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Conserved domains on  [gi|1958795123|ref|XP_038936975|]
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alpha-tectorin isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 1.49e-65

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 219.22  E-value: 1.49e-65
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123    98 PFWADVHNGIRGEIYYRETMDSAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958795123   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1800-2054 2.81e-62

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 213.79  E-value: 2.81e-62
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1800 TCKAAQMEVSISKCKLFQLGFEREGVRINDRQCSG---IEGEDFISFQINNTKgnCGNVVQSNGTHIMYKNTIWIesANN 1876
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1877 TGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINltVPTQEGSFTTKMALYKNASYKHPYRQGEVVLttRDVLYV 1956
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1957 GVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2034
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1958795123  2035 CAVSLCDSEKYS--CKINCPQN 2054
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 8.47e-46

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 162.96  E-value: 8.47e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   313 YCSPVET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   392 IPKGsYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLL-VTFDGQHYASISIPGSYINSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1958795123   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 1.29e-39

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 144.82  E-value: 1.29e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSrsiSDSFPKFIVTAKNEDRDpSLALWVKQVDVTVFGYSIVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCS---EEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPGDDLEMPMGL 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 1.34e-36

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 136.35  E-value: 1.34e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1487 CLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNlTIISPVYFYINEEQILINDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958795123 1567 TQVNVPFIT-GLATKIYSSeGFLVIDTSPDIQIYYNGFNV--IKISISERLQNKVCGLCGNFNGDMTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILGS-GFVVVDLSPGVGLQVDGDGRgqLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 1.56e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 130.60  E-value: 1.56e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   703 QGCFPKRE-TVCLLSQNQVLHTFDGAAYAFPSELSYTLLKTCPERPEYlEIDINKRKPDAGPAWLRGVRILVADQEVKIG 781
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   782 GVGaLEVKLNGQDVELPFFHPSGRLEIHRNKNSTTVE-SKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDN-GKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1958795123   861 CLPNG 865
Cdd:smart00216  159 RTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 4.53e-23

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 94.71  E-value: 4.53e-23
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123   517 LYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 6.53e-18

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 80.08  E-value: 6.53e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958795123   905 FYRSRSRCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 8.72e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 8.72e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795123 1300 LCSLIpNQNAGFAKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGVAVTGWRNYTSC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 597-650 2.08e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 72.03  E-value: 2.08e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  597 CPSFSHYSVCTSSCPDTCSDLTASQNCATPCTEGCECNEGFVLS-TSQCVPLHKC 650
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 1.02e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.04  E-value: 1.02e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHNC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 1.73e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 66.57  E-value: 1.73e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYAL-QGSQCVTRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGSaCPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1680-1752 3.24e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.82  E-value: 3.24e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958795123  1680 MQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGC-YNHKKFQLCGSLAAYGEACRSFGILSTEWIEKENC 1752
Cdd:smart00832    2 YYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2084-2116 1.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 1.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958795123 2084 EDNGGCEQVCTSRVDGPLCSCVTG-SLQEDGRSC 2116
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 652-706 2.25e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam12714:

Pssm-ID: 450195  Cd Length: 54  Bit Score: 40.75  E-value: 2.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  652 CDFEGHYYTMGEFfWATANCTVQCLCEeGGDVYCFNKTCRSGEVCAVEDGYQGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 1.49e-65

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 219.22  E-value: 1.49e-65
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123    98 PFWADVHNGIRGEIYYRETMDSAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958795123   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1800-2054 2.81e-62

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 213.79  E-value: 2.81e-62
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1800 TCKAAQMEVSISKCKLFQLGFEREGVRINDRQCSG---IEGEDFISFQINNTKgnCGNVVQSNGTHIMYKNTIWIesANN 1876
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1877 TGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINltVPTQEGSFTTKMALYKNASYKHPYRQGEVVLttRDVLYV 1956
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1957 GVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2034
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1958795123  2035 CAVSLCDSEKYS--CKINCPQN 2054
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
1801-2052 1.03e-53

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 189.35  E-value: 1.03e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1801 CKAAQMEVSISKCKLFQLGFEREGVR--INDRQCSG---IEGEDFISFQINNTkgNCGNVVQSNGTHIMYKNTIWIESAN 1875
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPvsnTNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1876 NtGNIITRDRTINVEFSCAYELDIKISLDSVVKPmlsVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLY 1955
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPP---SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1956 VGVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIG--IEENGVSLTCRFHVTVFKFIGDY-DEVH 2032
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1958795123 2033 LHCAVSLCDSEKYSCKINCP 2052
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 8.47e-46

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 162.96  E-value: 8.47e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   313 YCSPVET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   392 IPKGsYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLL-VTFDGQHYASISIPGSYINSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1958795123   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 322-478 1.49e-45

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 161.77  E-value: 1.49e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSlPFFSVEAKNEHRGGSAVsWVKELSVEVNGYKILIPKGsyGKVK 401
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958795123  402 VNDLVTSLPVTLELGAVKIYQSGM-STAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGR 478
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 1.29e-39

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 144.82  E-value: 1.29e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSrsiSDSFPKFIVTAKNEDRDpSLALWVKQVDVTVFGYSIVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCS---EEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPGDDLEMPMGL 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1090-1257 2.83e-39

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 144.08  E-value: 2.83e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1090 YYCQPRTDAS-CIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSrsisdSFPKFIVTAKNEDRDPSLAlWVKQVDVTVFGY 1168
Cdd:smart00216    1 WCCTQEECSPtCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCS-----SEPTFSVLLKNVPCGGGAT-CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1169 SIVIHRAyKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVV-YDWKTFLSITVPRSMQNSTYGLCGRYNGN 1247
Cdd:smart00216   75 EIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1958795123  1248 PGDDLEMPMG 1257
Cdd:smart00216  154 PEDDFRTPDG 163
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 163-251 1.28e-38

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 139.35  E-value: 1.28e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  163 VNTFQAVLVSDGSYTFTLFNY--YEINWTTGTASGGdpLTGLGGVMAQAGFNGGN-LTNFFSLPGSRTPEIVNIQETTNV 239
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYpdGGIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1958795123  240 NVPGRWAFKVDG 251
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 1.34e-36

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 136.35  E-value: 1.34e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1487 CLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNlTIISPVYFYINEEQILINDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958795123 1567 TQVNVPFIT-GLATKIYSSeGFLVIDTSPDIQIYYNGFNV--IKISISERLQNKVCGLCGNFNGDMTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILGS-GFVVVDLSPGVGLQVDGDGRgqLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1477-1638 1.61e-35

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 133.68  E-value: 1.61e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1477 RGCFSTKT-SYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISfqliINFDKWS-SPNLTIISPVYFYINEEQI 1554
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFS----VLLKNVPcGGGATCLKSVKVELNGDEI 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1555 LINDRN-TVKVNGTQVNVPFITGLAT-KIYSSEGFLVIDTSPDI-QIYYNGFNVIKISISERLQNKVCGLCGNFNGDMTD 1631
Cdd:smart00216   77 ELKDDNgKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1958795123  1632 DYVTLRG 1638
Cdd:smart00216  157 DFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 1.56e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 130.60  E-value: 1.56e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   703 QGCFPKRE-TVCLLSQNQVLHTFDGAAYAFPSELSYTLLKTCPERPEYlEIDINKRKPDAGPAWLRGVRILVADQEVKIG 781
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   782 GVGaLEVKLNGQDVELPFFHPSGRLEIHRNKNSTTVE-SKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDN-GKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1958795123   861 CLPNG 865
Cdd:smart00216  159 RTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 713-866 2.12e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 129.80  E-value: 2.12e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  713 CLLSQNQVLHTFDGAAYAFPSELSYTLLKTCPERPEYLEIDINKRKPDAGPAW-LRGVRILVADQEVKIggVGALEVKLN 791
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVcLKSVTVIVGDLEITL--QKGGTVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958795123  792 GQDVELPFFHPSGRLEIHRNKNSTTVESKGV-VSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANASDEFCLPNGK 866
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 4.53e-23

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 94.71  E-value: 4.53e-23
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123   517 LYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 6.53e-18

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 80.08  E-value: 6.53e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958795123   905 FYRSRSRCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 523-591 7.99e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 7.99e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795123  523 YCGFLNKtDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGC 591
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 911-980 8.47e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 8.47e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  911 RCGIINDpsNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFC 980
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 8.72e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 8.72e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795123 1300 LCSLIpNQNAGFAKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGVAVTGWRNYTSC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1298-1368 2.36e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 75.45  E-value: 2.36e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958795123  1298 QQLCSLIPNQNAGFAKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGVAVTGWRNYTSC 1368
Cdd:smart00832    5 CSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 597-650 2.08e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 72.03  E-value: 2.08e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  597 CPSFSHYSVCTSSCPDTCSDLTASQNCATPCTEGCECNEGFVLS-TSQCVPLHKC 650
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 6.45e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.81  E-value: 6.45e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  597 CPSFSHYSVCTSSCPDTCSDLTASQNCATPCTEGCECNEGFVLSTS-QCVPLHKC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 1.02e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.04  E-value: 1.02e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHNC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1372-1425 6.15e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 67.80  E-value: 6.15e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHNC 1425
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 1.73e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 66.57  E-value: 1.73e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYAL-QGSQCVTRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGSaCPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 984-1036 1.98e-11

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 60.86  E-value: 1.98e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYALQ-GSQCVTRSEC 1036
Cdd:pfam01826    1 CPANEVYSECGSaCPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1680-1752 3.24e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.82  E-value: 3.24e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958795123  1680 MQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGC-YNHKKFQLCGSLAAYGEACRSFGILSTEWIEKENC 1752
Cdd:smart00832    2 YYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1685-1752 1.48e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 53.15  E-value: 1.48e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795123 1685 YCLKLTDmKGFFQPCYGLLDPLPFYESCYLDGC-YNHKKFQLCGSLAAYGEACRSFGILSTEWIEKENC 1752
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2084-2116 1.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 1.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958795123 2084 EDNGGCEQVCTSRVDGPLCSCVTG-SLQEDGRSC 2116
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 652-706 2.25e-04

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 40.75  E-value: 2.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  652 CDFEGHYYTMGEFfWATANCTVQCLCEeGGDVYCFNKTCRSGEVCAVEDGYQGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 1.49e-65

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 219.22  E-value: 1.49e-65
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123    98 PFWADVHNGIRGEIYYRETMDSAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958795123   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1800-2054 2.81e-62

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 213.79  E-value: 2.81e-62
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1800 TCKAAQMEVSISKCKLFQLGFEREGVRINDRQCSG---IEGEDFISFQINNTKgnCGNVVQSNGTHIMYKNTIWIesANN 1876
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1877 TGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINltVPTQEGSFTTKMALYKNASYKHPYRQGEVVLttRDVLYV 1956
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1957 GVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2034
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1958795123  2035 CAVSLCDSEKYS--CKINCPQN 2054
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
1801-2052 1.03e-53

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 189.35  E-value: 1.03e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1801 CKAAQMEVSISKCKLFQLGFEREGVR--INDRQCSG---IEGEDFISFQINNTkgNCGNVVQSNGTHIMYKNTIWIESAN 1875
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPvsnTNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1876 NtGNIITRDRTINVEFSCAYELDIKISLDSVVKPmlsVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLY 1955
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPP---SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1956 VGVFVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIG--IEENGVSLTCRFHVTVFKFIGDY-DEVH 2032
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1958795123 2033 LHCAVSLCDSEKYSCKINCP 2052
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 8.47e-46

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 162.96  E-value: 8.47e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   313 YCSPVET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   392 IPKGsYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLL-VTFDGQHYASISIPGSYINSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1958795123   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 322-478 1.49e-45

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 161.77  E-value: 1.49e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSlPFFSVEAKNEHRGGSAVsWVKELSVEVNGYKILIPKGsyGKVK 401
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958795123  402 VNDLVTSLPVTLELGAVKIYQSGM-STAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGR 478
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 1.29e-39

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 144.82  E-value: 1.29e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSrsiSDSFPKFIVTAKNEDRDpSLALWVKQVDVTVFGYSIVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCS---EEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPGDDLEMPMGL 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1090-1257 2.83e-39

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 144.08  E-value: 2.83e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1090 YYCQPRTDAS-CIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSrsisdSFPKFIVTAKNEDRDPSLAlWVKQVDVTVFGY 1168
Cdd:smart00216    1 WCCTQEECSPtCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCS-----SEPTFSVLLKNVPCGGGAT-CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1169 SIVIHRAyKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVV-YDWKTFLSITVPRSMQNSTYGLCGRYNGN 1247
Cdd:smart00216   75 EIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1958795123  1248 PGDDLEMPMG 1257
Cdd:smart00216  154 PEDDFRTPDG 163
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 163-251 1.28e-38

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 139.35  E-value: 1.28e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  163 VNTFQAVLVSDGSYTFTLFNY--YEINWTTGTASGGdpLTGLGGVMAQAGFNGGN-LTNFFSLPGSRTPEIVNIQETTNV 239
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYpdGGIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1958795123  240 NVPGRWAFKVDG 251
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 1.34e-36

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 136.35  E-value: 1.34e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123 1487 CLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNlTIISPVYFYINEEQILINDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958795123 1567 TQVNVPFIT-GLATKIYSSeGFLVIDTSPDIQIYYNGFNV--IKISISERLQNKVCGLCGNFNGDMTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILGS-GFVVVDLSPGVGLQVDGDGRgqLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1477-1638 1.61e-35

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 133.68  E-value: 1.61e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1477 RGCFSTKT-SYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISfqliINFDKWS-SPNLTIISPVYFYINEEQI 1554
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFS----VLLKNVPcGGGATCLKSVKVELNGDEI 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  1555 LINDRN-TVKVNGTQVNVPFITGLAT-KIYSSEGFLVIDTSPDI-QIYYNGFNVIKISISERLQNKVCGLCGNFNGDMTD 1631
Cdd:smart00216   77 ELKDDNgKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1958795123  1632 DYVTLRG 1638
Cdd:smart00216  157 DFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 1.56e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 130.60  E-value: 1.56e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   703 QGCFPKRE-TVCLLSQNQVLHTFDGAAYAFPSELSYTLLKTCPERPEYlEIDINKRKPDAGPAWLRGVRILVADQEVKIG 781
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123   782 GVGaLEVKLNGQDVELPFFHPSGRLEIHRNKNSTTVE-SKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDN-GKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1958795123   861 CLPNG 865
Cdd:smart00216  159 RTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 713-866 2.12e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 129.80  E-value: 2.12e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  713 CLLSQNQVLHTFDGAAYAFPSELSYTLLKTCPERPEYLEIDINKRKPDAGPAW-LRGVRILVADQEVKIggVGALEVKLN 791
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVcLKSVTVIVGDLEITL--QKGGTVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958795123  792 GQDVELPFFHPSGRLEIHRNKNSTTVESKGV-VSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANASDEFCLPNGK 866
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 4.53e-23

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 94.71  E-value: 4.53e-23
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123   517 LYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 6.53e-18

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 80.08  E-value: 6.53e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958795123   905 FYRSRSRCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 523-591 7.99e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 7.99e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795123  523 YCGFLNKtDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRIQTGC 591
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 911-980 8.47e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 8.47e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958795123  911 RCGIINDpsNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFC 980
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 8.72e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 8.72e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795123 1300 LCSLIpNQNAGFAKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGVAVTGWRNYTSC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1298-1368 2.36e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 75.45  E-value: 2.36e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958795123  1298 QQLCSLIPNQNAGFAKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGVAVTGWRNYTSC 1368
Cdd:smart00832    5 CSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 597-650 2.08e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 72.03  E-value: 2.08e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  597 CPSFSHYSVCTSSCPDTCSDLTASQNCATPCTEGCECNEGFVLS-TSQCVPLHKC 650
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 6.45e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.81  E-value: 6.45e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  597 CPSFSHYSVCTSSCPDTCSDLTASQNCATPCTEGCECNEGFVLSTS-QCVPLHKC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 1.02e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.04  E-value: 1.02e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHNC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1372-1425 6.15e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 67.80  E-value: 6.15e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHNC 1425
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 1.73e-13

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 66.57  E-value: 1.73e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYAL-QGSQCVTRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGSaCPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 984-1036 1.98e-11

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 60.86  E-value: 1.98e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYALQ-GSQCVTRSEC 1036
Cdd:pfam01826    1 CPANEVYSECGSaCPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1680-1752 3.24e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.82  E-value: 3.24e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958795123  1680 MQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGC-YNHKKFQLCGSLAAYGEACRSFGILSTEWIEKENC 1752
Cdd:smart00832    2 YYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1685-1752 1.48e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 53.15  E-value: 1.48e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958795123 1685 YCLKLTDmKGFFQPCYGLLDPLPFYESCYLDGC-YNHKKFQLCGSLAAYGEACRSFGILSTEWIEKENC 1752
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2084-2116 1.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 1.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958795123 2084 EDNGGCEQVCTSRVDGPLCSCVTG-SLQEDGRSC 2116
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 652-706 2.25e-04

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 40.75  E-value: 2.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958795123  652 CDFEGHYYTMGEFfWATANCTVQCLCEeGGDVYCFNKTCRSGEVCAVEDGYQGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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