|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
209-388 |
3.58e-126 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 380.34 E-value: 3.58e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILMS 368
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 1911174477 369 ATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
217-778 |
6.22e-120 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 387.13 E-value: 6.22e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 217 ELVNMIDNHQVTVISGETGCGKTTQVTQFILDnyieRGKGSACRIVCTQPRRISAISVAERVAAERAETCGNgnSTGYQI 296
Cdd:COG1643 18 ELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE--TVGYRV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 297 RLQSRLpRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLL-NYRPDLKVILMSATLNAEK 375
Cdd:COG1643 92 RFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSATLDAER 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 376 FSEYFGNCPMIHIPGFTFPVveyllediiEkIRYVPEQKEHRsqfkrgfmqghvnrqekeekeatykeRWPDyvrelrkr 455
Cdd:COG1643 171 FARLLGDAPVIESSGRTYPV---------E-VRYRPLPADER--------------------------DLED-------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 456 ysastvdviemmdddkvdlnLIAALIRyIVLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLIIPLHSLMPTVNQ 535
Cdd:COG1643 207 --------------------AVADAVR-EALAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 536 TQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 615
Cdd:COG1643 263 DRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYR 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 616 LYNSLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAHFlsRLMDPPS----NEAVSLsikhLMELNALDKQEELTPL 691
Cdd:COG1643 343 LWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPParaiADARAL----LQELGALDADGRLTPL 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 692 GVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPfviplgkekvadaRRkelaKDSKSDHLTVVNAFEGWEEA 771
Cdd:COG1643 417 GRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQ 479
|
....*..
gi 1911174477 772 RRRGFRY 778
Cdd:COG1643 480 QREFLSY 486
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
207-773 |
5.70e-92 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 319.79 E-value: 5.70e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 207 EKLPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERAEtc 286
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICL----ELGRGSHGLIGHTQPRRLAARTVAQRIAEELGT-- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 287 GNGNSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVIL 366
Cdd:TIGR01967 138 PLGEKVGYKVRFHDQV-SSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIII 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 367 MSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPEQkehrsqfkrgfmqghvnrQEKEEkeatykerwp 446
Cdd:TIGR01967 217 TSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRPLV------------------EEQED---------- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 447 dyvrelrkrysastvdviemmDDDKVDLNLIAALIRyiVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDrflIIPL 526
Cdd:TIGR01967 259 ---------------------DDLDQLEAILDAVDE--LFAEGPGDILIFLPGEREIRDAAEILRKRNLRHTE---ILPL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 527 HSLMPTVNQTQVFKrtPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAG 606
Cdd:TIGR01967 313 YARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCG 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 607 RVQPGHCYHLYNSLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAHFlsRLMDPPSNEAVSLSIKHLMELNALDKQE 686
Cdd:TIGR01967 391 RVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAF--PFIEAPDPRAIRDGFRLLEELGALDDDE 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 687 ---ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELaKDSKSDHLTVVN 763
Cdd:TIGR01967 469 aepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARF-KDPRSDFLSRVN 547
|
570
....*....|
gi 1911174477 764 AFEGWEEARR 773
Cdd:TIGR01967 548 LWRHIEEQRQ 557
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
204-763 |
1.27e-85 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 301.59 E-value: 1.27e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 204 HFREKLPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERA 283
Cdd:PRK11131 68 TYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL----ELGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 284 etCGNGNSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLK 363
Cdd:PRK11131 144 --TELGGCVGYKVRFNDQV-SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 364 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPeqkehrsqfkrgfMQGHVNRQEKEEKEATYke 443
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP-------------IVEEADDTERDQLQAIF-- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 444 rwpDYVRELRkrysastvdviemmdddkvdlnliaaliryivlEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDrflI 523
Cdd:PRK11131 276 ---DAVDELG---------------------------------REGPGDILIFMSGEREIRDTADALNKLNLRHTE---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 524 IPLHSLMPTVNQTQVFKrtPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 603
Cdd:PRK11131 317 LPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 604 RAGRVQPGHCYHLY-----NSlRASLLDdyqlPEILRTPLEELCLQIKILRLGGIAHFlsRLMDPPSNEAVSLSIKHLME 678
Cdd:PRK11131 395 RCGRVSEGICIRLYseddfLS-RPEFTD----PEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEE 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 679 LNALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELAkD 753
Cdd:PRK11131 468 LGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFA-D 546
|
570
....*....|
gi 1911174477 754 SKSDHLTVVN 763
Cdd:PRK11131 547 KESDFLAFVN 556
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
463-617 |
1.17e-76 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 248.60 E-value: 1.17e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 463 VIEMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DRFLIIPLHSLMPTVNQTQVFKR 541
Cdd:cd18791 16 GISSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEP 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1911174477 542 TPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY 617
Cdd:cd18791 96 PPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
672-761 |
4.47e-28 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 108.86 E-value: 4.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 672 SIKHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 738
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 1911174477 739 -KEKVADARRKELAKDSKSDHLTV 761
Cdd:pfam04408 81 rRAADEKARAKFARLDLEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
212-394 |
4.45e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 106.81 E-value: 4.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 212 FGMQKELVN-MIDNHQVTVISGETGCGKTTQVTQFILDNYIergKGSACRIVCTQPRRISAISVAERVAAERAETCGN-- 288
Cdd:smart00487 10 RPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALK---RGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKvv 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQ-SRLPRKQGSILYCTTGIILQWLQSDP-HLSSVSHIVLDEIHER--NLQSDVLMTVIKDLlnyRPDLKV 364
Cdd:smart00487 87 GLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKLLKLL---PKNVQL 163
|
170 180 190
....*....|....*....|....*....|..
gi 1911174477 365 ILMSATL--NAEKFSEYFGNCPMIHIPGFTFP 394
Cdd:smart00487 164 LLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
678-762 |
1.04e-24 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 98.49 E-value: 1.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 678 ELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKVADARRKELAkDSKSD 757
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFA-DPESD 77
|
....*
gi 1911174477 758 HLTVV 762
Cdd:smart00847 78 HLTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
833-919 |
1.39e-18 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 81.14 E-value: 1.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 833 IKAVICAGLYPKVAKiRLNLGKKRKMVKvytkTDGLVSIHPKSVNVEQTEFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 912
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTTLS----DNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWL 75
|
....*..
gi 1911174477 913 LFFGGDI 919
Cdd:pfam07717 76 LLFAPHI 82
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
215-374 |
7.78e-12 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 64.57 E-value: 7.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 215 QKELVNMIDNHQVTVISGETGCGKTTqVTQF-ILDNYIERGKGSacRIVCTQPRRISAISVAERvAAERAETCG------ 287
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTL-AFLLpALEALDKLDNGP--QALVLAPTRELAEQIYEE-LKKLGKGLGlkvasl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 288 -NGNSTGYQIRLQSRLPrkqgsILYCTTGIILQWLQSDPHLSSVSHIVLDEIHE--RNLQSDVLMTVIKDLlnyRPDLKV 364
Cdd:pfam00270 80 lGGDSRKEQLEKLKGPD-----ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGPDLEEILRRL---PKKRQI 151
|
170
....*....|
gi 1911174477 365 ILMSATLNAE 374
Cdd:pfam00270 152 LLLSATLPRN 161
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
59-366 |
5.75e-03 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 40.56 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 59 HLKGRDIGLWYAKKQGQKSKEAERQERAVVHMDEHREEQIVQLLHSVQAKSDKDSEAQISWFAPEDHGYGSEAPAENKPN 138
Cdd:COG5635 26 AIALAALLLLALVALGLALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 139 SEKKLEDREKKLINQEKKTFRMRDKYIDRDSEYLLQENEPDVNLDQQLLEDLQkkkTDLRYIEMQHFREKLPSFGmqkel 218
Cdd:COG5635 106 ALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLY---VPLNLLERIESLKRLELLE----- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 219 vnmiDNHQVTVISGETGCGKTTqVTQFILDNYIERGKGSACRIvctqPRRISAISVAERVAAERAetcgngnstgyqirL 298
Cdd:COG5635 178 ----AKKKRLLILGEPGSGKTT-LLRYLALELAERYLDAEDPI----PILIELRDLAEEASLEDL--------------L 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1911174477 299 QSRLPRKQGSilycTTGIILQWLQSDphlssvsHIV-----LDEIHERNLQSDVLmTVIKDLLNYRPDLKVIL 366
Cdd:COG5635 235 AEALEKRGGE----PEDALERLLRNG-------RLLllldgLDEVPDEADRDEVL-NQLRRFLERYPKARVII 295
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
209-388 |
3.58e-126 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 380.34 E-value: 3.58e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILMS 368
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 1911174477 369 ATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
217-778 |
6.22e-120 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 387.13 E-value: 6.22e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 217 ELVNMIDNHQVTVISGETGCGKTTQVTQFILDnyieRGKGSACRIVCTQPRRISAISVAERVAAERAETCGNgnSTGYQI 296
Cdd:COG1643 18 ELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE--TVGYRV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 297 RLQSRLpRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLL-NYRPDLKVILMSATLNAEK 375
Cdd:COG1643 92 RFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSATLDAER 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 376 FSEYFGNCPMIHIPGFTFPVveyllediiEkIRYVPEQKEHRsqfkrgfmqghvnrqekeekeatykeRWPDyvrelrkr 455
Cdd:COG1643 171 FARLLGDAPVIESSGRTYPV---------E-VRYRPLPADER--------------------------DLED-------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 456 ysastvdviemmdddkvdlnLIAALIRyIVLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLIIPLHSLMPTVNQ 535
Cdd:COG1643 207 --------------------AVADAVR-EALAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 536 TQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 615
Cdd:COG1643 263 DRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYR 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 616 LYNSLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAHFlsRLMDPPS----NEAVSLsikhLMELNALDKQEELTPL 691
Cdd:COG1643 343 LWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPParaiADARAL----LQELGALDADGRLTPL 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 692 GVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPfviplgkekvadaRRkelaKDSKSDHLTVVNAFEGWEEA 771
Cdd:COG1643 417 GRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQ 479
|
....*..
gi 1911174477 772 RRRGFRY 778
Cdd:COG1643 480 QREFLSY 486
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
207-773 |
5.70e-92 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 319.79 E-value: 5.70e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 207 EKLPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERAEtc 286
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICL----ELGRGSHGLIGHTQPRRLAARTVAQRIAEELGT-- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 287 GNGNSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVIL 366
Cdd:TIGR01967 138 PLGEKVGYKVRFHDQV-SSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIII 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 367 MSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPEQkehrsqfkrgfmqghvnrQEKEEkeatykerwp 446
Cdd:TIGR01967 217 TSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRPLV------------------EEQED---------- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 447 dyvrelrkrysastvdviemmDDDKVDLNLIAALIRyiVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDrflIIPL 526
Cdd:TIGR01967 259 ---------------------DDLDQLEAILDAVDE--LFAEGPGDILIFLPGEREIRDAAEILRKRNLRHTE---ILPL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 527 HSLMPTVNQTQVFKrtPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAG 606
Cdd:TIGR01967 313 YARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCG 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 607 RVQPGHCYHLYNSLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAHFlsRLMDPPSNEAVSLSIKHLMELNALDKQE 686
Cdd:TIGR01967 391 RVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAF--PFIEAPDPRAIRDGFRLLEELGALDDDE 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 687 ---ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELaKDSKSDHLTVVN 763
Cdd:TIGR01967 469 aepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARF-KDPRSDFLSRVN 547
|
570
....*....|
gi 1911174477 764 AFEGWEEARR 773
Cdd:TIGR01967 548 LWRHIEEQRQ 557
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
225-388 |
4.23e-88 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 278.96 E-value: 4.23e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 225 HQVTVISGETGCGKTTQVTQFILDNYIERGKGsaCRIVCTQPRRISAISVAERVAAERAETCGNgnSTGYQIRLQSRLPR 304
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGK--GRIVCTQPRRIAAISVAERVAEERGEKLGE--EVGYQIRFESKTSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 305 KqGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILMSATLNAEKFSEYFGNCP 384
Cdd:cd17917 77 K-TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAP 155
|
....
gi 1911174477 385 MIHI 388
Cdd:cd17917 156 VIHI 159
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
204-763 |
1.27e-85 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 301.59 E-value: 1.27e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 204 HFREKLPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERA 283
Cdd:PRK11131 68 TYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL----ELGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 284 etCGNGNSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLK 363
Cdd:PRK11131 144 --TELGGCVGYKVRFNDQV-SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 364 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPeqkehrsqfkrgfMQGHVNRQEKEEKEATYke 443
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP-------------IVEEADDTERDQLQAIF-- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 444 rwpDYVRELRkrysastvdviemmdddkvdlnliaaliryivlEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDrflI 523
Cdd:PRK11131 276 ---DAVDELG---------------------------------REGPGDILIFMSGEREIRDTADALNKLNLRHTE---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 524 IPLHSLMPTVNQTQVFKrtPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 603
Cdd:PRK11131 317 LPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 604 RAGRVQPGHCYHLY-----NSlRASLLDdyqlPEILRTPLEELCLQIKILRLGGIAHFlsRLMDPPSNEAVSLSIKHLME 678
Cdd:PRK11131 395 RCGRVSEGICIRLYseddfLS-RPEFTD----PEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEE 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 679 LNALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELAkD 753
Cdd:PRK11131 468 LGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFA-D 546
|
570
....*....|
gi 1911174477 754 SKSDHLTVVN 763
Cdd:PRK11131 547 KESDFLAFVN 556
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
463-617 |
1.17e-76 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 248.60 E-value: 1.17e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 463 VIEMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DRFLIIPLHSLMPTVNQTQVFKR 541
Cdd:cd18791 16 GISSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEP 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1911174477 542 TPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLY 617
Cdd:cd18791 96 PPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
209-757 |
2.00e-74 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 262.39 E-value: 2.00e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsacrIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK-----IIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLN-YRPDLKVILM 367
Cdd:TIGR01970 76 --TVGYRVRGENKVSRRT-RLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSsLREDLKILAM 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 368 SATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPEQKEhrsqfkrgfmqghvnrqekeekeatykERWPD 447
Cdd:TIGR01970 153 SATLDGERLSSLLPDAPVVESEGRSFPV----------EIRYLPLRGD---------------------------QRLED 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 448 YVRelrkrysastvDVIEMMdddkvdlnliaaliryivLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLIIPLH 527
Cdd:TIGR01970 196 AVS-----------RAVEHA------------------LASETGSILVFLPGQAEIRRVQEQLAERL---DSDVLICPLY 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 528 SLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGR 607
Cdd:TIGR01970 244 GELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGR 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 608 VQPGHCYHLYNSLRASLLDDYQLPEILRTPLEELCLQikILRLGGIAHFLSRLMDPPSNEAVSLSIKHLMELNALDKQEE 687
Cdd:TIGR01970 324 LEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALE--LAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGR 401
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 688 LTPLGVHLARLPVEPHIGKMILFG------ALFCCLDPVLT-----------IAASLSFKDPFVIPLGKEkvADARRKEL 750
Cdd:TIGR01970 402 LTAHGKAMAALGCHPRLAAMLLSAhstglaALACDLAALLEerglprqggadLMNRLHRLQQGRQGRGQR--AQQLAKKL 479
|
....*..
gi 1911174477 751 AKDSKSD 757
Cdd:TIGR01970 480 RRRLRFS 486
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
209-388 |
2.39e-73 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 239.74 E-value: 2.39e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 gnSTGYQIRLQSRlpRKQGS-ILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILM 367
Cdd:cd17985 81 --SVGYQIRLESV--KSSATrLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILM 156
|
170 180
....*....|....*....|.
gi 1911174477 368 SATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17985 157 SATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
182-388 |
1.63e-70 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 234.34 E-value: 1.63e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 182 LDQQLLEDLQ-KKKTDLRYIEMQHFREKLPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACR 260
Cdd:cd17972 31 ISMDLKNELMyQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 261 IVCTQPRRISAISVAERVAAERAETCgnGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDphLSSVSHIVLDEIHE 340
Cdd:cd17972 111 IVVTQPRRISAVSVAERVAFERGEEV--GKSCGYSVRFESVLPRPHASILFCTVGVLLRKLEAG--IRGISHVIVDEIHE 186
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1911174477 341 RNLQSDVLMTVIKDLLNYRPDLKVILMSATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17972 187 RDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
209-388 |
8.07e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 227.37 E-value: 8.07e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 gnSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILMS 368
Cdd:cd17976 81 --NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMS 158
|
170 180
....*....|....*....|
gi 1911174477 369 ATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17976 159 ATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
209-388 |
9.52e-61 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 204.68 E-value: 9.52e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIErgKGSACRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYA--NGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQS-DPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILM 367
Cdd:cd17987 79 --TVGYQIRLESRVSPKT-LLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILS 155
|
170 180
....*....|....*....|.
gi 1911174477 368 SATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17987 156 SAALDVNLFIRYFGSCPVIYI 176
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
209-712 |
1.68e-60 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 222.11 E-value: 1.68e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyieRGKGSACRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLL-----QHGGINGKIIMLEPRRLAARNVAQRLAEQLGEKPGE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 gnSTGYQIRLQSRL-PRKQGSILycTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDV----LMTVIKDLlnyRPDLK 363
Cdd:PRK11664 79 --TVGYRMRAESKVgPNTRLEVV--TEGILTRMIQRDPELSGVGLVILDEFHERSLQADLalalLLDVQQGL---RDDLK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 364 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYVPeqkehrsqfkrgfmqghVNRQEKEEkEATYKE 443
Cdd:PRK11664 152 LLIMSATLDNDRLQQLLPDAPVIVSEGRSFPV----------ERRYQP-----------------LPAHQRFD-EAVARA 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 444 rwpdyVRELrkrysastvdviemmdddkvdlnliaaliryivLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLI 523
Cdd:PRK11664 204 -----TAEL---------------------------------LRQESGSLLLFLPGVGEIQRVQEQLASRV---ASDVLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 524 IPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 603
Cdd:PRK11664 243 CPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAG 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 604 RAGRVQPGHCYHLYNSLRASLLDDYQLPEILRTPLEELCLQikILRLGgiAHFLSRLM--DPPSNEAVSLSIKHLMELNA 681
Cdd:PRK11664 323 RAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLE--LLQWG--CHDPAQLSwlDQPPAAALAAAKRLLQQLGA 398
|
490 500 510
....*....|....*....|....*....|.
gi 1911174477 682 LDKQEELTPLGVHLARLPVEPHIGKMILFGA 712
Cdd:PRK11664 399 LDGQGRLTARGRKMAALGNDPRLAAMLVAAK 429
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
209-388 |
2.72e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 203.99 E-value: 2.72e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYI-ERGKGSACRIVCTQPRRISAISVAERVAAERAETCG 287
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 288 NG--NS-TGYQIRLQSRlPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKV 364
Cdd:cd17975 81 PGgkNSlCGYQIRMESR-TGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170 180
....*....|....*....|....
gi 1911174477 365 ILMSATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
206-389 |
8.79e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 182.30 E-value: 8.79e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 206 REKLPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFIldnyIERGKGSACRIVCTQPRRISAISVAERVAAERAet 285
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYL----AEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFG-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 286 CGNGNSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVI 365
Cdd:cd17971 77 CCLGQEVGYTIRFEDCTSPET-VIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLI 155
|
170 180
....*....|....*....|....
gi 1911174477 366 LMSATLNAEKFSEYFGNCPMIHIP 389
Cdd:cd17971 156 VTSATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
198-388 |
6.49e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 180.30 E-value: 6.49e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 198 RYIEMQHFREKLPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNyiERGKGSACRIVCTQPRRISAISVAER 277
Cdd:cd17973 2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDD--ELPHQPKKLVACTQPRRVAAMSVAQR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 278 VAAERAETCGNgnSTGYQIRLQSRLPRKqgSIL-YCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLL 356
Cdd:cd17973 80 VAEEMDVKLGE--EVGYSIRFEDCSSAK--TILkYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVV 155
|
170 180 190
....*....|....*....|....*....|..
gi 1911174477 357 NYRPDLKVILMSATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17973 156 RRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
209-395 |
2.26e-51 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 178.46 E-value: 2.26e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsACRIVCTQPRRISAISVAERVAAERAetCGN 288
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGK--YCNIVVTQPRRIAAISIARRVSQERE--WTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQsRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLL--NYRpDLKVIL 366
Cdd:cd17988 77 GSLVGYQVGLE-RPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLrtNSR-HVKIIL 154
|
170 180
....*....|....*....|....*....
gi 1911174477 367 MSATLNAEKFSEYFGncpMIHIPGFTFPV 395
Cdd:cd17988 155 MSATISCKEFADYFT---TPNNPAYVFEV 180
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
209-388 |
8.00e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 176.48 E-value: 8.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERgkgsacrIVCTQPRRISAISVAERVAAERAETcgN 288
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH-------IACTQPRRIACISLAKRVAFESLNQ--Y 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQ-SRLPRKQgsILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILM 367
Cdd:cd17979 72 GSKVAYQIRFErTRTLATK--LLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILM 149
|
170 180
....*....|....*....|.
gi 1911174477 368 SATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17979 150 SATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
209-388 |
1.98e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 169.99 E-value: 1.98e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGsacRIVCTQPRRISAISVAERVAAERAetCGN 288
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGG---KIGCTQPRRVAAMSVAARVAEEMG--VKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQSRLPRKqgSIL-YCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILM 367
Cdd:cd17974 76 GNEVGYSIRFEDCTSEK--TVLkYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLIS 153
|
170 180
....*....|....*....|.
gi 1911174477 368 SATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17974 154 SATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
209-388 |
3.15e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 169.18 E-value: 3.15e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFIL-DNYIERGKgsacrIVCTQPRRISAISVAERVAAERAETCG 287
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHeDGYTDYGM-----IGCTQPRRVAAMSVAKRVSEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 288 NgnSTGYQIRLQSrLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILM 367
Cdd:cd17983 76 E--EVGYAIRFED-CTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVT 152
|
170 180
....*....|....*....|.
gi 1911174477 368 SATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17983 153 SATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
209-388 |
3.71e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 166.38 E-value: 3.71e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRISAISVAERVAAERAetCGN 288
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG----MIGITQPRRVAAVSVAKRVAEEMG--VEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQSRLPRkQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYR-----PDLK 363
Cdd:cd17978 75 GQLVGYSVRFDDVTSE-ETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLK 153
|
170 180
....*....|....*....|....*
gi 1911174477 364 VILMSATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17978 154 VIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
209-380 |
1.17e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 162.25 E-value: 1.17e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACR-IVCTQPRRISAISVAERVAAERAETCG 287
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLA----EAGWTAGGRvVGCTQPRRVAAVTVAGRVAEEMGAVLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 288 NgnSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILM 367
Cdd:cd17980 77 H--EVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVA 154
|
170
....*....|...
gi 1911174477 368 SATLNAEKFSEYF 380
Cdd:cd17980 155 SATLDAEKFRDFF 167
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
209-388 |
1.33e-42 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 152.99 E-value: 1.33e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICL----ELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILMS 368
Cdd:cd17989 77 --AVGYKVRFTDQTSDET-CVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITS 153
|
170 180
....*....|....*....|
gi 1911174477 369 ATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17989 154 ATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
209-388 |
2.70e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 143.84 E-value: 2.70e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILdnyiERGKGSACRIVCTQPRRISAISVAERVAAERAetCGN 288
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLY----EAGFSQHGMIGVTQPRRVAAISVAQRVAEEMK--CTL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQSrLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLL-----NYRPDLK 363
Cdd:cd17984 75 GSKVGYQVRFDD-CSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFqekspNRKEHLK 153
|
170 180
....*....|....*....|....*
gi 1911174477 364 VILMSATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17984 154 VVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
209-378 |
5.56e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 140.57 E-value: 5.56e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILD-NYIERGKGSACRIVCTQPRRISAISVAERVAaerAETCG 287
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEaGFGSPESDNPGMIGITQPRRVAAVSMAKRVA---EELNV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 288 NGNSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPD------ 361
Cdd:cd17982 78 FGKEVSYQIRYDSTV-SENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdq 156
|
170 180
....*....|....*....|.
gi 1911174477 362 ----LKVILMSATLNAEKFSE 378
Cdd:cd17982 157 tvkpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
209-386 |
3.39e-35 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 132.07 E-value: 3.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRISAISVAERVAAERAETCGN 288
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG----KIIVLEPRRVAARAAARRLATLLGEAPGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLN-YRPDLKVILM 367
Cdd:cd17990 77 --TVGYRVRGESRVGRRT-RVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAM 153
|
170
....*....|....*....
gi 1911174477 368 SATLNAEKFSEYFGNCPMI 386
Cdd:cd17990 154 SATLDGDGLAALLPEAPVV 172
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
672-761 |
4.47e-28 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 108.86 E-value: 4.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 672 SIKHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 738
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 1911174477 739 -KEKVADARRKELAKDSKSDHLTV 761
Cdd:pfam04408 81 rRAADEKARAKFARLDLEGDHLTL 104
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
209-388 |
1.40e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 107.22 E-value: 1.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 209 LPSFGMQKELVNMIDNHQVTVISGETGCGKTTQVTQ----FILDNYIERGKgsacrIVCTQPRRISAISVAERVAAERAE 284
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLSAHYQHGV-----VVCTQVHKQTAVWLALRVADEMDV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 285 TCGNgnSTGYQIRLQSRLprKQGSIL-YCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLK 363
Cdd:cd17977 76 NIGH--EVGYVIPFENCC--TNETILrYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELK 151
|
170 180
....*....|....*....|....*
gi 1911174477 364 VILMSATLNAEKFSEYFGNCPMIHI 388
Cdd:cd17977 152 LVIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
212-394 |
4.45e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 106.81 E-value: 4.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 212 FGMQKELVN-MIDNHQVTVISGETGCGKTTQVTQFILDNYIergKGSACRIVCTQPRRISAISVAERVAAERAETCGN-- 288
Cdd:smart00487 10 RPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALK---RGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKvv 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQ-SRLPRKQGSILYCTTGIILQWLQSDP-HLSSVSHIVLDEIHER--NLQSDVLMTVIKDLlnyRPDLKV 364
Cdd:smart00487 87 GLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKLLKLL---PKNVQL 163
|
170 180 190
....*....|....*....|....*....|..
gi 1911174477 365 ILMSATL--NAEKFSEYFGNCPMIHIPGFTFP 394
Cdd:smart00487 164 LLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
678-762 |
1.04e-24 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 98.49 E-value: 1.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 678 ELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKVADARRKELAkDSKSD 757
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFA-DPESD 77
|
....*
gi 1911174477 758 HLTVV 762
Cdd:smart00847 78 HLTLL 82
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
227-388 |
9.82e-23 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 96.51 E-value: 9.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 227 VTVISGETGCGKTTQVTQFILDNYIERG--KGSacrIVCTQPRRISAISVAERVAAERAETCGNgnSTGYQIRlQSRLPR 304
Cdd:cd17986 20 IVLVSGEPGSGKSTQVPQWCAEFALSRGfqKGQ---VTVTQPHPLAARSLALRVADEMDLNLGH--EVGYSIP-QEDCTG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 305 KQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNYRPDLKVILMSATLNAEKFSEYFGNCP 384
Cdd:cd17986 94 PNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPALEPKLRAFWGNPP 173
|
....
gi 1911174477 385 MIHI 388
Cdd:cd17986 174 VVHV 177
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
833-919 |
1.39e-18 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 81.14 E-value: 1.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 833 IKAVICAGLYPKVAKiRLNLGKKRKMVKvytkTDGLVSIHPKSVNVEQTEFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 912
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTTLS----DNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWL 75
|
....*..
gi 1911174477 913 LFFGGDI 919
Cdd:pfam07717 76 LLFAPHI 82
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
228-370 |
1.02e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 72.44 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 228 TVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRISAISVAERVAAERAE--TCGnGNSTGYQIRLQSRLPRK 305
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGK----KVLVLVPTKALALQTAERLRELFGPgiRVA-VLVGGSSAEEREKNKLG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1911174477 306 QGSILYCTTGIILQWLQSD--PHLSSVSHIVLDEIHERNLQSDVLMTVIKDLLNY-RPDLKVILMSAT 370
Cdd:cd00046 79 DADIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAgLKNAQVILLSAT 146
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
214-611 |
1.83e-14 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 77.71 E-value: 1.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 214 MQKELVNMIDNHQVTVISGETGCGKTTQVTQFIL----------------DNYIERgkgsacRIVCTQPRrisaisvaer 277
Cdd:PHA02653 168 VQLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfdnldkidPNFIER------PIVLSLPR---------- 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 278 VAAERAETCGNGNSTGY-QI--------------RLQSRLPRKQGsILYCTTGIILQwlqsdpHLSSVSHIVLDEIHERN 342
Cdd:PHA02653 232 VALVRLHSITLLKSLGFdEIdgspislkygsipdELINTNPKPYG-LVFSTHKLTLN------KLFDYGTVIIDEVHEHD 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 343 LQSDVLMTVI-KDLLNYRpdlKVILMSATL--NAEKFSEYFGNCPMIHIPGFT-FPVVEylledIIEKIRYVPEQKehrs 418
Cdd:PHA02653 305 QIGDIIIAVArKHIDKIR---SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISE-----VYVKNKYNPKNK---- 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 419 qfkrgfmqghvnRQEKEEkeatykerwpdyvrELRkrysastvdviemmdddkvdlNLIAALIRYIVLEEEDGaiLVFLP 498
Cdd:PHA02653 373 ------------RAYIEE--------------EKK---------------------NIVTALKKYTPPKGSSG--IVFVA 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 499 gwdNISTLHDL--LMSQvmfKSDRFLIIPLHSLMPTVNQ--TQVFKRTPPgvrKIVIATNIAETSITIDDVVYVIDGGKI 574
Cdd:PHA02653 404 ---SVSQCEEYkkYLEK---RLPIYDFYIIHGKVPNIDEilEKVYSSKNP---SIIISTPYLESSVTIRNATHVYDTGRV 474
|
410 420 430
....*....|....*....|....*....|....*..
gi 1911174477 575 KETHFDTQNNIstmsaeWVSKANAKQRKGRAGRVQPG 611
Cdd:PHA02653 475 YVPEPFGGKEM------FISKSMRTQRKGRVGRVSPG 505
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
479-608 |
2.70e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 69.93 E-value: 2.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 479 ALIRYIVLEEEDGAILVFLPGWDnistlhdLLMSQVMFKSDRFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAET 558
Cdd:pfam00271 4 EALLELLKKERGGKVLIFSQTKK-------TLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1911174477 559 SITIDDVVYVIdggkiketHFDTQNNISTMsaewvskanaKQRKGRAGRV 608
Cdd:pfam00271 77 GLDLPDVDLVI--------NYDLPWNPASY----------IQRIGRAGRA 108
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
515-607 |
2.09e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.47 E-value: 2.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 515 MFKSDRFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIdggkiketHFDTqnnistmsaeWVS 594
Cdd:smart00490 6 LLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI--------IYDL----------PWS 67
|
90
....*....|...
gi 1911174477 595 KANAKQRKGRAGR 607
Cdd:smart00490 68 PASYIQRIGRAGR 80
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
215-374 |
7.78e-12 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 64.57 E-value: 7.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 215 QKELVNMIDNHQVTVISGETGCGKTTqVTQF-ILDNYIERGKGSacRIVCTQPRRISAISVAERvAAERAETCG------ 287
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTL-AFLLpALEALDKLDNGP--QALVLAPTRELAEQIYEE-LKKLGKGLGlkvasl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 288 -NGNSTGYQIRLQSRLPrkqgsILYCTTGIILQWLQSDPHLSSVSHIVLDEIHE--RNLQSDVLMTVIKDLlnyRPDLKV 364
Cdd:pfam00270 80 lGGDSRKEQLEKLKGPD-----ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGPDLEEILRRL---PKKRQI 151
|
170
....*....|
gi 1911174477 365 ILMSATLNAE 374
Cdd:pfam00270 152 LLLSATLPRN 161
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
215-389 |
2.67e-09 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 57.66 E-value: 2.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 215 QKELVNMIDNHQV-TVISGETGCGKTTQVTQFILDNYIERGKgsacRIVCTQPRRisaiSVAERVAAERAETCGN----- 288
Cdd:cd17921 6 QREALRALYLSGDsVLVSAPTSSGKTLIAELAILRALATSGG----KAVYIAPTR----ALVNQKEADLRERFGPlgknv 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 289 GNSTGYQIRLQSRLPRKQgsILYCTTGIILQWLQSDPH--LSSVSHIVLDEIHERNLQS--DVLMTVIKDLLNYRPDLKV 364
Cdd:cd17921 78 GLLTGDPSVNKLLLAEAD--ILVATPEKLDLLLRNGGErlIQDVRLVVVDEAHLIGDGErgVVLELLLSRLLRINKNARF 155
|
170 180
....*....|....*....|....*.
gi 1911174477 365 ILMSATL-NAEKFSEYFGNCPMIHIP 389
Cdd:cd17921 156 VGLSATLpNAEDLAEWLGVEDLIRFD 181
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
215-255 |
8.58e-04 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 41.00 E-value: 8.58e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1911174477 215 QKELVNMIDNHQVTVISGETGCGKTTqVTQFILDNYIERGK 255
Cdd:cd17933 2 QKAAVRLVLRNRVSVLTGGAGTGKTT-TLKALLAALEAEGK 41
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
188-567 |
1.61e-03 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 42.38 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 188 EDLQKKKTDLRYIEMQHFREKLPSFG--------MQKELVNMI-----DNHQVTVISGETGCGKTTQVTQFILDNyieRG 254
Cdd:COG1203 97 ANFDMARQALDHLLAERLERLLPKKSkprtpinpLQNEALELAleaaeEEPGLFILTAPTGGGKTEAALLFALRL---AA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 255 KGSACRIVCTQP------------RRISAISVAE---RVAAERAETCGNGNSTGYQIRLQSRL---PrkqgsILYCTtgi 316
Cdd:COG1203 174 KHGGRRIIYALPftsiinqtydrlRDLFGEDVLLhhsLADLDLLEEEEEYESEARWLKLLKELwdaP-----VVVTT--- 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 317 ILQWLQSdpHLSSVSH------------IVLDEIH--ERNLQSdVLMTVIKDLLNYrpDLKVILMSATLnaekfseyfgn 382
Cdd:COG1203 246 IDQLFES--LFSNRKGqerrlhnlansvIILDEVQayPPYMLA-LLLRLLEWLKNL--GGSVILMTATL----------- 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 383 cPMIHIPGFtFPVVEYLLEDIIEKIRYVPEQKEHRSQFKRGFMQghvnrqekeekeatykerWPDYVRELRKRYSAS-TV 461
Cdd:COG1203 310 -PPLLREEL-LEAYELIPDEPEELPEYFRAFVRKRVELKEGPLS------------------DEELAELILEALHKGkSV 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 462 DVIemmdddkvdLNLIAALIR-YIVLEEEDGAILVFLpgwdnistLHdllmSQVMFKsDRFLIIplhslmptvnqTQVFK 540
Cdd:COG1203 370 LVI---------VNTVKDAQElYEALKEKLPDEEVYL--------LH----SRFCPA-DRSEIE-----------KEIKE 416
|
410 420
....*....|....*....|....*...
gi 1911174477 541 RTPPGVRKIVIATNIAETSITID-DVVY 567
Cdd:COG1203 417 RLERGKPCILVSTQVVEAGVDIDfDVVI 444
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
223-367 |
1.78e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 39.63 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 223 DNHQVTVISGETGCGKTTqVTQFILDNYIERGKGSAcRIVCTQPRriSAISVAERVAAEraetcgngnstgYQIRLQSRL 302
Cdd:pfam13401 3 FGAGILVLTGESGTGKTT-LLRRLLEQLPEVRDSVV-FVDLPSGT--SPKDLLRALLRA------------LGLPLSGRL 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1911174477 303 PRKQGsilyctTGIILQWLQsdpHLSSVSHIVLDEIHerNLQSDVLMTvIKDLLNYRP-DLKVILM 367
Cdd:pfam13401 67 SKEEL------LAALQQLLL---ALAVAVVLIIDEAQ--HLSLEALEE-LRDLLNLSSkLLQLILV 120
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
59-366 |
5.75e-03 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 40.56 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 59 HLKGRDIGLWYAKKQGQKSKEAERQERAVVHMDEHREEQIVQLLHSVQAKSDKDSEAQISWFAPEDHGYGSEAPAENKPN 138
Cdd:COG5635 26 AIALAALLLLALVALGLALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 139 SEKKLEDREKKLINQEKKTFRMRDKYIDRDSEYLLQENEPDVNLDQQLLEDLQkkkTDLRYIEMQHFREKLPSFGmqkel 218
Cdd:COG5635 106 ALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLY---VPLNLLERIESLKRLELLE----- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 219 vnmiDNHQVTVISGETGCGKTTqVTQFILDNYIERGKGSACRIvctqPRRISAISVAERVAAERAetcgngnstgyqirL 298
Cdd:COG5635 178 ----AKKKRLLILGEPGSGKTT-LLRYLALELAERYLDAEDPI----PILIELRDLAEEASLEDL--------------L 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1911174477 299 QSRLPRKQGSilycTTGIILQWLQSDphlssvsHIV-----LDEIHERNLQSDVLmTVIKDLLNYRPDLKVIL 366
Cdd:COG5635 235 AEALEKRGGE----PEDALERLLRNG-------RLLllldgLDEVPDEADRDEVL-NQLRRFLERYPKARVII 295
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
306-372 |
6.19e-03 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 39.10 E-value: 6.19e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1911174477 306 QGSILYCTTGIILQWLQSdpHLSSVSHI---VLDE----IHERNLQSDVLMtvIKDLLnyRPDLKVILMSATLN 372
Cdd:cd17963 111 TAQIVIGTPGTVLDWLKK--RQLDLKKIkilVLDEadvmLDTQGHGDQSIR--IKRML--PRNCQILLFSATFP 178
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
548-607 |
8.20e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 36.14 E-value: 8.20e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1911174477 548 KIVIATNIAETSITIDDVVYVIdggkiketHFDtqnnistmsaEWVSKANAKQRKGRAGR 607
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVI--------FFD----------PPSSAASYIQRVGRAGR 65
|
|
| |
