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Conserved domains on  [gi|1958803874|ref|XP_038940099|]
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inducible T-cell costimulator isoform X4 [Rattus norvegicus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
V-set_2 super family cl46293
ICOS V-set domain; This family contains divergent V-set ig domains found in the ICOS protein.
21-58 3.86e-15

ICOS V-set domain; This family contains divergent V-set ig domains found in the ICOS protein.


The actual alignment was detected with superfamily member pfam15910:

Pssm-ID: 464936  Cd Length: 112  Bit Score: 65.98  E-value: 3.86e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958803874  21 NADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQ 58
Cdd:pfam15910  75 NLDSSHASYYFCCLSIFDPPPFIHCILSGEYLYIYESQ 112
 
Name Accession Description Interval E-value
V-set_2 pfam15910
ICOS V-set domain; This family contains divergent V-set ig domains found in the ICOS protein.
21-58 3.86e-15

ICOS V-set domain; This family contains divergent V-set ig domains found in the ICOS protein.


Pssm-ID: 464936  Cd Length: 112  Bit Score: 65.98  E-value: 3.86e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958803874  21 NADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQ 58
Cdd:pfam15910  75 NLDSSHASYYFCCLSIFDPPPFIHCILSGEYLYIYESQ 112
 
Name Accession Description Interval E-value
V-set_2 pfam15910
ICOS V-set domain; This family contains divergent V-set ig domains found in the ICOS protein.
21-58 3.86e-15

ICOS V-set domain; This family contains divergent V-set ig domains found in the ICOS protein.


Pssm-ID: 464936  Cd Length: 112  Bit Score: 65.98  E-value: 3.86e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958803874  21 NADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQ 58
Cdd:pfam15910  75 NLDSSHASYYFCCLSIFDPPPFIHCILSGEYLYIYESQ 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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