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Conserved domains on  [gi|1958665570|ref|XP_038944299|]
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NF-kappa-B inhibitor zeta isoform X2 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
465-578 1.05e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 465 RDGDGDTFLHIAVAQGRRAL-SYVLARKMNalhmLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLH 543
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIvKLLLEAGAD----VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958665570 544 VCAEKGHSQVLQA-IQKGAvrsnqfvDLEATNYDGE 578
Cdd:COG0666   192 LAAENGHLEIVKLlLEAGA-------DVNAKDNDGK 220
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
465-578 1.05e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 465 RDGDGDTFLHIAVAQGRRAL-SYVLARKMNalhmLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLH 543
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIvKLLLEAGAD----VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958665570 544 VCAEKGHSQVLQA-IQKGAvrsnqfvDLEATNYDGE 578
Cdd:COG0666   192 LAAENGHLEIVKLlLEAGA-------DVNAKDNDGK 220
Ank_2 pfam12796
Ankyrin repeats (3 copies);
473-561 1.58e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 473 LHIAVAQGRRALSYVLARKMNALHMLDvkeHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDcwGRTPLHVCAEKGHSQ 552
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD---KNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLE 75

                          90
                  ....*....|
gi 1958665570 553 VLQA-IQKGA 561
Cdd:pfam12796  76 IVKLlLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 465-549 3.45e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 465 RDGDGDTFLHIAVAQGrralsyvlarKMNALHML-------DVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCW 537
Cdd:PHA02874  120 KDAELKTFLHYAIKKG----------DLESIKMLfeygadvNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNN 189

                          90
                  ....*....|..
gi 1958665570 538 GRTPLHVCAEKG 549
Cdd:PHA02874  190 GESPLHNAAEYG 201
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
465-578 1.05e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 465 RDGDGDTFLHIAVAQGRRAL-SYVLARKMNalhmLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLH 543
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIvKLLLEAGAD----VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958665570 544 VCAEKGHSQVLQA-IQKGAvrsnqfvDLEATNYDGE 578
Cdd:COG0666   192 LAAENGHLEIVKLlLEAGA-------DVNAKDNDGK 220
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
465-578 1.94e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.14  E-value: 1.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 465 RDGDGDTFLHIAVAQGRR-ALSYVLARKMNalhmLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLH 543
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLeIVKLLLEAGAD----VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958665570 544 VCAEKGHSQVLQA-IQKGAvrsnqfvDLEATNYDGE 578
Cdd:COG0666   159 LAAANGNLEIVKLlLEAGA-------DVNARDNDGE 187
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
453-578 2.43e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 2.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 453 KLANISQEQFLSRDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDvkeHNGQSAFQVAVAANQHLIVQDLVNLGAQVN 532
Cdd:COG0666    38 LLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD---DGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958665570 533 TTDCWGRTPLHVCAEKGHSQVLQA-IQKGAvrsnqfvDLEATNYDGE 578
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLlLEAGA-------DVNAQDNDGN 154
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
465-559 5.84e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 5.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 465 RDGDGDTFLHIAVAQGR-RALSYVLARKMNalhmLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLH 543
Cdd:COG0666   149 QDNDGNTPLHLAAANGNlEIVKLLLEAGAD----VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD 224

                          90
                  ....*....|....*.
gi 1958665570 544 VCAEKGHSQVLQAIQK 559
Cdd:COG0666   225 LAAENGNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
473-561 1.58e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 473 LHIAVAQGRRALSYVLARKMNALHMLDvkeHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDcwGRTPLHVCAEKGHSQ 552
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD---KNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLE 75

                          90
                  ....*....|
gi 1958665570 553 VLQA-IQKGA 561
Cdd:pfam12796  76 IVKLlLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
509-565 2.00e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 2.00e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958665570 509 FQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQA-IQKGAVRSN 565
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLlLEHADVNLK 58
Ank_4 pfam13637
Ankyrin repeats (many copies);
507-555 4.59e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 4.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958665570 507 SAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 555
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
464-535 3.18e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.10  E-value: 3.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958665570 464 SRDGDGDTFLHIAVAQGRRALSYVLARKMNalhmLDVKEhNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTD 535
Cdd:pfam12796  25 LQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 465-549 3.45e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 465 RDGDGDTFLHIAVAQGrralsyvlarKMNALHML-------DVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCW 537
Cdd:PHA02874  120 KDAELKTFLHYAIKKG----------DLESIKMLfeygadvNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNN 189

                          90
                  ....*....|..
gi 1958665570 538 GRTPLHVCAEKG 549
Cdd:PHA02874  190 GESPLHNAAEYG 201
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
453-578 2.36e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665570 453 KLANISQEQFLSRDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVN 532
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958665570 533 TTDCWGRTPLHVCAEKGHSQVLQA-IQKGAvrsnqfvDLEATNYDGE 578
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLlLEAGA-------DVNARDKDGE 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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