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Conserved domains on  [gi|1912630707|ref|XP_036317259|]
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DNA/RNA-binding protein KIN17 isoform X1 [Pipistrellus kuhlii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Kin17_mid pfam10357
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ...
 129-237 1.85e-69

Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle.


:

Pssm-ID: 463057  Cd Length: 123  Bit Score: 216.20  E-value: 1.85e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912630707 129 TREFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPET 208
Cdd:pfam10357  15 SKEFEKDFLQLLRTRHGTKRVHANKVYQEYIADKDHIHMNATRWTSLTEFVKYLGREGKCRVEETEKGWFISYIDRSPEA 94

                          90       100
                  ....*....|....*....|....*....
gi 1912630707 209 IRRQLELEKKKKQDLDDEEKTAKFIEEQV 237
Cdd:pfam10357  95 LARQEALRKKEKQEKDDEEREQKLIEEQI 123
KOW_KIN17 cd13155
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ...
 398-451 6.21e-26

KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control.


:

Pssm-ID: 240519  Cd Length: 54  Bit Score: 99.53  E-value: 6.21e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1912630707 398 PGKRILVLNGGYRGNEAILESINEKTFSATIVIETGPLKGRRVEGIQYEDISKL 451
Cdd:cd13155     1 IGGRVLVVNGAYRGCEATLESIDEDKFSATVRLDSGPLKGRVVEGVPYEDISKL 54
KN17_SH3 pfam18131
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ...
 335-387 6.53e-24

KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution.


:

Pssm-ID: 407963  Cd Length: 53  Bit Score: 93.95  E-value: 6.53e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1912630707 335 RTDYWLQPEIIVKIITKKLGEKYHKKKGIVKEVIDKYTAVVKMIDSGDKLKLD 387
Cdd:pfam18131   1 RKDYWLAPGIVVKIMSKKLGDKYYKQKGVIIEVIEEYVALVKMLDSGDVLKVD 53
 
Name Accession Description Interval E-value
Kin17_mid pfam10357
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ...
 129-237 1.85e-69

Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle.


Pssm-ID: 463057  Cd Length: 123  Bit Score: 216.20  E-value: 1.85e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912630707 129 TREFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPET 208
Cdd:pfam10357  15 SKEFEKDFLQLLRTRHGTKRVHANKVYQEYIADKDHIHMNATRWTSLTEFVKYLGREGKCRVEETEKGWFISYIDRSPEA 94

                          90       100
                  ....*....|....*....|....*....
gi 1912630707 209 IRRQLELEKKKKQDLDDEEKTAKFIEEQV 237
Cdd:pfam10357  95 LARQEALRKKEKQEKDDEEREQKLIEEQI 123
KOW_KIN17 cd13155
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ...
 398-451 6.21e-26

KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control.


Pssm-ID: 240519  Cd Length: 54  Bit Score: 99.53  E-value: 6.21e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1912630707 398 PGKRILVLNGGYRGNEAILESINEKTFSATIVIETGPLKGRRVEGIQYEDISKL 451
Cdd:cd13155     1 IGGRVLVVNGAYRGCEATLESIDEDKFSATVRLDSGPLKGRVVEGVPYEDISKL 54
KN17_SH3 pfam18131
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ...
 335-387 6.53e-24

KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution.


Pssm-ID: 407963  Cd Length: 53  Bit Score: 93.95  E-value: 6.53e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1912630707 335 RTDYWLQPEIIVKIITKKLGEKYHKKKGIVKEVIDKYTAVVKMIDSGDKLKLD 387
Cdd:pfam18131   1 RKDYWLAPGIVVKIMSKKLGDKYYKQKGVIIEVIEEYVALVKMLDSGDVLKVD 53
 
Name Accession Description Interval E-value
Kin17_mid pfam10357
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ...
 129-237 1.85e-69

Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle.


Pssm-ID: 463057  Cd Length: 123  Bit Score: 216.20  E-value: 1.85e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1912630707 129 TREFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPET 208
Cdd:pfam10357  15 SKEFEKDFLQLLRTRHGTKRVHANKVYQEYIADKDHIHMNATRWTSLTEFVKYLGREGKCRVEETEKGWFISYIDRSPEA 94

                          90       100
                  ....*....|....*....|....*....
gi 1912630707 209 IRRQLELEKKKKQDLDDEEKTAKFIEEQV 237
Cdd:pfam10357  95 LARQEALRKKEKQEKDDEEREQKLIEEQI 123
KOW_KIN17 cd13155
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ...
 398-451 6.21e-26

KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control.


Pssm-ID: 240519  Cd Length: 54  Bit Score: 99.53  E-value: 6.21e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1912630707 398 PGKRILVLNGGYRGNEAILESINEKTFSATIVIETGPLKGRRVEGIQYEDISKL 451
Cdd:cd13155     1 IGGRVLVVNGAYRGCEATLESIDEDKFSATVRLDSGPLKGRVVEGVPYEDISKL 54
KN17_SH3 pfam18131
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ...
 335-387 6.53e-24

KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution.


Pssm-ID: 407963  Cd Length: 53  Bit Score: 93.95  E-value: 6.53e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1912630707 335 RTDYWLQPEIIVKIITKKLGEKYHKKKGIVKEVIDKYTAVVKMIDSGDKLKLD 387
Cdd:pfam18131   1 RKDYWLAPGIVVKIMSKKLGDKYYKQKGVIIEVIEEYVALVKMLDSGDVLKVD 53
KOW cd00380
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ...
 399-448 1.84e-05

KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues.


Pssm-ID: 240504  Cd Length: 49  Bit Score: 41.82  E-value: 1.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1912630707 399 GKRILVLNGGYRGNEAILESINEKTFSATIVIETGPLKGRRveGIQYEDI 448
Cdd:cd00380     1 GDVVRVLRGPYKGREGVVVDIDPRFGIVTVKGATGSKGAEL--KVRFDDV 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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