGSLKMETKNKGLKQQQQQHK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 203 KLLAAMLSQDSFESIHSPTPSVIEEDIDNEDDAMELLENLDDLRMEGVTTLVLSGSKFNQGRPTHPAEPQAKVTLNICS- 281
Cdd:pfam17824 238 KLLAAMLSQDSFDSIHSPAPSVTEEEMEDEDDAMELLEDLDDLRMEGVTGLVPSGSKFSQGRSSYPAEPQAKVTLNICSr 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 282 --RLQGDNLMERTEDTLQILHTPDEIIPDSLDSLPGteeTLMEEGEDFEKTSNLTEPGEASSG-AHSLKSYMEEDESLKQ 358
Cdd:pfam17824 318 caRLQGDSLEERREEEEPILHSPEQAVPDSFCSLPG---ALMEEGDGFEKASKLTGPGEASSGvGHSLKNYMEEDESLKQ 394


                  ....*...
gi 1907069387 359 LQVVHQPW 366
Cdd:pfam17824 395 LQVIRQPW 402
 
Name Accession Description Interval E-value
DUF5586 pfam17824
Family of unknown function (DUF5586); This is a family of unknown function found in chordata.
 6-366 0e+00

Family of unknown function (DUF5586); This is a family of unknown function found in chordata.


Pssm-ID: 465522  Cd Length: 402  Bit Score: 530.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387   6 QTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGNQGQLQRALSGSAALWAESeSSEPKGTRRDFRSYD 85
Cdd:pfam17824   1 QTRIQAYLEKNKIGPLFEELMTKLITETPDHPIPFLIDHLQTKQGSPGQLQRTLSGSAALWAES-SKESKGTRRDFRSYE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387  86 KPWQMNAKKPKKSKSDLAVSNISPPSPDSKS-------------------------------------------CIAISD 122
Cdd:pfam17824  80 KPWQIHPKKPKKSKSDLAVSNISPPSPESKSlprsiehpkwdwrtkpqsrdfdelnhilqeskklgkalenlsrSIAISD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 123 ELDKETLAFNSsLLRPRVIGEWIGRAENDADPLAAEMLQPPVPRSKNDSWESEDSSSsPAGSLKMEPKTKGLKQQQQQHK 202
Cdd:pfam17824 160 ELDKETVTYNS-VLRPRVVGEWVGREEEDADPLAAEMLQPPVPRAKTEQWESEDGSS-PAGSLKMETKNKGLKQQQQQHK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 203 KLLAAMLSQDSFESIHSPTPSVIEEDIDNEDDAMELLENLDDLRMEGVTTLVLSGSKFNQGRPTHPAEPQAKVTLNICS- 281
Cdd:pfam17824 238 KLLAAMLSQDSFDSIHSPAPSVTEEEMEDEDDAMELLEDLDDLRMEGVTGLVPSGSKFSQGRSSYPAEPQAKVTLNICSr 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 282 --RLQGDNLMERTEDTLQILHTPDEIIPDSLDSLPGteeTLMEEGEDFEKTSNLTEPGEASSG-AHSLKSYMEEDESLKQ 358
Cdd:pfam17824 318 caRLQGDSLEERREEEEPILHSPEQAVPDSFCSLPG---ALMEEGDGFEKASKLTGPGEASSGvGHSLKNYMEEDESLKQ 394


                  ....*...
gi 1907069387 359 LQVVHQPW 366
Cdd:pfam17824 395 LQVIRQPW 402
DD_VEST1 cd22980
dimerization/docking (D/D) domain found in protein VEST-1 and similar proteins; VEST-1 (also ...
 6-50 7.15e-23

dimerization/docking (D/D) domain found in protein VEST-1 and similar proteins; VEST-1 (also called protein C8orf34) is an uncharacterized protein which contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438549  Cd Length: 45  Bit Score: 90.39  E-value: 7.15e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907069387   6 QTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQG 50
Cdd:cd22980     1 QQRIQAYLEKHKIGALFEDLMAKLIRDTPDEPIPYLIKVLQKKAG 45
 
Name Accession Description Interval E-value
DUF5586 pfam17824
Family of unknown function (DUF5586); This is a family of unknown function found in chordata.
 6-366 0e+00

Family of unknown function (DUF5586); This is a family of unknown function found in chordata.


Pssm-ID: 465522  Cd Length: 402  Bit Score: 530.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387   6 QTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGNQGQLQRALSGSAALWAESeSSEPKGTRRDFRSYD 85
Cdd:pfam17824   1 QTRIQAYLEKNKIGPLFEELMTKLITETPDHPIPFLIDHLQTKQGSPGQLQRTLSGSAALWAES-SKESKGTRRDFRSYE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387  86 KPWQMNAKKPKKSKSDLAVSNISPPSPDSKS-------------------------------------------CIAISD 122
Cdd:pfam17824  80 KPWQIHPKKPKKSKSDLAVSNISPPSPESKSlprsiehpkwdwrtkpqsrdfdelnhilqeskklgkalenlsrSIAISD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 123 ELDKETLAFNSsLLRPRVIGEWIGRAENDADPLAAEMLQPPVPRSKNDSWESEDSSSsPAGSLKMEPKTKGLKQQQQQHK 202
Cdd:pfam17824 160 ELDKETVTYNS-VLRPRVVGEWVGREEEDADPLAAEMLQPPVPRAKTEQWESEDGSS-PAGSLKMETKNKGLKQQQQQHK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 203 KLLAAMLSQDSFESIHSPTPSVIEEDIDNEDDAMELLENLDDLRMEGVTTLVLSGSKFNQGRPTHPAEPQAKVTLNICS- 281
Cdd:pfam17824 238 KLLAAMLSQDSFDSIHSPAPSVTEEEMEDEDDAMELLEDLDDLRMEGVTGLVPSGSKFSQGRSSYPAEPQAKVTLNICSr 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069387 282 --RLQGDNLMERTEDTLQILHTPDEIIPDSLDSLPGteeTLMEEGEDFEKTSNLTEPGEASSG-AHSLKSYMEEDESLKQ 358
Cdd:pfam17824 318 caRLQGDSLEERREEEEPILHSPEQAVPDSFCSLPG---ALMEEGDGFEKASKLTGPGEASSGvGHSLKNYMEEDESLKQ 394


                  ....*...
gi 1907069387 359 LQVVHQPW 366
Cdd:pfam17824 395 LQVIRQPW 402
DD_VEST1 cd22980
dimerization/docking (D/D) domain found in protein VEST-1 and similar proteins; VEST-1 (also ...
 6-50 7.15e-23

dimerization/docking (D/D) domain found in protein VEST-1 and similar proteins; VEST-1 (also called protein C8orf34) is an uncharacterized protein which contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438549  Cd Length: 45  Bit Score: 90.39  E-value: 7.15e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907069387   6 QTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQG 50
Cdd:cd22980     1 QQRIQAYLEKHKIGALFEDLMAKLIRDTPDEPIPYLIKVLQKKAG 45
DD_TEX55-like cd22961
dimerization/docking (D/D) domain found in the testis-specific expressed protein 55 (TEX55) ...
 8-46 3.04e-12

dimerization/docking (D/D) domain found in the testis-specific expressed protein 55 (TEX55)-like family; The TEX55-like family includes TEX55, F-box/LRR-repeat protein 13 (FBXL13), adenylate kinase isoenzymes AK5 and AK8, as well as uncharacterized EF-hand calcium-binding domain-containing protein 10 (EFCAB10), and protein VEST-1. TEX55, also called testis-specific conserved cAMP-dependent type II PK-anchoring protein (TSCPA), is a putative A-kinase anchoring protein (AKAP) that is dispensable for male fertility. FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6 (DRC6), is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It may also function as a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. AK5 and AK8 act as nucleoside monophosphate (NMP) kinases that catalyze the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Members of this family contain a conserved helical bundle domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438530  Cd Length: 43  Bit Score: 60.89  E-value: 3.04e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907069387   8 RIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQ 46
Cdd:cd22961     3 DAEEYLEKHKIPELFESLLTALLIEKPEDPIEFLIDKLQ 41
DD_AK8 cd22979
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar ...
 6-47 6.07e-10

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar proteins; AK8 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 8, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. It also displays broad nucleoside diphosphate kinase activity. AK8 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438548  Cd Length: 45  Bit Score: 54.39  E-value: 6.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907069387   6 QTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQS 47
Cdd:cd22979     3 PPEFAAYAEKHRIFELFQDLLKQLLIHKPEDPLQFLIDYLQK 44
DD_EFCAB10 cd22976
dimerization/docking (D/D) domain found in EF-hand calcium-binding domain-containing protein ...
 6-50 1.68e-08

dimerization/docking (D/D) domain found in EF-hand calcium-binding domain-containing protein 10 (EFCAB10) and similar proteins; The subfamily includes uncharacterized EF-hand calcium-binding domain-containing protein 10 (EFCAB10), which contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438545  Cd Length: 47  Bit Score: 50.18  E-value: 1.68e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907069387   6 QTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQG 50
Cdd:cd22976     1 EEEAEEYLEKHKIPELFENLTSLLLYHRPEDPKAFLIEQLEKLKE 45
DD_CrRSP_unchar cd22964
dimerization/docking (D/D) domain of an uncharacterized subunit found in Chlamydomonas ...
 9-49 1.33e-07

dimerization/docking (D/D) domain of an uncharacterized subunit found in Chlamydomonas reinhardtii radial spoke 1; Flagellar radial spokes contribute to the regulation of dynein arm activity and thus the pattern of flagellar bending. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. This subfamily includes an uncharacterized protein found in Chlamydomonas reinhardtii radial spoke 1. It contains a conserved domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438533  Cd Length: 46  Bit Score: 47.61  E-value: 1.33e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907069387   9 IQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQ 49
Cdd:cd22964     5 KKEYLQQKVINPILEQLVTDLLQEKPEDPVPFMIQWLRKKR 45
DD_TbAK-like cd22981
dimerization/docking (D/D) domain found in Trypanosoma brucei adenylate kinase (AK) and ...
 10-47 2.25e-07

dimerization/docking (D/D) domain found in Trypanosoma brucei adenylate kinase (AK) and similar proteins; AK (EC 2.7.4.3), also called ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, or adenylate monophosphate kinase, catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Members of this subfamily contain an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438550  Cd Length: 44  Bit Score: 47.02  E-value: 2.25e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907069387  10 QAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQS 47
Cdd:cd22981     6 QKYLKEKNIPQLFEFLLRHLLLDKPENPLEYLHDLLER 43
DD_AK5 cd22978
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar ...
 10-47 1.19e-05

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar proteins; AK5 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 5, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It is active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. It also displays broad nucleoside diphosphate kinase activity. AK5 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438547  Cd Length: 44  Bit Score: 42.14  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907069387  10 QAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQS 47
Cdd:cd22978     5 KDYLSRKEIPQLFESLMTGLMYNRPDDPIEFLEDCLEK 42
DD_TEX55 cd22975
dimerization/docking (D/D) domain found in testis-specific expressed protein 55 (TEX55) and ...
 7-49 1.47e-05

dimerization/docking (D/D) domain found in testis-specific expressed protein 55 (TEX55) and similar proteins; TEX55, also called testis-specific conserved cAMP-dependent type II PK-anchoring protein (TSCPA), is a putative A-kinase anchoring protein (AKAP) that is dispensable for male fertility. It contains a C-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438544  Cd Length: 50  Bit Score: 42.17  E-value: 1.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907069387   7 TRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQ 49
Cdd:cd22975     5 EKAVKYLEKHNILQLFQELTAGLVYERPDDPIQFMIDEIEKII 47
DD_FBXL13 cd22977
dimerization/docking (D/D) domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar ...
 12-47 2.99e-03

dimerization/docking (D/D) domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6 (DRC6), is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It may also function as a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438546  Cd Length: 43  Bit Score: 35.22  E-value: 2.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907069387  12 YLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQS 47
Cdd:cd22977     7 YLRKHKLPDVYEALLTGLAVMCPEDPLRFIEEKLKE 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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