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Conserved domains on  [gi|1941228236|ref|XP_037909834|]
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uncharacterized protein LOC119650787 isoform X3 [Hermetia illucens]

Protein Classification

ankyrin repeat and fibronectin type-III domain-containing protein( domain architecture ID 13837917)

ankyrin repeat and fibronectin type-III domain-containing protein similar to Drosophila melanogaster wide awake

Gene Ontology:  GO:0005515
PubMed:  17176038|8981327

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RA_ANKFN1_like cd17117
Ras-associating (RA) domain found in Ankyrin repeat and fibronectin type-III domain-containing ...
1223-1319 4.88e-58

Ras-associating (RA) domain found in Ankyrin repeat and fibronectin type-III domain-containing protein 1 (ANKFN1) and similar proteins; ANKFN1 is a multi-domain protein, with unknown function, that contains two ankyrin repeats and one fibronectin type-III domain. Except for the mammalian homologs, most metazon ANKFN1 harbor a RA domain at the C-terminus. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin.


:

Pssm-ID: 340637  Cd Length: 97  Bit Score: 194.78  E-value: 4.88e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236 1223 IIQVYAAYETGLASGTSLKLHVTPKTTAREVVDLVVKQLNMAVVLKGKDGPIYTPDKLENFCLVAVIGARERCLRDDFKP 1302
Cdd:cd17117      1 ILRVYAAYETGLPKGTSVKLHVTPKTTAREVVNLVVQQLNKAVRSKGKGGPVYSEDQLDDFCLVAVVGARERCLRDDFQP 80
                           90
                   ....*....|....*..
gi 1941228236 1303 LQLQNPWKKGKLYVRQK 1319
Cdd:cd17117     81 LQLQNPWTKGRLYVRLK 97
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
148-256 2.53e-08

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 2.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  148 ILLSANSNNNVFSHSDHIDQITNNNNNNKMTKKQLKLAQAQLDKLTQINIHLHALFSAVEHGHLDKARTILEStDVDVNS 227
Cdd:COG0666     37 LLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNA 115
                           90       100
                   ....*....|....*....|....*....
gi 1941228236  228 LNSDGLSPLDVAVLSNNRSMTKMLLQHGA 256
Cdd:COG0666    116 RDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
349-446 1.01e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  349 PDEPSAVTVDVSGQNSVSISILEPLE--GPIgTKFKVQWSSKADfsnimgereiTQWTSYQGVMGAT--CRISDLTQGRR 424
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdgGPI-TGYVVEYREKGS----------GDWKEVEVTPGSEtsYTLTGLKPGTE 69
                           90       100
                   ....*....|....*....|..
gi 1941228236  425 YFFRACCGNVKGWGPYHTTVPA 446
Cdd:cd00063     70 YEFRVRAVNGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
RA_ANKFN1_like cd17117
Ras-associating (RA) domain found in Ankyrin repeat and fibronectin type-III domain-containing ...
1223-1319 4.88e-58

Ras-associating (RA) domain found in Ankyrin repeat and fibronectin type-III domain-containing protein 1 (ANKFN1) and similar proteins; ANKFN1 is a multi-domain protein, with unknown function, that contains two ankyrin repeats and one fibronectin type-III domain. Except for the mammalian homologs, most metazon ANKFN1 harbor a RA domain at the C-terminus. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin.


Pssm-ID: 340637  Cd Length: 97  Bit Score: 194.78  E-value: 4.88e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236 1223 IIQVYAAYETGLASGTSLKLHVTPKTTAREVVDLVVKQLNMAVVLKGKDGPIYTPDKLENFCLVAVIGARERCLRDDFKP 1302
Cdd:cd17117      1 ILRVYAAYETGLPKGTSVKLHVTPKTTAREVVNLVVQQLNKAVRSKGKGGPVYSEDQLDDFCLVAVVGARERCLRDDFQP 80
                           90
                   ....*....|....*..
gi 1941228236 1303 LQLQNPWKKGKLYVRQK 1319
Cdd:cd17117     81 LQLQNPWTKGRLYVRLK 97
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
148-256 2.53e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 2.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  148 ILLSANSNNNVFSHSDHIDQITNNNNNNKMTKKQLKLAQAQLDKLTQINIHLHALFSAVEHGHLDKARTILEStDVDVNS 227
Cdd:COG0666     37 LLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNA 115
                           90       100
                   ....*....|....*....|....*....
gi 1941228236  228 LNSDGLSPLDVAVLSNNRSMTKMLLQHGA 256
Cdd:COG0666    116 RDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
Ank_4 pfam13637
Ankyrin repeats (many copies);
198-252 5.23e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 5.23e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1941228236  198 HLHALFSAVEHGHLDKARTILESTdVDVNSLNSDGLSPLDVAVLSNNRSMTKMLL 252
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
RA pfam00788
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
1222-1319 1.58e-07

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.


Pssm-ID: 425871  Cd Length: 93  Bit Score: 50.41  E-value: 1.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236 1222 GIIQVYAayeTGLASGTSLK-LHVTPKTTAREVVDLVVKQLNMAvvlkgkDGPiytpdklENFCLVAVI--GARERCLRD 1298
Cdd:pfam00788    3 GVLKVYT---EDGKPGTTYKtILVSSSTTAEEVIEALLEKFGLE------DDP-------RDYVLVEVLerGGGERRLPD 66
                           90       100
                   ....*....|....*....|....*
gi 1941228236 1299 DFKPLQLQNPWKKG----KLYVRQK 1319
Cdd:pfam00788   67 DECPLQIQLQWPRDasdsRFLLRKR 91
RA smart00314
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
1222-1321 1.69e-06

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Kalhammer et al. have shown that not all RA domains bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase. Predicted RA domains in PLC210 and nore1 found to bind RasGTP. Included outliers (Grb7, Grb14, adenylyl cyclases etc.)


Pssm-ID: 214612  Cd Length: 90  Bit Score: 47.29  E-value: 1.69e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  1222 GIIQVYAAYetgLASGTSLKLHVTPKTTAREVVDLVVKQLNMAvvlkgkDGPiytpdklENFCLVAVI-GARERCLRDDF 1300
Cdd:smart00314    3 FVLRVYVDD---LPGGTYKTLRVSSRTTARDVIQQLLEKFHLT------DDP-------EEYVLVEVLpDGKERVLPDDE 66
                            90       100
                    ....*....|....*....|....
gi 1941228236  1301 KPLQLQNPWKKGKL---YVRQKHD 1321
Cdd:smart00314   67 NPLQLQKLWPRRGPnlrFVLRKRD 90
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
349-446 1.01e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  349 PDEPSAVTVDVSGQNSVSISILEPLE--GPIgTKFKVQWSSKADfsnimgereiTQWTSYQGVMGAT--CRISDLTQGRR 424
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdgGPI-TGYVVEYREKGS----------GDWKEVEVTPGSEtsYTLTGLKPGTE 69
                           90       100
                   ....*....|....*....|..
gi 1941228236  425 YFFRACCGNVKGWGPYHTTVPA 446
Cdd:cd00063     70 YEFRVRAVNGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
349-438 5.44e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 5.44e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236   349 PDEPSAVTVDVSGQNSVSISIlEPLEGPIGTKFKVQWSskadfsnIMGEREITQWTSYQGVMGAT-CRISDLTQGRRYFF 427
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-EPPPDDGITGYIVGYR-------VEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEF 72
                            90
                    ....*....|.
gi 1941228236   428 RACCGNVKGWG 438
Cdd:smart00060   73 RVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
350-441 4.93e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  350 DEPSAVTVDVSGQNSVSISILEP--LEGPIgTKFKVQWSSKadfsnimgeREITQWTSYQGVMGA-TCRISDLTQGRRYF 426
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPI-TGYEVEYRPK---------NSGEPWNEITVPGTTtSVTLTGLKPGTEYE 70
                           90
                   ....*....|....*
gi 1941228236  427 FRACCGNVKGWGPYH 441
Cdd:pfam00041   71 VRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
RA_ANKFN1_like cd17117
Ras-associating (RA) domain found in Ankyrin repeat and fibronectin type-III domain-containing ...
1223-1319 4.88e-58

Ras-associating (RA) domain found in Ankyrin repeat and fibronectin type-III domain-containing protein 1 (ANKFN1) and similar proteins; ANKFN1 is a multi-domain protein, with unknown function, that contains two ankyrin repeats and one fibronectin type-III domain. Except for the mammalian homologs, most metazon ANKFN1 harbor a RA domain at the C-terminus. The RA domain has the beta-grasp ubiquitin-like fold with low sequence similarity to ubiquitin.


Pssm-ID: 340637  Cd Length: 97  Bit Score: 194.78  E-value: 4.88e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236 1223 IIQVYAAYETGLASGTSLKLHVTPKTTAREVVDLVVKQLNMAVVLKGKDGPIYTPDKLENFCLVAVIGARERCLRDDFKP 1302
Cdd:cd17117      1 ILRVYAAYETGLPKGTSVKLHVTPKTTAREVVNLVVQQLNKAVRSKGKGGPVYSEDQLDDFCLVAVVGARERCLRDDFQP 80
                           90
                   ....*....|....*..
gi 1941228236 1303 LQLQNPWKKGKLYVRQK 1319
Cdd:cd17117     81 LQLQNPWTKGRLYVRLK 97
RA cd17043
Ras-associating (RA) domain, structurally similar to a beta-grasp ubiquitin-like fold; RA ...
1223-1317 2.45e-08

Ras-associating (RA) domain, structurally similar to a beta-grasp ubiquitin-like fold; RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in various functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub); Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. RA-containing proteins include RalGDS, AF6, RIN, RASSF1, SNX27, CYR1, STE50, and phospholipase C epsilon.


Pssm-ID: 340563  Cd Length: 87  Bit Score: 52.71  E-value: 2.45e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236 1223 IIQVYAAYETGLASGTSLklHVTPKTTAREVVDLVVKQLNmavvlkgkdgpiyTPDKLENFCL--VAVIGARERCLRDDF 1300
Cdd:cd17043      1 VLKVYDDDLAPGSAYKSI--LVSSTTTAREVVQLLLEKYG-------------LEEDPEDYSLyeVSEKQETERVLHDDE 65
                           90
                   ....*....|....*..
gi 1941228236 1301 KPLQLQNPWKKGKLYVR 1317
Cdd:cd17043     66 CPLLIQLEWGPQGTEFR 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
148-256 2.53e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 2.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  148 ILLSANSNNNVFSHSDHIDQITNNNNNNKMTKKQLKLAQAQLDKLTQINIHLHALFSAVEHGHLDKARTILEStDVDVNS 227
Cdd:COG0666     37 LLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNA 115
                           90       100
                   ....*....|....*....|....*....
gi 1941228236  228 LNSDGLSPLDVAVLSNNRSMTKMLLQHGA 256
Cdd:COG0666    116 RDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
Ank_4 pfam13637
Ankyrin repeats (many copies);
198-252 5.23e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 5.23e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1941228236  198 HLHALFSAVEHGHLDKARTILESTdVDVNSLNSDGLSPLDVAVLSNNRSMTKMLL 252
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
179-256 7.33e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.73  E-value: 7.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  179 KKQLKLAQAQLDKLTQINIHLH----ALFSAVEHGHLDKARTILEStDVDVNSLNSDGLSPLDVAVLSNNRSMTKMLLQH 254
Cdd:COG0666     97 NGDLEIVKLLLEAGADVNARDKdgetPLHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                   ..
gi 1941228236  255 GA 256
Cdd:COG0666    176 GA 177
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
201-256 9.79e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.35  E-value: 9.79e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1941228236  201 ALFSAVEHGHLDKARTILEStDVDVNSLNSDGLSPLDVAVLSNNRSMTKMLLQHGA 256
Cdd:COG0666    156 PLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
RA pfam00788
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
1222-1319 1.58e-07

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.


Pssm-ID: 425871  Cd Length: 93  Bit Score: 50.41  E-value: 1.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236 1222 GIIQVYAayeTGLASGTSLK-LHVTPKTTAREVVDLVVKQLNMAvvlkgkDGPiytpdklENFCLVAVI--GARERCLRD 1298
Cdd:pfam00788    3 GVLKVYT---EDGKPGTTYKtILVSSSTTAEEVIEALLEKFGLE------DDP-------RDYVLVEVLerGGGERRLPD 66
                           90       100
                   ....*....|....*....|....*
gi 1941228236 1299 DFKPLQLQNPWKKG----KLYVRQK 1319
Cdd:pfam00788   67 DECPLQIQLQWPRDasdsRFLLRKR 91
RA smart00314
Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); ...
1222-1321 1.69e-06

Ras association (RalGDS/AF-6) domain; RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Kalhammer et al. have shown that not all RA domains bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase. Predicted RA domains in PLC210 and nore1 found to bind RasGTP. Included outliers (Grb7, Grb14, adenylyl cyclases etc.)


Pssm-ID: 214612  Cd Length: 90  Bit Score: 47.29  E-value: 1.69e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  1222 GIIQVYAAYetgLASGTSLKLHVTPKTTAREVVDLVVKQLNMAvvlkgkDGPiytpdklENFCLVAVI-GARERCLRDDF 1300
Cdd:smart00314    3 FVLRVYVDD---LPGGTYKTLRVSSRTTARDVIQQLLEKFHLT------DDP-------EEYVLVEVLpDGKERVLPDDE 66
                            90       100
                    ....*....|....*....|....
gi 1941228236  1301 KPLQLQNPWKKGKL---YVRQKHD 1321
Cdd:smart00314   67 NPLQLQKLWPRRGPnlrFVLRKRD 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
179-256 1.86e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  179 KKQLKLAQAQLDKLTQINIHLH----ALFSAVEHGHLDKARTILESTDVDVNSlnsDGLSPLDVAVLSNNRSMTKMLLQH 254
Cdd:pfam12796    7 NGNLELVKLLLENGADANLQDKngrtALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIVKLLLEK 83

                   ..
gi 1941228236  255 GA 256
Cdd:pfam12796   84 GA 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
349-446 1.01e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  349 PDEPSAVTVDVSGQNSVSISILEPLE--GPIgTKFKVQWSSKADfsnimgereiTQWTSYQGVMGAT--CRISDLTQGRR 424
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdgGPI-TGYVVEYREKGS----------GDWKEVEVTPGSEtsYTLTGLKPGTE 69
                           90       100
                   ....*....|....*....|..
gi 1941228236  425 YFFRACCGNVKGWGPYHTTVPA 446
Cdd:cd00063     70 YEFRVRAVNGGGESPPSESVTV 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
201-290 4.13e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 47.26  E-value: 4.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  201 ALFSAVEHGHLDKARTILEStDVDVNSLNSDGLSPLDVAVLSNNRSMTKMLLQHGATEGSQFKSADSLGNHLNGLLHDAE 280
Cdd:COG0666    189 PLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267
                           90
                   ....*....|
gi 1941228236  281 NRIHDLSTAD 290
Cdd:COG0666    268 VKLLLLALLL 277
Ank_2 pfam12796
Ankyrin repeats (3 copies);
202-258 2.87e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 2.87e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1941228236  202 LFSAVEHGHLDKARTILEStDVDVNSLNSDGLSPLDVAVLSNNRSMTKMLLQHGATE 258
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN 56
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
349-438 5.44e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 5.44e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236   349 PDEPSAVTVDVSGQNSVSISIlEPLEGPIGTKFKVQWSskadfsnIMGEREITQWTSYQGVMGAT-CRISDLTQGRRYFF 427
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-EPPPDDGITGYIVGYR-------VEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEF 72
                            90
                    ....*....|.
gi 1941228236   428 RACCGNVKGWG 438
Cdd:smart00060   73 RVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
350-441 4.93e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236  350 DEPSAVTVDVSGQNSVSISILEP--LEGPIgTKFKVQWSSKadfsnimgeREITQWTSYQGVMGA-TCRISDLTQGRRYF 426
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPI-TGYEVEYRPK---------NSGEPWNEITVPGTTtSVTLTGLKPGTEYE 70
                           90
                   ....*....|....*
gi 1941228236  427 FRACCGNVKGWGPYH 441
Cdd:pfam00041   71 VRVQAVNGGGEGPPS 85
RA2_DAGK-theta cd01783
Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar ...
1222-1305 9.14e-03

Ras-associating (RA) domain 2 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins; DAGK phosphorylates the second messenger diacylglycerol to phosphatidic acid as part of a protein kinase C pathway. DAGK-theta is characterized as a type V DAGK that has three cysteine-rich domains (all other isoforms have two), a proline/glycine-rich domain at its N-terminal, and a proposed Ras-associating (RA) domain. RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in several different functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has a beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub). Ub is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes. There are ten mammalian isoforms of DAGK have been identified to date, these are organized into five categories based on the domain architecture. DAGK-theta also contains a pleckstrin homology (PH) domain. The subcellular localization and the activity of DAGK-theta are regulated in a complex (stimulation- and cell type-dependent) manner. This family corresponds to the second RA domain of DAGK-theta.


Pssm-ID: 340481  Cd Length: 95  Bit Score: 36.82  E-value: 9.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941228236 1222 GIIQVYAAyetGLASGTSLK-LHVTPKTTAREVVDLVVKQLNmavvLKGKDgpiytpdkLENFCLVAVI---GARERCLR 1297
Cdd:cd01783      1 GYIRVYPG---WLKVGVAYKsIPVTKETTVEEVIKEALPKFG----LQDED--------PEDFRLVEVLmdkGVVERVML 65

                   ....*...
gi 1941228236 1298 DDFKPLQL 1305
Cdd:cd01783     66 RDECPWLI 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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