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Conserved domains on  [gi|1958792522|ref|XP_038936115|]
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deoxyribonuclease TATDN1 isoform X1 [Rattus norvegicus]

Protein Classification

TatD family hydrolase( domain architecture ID 10101392)

TatD family hydrolase is a metal-dependent hydrolase similar to Saccharomyces cerevisiae deoxyribonuclease Tat-D, a cytoplasmic protein that exhibits magnesium-dependent exo- and endonuclease activities, and to Homo sapiens deoxyribonuclease TATDN1 which catalyzes (in vitro) the decatenation of kinetoplast DNA

CATH:  3.20.20.140
EC:  3.1.-.-
Gene Ontology:  GO:0004536|GO:0046872|GO:0016788

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
13-278 4.17e-91

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


:

Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 270.21  E-value: 4.17e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  13 QDDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQylagLLHLAENNKgkVV 92
Cdd:cd01310    14 DADRDDVLARAREAGVIKIIVVGTDLKSSKRALELAKKYDNVYAAVGLHPHDADEHVDEDLDL----LELLAANPK--VV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  93 AIGECGLDFDRLQFcPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRcVGGVVHSFDGTKEAAAALID 172
Cdd:cd01310    88 AIGEIGLDYYRDKS-PREVQKEVFRAQLELAKELNLPVVIHSRDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLD 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 173 LDLYIGFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPWCGVKSTHagskyiktafptkkkweagcclKDRNEPCHIVQI 250
Cdd:cd01310   166 LGFYISISGIVTFKNANelREVVKEIPLERLLLETDSPYLAPVPFR----------------------GKRNEPAYVKHV 223
                         250       260
                  ....*....|....*....|....*...
gi 1958792522 251 LEIMSAVREEDPLELANTLYNNTIKIFF 278
Cdd:cd01310   224 AEKIAELKGISVEEVAEVTTENAKRLFG 251
 
Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
13-278 4.17e-91

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 270.21  E-value: 4.17e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  13 QDDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQylagLLHLAENNKgkVV 92
Cdd:cd01310    14 DADRDDVLARAREAGVIKIIVVGTDLKSSKRALELAKKYDNVYAAVGLHPHDADEHVDEDLDL----LELLAANPK--VV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  93 AIGECGLDFDRLQFcPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRcVGGVVHSFDGTKEAAAALID 172
Cdd:cd01310    88 AIGEIGLDYYRDKS-PREVQKEVFRAQLELAKELNLPVVIHSRDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLD 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 173 LDLYIGFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPWCGVKSTHagskyiktafptkkkweagcclKDRNEPCHIVQI 250
Cdd:cd01310   166 LGFYISISGIVTFKNANelREVVKEIPLERLLLETDSPYLAPVPFR----------------------GKRNEPAYVKHV 223
                         250       260
                  ....*....|....*....|....*...
gi 1958792522 251 LEIMSAVREEDPLELANTLYNNTIKIFF 278
Cdd:cd01310   224 AEKIAELKGISVEEVAEVTTENAKRLFG 251
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
13-277 1.13e-74

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 228.40  E-value: 1.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  13 QDDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFekdsPDQYLAGLLHLAENNKgkVV 92
Cdd:COG0084    14 DEDRDEVLARARAAGVERIVVVGTDLESSERALELAERYPNVYAAVGLHPHDAKEH----DEEDLAELEELAAHPK--VV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  93 AIGECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALID 172
Cdd:COG0084    88 AIGEIGLDYYR-DKSPREVQEEAFRAQLALAKELGLPVIIHSRDAHDDTLEILKEEGAPALGGVFHCFSGSLEQAKRALD 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 173 LDLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPwcgvksthagskYIkTAFPTKKKweagcclkdRNEPCHIVQI 250
Cdd:COG0084   167 LGFYISFGGiVTFKNAKKLrEVAAAIPLDRLLLETDAP------------YL-APVPFRGK---------RNEPAYVPHV 224
                         250       260
                  ....*....|....*....|....*..
gi 1958792522 251 LEIMSAVREEDPLELANTLYNNTIKIF 277
Cdd:COG0084   225 AEKLAELRGISLEELAEATTANARRLF 251
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
14-277 3.59e-71

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 219.44  E-value: 3.59e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  14 DDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMF-FSTVGCHPTRCDEFEKDSpdqyLAGLLHLAENnkGKVV 92
Cdd:pfam01026  14 EDRDEVIERAREAGVTGVVVVGTDLEDFLRVLELAEKYPDRvYAAVGVHPHEADEASEDD----LEALEKLAEH--PKVV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  93 AIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALID 172
Cdd:pfam01026  88 AIGEIGLDYYYVDESPKEAQEEVFRRQLELAKELGLPVVIHTRDAEEDLLEILKEAGAPGARGVLHCFTGSVEEARKFLD 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 173 LDLYIGFNGCSLKTEANL--EVLKSIPSEKLMIETDAPWCGvksthagskyiktafPTKKKweagcclKDRNEPCHIVQI 250
Cdd:pfam01026 168 LGFYISISGIVTFKNAKKlrEVAAAIPLDRLLVETDAPYLA---------------PVPYR-------GKRNEPAYVPYV 225
                         250       260
                  ....*....|....*....|....*..
gi 1958792522 251 LEIMSAVREEDPLELANTLYNNTIKIF 277
Cdd:pfam01026 226 VEKLAELKGISPEEVAEITTENAERLF 252
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
14-279 5.04e-53

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 172.83  E-value: 5.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  14 DDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQylagLLHLAenNKGKVVA 93
Cdd:TIGR00010  15 EDVEEVIERAKAAGVTAVVAVGTDLEDFLRALELAEKYPNVYAAVGVHPLDVDDDTKEDIKE----LERLA--AHPKVVA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  94 IGECGLDFdRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCvGGVVHSFDGTKEAAAALIDL 173
Cdd:TIGR00010  89 IGETGLDY-YKADEYKRRQEEVFRAQLQLAEELNLPVIIHARDAEEDVLDILREEKPKV-GGVLHCFTGDAELAKKLLDL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 174 DLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPWCgvksthagskyikTAFPTKKKweagcclkdRNEPCHIVQIL 251
Cdd:TIGR00010 167 GFYISISGiVTFKNAKSLrEVVRKIPLERLLVETDSPYL-------------APVPYRGK---------RNEPAFVRYTV 224
                         250       260
                  ....*....|....*....|....*...
gi 1958792522 252 EIMSAVREEDPLELANTLYNNtIKIFFS 279
Cdd:TIGR00010 225 EAIAEIKGIDVEELAQITTKN-AKRLFG 251
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
15-277 3.38e-52

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 171.01  E-value: 3.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  15 DLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQylagLLHLAEnnKGKVVAI 94
Cdd:PRK10425   16 DRDDVVARAFAAGVNGMLITGTNLRESQQAQKLARQYPSCWSTAGVHPHDSSQWQAATEEA----IIELAA--QPEVVAI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  95 GECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLD 174
Cdd:PRK10425   90 GECGLDFNR-NFSTPEEQERAFVAQLAIAAELNMPVFMHCRDAHERFMALLEPWLDKLPGAVLHCFTGTREEMQACLARG 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 175 LYIGFNG--CSLKTEANL-EVLKSIPSEKLMIETDAPWCGVKSTHAGskyiktafPTKKkweagcclkdRNEPCHIVQIL 251
Cdd:PRK10425  169 LYIGITGwvCDERRGLELrELLPLIPAERLLLETDAPYLLPRDLTPK--------PASR----------RNEPAFLPHIL 230
                         250       260
                  ....*....|....*....|....*.
gi 1958792522 252 EIMSAVREEDPLELANTLYNNTIKIF 277
Cdd:PRK10425  231 QRIAHWRGEDAAWLAATTDANARTLF 256
 
Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
13-278 4.17e-91

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 270.21  E-value: 4.17e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  13 QDDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQylagLLHLAENNKgkVV 92
Cdd:cd01310    14 DADRDDVLARAREAGVIKIIVVGTDLKSSKRALELAKKYDNVYAAVGLHPHDADEHVDEDLDL----LELLAANPK--VV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  93 AIGECGLDFDRLQFcPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRcVGGVVHSFDGTKEAAAALID 172
Cdd:cd01310    88 AIGEIGLDYYRDKS-PREVQKEVFRAQLELAKELNLPVVIHSRDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLD 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 173 LDLYIGFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPWCGVKSTHagskyiktafptkkkweagcclKDRNEPCHIVQI 250
Cdd:cd01310   166 LGFYISISGIVTFKNANelREVVKEIPLERLLLETDSPYLAPVPFR----------------------GKRNEPAYVKHV 223
                         250       260
                  ....*....|....*....|....*...
gi 1958792522 251 LEIMSAVREEDPLELANTLYNNTIKIFF 278
Cdd:cd01310   224 AEKIAELKGISVEEVAEVTTENAKRLFG 251
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
13-277 1.13e-74

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 228.40  E-value: 1.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  13 QDDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFekdsPDQYLAGLLHLAENNKgkVV 92
Cdd:COG0084    14 DEDRDEVLARARAAGVERIVVVGTDLESSERALELAERYPNVYAAVGLHPHDAKEH----DEEDLAELEELAAHPK--VV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  93 AIGECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALID 172
Cdd:COG0084    88 AIGEIGLDYYR-DKSPREVQEEAFRAQLALAKELGLPVIIHSRDAHDDTLEILKEEGAPALGGVFHCFSGSLEQAKRALD 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 173 LDLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPwcgvksthagskYIkTAFPTKKKweagcclkdRNEPCHIVQI 250
Cdd:COG0084   167 LGFYISFGGiVTFKNAKKLrEVAAAIPLDRLLLETDAP------------YL-APVPFRGK---------RNEPAYVPHV 224
                         250       260
                  ....*....|....*....|....*..
gi 1958792522 251 LEIMSAVREEDPLELANTLYNNTIKIF 277
Cdd:COG0084   225 AEKLAELRGISLEELAEATTANARRLF 251
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
14-277 3.59e-71

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 219.44  E-value: 3.59e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  14 DDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMF-FSTVGCHPTRCDEFEKDSpdqyLAGLLHLAENnkGKVV 92
Cdd:pfam01026  14 EDRDEVIERAREAGVTGVVVVGTDLEDFLRVLELAEKYPDRvYAAVGVHPHEADEASEDD----LEALEKLAEH--PKVV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  93 AIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALID 172
Cdd:pfam01026  88 AIGEIGLDYYYVDESPKEAQEEVFRRQLELAKELGLPVVIHTRDAEEDLLEILKEAGAPGARGVLHCFTGSVEEARKFLD 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 173 LDLYIGFNGCSLKTEANL--EVLKSIPSEKLMIETDAPWCGvksthagskyiktafPTKKKweagcclKDRNEPCHIVQI 250
Cdd:pfam01026 168 LGFYISISGIVTFKNAKKlrEVAAAIPLDRLLVETDAPYLA---------------PVPYR-------GKRNEPAYVPYV 225
                         250       260
                  ....*....|....*....|....*..
gi 1958792522 251 LEIMSAVREEDPLELANTLYNNTIKIF 277
Cdd:pfam01026 226 VEKLAELKGISPEEVAEITTENAERLF 252
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
14-279 5.04e-53

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 172.83  E-value: 5.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  14 DDLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQylagLLHLAenNKGKVVA 93
Cdd:TIGR00010  15 EDVEEVIERAKAAGVTAVVAVGTDLEDFLRALELAEKYPNVYAAVGVHPLDVDDDTKEDIKE----LERLA--AHPKVVA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  94 IGECGLDFdRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCvGGVVHSFDGTKEAAAALIDL 173
Cdd:TIGR00010  89 IGETGLDY-YKADEYKRRQEEVFRAQLQLAEELNLPVIIHARDAEEDVLDILREEKPKV-GGVLHCFTGDAELAKKLLDL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 174 DLYIGFNG-CSLKTEANL-EVLKSIPSEKLMIETDAPWCgvksthagskyikTAFPTKKKweagcclkdRNEPCHIVQIL 251
Cdd:TIGR00010 167 GFYISISGiVTFKNAKSLrEVVRKIPLERLLVETDSPYL-------------APVPYRGK---------RNEPAFVRYTV 224
                         250       260
                  ....*....|....*....|....*...
gi 1958792522 252 EIMSAVREEDPLELANTLYNNtIKIFFS 279
Cdd:TIGR00010 225 EAIAEIKGIDVEELAQITTKN-AKRLFG 251
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
15-277 3.38e-52

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 171.01  E-value: 3.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  15 DLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQylagLLHLAEnnKGKVVAI 94
Cdd:PRK10425   16 DRDDVVARAFAAGVNGMLITGTNLRESQQAQKLARQYPSCWSTAGVHPHDSSQWQAATEEA----IIELAA--QPEVVAI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  95 GECGLDFDRlQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALIDLD 174
Cdd:PRK10425   90 GECGLDFNR-NFSTPEEQERAFVAQLAIAAELNMPVFMHCRDAHERFMALLEPWLDKLPGAVLHCFTGTREEMQACLARG 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 175 LYIGFNG--CSLKTEANL-EVLKSIPSEKLMIETDAPWCGVKSTHAGskyiktafPTKKkweagcclkdRNEPCHIVQIL 251
Cdd:PRK10425  169 LYIGITGwvCDERRGLELrELLPLIPAERLLLETDAPYLLPRDLTPK--------PASR----------RNEPAFLPHIL 230
                         250       260
                  ....*....|....*....|....*.
gi 1958792522 252 EIMSAVREEDPLELANTLYNNTIKIF 277
Cdd:PRK10425  231 QRIAHWRGEDAAWLAATTDANARTLF 256
PRK11449 PRK11449
metal-dependent hydrolase;
20-277 6.30e-28

metal-dependent hydrolase;


Pssm-ID: 171118 [Multi-domain]  Cd Length: 258  Bit Score: 108.13  E-value: 6.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  20 IGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEFEKDSPDQYLAGLlhlaENNKGKVVAIGECGL 99
Cdd:PRK11449   25 LQRAAQAGVGKIIVPATEAENFARVLALAERYQPLYAALGLHPGMLEKHSDVSLDQLQQAL----ERRPAKVVAVGEIGL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 100 DF--DRLQFcpkDTQLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVgGVVHSFDGTKEAAAALIDLDLYI 177
Cdd:PRK11449  101 DLfgDDPQF---ERQQWLLDEQLKLAKRYDLPVILHSRRTHDKLAMHLKRHDLPRT-GVVHGFSGSLQQAERFVQLGYKI 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522 178 GFNGCSLKTEAN--LEVLKSIPSEKLMIETDAPWCGVKSTHAgskyiktafptkkkweagcclkDRNEPCHIVQILEIMS 255
Cdd:PRK11449  177 GVGGTITYPRASktRDVIAKLPLASLLLETDAPDMPLNGFQG----------------------QPNRPEQAARVFDVLC 234
                         250       260
                  ....*....|....*....|..
gi 1958792522 256 AVREEDPLELANTLYNNTIKIF 277
Cdd:PRK11449  235 ELRPEPADEIAEVLLNNTYTLF 256
PRK10812 PRK10812
putative DNAse; Provisional
15-209 3.52e-16

putative DNAse; Provisional


Pssm-ID: 236767 [Multi-domain]  Cd Length: 265  Bit Score: 76.33  E-value: 3.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  15 DLQDVIGRAVQIGVKKFMITGGSLQDSKDALRLAQTNDMFFSTVGCHPTRCDEfekdsPDQYlAGLLHLAENNKgkVVAI 94
Cdd:PRK10812   21 DVDDVLAKAAARDVKFCLAVATTLPGYRHMRDLVGERDNVVFSCGVHPLNQDE-----PYDV-EELRRLAAEEG--VVAM 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  95 GECGLDFdrlqFCPKDT---QLKYFEKQFELSEQTKLPMFLHCRNSHTEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALI 171
Cdd:PRK10812   93 GETGLDY----YYTPETkvrQQESFRHHIQIGRELNKPVIVHTRDARADTLAILREEKVTDCGGVLHCFTEDRETAGKLL 168
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958792522 172 DLDLYIGFNGCSL--KTEANLEVLKSIPSEKLMIETDAPW 209
Cdd:PRK10812  169 DLGFYISFSGIVTfrNAEQLRDAARYVPLDRLLVETDSPY 208
COG1099 COG1099
Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];
88-209 7.66e-05

Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];


Pssm-ID: 440716 [Multi-domain]  Cd Length: 260  Bit Score: 43.29  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792522  88 KGKVVAIGECGLDFDRlqfcpkDTQLKYFEKQFELSEQTKLPMFLHC--RN--SHTE-FLDIMRR---NRDRCVggVVHs 159
Cdd:COG1099    98 KEGVVAIGEIGLDDQT------PEEEEVFREQLELARELDLPVLVHTphRDkkEGTRrILDVLREsglDPERVL--IDH- 168
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958792522 160 fdGTKEAAAALIDLDLYIGFN---GCSLKTEANLEVLKSIPSEKLMIETDAPW 209
Cdd:COG1099   169 --NNEETVKLVLDTGFWAGFTiypSTKMSPERAVDILEEYGTERILVNSAADW 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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