catenin beta-1 isoform X1 [Rattus norvegicus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
CTNNAbd_CTNNB1 | cd21724 | alpha-catenin binding domain found in catenin beta-1 (CTNNB1) and similar proteins; CTNNB1, ... |
78-151 | 3.27e-45 | |||||
alpha-catenin binding domain found in catenin beta-1 (CTNNB1) and similar proteins; CTNNB1, also called beta-catenin, is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues, and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion as a component of an E-cadherin:catenin adhesion complex. It acts as a negative regulator of centrosome cohesion. It is involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. It blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. It disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. This model corresponds to a small region at the C-terminus of CTNNB1, which is responsible for alpha-catenin binding. : Pssm-ID: 439241 Cd Length: 74 Bit Score: 156.19 E-value: 3.27e-45
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
350-390 | 1.20e-06 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. : Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 45.50 E-value: 1.20e-06
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
583-622 | 1.97e-05 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. : Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 42.06 E-value: 1.97e-05
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
230-262 | 7.69e-05 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. : Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 40.49 E-value: 7.69e-05
|
|||||||||
SRP1 super family | cl34886 | Karyopherin (importin) alpha [Intracellular trafficking and secretion]; |
142-431 | 8.14e-04 | |||||
Karyopherin (importin) alpha [Intracellular trafficking and secretion]; The actual alignment was detected with superfamily member COG5064: Pssm-ID: 227396 [Multi-domain] Cd Length: 526 Bit Score: 42.96 E-value: 8.14e-04
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
431-473 | 1.34e-03 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. : Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.05 E-value: 1.34e-03
|
|||||||||
Name | Accession | Description | Interval | E-value | |||||
CTNNAbd_CTNNB1 | cd21724 | alpha-catenin binding domain found in catenin beta-1 (CTNNB1) and similar proteins; CTNNB1, ... |
78-151 | 3.27e-45 | |||||
alpha-catenin binding domain found in catenin beta-1 (CTNNB1) and similar proteins; CTNNB1, also called beta-catenin, is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues, and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion as a component of an E-cadherin:catenin adhesion complex. It acts as a negative regulator of centrosome cohesion. It is involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. It blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. It disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. This model corresponds to a small region at the C-terminus of CTNNB1, which is responsible for alpha-catenin binding. Pssm-ID: 439241 Cd Length: 74 Bit Score: 156.19 E-value: 3.27e-45
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
350-390 | 1.20e-06 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 45.50 E-value: 1.20e-06
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
353-390 | 5.44e-06 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 43.60 E-value: 5.44e-06
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
583-622 | 1.97e-05 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 42.06 E-value: 1.97e-05
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
230-262 | 7.69e-05 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 40.49 E-value: 7.69e-05
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
230-262 | 1.98e-04 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 1.98e-04
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
583-623 | 5.95e-04 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 37.79 E-value: 5.95e-04
|
|||||||||
SRP1 | COG5064 | Karyopherin (importin) alpha [Intracellular trafficking and secretion]; |
142-431 | 8.14e-04 | |||||
Karyopherin (importin) alpha [Intracellular trafficking and secretion]; Pssm-ID: 227396 [Multi-domain] Cd Length: 526 Bit Score: 42.96 E-value: 8.14e-04
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
431-473 | 1.34e-03 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.05 E-value: 1.34e-03
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
431-473 | 4.94e-03 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 35.48 E-value: 4.94e-03
|
|||||||||
Name | Accession | Description | Interval | E-value | |||||
CTNNAbd_CTNNB1 | cd21724 | alpha-catenin binding domain found in catenin beta-1 (CTNNB1) and similar proteins; CTNNB1, ... |
78-151 | 3.27e-45 | |||||
alpha-catenin binding domain found in catenin beta-1 (CTNNB1) and similar proteins; CTNNB1, also called beta-catenin, is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues, and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. CTNNB1 is involved in the regulation of cell adhesion as a component of an E-cadherin:catenin adhesion complex. It acts as a negative regulator of centrosome cohesion. It is involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. It blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. It disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. This model corresponds to a small region at the C-terminus of CTNNB1, which is responsible for alpha-catenin binding. Pssm-ID: 439241 Cd Length: 74 Bit Score: 156.19 E-value: 3.27e-45
|
|||||||||
CTNNAbd_dArm | cd21726 | alpha-catenin binding domain found in Drosophila melanogaster armadillo segment polarity ... |
77-151 | 1.99e-41 | |||||
alpha-catenin binding domain found in Drosophila melanogaster armadillo segment polarity protein (dArm) and similar proteins; dArm is a Drosophila catenin that plays a role during central nervous system development. It can associate with alpha-catenin. The neural isoform of dArm may associate with CadN and participate in the transmission of developmental information. Its cytoplasmic isoform accumulates through Wingless (Wg) signaling; arm function in Wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. This model corresponds to a small region at the C-terminus of dArm, which shows high sequence similarity with alpha-catenin binding domain of catenin beta-1 (CTNNB1). Pssm-ID: 439243 Cd Length: 75 Bit Score: 145.63 E-value: 1.99e-41
|
|||||||||
CTNNAbd_CTNNB1-like | cd21719 | alpha-catenin binding domain found in catenin beta-1 (CTNNB1), catenin gamma (CTNNG) and ... |
82-151 | 8.83e-39 | |||||
alpha-catenin binding domain found in catenin beta-1 (CTNNB1), catenin gamma (CTNNG) and similar proteins; This family includes alpha-catenin binding domain found in catenin beta-1 (CTNNB1), catenin gamma (CTNNG), as well as Drosophila melanogaster armadillo segment polarity protein (dArm). CTNNB1, also called beta-catenin, is a key downstream component of the canonical Wnt signaling pathway. It is involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. It acts as a negative regulator of centrosome cohesion. It is involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. It blocks anoikis of malignant kidney and intestinal epithelial cells, and promotes their anchorage-independent growth by down-regulating DAPK2. It disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. CTNNG, also called junction plakoglobin (JUP), or desmoplakin III, or desmoplakin-3 (DP3), is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. CTNNG acts as a substrate for VE-PTP and is required to stimulate VE-cadherin function in endothelial cells. It can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. dArm, which shows high sequence similarity with CTNNB1, is a Drosophila catenin that plays a role during central nervous system development. It can associate with alpha-catenin. Its neural isoform may associate with CadN and participate in the transmission of developmental information. Its cytoplasmic isoform accumulates through Wingless (Wg) signaling; arm function in Wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. This model corresponds to a small region at the C-termini of dArm, CTNNB1 and CTNNG; in CTNNB1, this region is responsible for alpha-catenin binding. Pssm-ID: 439240 Cd Length: 70 Bit Score: 137.80 E-value: 8.83e-39
|
|||||||||
CTNNAbd_CTNNG | cd21725 | alpha-catenin binding domain found in catenin gamma (CTNNG) and similar proteins; CTNNG, also ... |
82-151 | 1.12e-30 | |||||
alpha-catenin binding domain found in catenin gamma (CTNNG) and similar proteins; CTNNG, also called junction plakoglobin (JUP), or desmoplakin III, or desmoplakin-3 (DP3), is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. CTNNG acts as a substrate for VE-PTP and is required to stimulate VE-cadherin function in endothelial cells. It can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. This model corresponds to a small region at the C-terminus of CTNNG, which shows high sequence similarity with alpha-catenin binding domain of catenin beta-1 (CTNNB1). Pssm-ID: 439242 Cd Length: 70 Bit Score: 114.97 E-value: 1.12e-30
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
350-390 | 1.20e-06 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 45.50 E-value: 1.20e-06
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
353-390 | 5.44e-06 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 43.60 E-value: 5.44e-06
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
583-622 | 1.97e-05 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 42.06 E-value: 1.97e-05
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
230-262 | 7.69e-05 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 40.49 E-value: 7.69e-05
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
230-262 | 1.98e-04 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 1.98e-04
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
583-623 | 5.95e-04 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 37.79 E-value: 5.95e-04
|
|||||||||
SRP1 | COG5064 | Karyopherin (importin) alpha [Intracellular trafficking and secretion]; |
142-431 | 8.14e-04 | |||||
Karyopherin (importin) alpha [Intracellular trafficking and secretion]; Pssm-ID: 227396 [Multi-domain] Cd Length: 526 Bit Score: 42.96 E-value: 8.14e-04
|
|||||||||
Arm | pfam00514 | Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
431-473 | 1.34e-03 | |||||
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats. Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 37.05 E-value: 1.34e-03
|
|||||||||
ARM | smart00185 | Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
431-473 | 4.94e-03 | |||||
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin. Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 35.48 E-value: 4.94e-03
|
|||||||||
Blast search parameters | ||||
|