|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1787-2119 |
3.86e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
:
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 317.59 E-value: 3.86e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1787 AMLRGRTVIYTASpASRAQSKGISGPCSAPKKMgtsgttqpETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPP 1866
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1867 ARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGP------LPGPGGSPVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1938
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRlpgsggRNKLSPLPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1939 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 2013
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2014 SSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAA--QRVPQAKPGLAPRAPRRTSSESPSRLPVRATPG 2091
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 1958788266 2092 RPETVKRYASLPHISVSRRPDSAVSVPT 2119
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
379-452 |
5.33e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
:
Pssm-ID: 465870 Cd Length: 74 Bit Score: 131.52 E-value: 5.33e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958788266 379 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAM 452
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
30-81 |
6.67e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
:
Pssm-ID: 435517 Cd Length: 52 Bit Score: 101.99 E-value: 6.67e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1958788266 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 81
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
148-228 |
4.01e-18 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
:
Pssm-ID: 463275 Cd Length: 82 Bit Score: 80.76 E-value: 4.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 148 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDT-FSMQMDLIRQQLEFEAQHIRSLMEERFG 226
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTyFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 1958788266 227 TS 228
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 super family |
cl25003 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
718-964 |
4.88e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
The actual alignment was detected with superfamily member pfam16629:
Pssm-ID: 435476 Cd Length: 293 Bit Score: 84.25 E-value: 4.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 718 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGlPEAETTSKKplpplRHLDGLVQDYASDSG 797
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 798 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEKE-----------------TGGEAAVA 860
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKDrsldrergaglsnfhpaTENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 861 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 936
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 1958788266 937 AAHTSLSNDSLNSGSTSDGYCTREHMTP 964
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
636-675 |
1.43e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.43e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1958788266 636 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 675
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1621-1642 |
7.34e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
:
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 7.34e-05
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
1527-1952 |
8.36e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1527 DSDEEPPATAPPTRRASAIPRALKREKPAGRKETP---TRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASE 1603
Cdd:PHA03247 2546 DDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1604 QPACHPR---VEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPS--------SRRRKPRAVRSDIRPteLPQKCREEV 1672
Cdd:PHA03247 2626 PPPPSPSpaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaqasspPQRPRRRAARPTVGS--LTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1673 PGSDPASdldsVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRP 1752
Cdd:PHA03247 2704 PPPTPEP----APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1753 EKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAgesAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATK 1832
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1833 TPSPEQQRSRSLHRPgkISELAALSHPP-RSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPK 1911
Cdd:PHA03247 2857 APGGDVRRRPPSRSP--AAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958788266 1912 SPARALLAKQHKTQKSPVRIPFMQRPA---------------RRVPPPL-ARPSPEP 1952
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalvpgrvavprFRVPQPApSREAPAS 2991
|
|
| DUF5585 super family |
cl39316 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2064-2303 |
2.69e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
The actual alignment was detected with superfamily member pfam17823:
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2064 AKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVS-VPTTQANATRRGSdgearPLPRVAAP 2142
Cdd:pfam17823 106 AADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPrAAIAAASAPHAAS-----PAPRTAAS 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2143 GTTW--RRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVV----------------------------- 2191
Cdd:pfam17823 181 STTAasSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVgnsspaagtvtaavgtvtpaalatlaaaa 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2192 QTEDVATSKTNS----STSPSLESRDPPQAPISGPVAPLGSDVDGPVLAkppasapFTHEGLSVVTGGFPTSrhgSPSRA 2267
Cdd:pfam17823 261 GTVASAAGTINMgdphARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQ-------VSTDQPVHNTAGEPTP---SPSNT 330
|
250 260 270
....*....|....*....|....*....|....*.
gi 1958788266 2268 ARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLL 2303
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL 366
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1400-1422 |
6.59e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.59e-04
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
677-717 |
3.14e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.14e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1958788266 677 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 717
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1276-1297 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.60e-03
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1164-1187 |
5.82e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.82e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1787-2119 |
3.86e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 317.59 E-value: 3.86e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1787 AMLRGRTVIYTASpASRAQSKGISGPCSAPKKMgtsgttqpETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPP 1866
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1867 ARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGP------LPGPGGSPVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1938
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRlpgsggRNKLSPLPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1939 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 2013
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2014 SSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAA--QRVPQAKPGLAPRAPRRTSSESPSRLPVRATPG 2091
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 1958788266 2092 RPETVKRYASLPHISVSRRPDSAVSVPT 2119
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
379-452 |
5.33e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 131.52 E-value: 5.33e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958788266 379 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAM 452
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
30-81 |
6.67e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Pssm-ID: 435517 Cd Length: 52 Bit Score: 101.99 E-value: 6.67e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1958788266 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 81
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
148-228 |
4.01e-18 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 80.76 E-value: 4.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 148 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDT-FSMQMDLIRQQLEFEAQHIRSLMEERFG 226
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTyFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 1958788266 227 TS 228
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
718-964 |
4.88e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 84.25 E-value: 4.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 718 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGlPEAETTSKKplpplRHLDGLVQDYASDSG 797
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 798 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEKE-----------------TGGEAAVA 860
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKDrsldrergaglsnfhpaTENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 861 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 936
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 1958788266 937 AAHTSLSNDSLNSGSTSDGYCTREHMTP 964
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
636-675 |
1.43e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.43e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1958788266 636 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 675
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1798-2304 |
1.46e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1798 ASPASRAQSKGISGPCSAPKKMGTSGTTQpETATKTPsPEQQRSRSlhrPGKISELAALSHPPrSATPPArlTKTPSSSS 1877
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSR-ARRPDAP-PQSARPRA---PVDDRGDPRGPAPP-SPLPPD--THAPDPPP 2628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1878 SQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPKSPARALLAKQHKTQKSPvripfMQRPARRVPPP-------LARPSP 1950
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP-----PQRPRRRAARPtvgsltsLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1951 EPGSrgragAEGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVSTSQTASPCR 2030
Cdd:PHA03247 2704 PPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2031 GRPALPAVFLCSSrcDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPETvkryaslphisvsrr 2110
Cdd:PHA03247 2779 PPRRLTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--------------- 2841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2111 PDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRrikdedvPHILRSTLPATALPlRGSSPEDSPAGTPHRKtsdav 2190
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP-------ARPPVRRLARPAVS-RSTESFALPPDQPERP----- 2908
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2191 vQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGlSVVTGGFPTSRHGSPSRAARV 2270
Cdd:PHA03247 2909 -PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPAPSR 2986
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1958788266 2271 PPFNYVPSPMV------VATMTSDSAVEKAPVTSPASLLE 2304
Cdd:PHA03247 2987 EAPASSTPPLTghslsrVSSWASSLALHEETDPPPVSLKQ 3026
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
635-675 |
2.29e-06 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 46.27 E-value: 2.29e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1958788266 635 REDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 675
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1621-1642 |
7.34e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 7.34e-05
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1527-1952 |
8.36e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1527 DSDEEPPATAPPTRRASAIPRALKREKPAGRKETP---TRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASE 1603
Cdd:PHA03247 2546 DDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1604 QPACHPR---VEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPS--------SRRRKPRAVRSDIRPteLPQKCREEV 1672
Cdd:PHA03247 2626 PPPPSPSpaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaqasspPQRPRRRAARPTVGS--LTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1673 PGSDPASdldsVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRP 1752
Cdd:PHA03247 2704 PPPTPEP----APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1753 EKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAgesAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATK 1832
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1833 TPSPEQQRSRSLHRPgkISELAALSHPP-RSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPK 1911
Cdd:PHA03247 2857 APGGDVRRRPPSRSP--AAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958788266 1912 SPARALLAKQHKTQKSPVRIPFMQRPA---------------RRVPPPL-ARPSPEP 1952
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalvpgrvavprFRVPQPApSREAPAS 2991
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2064-2303 |
2.69e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2064 AKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVS-VPTTQANATRRGSdgearPLPRVAAP 2142
Cdd:pfam17823 106 AADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPrAAIAAASAPHAAS-----PAPRTAAS 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2143 GTTW--RRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVV----------------------------- 2191
Cdd:pfam17823 181 STTAasSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVgnsspaagtvtaavgtvtpaalatlaaaa 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2192 QTEDVATSKTNS----STSPSLESRDPPQAPISGPVAPLGSDVDGPVLAkppasapFTHEGLSVVTGGFPTSrhgSPSRA 2267
Cdd:pfam17823 261 GTVASAAGTINMgdphARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQ-------VSTDQPVHNTAGEPTP---SPSNT 330
|
250 260 270
....*....|....*....|....*....|....*.
gi 1958788266 2268 ARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLL 2303
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL 366
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1400-1422 |
6.59e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.59e-04
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
15-285 |
1.62e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 43.35 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 15 FGNQALQELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVL--VSSG 92
Cdd:COG4372 16 FGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLqaAQAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 93 QTEVLEQLKALQTDISSLynlkfhapalgpepaaqtpegspvhgpapskdsfgelsRATIrllEELDQERCFLLSEIeke 172
Cdd:COG4372 96 LAQAQEELESLQEEAEEL--------------------------------------QEEL---EELQKERQDLEQQR--- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 173 ekeklwyySQLQGLSKRLDELphVDTFSMQMDLIRQQLEFEAQHIRSLmeerfgtsdEMVQRAQIRASRLEQIDKELLEA 252
Cdd:COG4372 132 --------KQLEAQIAELQSE--IAEREEELKELEEQLESLQEELAAL---------EQELQALSEAEAEQALDELLKEA 192
|
250 260 270
....*....|....*....|....*....|...
gi 1958788266 253 QDRVQQTEPQALLAVKPVAVEEQEAEVPTHPED 285
Cdd:COG4372 193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKD 225
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
677-717 |
3.14e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.14e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1958788266 677 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 717
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1276-1297 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.60e-03
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1164-1187 |
5.82e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.82e-03
|
| ZapB |
COG3074 |
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ... |
17-82 |
6.64e-03 |
|
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442308 [Multi-domain] Cd Length: 79 Bit Score: 37.64 E-value: 6.64e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958788266 17 NQALQEL--KMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLE 82
Cdd:COG3074 3 LELLEELeaKVQQAVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIR 70
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
1787-2119 |
3.86e-97 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 317.59 E-value: 3.86e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1787 AMLRGRTVIYTASpASRAQSKGISGPCSAPKKMgtsgttqpETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPP 1866
Cdd:pfam05956 1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKT--------DAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1867 ARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGP------LPGPGGSPVPKSPARALLAKQ--HKTQKSPVRIPFMQRPA 1938
Cdd:pfam05956 72 ARISKAPSSGSSRDSTPSRPPQKKLTSPSQSPGRlpgsggRNKLSPLPKTKSPARASTKKSgsHKTQKSPVRIPFMQTPT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1939 R-----RVPPPLARPSPEPgsRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSgFRRQLTFIKESPGLLRRRRSEL 2013
Cdd:pfam05956 152 KqtglpRNPSPLVTNQPEP--RSESASKGLRSLPGKRLDLVRMSSARSSGSESDRSG-FLRQLTFIKESPSLLLRRRLEL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2014 SSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAA--QRVPQAKPGLAPRAPRRTSSESPSRLPVRATPG 2091
Cdd:pfam05956 229 SASESLSPSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPnsRAEPSDRPLTRRRPPRRTSSESPSRLPVRNGTW 308
|
330 340
....*....|....*....|....*...
gi 1958788266 2092 RPETVKRYASLPHISVSRRPDSAVSVPT 2119
Cdd:pfam05956 309 KRETFKRYSSLPHINVWRRTGSSSSILS 336
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
379-452 |
5.33e-36 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 131.52 E-value: 5.33e-36
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958788266 379 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAM 452
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_N_CC |
pfam16689 |
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ... |
30-81 |
6.67e-26 |
|
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Pssm-ID: 435517 Cd Length: 52 Bit Score: 101.99 E-value: 6.67e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1958788266 30 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 81
Cdd:pfam16689 1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
148-228 |
4.01e-18 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 80.76 E-value: 4.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 148 SRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDT-FSMQMDLIRQQLEFEAQHIRSLMEERFG 226
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTyFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 1958788266 227 TS 228
Cdd:pfam11414 81 LI 82
|
|
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
718-964 |
4.88e-17 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 84.25 E-value: 4.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 718 HRPAKYQAAAMaVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGlPEAETTSKKplpplRHLDGLVQDYASDSG 797
Cdd:pfam16629 1 NRPAKYKDANI-MSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS-PKASHRNKQ-----RHKQNVYSEYVLDSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 798 CFDDddapsLAAAATTAEPASPAVMSMFLGGPFLQGQAlARTPPARQGGLEAEKE-----------------TGGEAAVA 860
Cdd:pfam16629 74 RHDD-----SVCRSDNFNTGNVTVLSPYLNTTVLPSSS-SRDSRGNAESSRSEKDrsldrergaglsnfhpaTENSGNSS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 861 AKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP---GQEAPREGRAQSCSPCRGTEG-GRREAGSRAHPLLRLK 936
Cdd:pfam16629 148 KRIGMQISTTAAQIAKVMEEVSSMHISQEDRSSGSTSDMhcmQDDRNSIRRSSTAHPHSNVYSfNKSESSNRPCPMPYMK 227
|
250 260
....*....|....*....|....*...
gi 1958788266 937 AAHTSLSNDSLNSGSTSDGYCTREHMTP 964
Cdd:pfam16629 228 MEYKRASNDSLNSVSSSDGYGKRGQMKP 255
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
636-675 |
1.43e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 46.68 E-value: 1.43e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1958788266 636 EDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 675
Cdd:pfam00514 2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1798-2304 |
1.46e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1798 ASPASRAQSKGISGPCSAPKKMGTSGTTQpETATKTPsPEQQRSRSlhrPGKISELAALSHPPrSATPPArlTKTPSSSS 1877
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSR-ARRPDAP-PQSARPRA---PVDDRGDPRGPAPP-SPLPPD--THAPDPPP 2628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1878 SQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPKSPARALLAKQHKTQKSPvripfMQRPARRVPPP-------LARPSP 1950
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP-----PQRPRRRAARPtvgsltsLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1951 EPGSrgragAEGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVSTSQTASPCR 2030
Cdd:PHA03247 2704 PPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2031 GRPALPAVFLCSSrcDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPETvkryaslphisvsrr 2110
Cdd:PHA03247 2779 PPRRLTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--------------- 2841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2111 PDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRrikdedvPHILRSTLPATALPlRGSSPEDSPAGTPHRKtsdav 2190
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP-------ARPPVRRLARPAVS-RSTESFALPPDQPERP----- 2908
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2191 vQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGlSVVTGGFPTSRHGSPSRAARV 2270
Cdd:PHA03247 2909 -PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPAPSR 2986
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1958788266 2271 PPFNYVPSPMV------VATMTSDSAVEKAPVTSPASLLE 2304
Cdd:PHA03247 2987 EAPASSTPPLTghslsrVSSWASSLALHEETDPPPVSLKQ 3026
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
635-675 |
2.29e-06 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 46.27 E-value: 2.29e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1958788266 635 REDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSA 675
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1935-2269 |
6.46e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 51.71 E-value: 6.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1935 QRPARRVPPPLARPSPEPGSRGRAGAeGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTfikESPGLLRRRRSELS 2014
Cdd:PHA03307 80 PANESRSTPTWSLSTLAPASPAREGS-PTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPV---GSPGPPPAASPPAA 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2015 SADSTVSTSQTASPCRGRPALPAVflcssrcDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPE 2094
Cdd:PHA03307 156 GASPAAVASDAASSRQAALPLSSP-------EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2095 TVKRYASLPHISVSRRPDSAVSVPttqanatrrgsdgEARPLPRvAAPGTTWRRIkDEDVPHILRSTLPATALP------ 2168
Cdd:PHA03307 229 ADDAGASSSDSSSSESSGCGWGPE-------------NECPLPR-PAPITLPTRI-WEASGWNGPSSRPGPASSssspre 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2169 LRGSSPEDSPAGTPHRKTSDAVVQTEDVATSKTnSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPP----ASAPF 2244
Cdd:PHA03307 294 RSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS-SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSsprkRPRPS 372
|
330 340
....*....|....*....|....*
gi 1958788266 2245 THEGLSVVTGGFPTSRHGSPSRAAR 2269
Cdd:PHA03307 373 RAPSSPAASAGRPTRRRARAAVAGR 397
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1932-2291 |
2.62e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1932 PFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRVASTRSSGSEssdrsgfrRQLTFIKespGLlrrrrS 2011
Cdd:PHA03247 2478 PVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHP--------RMLTWIR---GL-----E 2541
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2012 ELSSADS--------------TVSTSQTASPCRGRPALPAVFLCSSRCD------------ELRASPRQPLAAQRVPQAK 2065
Cdd:PHA03247 2542 ELASDDAgdpppplppaappaAPDRSVPPPRPAPRPSEPAVTSRARRPDappqsarprapvDDRGDPRGPAPPSPLPPDT 2621
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2066 PGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPdSAVSVPTTQANATRRGSDGEARP-------LPR 2138
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA-RRLGRAAQASSPPQRPRRRAARPtvgsltsLAD 2700
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2139 VAAPGTTwrrikDEDVPHILRSTLPATALPL--RGSSPEDSPAGTPHRKTSDAVVQTEDV------ATSKTNSSTSPSLE 2210
Cdd:PHA03247 2701 PPPPPPT-----PEPAPHALVSATPLPPGPAaaRQASPALPAAPAPPAVPAGPATPGGPArparppTTAGPPAPAPPAAP 2775
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2211 SRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGLSVVTGGFPTSRHGSPSRAARVPPFNYVPSPMVVATMTSDSA 2290
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
|
.
gi 1958788266 2291 V 2291
Cdd:PHA03247 2856 V 2856
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1621-1642 |
7.34e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 41.42 E-value: 7.34e-05
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1527-1952 |
8.36e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1527 DSDEEPPATAPPTRRASAIPRALKREKPAGRKETP---TRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASE 1603
Cdd:PHA03247 2546 DDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPavtSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1604 QPACHPR---VEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPS--------SRRRKPRAVRSDIRPteLPQKCREEV 1672
Cdd:PHA03247 2626 PPPPSPSpaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaqasspPQRPRRRAARPTVGS--LTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1673 PGSDPASdldsVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRP 1752
Cdd:PHA03247 2704 PPPTPEP----APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1753 EKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAgesAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATK 1832
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1833 TPSPEQQRSRSLHRPgkISELAALSHPP-RSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPK 1911
Cdd:PHA03247 2857 APGGDVRRRPPSRSP--AAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958788266 1912 SPARALLAKQHKTQKSPVRIPFMQRPA---------------RRVPPPL-ARPSPEP 1952
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalvpgrvavprFRVPQPApSREAPAS 2991
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2064-2303 |
2.69e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2064 AKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVS-VPTTQANATRRGSdgearPLPRVAAP 2142
Cdd:pfam17823 106 AADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPrAAIAAASAPHAAS-----PAPRTAAS 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2143 GTTW--RRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVV----------------------------- 2191
Cdd:pfam17823 181 STTAasSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVgnsspaagtvtaavgtvtpaalatlaaaa 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2192 QTEDVATSKTNS----STSPSLESRDPPQAPISGPVAPLGSDVDGPVLAkppasapFTHEGLSVVTGGFPTSrhgSPSRA 2267
Cdd:pfam17823 261 GTVASAAGTINMgdphARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQ-------VSTDQPVHNTAGEPTP---SPSNT 330
|
250 260 270
....*....|....*....|....*....|....*.
gi 1958788266 2268 ARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLL 2303
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL 366
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1751-2225 |
2.71e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1751 RPEKRGTTSTKGSGSPRFPSGPEKAKGtqKTMAGESAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGT-TQPET 1829
Cdd:PHA03247 2572 RPAPRPSEPAVTSRARRPDAPPQSARP--RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPpTVPPP 2649
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1830 ATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPV 1909
Cdd:PHA03247 2650 ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1910 PKSPARALLAKQHKTQKSPVrIPFMQRPARRVPPPLARPSPEPGsrgrAGAEGTPGARGSRLGLVRVASTRSSGSESsdr 1989
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTAGPPAPAPP----AAPAAGPPRRLTRPAVASLSESRESLPSP--- 2801
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 1990 sgfrrqltfikespgllrrrrSELSSADSTVSTSQTASPCRGRPALPAVFLCSSrcdeLRASPRQPLAAQRVPQAKPG-L 2068
Cdd:PHA03247 2802 ---------------------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSA----QPTAPPPPPGPPPPSLPLGGsV 2856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2069 APRAPRRTSSESPSRLPVRATPGRPetvkRYASLPHISVSRRPDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRR 2148
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARP----PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958788266 2149 IKDEDVPhilrstlPATALPLRGSSPEDSPAGTPHRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAP 2225
Cdd:PHA03247 2933 PPPPPRP-------QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2002-2234 |
3.98e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2002 SPGLLRRRRSELSSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASP-RQPLAAQRVPQAKPGLAPRAPR------ 2074
Cdd:PHA03247 256 APPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPlALPAPPDPPPPAPAGDAEEEDDedgame 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2075 ------RTSSESPSRLPVRATPgrpeTVKRYASLPHISVSRRPDSAVSVPTTQANATR-------RGSDGEARPLPRVAA 2141
Cdd:PHA03247 336 vvsplpRPRQHYPLGFPKRRRP----TWTPPSSLEDLSAGRHHPKRASLPTRKRRSARhaatpfaRGPGGDDQTRPAAPV 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 2142 PGTTwrriKDEDVPHILRSTLPATALPLRGSSP--EDSPAGTPHRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPI 2219
Cdd:PHA03247 412 PASV----PTPAPTPVPASAPPPPATPLPSAEPgsDDGPAPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPEPPG 487
|
250
....*....|....*..
gi 1958788266 2220 SGPVAPLGS--DVDGPV 2234
Cdd:PHA03247 488 ADLAELLGRhpDTAGTV 504
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1400-1422 |
6.59e-04 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 38.90 E-value: 6.59e-04
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
15-285 |
1.62e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 43.35 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 15 FGNQALQELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVL--VSSG 92
Cdd:COG4372 16 FGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLqaAQAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 93 QTEVLEQLKALQTDISSLynlkfhapalgpepaaqtpegspvhgpapskdsfgelsRATIrllEELDQERCFLLSEIeke 172
Cdd:COG4372 96 LAQAQEELESLQEEAEEL--------------------------------------QEEL---EELQKERQDLEQQR--- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958788266 173 ekeklwyySQLQGLSKRLDELphVDTFSMQMDLIRQQLEFEAQHIRSLmeerfgtsdEMVQRAQIRASRLEQIDKELLEA 252
Cdd:COG4372 132 --------KQLEAQIAELQSE--IAEREEELKELEEQLESLQEELAAL---------EQELQALSEAEAEQALDELLKEA 192
|
250 260 270
....*....|....*....|....*....|...
gi 1958788266 253 QDRVQQTEPQALLAVKPVAVEEQEAEVPTHPED 285
Cdd:COG4372 193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKD 225
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
677-717 |
3.14e-03 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.43 E-value: 3.14e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1958788266 677 SPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLA 717
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1276-1297 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.59 E-value: 3.60e-03
|
| ZapB |
pfam06005 |
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ... |
22-83 |
4.73e-03 |
|
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.
Pssm-ID: 428718 [Multi-domain] Cd Length: 71 Bit Score: 37.63 E-value: 4.73e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958788266 22 ELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQ 83
Cdd:pfam06005 10 ETKIQAAVDTIALLQMENEELKEENEELKEEANELEEENQQLKQERNQWQERIRGLLGKLDE 71
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1164-1187 |
5.82e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 5.82e-03
|
| ZapB |
COG3074 |
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ... |
17-82 |
6.64e-03 |
|
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442308 [Multi-domain] Cd Length: 79 Bit Score: 37.64 E-value: 6.64e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958788266 17 NQALQEL--KMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLE 82
Cdd:COG3074 3 LELLEELeaKVQQAVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIR 70
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2231-2279 |
9.94e-03 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
Pssm-ID: 399141 Cd Length: 174 Bit Score: 39.21 E-value: 9.94e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1958788266 2231 DGPVLAKPPASAPFTHEGLSVVTGGFPT---SRHGSPSR--AARVPPFNYVPSP 2279
Cdd:pfam05937 68 ETKPLQNNPVPTPETNENPVSERTPFSSsssSKHSSPSGavAARVTPFNYNPSP 121
|
|
| |
