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Conserved domains on  [gi|1958656154|ref|XP_038940999|]
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teneurin-2 isoform X6 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
10-374 0e+00

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


:

Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 643.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154   10 SLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGANFTLAELGICEP 89
Cdd:pfam06484    1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154   90 SP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDDNG 168
Cdd:pfam06484   81 SPrHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  169 RPIPPTSSSSLLPsaqlpSSHNPPP---VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 245
Cdd:pfam06484  161 PPIPPSSSSSSPV-----EQHSPPPpslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  246 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 322
Cdd:pfam06484  236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958656154  323 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 374
Cdd:pfam06484  316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1169-1499 1.04e-46

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 171.94  E-value: 1.04e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1169 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILELRNKEFKHSNSPGHKYY----LAVDPvTGSLYVSDTNSRRIYRV 1242
Cdd:cd14953     25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1243 kslsgakDLAGNSEVVAGTGEqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLG 1320
Cdd:cd14953    104 -------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1321 sndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSLSKLA 1398
Cdd:cd14953    170 ----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSGDGGA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1399 IHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNSPSSL 1478
Cdd:cd14953    237 TAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPTGV 302
                          330       340
                   ....*....|....*....|.
gi 1958656154 1479 AVAPDGTIYIADLGNIRIRAV 1499
Cdd:cd14953    303 AVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2619-2696 4.10e-37

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


:

Pssm-ID: 464783  Cd Length: 78  Bit Score: 135.05  E-value: 4.10e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958656154 2619 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2696
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1460-2397 2.16e-29

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


:

Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 129.11  E-value: 2.16e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1460 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVT 1539
Cdd:COG3209    113 ASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLA 192
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1540 GEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTGLLA 1619
Cdd:COG3209    193 TGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGA 272
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1620 TKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQL 1699
Cdd:COG3209    273 GLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVGGG 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1700 CSNGTLRVMYANGMGVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSID 1779
Cdd:COG3209    353 GSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTA 432
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1780 YDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGK 1859
Cdd:COG3209    433 TGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTT 512
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1860 VWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTS 1939
Cdd:COG3209    513 TAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTT 592
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1940 FLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRFSEEGMINARFD 2019
Cdd:COG3209    593 TVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAG 672
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2020 YTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMF-R 2098
Cdd:COG3209    673 LTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTtT 752
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2099 SLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH-----LLNPGNSARLM 2173
Cdd:COG3209    753 TTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitvGSGGGTDLQDR 832
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2174 PLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVSRRASyKTNLGHHlQYFYS 2253
Cdd:COG3209    833 TYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RTDGGTT-TYTYD 900
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2254 DLHHPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPD 2333
Cdd:COG3209    901 ALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGA 961
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958656154 2334 FQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrNVGKEPAPfNLYMFKNNNPLSN 2397
Cdd:COG3209    962 AANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVNY 1019
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
772-802 2.33e-08

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


:

Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 51.75  E-value: 2.33e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958656154  772 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 802
Cdd:NF033662     2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
580-602 3.00e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 3.00e-04
                           10        20
                   ....*....|....*....|....*
gi 1958656154  580 CHGNGECVS--GLCHCFPGFLGADC 602
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
645-667 1.07e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.07e-03
                           10        20
                   ....*....|....*....|....*
gi 1958656154  645 CGGHGSCID--GNCVCAAGYKGEHC 667
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
671-700 1.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958656154  671 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 700
Cdd:cd00054      4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
736-769 3.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958656154  736 VDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 769
Cdd:cd00054      2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
611-628 6.04e-03

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 36.31  E-value: 6.04e-03
                           10
                   ....*....|....*...
gi 1958656154  611 CSGNGQYSKGTCQCYSGW 628
Cdd:pfam18372   12 CSGNGTFVCGVCVCNPGY 29
 
Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
10-374 0e+00

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 643.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154   10 SLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGANFTLAELGICEP 89
Cdd:pfam06484    1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154   90 SP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDDNG 168
Cdd:pfam06484   81 SPrHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  169 RPIPPTSSSSLLPsaqlpSSHNPPP---VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 245
Cdd:pfam06484  161 PPIPPSSSSSSPV-----EQHSPPPpslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  246 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 322
Cdd:pfam06484  236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958656154  323 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 374
Cdd:pfam06484  316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1169-1499 1.04e-46

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 171.94  E-value: 1.04e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1169 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILELRNKEFKHSNSPGHKYY----LAVDPvTGSLYVSDTNSRRIYRV 1242
Cdd:cd14953     25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1243 kslsgakDLAGNSEVVAGTGEqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLG 1320
Cdd:cd14953    104 -------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1321 sndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSLSKLA 1398
Cdd:cd14953    170 ----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSGDGGA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1399 IHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNSPSSL 1478
Cdd:cd14953    237 TAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPTGV 302
                          330       340
                   ....*....|....*....|.
gi 1958656154 1479 AVAPDGTIYIADLGNIRIRAV 1499
Cdd:cd14953    303 AVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2619-2696 4.10e-37

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 135.05  E-value: 4.10e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958656154 2619 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2696
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1460-2397 2.16e-29

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 129.11  E-value: 2.16e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1460 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVT 1539
Cdd:COG3209    113 ASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLA 192
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1540 GEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTGLLA 1619
Cdd:COG3209    193 TGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGA 272
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1620 TKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQL 1699
Cdd:COG3209    273 GLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVGGG 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1700 CSNGTLRVMYANGMGVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSID 1779
Cdd:COG3209    353 GSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTA 432
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1780 YDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGK 1859
Cdd:COG3209    433 TGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTT 512
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1860 VWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTS 1939
Cdd:COG3209    513 TAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTT 592
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1940 FLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRFSEEGMINARFD 2019
Cdd:COG3209    593 TVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAG 672
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2020 YTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMF-R 2098
Cdd:COG3209    673 LTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTtT 752
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2099 SLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH-----LLNPGNSARLM 2173
Cdd:COG3209    753 TTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitvGSGGGTDLQDR 832
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2174 PLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVSRRASyKTNLGHHlQYFYS 2253
Cdd:COG3209    833 TYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RTDGGTT-TYTYD 900
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2254 DLHHPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPD 2333
Cdd:COG3209    901 ALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGA 961
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958656154 2334 FQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrNVGKEPAPfNLYMFKNNNPLSN 2397
Cdd:COG3209    962 AANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVNY 1019
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1169-1499 3.70e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 69.28  E-value: 3.70e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1169 PVALAVGIDGSLFVGDF--NYIRRIFPsrnvtsilelRNKEFK-HSNSPGHKYY-LAVDPvTGSLYVSDTNSRRIYRVks 1244
Cdd:COG4257     19 PRDVAVDPDGAVWFTDQggGRIGRLDP----------ATGEFTeYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI-- 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1245 lsGAKDlaGNSEVVAGTGEQCLPFdearcgdggkavdatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgs 1321
Cdd:COG4257     86 --DPKT--GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF--- 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1322 ndltavrPLSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslskla 1398
Cdd:COG4257    139 -------PLPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL------------------ 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1399 iHSALESASAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncicysgdDAYATDAILNSPSSL 1478
Cdd:COG4257    184 -PTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGV 236
                          330       340
                   ....*....|....*....|.
gi 1958656154 1479 AVAPDGTIYIADLGNIRIRAV 1499
Cdd:COG4257    237 AVDGDGRVWFAESGANRIVRF 257
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
2320-2397 8.60e-10

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 57.12  E-value: 8.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2320 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrnvgkePA----PFNLYMFKNNNPL 2395
Cdd:TIGR03696    1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69

                   ..
gi 1958656154 2396 SN 2397
Cdd:TIGR03696   70 NW 71
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
772-802 2.33e-08

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 51.75  E-value: 2.33e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958656154  772 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 802
Cdd:NF033662     2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
1611-1647 7.06e-05

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 42.20  E-value: 7.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958656154 1611 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1647
Cdd:pfam05593    1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
580-602 3.00e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 3.00e-04
                           10        20
                   ....*....|....*....|....*
gi 1958656154  580 CHGNGECVS--GLCHCFPGFLGADC 602
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
645-667 1.07e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.07e-03
                           10        20
                   ....*....|....*....|....*
gi 1958656154  645 CGGHGSCID--GNCVCAAGYKGEHC 667
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
671-700 1.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958656154  671 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 700
Cdd:cd00054      4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
638-668 1.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958656154  638 NQCIDPS-CGGHGSCIDG----NCVCAAGYKGEHCE 668
Cdd:cd00054      3 DECASGNpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
583-693 2.21e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 40.90  E-value: 2.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  583 NGECVSglchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGSCIDGNC 656
Cdd:NF041328    29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGAACAPGQ 94
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1958656154  657 VCAAGYKGEHCEE--VDCldptcssHGVCVN--------GEC--LCSPG 693
Cdd:NF041328    95 VCEGGACREACSEglTRC-------GGACVDlatdplhcGACgvACDPG 136
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
736-769 3.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958656154  736 VDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 769
Cdd:cd00054      2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
611-628 6.04e-03

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 36.31  E-value: 6.04e-03
                           10
                   ....*....|....*...
gi 1958656154  611 CSGNGQYSKGTCQCYSGW 628
Cdd:pfam18372   12 CSGNGTFVCGVCVCNPGY 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
739-767 6.73e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 6.73e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958656154  739 CPDL-CNGNGRCTLGQNSWQCVCQTGWRGP 767
Cdd:pfam00008    1 CAPNpCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
10-374 0e+00

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 643.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154   10 SLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGANFTLAELGICEP 89
Cdd:pfam06484    1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154   90 SP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDDNG 168
Cdd:pfam06484   81 SPrHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNENG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  169 RPIPPTSSSSLLPsaqlpSSHNPPP---VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 245
Cdd:pfam06484  161 PPIPPSSSSSSPV-----EQHSPPPpslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  246 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 322
Cdd:pfam06484  236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958656154  323 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 374
Cdd:pfam06484  316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1169-1499 1.04e-46

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 171.94  E-value: 1.04e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1169 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILELRNKEFKHSNSPGHKYY----LAVDPvTGSLYVSDTNSRRIYRV 1242
Cdd:cd14953     25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGNLYVADTGNHRIRKI 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1243 kslsgakDLAGNSEVVAGTGEqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLG 1320
Cdd:cd14953    104 -------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVAG 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1321 sndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSLSKLA 1398
Cdd:cd14953    170 ----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSGDGGA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1399 IHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNSPSSL 1478
Cdd:cd14953    237 TAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNNPTGV 302
                          330       340
                   ....*....|....*....|.
gi 1958656154 1479 AVAPDGTIYIADLGNIRIRAV 1499
Cdd:cd14953    303 AVDAAGNLYVADTGNNRIRKI 323
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1220-1500 2.18e-40

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 153.45  E-value: 2.18e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1220 LAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGEqclpfdEARCGDGGKAvdATLMSPRGIAVDKNGLMY 1299
Cdd:cd14953     28 VAVDA-AGNLYVADRGNHRIRKI-------TPDGVVTTVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGNLY 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1300 FVDAT--MIRKVDQNGIISTLLGsndlTAVRPLSCDSSMDVAQvrLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQV 1375
Cdd:cd14953     92 VADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGATAAQ--FNYPTGVAVDAAGN-LYVADtgNHRIRKITPDGVV 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1376 SIIAGRPmhcqVPGidYSLSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndv 1455
Cdd:cd14953    165 TTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA------- 228
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1958656154 1456 ncicYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVS 1500
Cdd:cd14953    229 ----GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2619-2696 4.10e-37

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 135.05  E-value: 4.10e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958656154 2619 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2696
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1257-1500 6.66e-32

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 128.80  E-value: 6.66e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1257 VVAGTGeqclpfdeARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLL-----GSNDLTAvrp 1329
Cdd:cd14953      3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAgtgtaGFADGGG--- 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1330 lscdssmdvAQVRLEWPTDLAVNPMDNsLYV--LENNVILRITENHQVSIIAGRPmhcqVPGidYSLSKLAIHSALESAS 1407
Cdd:cd14953     72 ---------AAAQFNTPSGVAVDAAGN-LYVadTGNHRIRKITPDGVVSTLAGTG----TAG--FSDDGGATAAQFNYPT 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1408 AIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncicYSGDDAYATDAILNSPSSLAVAPDGTIY 1487
Cdd:cd14953    136 GVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNLY 201
                          250
                   ....*....|...
gi 1958656154 1488 IADLGNIRIRAVS 1500
Cdd:cd14953    202 VADRGNHRIRKIT 214
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1460-2397 2.16e-29

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 129.11  E-value: 2.16e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1460 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVT 1539
Cdd:COG3209    113 ASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLA 192
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1540 GEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTGLLA 1619
Cdd:COG3209    193 TGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGASGA 272
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1620 TKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQL 1699
Cdd:COG3209    273 GLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVGGG 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1700 CSNGTLRVMYANGMGVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSID 1779
Cdd:COG3209    353 GSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGGTA 432
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1780 YDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGK 1859
Cdd:COG3209    433 TGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTTTT 512
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1860 VWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTS 1939
Cdd:COG3209    513 TAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGTATTT 592
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1940 FLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRFSEEGMINARFD 2019
Cdd:COG3209    593 TVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAG 672
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2020 YTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMF-R 2098
Cdd:COG3209    673 LTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTtT 752
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2099 SLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH-----LLNPGNSARLM 2173
Cdd:COG3209    753 TTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitvGSGGGTDLQDR 832
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2174 PLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVSRRASyKTNLGHHlQYFYS 2253
Cdd:COG3209    833 TYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RTDGGTT-TYTYD 900
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2254 DLHHPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPD 2333
Cdd:COG3209    901 ALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNLLAETSGA 961
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958656154 2334 FQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrNVGKEPAPfNLYMFKNNNPLSN 2397
Cdd:COG3209    962 AANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVNY 1019
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1220-1518 1.60e-17

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 85.06  E-value: 1.60e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1220 LAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGeqclpfdearcGDGgkavDATLMSPRGIAVDKNGLMY 1299
Cdd:cd05819     13 IAVDS-SGNIYVADTGNNRIQVF-------DPDGNFITSFGSF-----------GSG----DGQFNEPAGVAVDSDGNLY 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1300 FVDAT--MIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL--ENNVILRITENHQV 1375
Cdd:cd05819     70 VADTGnhRIQKFDPDGNFLASFGGSGDG--------------DGEFNGPRGIAVDSSGN-IYVAdtGNHRIQKFDPDGEF 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1376 SIIAGrpmhcqvpgidyslSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndv 1455
Cdd:cd05819    135 LTTFG--------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGN---HRIQVFDPDGNFLTTFG----------- 186
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958656154 1456 ncicysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPG 1518
Cdd:cd05819    187 --------STGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQ 241
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1139-1309 2.25e-17

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 86.04  E-value: 2.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1139 IITSIMGNGRRRSiscpSCNGLAEGNKLLAPVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILELRNKEFKHS----- 1211
Cdd:cd14953    163 VVTTVAGTGGAGY----AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFSGDggata 238
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1212 ---NSPghkYYLAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAGNSEVVAGTGeQCLPfdearcGDGGKAVDATLMSPR 1288
Cdd:cd14953    239 aqlNNP---TGVAVDA-AGNLYVADSGNHRIRKI-------TPAGVVTTVAGGG-AGFS------GDGGPATSAQFNNPT 300
                          170       180
                   ....*....|....*....|...
gi 1958656154 1289 GIAVDKNGLMYFVDAT--MIRKV 1309
Cdd:cd14953    301 GVAVDAAGNLYVADTGnnRIRKI 323
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1164-1497 3.13e-16

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 81.21  E-value: 3.13e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1164 NKLLAPVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILELRNKEFKHSNSPghkYYLAVDPvTGSLYVSDTNSRRIYR 1241
Cdd:cd05819      5 GELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEP---AGVAVDS-DGNLYVADTGNHRIQK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1242 VkslsgakDLAGNSEVVAGTGeqclpfdearcGDGgkavDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLL 1319
Cdd:cd05819     81 F-------DPDGNFLASFGGS-----------GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEFLTTF 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1320 GSNdltavrplscdsSMDVAQvrLEWPTDLAVNPmDNSLYVLE--NNVILRITENHQVSIIAGRPmhCQVPGidyslskl 1397
Cdd:cd05819    139 GSG------------GSGPGQ--FNGPTGVAVDS-DGNIYVADtgNHRIQVFDPDGNFLTTFGST--GTGPG-------- 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1398 aihsALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndvncicysgdDAYATDAILNSPSS 1477
Cdd:cd05819    194 ----QFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNG-------------------NFLGSDGQFNRPSG 247
                          330       340
                   ....*....|....*....|
gi 1958656154 1478 LAVAPDGTIYIADLGNIRIR 1497
Cdd:cd05819    248 LAVDSDGNLYVADTGNNRIQ 267
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1158-1369 4.19e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 78.13  E-value: 4.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1158 NGLAEGNkLLAPVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSIL---ELRNKEFkhsNSPghkYYLAVDPvTGSLYVS 1232
Cdd:cd05819     94 SGDGDGE-FNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsgGSGPGQF---NGP---TGVAVDS-DGNIYVA 165
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1233 DTNSRRIYRVKSlsgakdlagNSEVVAGTGEQClpfdearcgdggkAVDATLMSPRGIAVDKNGLMYFVDATM--IRKVD 1310
Cdd:cd05819    166 DTGNHRIQVFDP---------DGNFLTTFGSTG-------------TGPGQFNYPTGIAVDSDGNIYVADSGNnrVQVFD 223
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958656154 1311 QNGIISTLLGSNdltavrplscdssmDVAQVRLEWPTDLAVNPmDNSLYVLE--NNVILRI 1369
Cdd:cd05819    224 PDGAGFGGNGNF--------------LGSDGQFNRPSGLAVDS-DGNLYVADtgNNRIQVF 269
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1281-1512 9.72e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 76.97  E-value: 9.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1281 DATLMSPRGIAVDKNGLMYFVDATM--IRKVDQNGIISTLLGSNDltavrplscdssmdVAQVRLEWPTDLAVNPmDNSL 1358
Cdd:cd05819      4 PGELNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNL 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1359 YVL--ENNVILRITENHQVSIIAGRPmhcqvpGIDYSlsklaihsALESASAIAISHTGVLYITETDEkkiNRLRQVTTN 1436
Cdd:cd05819     69 YVAdtGNHRIQKFDPDGNFLASFGGS------GDGDG--------EFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPD 131
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958656154 1437 GEICLLAGAASDCDCKndvncicysgddayatdaiLNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQY 1512
Cdd:cd05819    132 GEFLTTFGSGGSGPGQ-------------------FNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGST 188
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1165-1430 1.39e-13

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 73.51  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1165 KLLAPVALAVGIDGSLFVGDFNYIR-RIFPS----RNVTSILELRNKEFkhsNSPghkYYLAVDPvTGSLYVSDTNSRRI 1239
Cdd:cd05819     53 QFNEPAGVAVDSDGNLYVADTGNHRiQKFDPdgnfLASFGGSGDGDGEF---NGP---RGIAVDS-SGNIYVADTGNHRI 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1240 YRVkslsgakDLAGNSEVVAGtgeqclpfdearcgdGGKAVDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIST 1317
Cdd:cd05819    126 QKF-------DPDGEFLTTFG---------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGNFLT 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1318 LLGSNdltavrplscdssmDVAQVRLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGrpmhcqvpgidyslS 1395
Cdd:cd05819    184 TFGST--------------GTGPGQFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------N 234
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1958656154 1396 KLAIHSALESASAIAISHTGVLYITETDEKKINRL 1430
Cdd:cd05819    235 FLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1169-1499 3.70e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 69.28  E-value: 3.70e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1169 PVALAVGIDGSLFVGDF--NYIRRIFPsrnvtsilelRNKEFK-HSNSPGHKYY-LAVDPvTGSLYVSDTNSRRIYRVks 1244
Cdd:COG4257     19 PRDVAVDPDGAVWFTDQggGRIGRLDP----------ATGEFTeYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGRI-- 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1245 lsGAKDlaGNSEVVAGTGEQCLPFdearcgdggkavdatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgs 1321
Cdd:COG4257     86 --DPKT--GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF--- 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1322 ndltavrPLSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslskla 1398
Cdd:COG4257    139 -------PLPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL------------------ 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1399 iHSALESASAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncicysgdDAYATDAILNSPSSL 1478
Cdd:COG4257    184 -PTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGV 236
                          330       340
                   ....*....|....*....|.
gi 1958656154 1479 AVAPDGTIYIADLGNIRIRAV 1499
Cdd:COG4257    237 AVDGDGRVWFAESGANRIVRF 257
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
2320-2397 8.60e-10

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 57.12  E-value: 8.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 2320 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwrnvgkePA----PFNLYMFKNNNPL 2395
Cdd:TIGR03696    1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69

                   ..
gi 1958656154 2396 SN 2397
Cdd:TIGR03696   70 NW 71
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1206-1529 2.45e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1206 KEFKHSNSPGHKYYLAVDPvTGSLYVSDTNSRRIYRVkslsgakDLAgnsevvagTGEqclpFDEARCGDGGkavdatlm 1285
Cdd:COG4257      8 TEYPVPAPGSGPRDVAVDP-DGAVWFTDQGGGRIGRL-------DPA--------TGE----FTEYPLGGGS-------- 59
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1286 SPRGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLLGSNDLTAvrplscdssmdvaqvrlewPTDLAVNPmDNSLYV-- 1360
Cdd:COG4257     60 GPHGIAVDPDGNLWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFtd 119
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1361 LENNVILRIT-ENHQVSIIAGRPMHCQvpgidyslsklaihsalesASAIAISHTGVLYITETdekKINRLRQVTT-NGE 1438
Cdd:COG4257    120 QGGNRIGRLDpATGEVTEFPLPTGGAG-------------------PYGIAVDPDGNLWVTDF---GANAIGRIDPdTGT 177
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1439 IcllagaasdcdckndvncicysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSknkPVLNAFNQYeAASPG 1518
Cdd:COG4257    178 L------------------------TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD---PKTGTVTEY-PLPGG 229
                          330
                   ....*....|...
gi 1958656154 1519 EQELY--VFNADG 1529
Cdd:COG4257    230 GARPYgvAVDGDG 242
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
772-802 2.33e-08

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 51.75  E-value: 2.33e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958656154  772 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 802
Cdd:NF033662     2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1164-1439 2.40e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.72  E-value: 2.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1164 NKLLAPVALAVGIDGSLFVGD--FNYIRRIFPSRNVTSILELRNKEfkhsNSPghkYYLAVDPvTGSLYVSDTNSRRIYR 1241
Cdd:COG4257     56 GGGSGPHGIAVDPDGNLWFTDngNNRIGRIDPKTGEITTFALPGGG----SNP---HGIAFDP-DGNLWFTDQGGNRIGR 127
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1242 VkslsgakDLAGNsEVVAGTgeqcLPFDEARcgdggkavdatlmsPRGIAVDKNGLMYFVD--ATMIRKVD-QNGIISTL 1318
Cdd:COG4257    128 L-------DPATG-EVTEFP----LPTGGAG--------------PYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEY 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1319 LGSNDLTAvrplscdssmdvaqvrlewPTDLAVNPmDNSLYVLE--NNVILRITENhqvsiiagrpmhcqvpgiDYSLSK 1396
Cdd:COG4257    182 ALPTPGAG-------------------PRGLAVDP-DGNLWVADtgSGRIGRFDPK------------------TGTVTE 223
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1958656154 1397 LAIHSALESASAIAISHTGVLYITETDekkINRLRQVTTNGEI 1439
Cdd:COG4257    224 YPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTEL 263
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
1220-1496 1.05e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 55.68  E-value: 1.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1220 LAVDPvTGSLYVSDTNSRRIYRvkslsgakdLAgnsevvAGTGEQC-LPFDEarcgdggkavdatLMSPRGIAVDKNGLM 1298
Cdd:cd14952     15 VAVDA-AGNVYVADSGNNRVLK---------LA------AGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1299 YFVDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPMDNsLYVLE--NNVILRITenhqvs 1376
Cdd:cd14952     66 YVTDF------GNNRVLKLAAGSTTQTVL-PFT----------GLNDPTGVAVDAAGN-VYVADtgNNRVLKLA------ 121
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1377 iiAGRPMHCQVPGIDyslsklaihsaLESASAIAISHTGVLYITETDEkkiNRLRQvttngeicLLAGAASdcdckndvn 1456
Cdd:cd14952    122 --AGSNTQTVLPFTG-----------LSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAGSTT--------- 168
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1958656154 1457 cicysgddayATD---AILNSPSSLAVAPDGTIYIADLGNIRI 1496
Cdd:cd14952    169 ----------QTVlpfTGLNSPSGVAVDTAGNVYVTDHGNNRV 201
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
1284-1563 9.39e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 49.96  E-value: 9.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1284 LMSPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL 1361
Cdd:cd14957     17 FNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGVYSYSIGSGGTG--------------SGQFNSPYGIAVDSNGN-IYVA 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1362 EnnvilriTENHQVSII--AGrpmhcqvpGIDYSL-SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGE 1438
Cdd:cd14957     82 D-------TDNNRIQVFnsSG--------VYQYSIgTGGSGDGQFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGT 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1439 ICllagaasdcdckndvncicYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRavsknkpvlnafnqyeaaspg 1518
Cdd:cd14957    144 FS-------------------YSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ--------------------- 183
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1958656154 1519 eqelyVFNADGIHQYTV-SLVTGEYLYNFTYsadnDVTelIDNNGN 1563
Cdd:cd14957    184 -----VFTSSGTFQYTFgSSGSGPGQFSDPY----GIA--VDSDGN 218
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1461-1502 2.02e-05

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 49.45  E-value: 2.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958656154 1461 SGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKN 1502
Cdd:cd14953     11 GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
1169-1497 3.09e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 48.42  E-value: 3.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1169 PVALAVGIDGSLFVGDFNYIR-RIF-PSRNVTSIL---ELRNKEFkhsNSPghkYYLAVDPvTGSLYVSDTNSRRIyRVK 1243
Cdd:cd14957     20 PRGIAVDSAGNIYVADTGNNRiQVFtSSGVYSYSIgsgGTGSGQF---NSP---YGIAVDS-NGNIYVADTDNNRI-QVF 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1244 SLSGAKDLAgnsevVAGTGEQCLPFDEarcgdggkavdatlmsPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGS 1321
Cdd:cd14957     92 NSSGVYQYS-----IGTGGSGDGQFNG----------------PYGIAVDSNGNIYVADTgnHRIQVFTSSGTFSYSIGS 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1322 ndltavrplscdSSMDVAQVRLewPTDLAVNPMDNsLYVLENNvilriteNHQVSII--AGRPmhcqvpgiDYSL-SKLA 1398
Cdd:cd14957    151 ------------GGTGPGQFNG--PQGIAVDSDGN-IYVADTG-------NHRIQVFtsSGTF--------QYTFgSSGS 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1399 IHSALESASAIAISHTGVLYITETDEKKInrlrQVTTNgeicllagaasdcdckndvncicySGDDAYA------TDAIL 1472
Cdd:cd14957    201 GPGQFSDPYGIAVDSDGNIYVADTGNHRI----QVFTS------------------------SGAYQYSigtsgsGNGQF 252
                          330       340
                   ....*....|....*....|....*
gi 1958656154 1473 NSPSSLAVAPDGTIYIADLGNIRIR 1497
Cdd:cd14957    253 NYPYGIAVDNDGKIYVADSNNNRIQ 277
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
1611-1647 7.06e-05

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 42.20  E-value: 7.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958656154 1611 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1647
Cdd:pfam05593    1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
1166-1360 1.05e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.43  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1166 LLAPVALAVGIDGSLFVGDFNYIR--RIFPSRNVTSILELRNKEFKHSnspghkyyLAVDPVtGSLYVSDTNSRRIYRVK 1243
Cdd:cd14952     51 LYQPQGVAVDAAGTVYVTDFGNNRvlKLAAGSTTQTVLPFTGLNDPTG--------VAVDAA-GNVYVADTGNNRVLKLA 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1244 S------------LSGAKDLA------------GNSEVV---AGTGEQC-LPFDEarcgdggkavdatLMSPRGIAVDKN 1295
Cdd:cd14952    122 AgsntqtvlpftgLSNPDGVAvdgagnvyvtdtGNNRVLklaAGSTTQTvLPFTG-------------LNSPSGVAVDTA 188
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958656154 1296 GLMYFVDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPmDNSLYV 1360
Cdd:cd14952    189 GNVYVTDH------GNNRVLKLAAGSTTPTVL-PFT----------GLNGPLGVAVDA-AGNVYV 235
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
580-602 3.00e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 3.00e-04
                           10        20
                   ....*....|....*....|....*
gi 1958656154  580 CHGNGECVS--GLCHCFPGFLGADC 602
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
1172-1332 3.52e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.88  E-value: 3.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1172 LAVGIDGSLFVGDFNY------IRRIFPSRNVTSILElrnkEFKHSNSpghkyyLAVDPVTGSLYVSDTNSRRIYRVksl 1245
Cdd:COG3386     98 GVVDPDGRLYFTDMGEylptgaLYRVDPDGSLRVLAD----GLTFPNG------IAFSPDGRTLYVADTGAGRIYRF--- 164
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1246 sgakDLAGNSEVVAGTgeqclPFDEARCGDGGkavdatlmsPRGIAVDKNGLMY--FVDATMIRKVDQNGiisTLLGSND 1323
Cdd:COG3386    165 ----DLDADGTLGNRR-----VFADLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDG---ELLGRIE 223

                   ....*....
gi 1958656154 1324 LTAVRPLSC 1332
Cdd:COG3386    224 LPERRPTNV 232
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
645-667 1.07e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.07e-03
                           10        20
                   ....*....|....*....|....*
gi 1958656154  645 CGGHGSCID--GNCVCAAGYKGEHC 667
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
671-700 1.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958656154  671 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 700
Cdd:cd00054      4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
638-668 1.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958656154  638 NQCIDPS-CGGHGSCIDG----NCVCAAGYKGEHCE 668
Cdd:cd00054      3 DECASGNpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
583-693 2.21e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 40.90  E-value: 2.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  583 NGECVSglchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGSCIDGNC 656
Cdd:NF041328    29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGAACAPGQ 94
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1958656154  657 VCAAGYKGEHCEE--VDCldptcssHGVCVN--------GEC--LCSPG 693
Cdd:NF041328    95 VCEGGACREACSEglTRC-------GGACVDlatdplhcGACgvACDPG 136
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1218-1422 3.07e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.19  E-value: 3.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1218 YYLAVDPvTGSLYVSDTNSRRIYRvkslsgakdlagnsevvagtgeqclpFDEARcgdG-----GKAVDATLMSPRGIAV 1292
Cdd:cd14962     15 YGVAADG-RGRIYVADTGRGAVFV--------------------------FDLPN---GkvfviGNAGPNRFVSPIGVAI 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1293 DKNGLMYFVDAT--MIRKVDQNGIISTLLGSNDLtavrplscdssmdvaQVRlewPTDLAVNPMDNSLYVLEnnvilriT 1370
Cdd:cd14962     65 DANGNLYVSDAElgKVFVFDRDGKFLRAIGAGAL---------------FKR---PTGIAVDPAGKRLYVVD-------T 119
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958656154 1371 ENHQVSIIAGRPMHCQVPGIDYSlsklaIHSALESASAIAISHTGVLYITET 1422
Cdd:cd14962    120 LAHKVKVFDLDGRLLFDIGKRGS-----GPGEFNLPTDLAVDRDGNLYVTDT 166
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1159-1323 3.28e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1159 GLAEGnKLLAPVALAVGIDGSLFVGDFnYIRRI------------FPSRnvtsilelrnKEFKHSNSPGHkyyLAVDpvT 1226
Cdd:cd14963     49 GTGPG-EFKYPYGIAVDSDGNIYVADL-YNGRIqvfdpdgkflkyFPEK----------KDRVKLISPAG---LAID--D 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1227 GSLYVSDTNSRRIYrvkslsgakdlagnseVVAGTGEQCLPFDEARCGDGgkavdaTLMSPRGIAVDKNGLMYFVDATMI 1306
Cdd:cd14963    112 GKLYVSDVKKHKVI----------------VFDLEGKLLLEFGKPGSEPG------ELSYPNGIAVDEDGNIYVADSGNG 169
                          170       180
                   ....*....|....*....|
gi 1958656154 1307 R-KV-DQNG-IISTLLGSND 1323
Cdd:cd14963    170 RiQVfDKNGkFIKELNGSPD 189
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
1611-1653 3.76e-03

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 37.18  E-value: 3.76e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958656154 1611 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLH 1653
Cdd:TIGR01643    1 YDAA-GRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
736-769 3.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958656154  736 VDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 769
Cdd:cd00054      2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
185-349 5.63e-03

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 41.72  E-value: 5.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  185 LPSSHNPPPVScQMPLLDSNTSHQIMDTNPDEEF----SPNSYLLRACSGPQQ---ASSSGPPNHHSQSTLRPPLPPPhn 257
Cdd:pfam15279  127 APKPHEPPSLP-PPPLPPKKGRRHRPGLHPPLGRppgsPPMSMTPRGLLGKPQqhpPPSPLPAFMEPSSMPPPFLRPP-- 203
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154  258 htlsHHHSSANSlnrnSLTNRRSQIHAPAPAP-NDLATTPEsvqlqdswvlnsnvPLEtRHFLFKTSSGSTPLFSSSSPG 336
Cdd:pfam15279  204 ----PSIPQPNS----PLSNPMLPGIGPPPKPpRNLGPPSN--------------PMH-RPPFSPHHPPPPPTPPGPPPG 260
                          170
                   ....*....|...
gi 1958656154  337 YPLTSGTVYTPPP 349
Cdd:pfam15279  261 LPPPPPRGFTPPF 273
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
611-628 6.04e-03

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 36.31  E-value: 6.04e-03
                           10
                   ....*....|....*...
gi 1958656154  611 CSGNGQYSKGTCQCYSGW 628
Cdd:pfam18372   12 CSGNGTFVCGVCVCNPGY 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
739-767 6.73e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 6.73e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958656154  739 CPDL-CNGNGRCTLGQNSWQCVCQTGWRGP 767
Cdd:pfam00008    1 CAPNpCSNGGTCVDTPGGYTCICPEGYTGK 30
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
1169-1302 7.94e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.65  E-value: 7.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1169 PVALAVGIDGSLFVGDF--NYIRRIFPSRNVTSILElrnkeFKHSNSPGHkyyLAVDPvTGSLYVSDTNSRRIYRvksls 1246
Cdd:cd14952    138 PDGVAVDGAGNVYVTDTgnNRVLKLAAGSTTQTVLP-----FTGLNSPSG---VAVDT-AGNVYVTDHGNNRVLK----- 203
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958656154 1247 gakdLAgnsevvAGTGEQC-LPFDEarcgdggkavdatLMSPRGIAVDKNGLMYFVD 1302
Cdd:cd14952    204 ----LA------AGSTTPTvLPFTG-------------LNGPLGVAVDAAGNVYVAD 237
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
1414-1499 8.10e-03

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 41.02  E-value: 8.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958656154 1414 TGVLYITETDEKKINRL----RQVTTngeiclLAGaasdcdckndvncicySGDDAYA-TDAILNSPSSLAVAPDGTIYI 1488
Cdd:cd14951    206 DGSVYVADTYNHKIKRVdpatGEVST------LAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLYV 263
                           90
                   ....*....|.
gi 1958656154 1489 ADLGNIRIRAV 1499
Cdd:cd14951    264 ADTNNHRIRRL 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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