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Conserved domains on  [gi|1958670650|ref|XP_038946031|]
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glycosyltransferase 1 domain-containing protein 1 isoform X2 [Rattus norvegicus]

Protein Classification

Glyco4_Geo_Pelo superfamily-containing protein( domain architecture ID 1908431)

Glyco4_Geo_Pelo superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco4_Geo_Pelo super family cl45694
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 4-237 3.27e-47

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


The actual alignment was detected with superfamily member NF038229:

Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 159.38  E-value: 3.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650   4 VLEEARFAVAFTEAMKDTAEVQWPHATGKIFVQSQGIaTIPNADFNWntflqqSEIDQSADDLHIFLVICGLRPVKDPLY 83
Cdd:NF038229  106 VLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-ELGGEPFPL------RELGLFDSDEFVFLLPAGLRPVKGVLF 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  84 LVDAFSEWHQETPNVYMVIVGPEVDPVFTREVKDRVRRASGVRLIREMCQEDLHAVVKSCFALVNSSVSEGMSAAILEAM 163
Cdd:NF038229  179 LLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRPWARYLGEIPHDAMGALYRRADVVLNNSLFEGMANALLEAM 258

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958670650 164 DLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTYQRL 237
Cdd:NF038229  259 ALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQLLQDPALRRRLGRPGRQLVRERYSPEREAEAYLRL 332
 
Name Accession Description Interval E-value
Glyco4_Geo_Pelo NF038229
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 4-237 3.27e-47

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 159.38  E-value: 3.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650   4 VLEEARFAVAFTEAMKDTAEVQWPHATGKIFVQSQGIaTIPNADFNWntflqqSEIDQSADDLHIFLVICGLRPVKDPLY 83
Cdd:NF038229  106 VLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-ELGGEPFPL------RELGLFDSDEFVFLLPAGLRPVKGVLF 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  84 LVDAFSEWHQETPNVYMVIVGPEVDPVFTREVKDRVRRASGVRLIREMCQEDLHAVVKSCFALVNSSVSEGMSAAILEAM 163
Cdd:NF038229  179 LLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRPWARYLGEIPHDAMGALYRRADVVLNNSLFEGMANALLEAM 258

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958670650 164 DLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTYQRL 237
Cdd:NF038229  259 ALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQLLQDPALRRRLGRPGRQLVRERYSPEREAEAYLRL 332
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 12-238 2.14e-30

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 115.71  E-value: 2.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  12 VAFTEAMKDTAEVQWPHATGKIFVqsqgiatIPNA-DFNWNTFLQQSEIDQSADDLhIFLVICGLRPVKDPLYLVDAFSE 90
Cdd:cd03801   145 IAVSEALRDELRALGGIPPEKIVV-------IPNGvDLERFSPPLRRKLGIPPDRP-VLLFVGRLSPRKGVDLLLEALAK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  91 WHQETPNVYMVIVGPEvDPVFTREVKDRVRRASGVRLIREMCQEDLHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVL 170
Cdd:cd03801   217 LLRRGPDVRLVIVGGD-GPLRAELEELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVV 295

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 171 ARNIPGNSAVVEHGVTGLLFS--NPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTYQRLI 238
Cdd:cd03801   296 ATDVGGLPEVVEDGEGGLVVPpdDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 136-241 9.11e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 86.97  E-value: 9.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 136 LHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLF--SNPQEFIQLAKRLVSDPALEKEI 213
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRLLEDPELRRRL 93

                          90       100
                  ....*....|....*....|....*...
gi 1958670650 214 VTNGREYVRTHHSWQVERDTYQRLIGKL 241
Cdd:COG0438    94 GEAARERAEERFSWEAIAERLLALYEEL 121
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 68-219 2.46e-20

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 84.25  E-value: 2.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  68 IFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVGPEvdpvftrEVKDRVRRASGVRLIREMCQ-------EDLHAVV 140
Cdd:pfam00534   4 IILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDG-------EEEKRLKKLAEKLGLGDNVIflgfvsdEDLPELL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 141 KSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLF--SNPQEFIQLAKRLVSDPALEKEIVTNGR 218
Cdd:pfam00534  77 KIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENAR 156


                  .
gi 1958670650 219 E 219
Cdd:pfam00534 157 K 157
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
40-228 7.93e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 46.32  E-value: 7.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  40 IATIPNA------DFNwNTFLQQSEIDQSADDLHIFLVicG-LRPVKDPLYLVDAFSEWHQETPNVYMVIVGpevDPV-- 110
Cdd:PRK15484  163 ISIVPNGfcletyQSN-PQPNLRQQLNISPDETVLLYA--GrISPDKGILLLMQAFEKLATAHSNLKLVVVG---DPTas 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 111 -------FTREVKDRVRRAsGVRLIREMCQ--EDLHAVVK-SCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAV 180
Cdd:PRK15484  237 skgekaaYQKKVLEAAKRI-GDRCIMLGGQppEKMHNYYPlADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEF 315

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958670650 181 VEHGVTGLLFSNP---QEFIQLAKRLVSDPALEkEIVTNGREYVRTHHSWQ 228
Cdd:PRK15484  316 VLEGITGYHLAEPmtsDSIISDINRTLADPELT-QIAEQAKDFVFSKYSWE 365
 
Name Accession Description Interval E-value
Glyco4_Geo_Pelo NF038229
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 4-237 3.27e-47

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 159.38  E-value: 3.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650   4 VLEEARFAVAFTEAMKDTAEVQWPHATGKIFVQSQGIaTIPNADFNWntflqqSEIDQSADDLHIFLVICGLRPVKDPLY 83
Cdd:NF038229  106 VLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-ELGGEPFPL------RELGLFDSDEFVFLLPAGLRPVKGVLF 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  84 LVDAFSEWHQETPNVYMVIVGPEVDPVFTREVKDRVRRASGVRLIREMCQEDLHAVVKSCFALVNSSVSEGMSAAILEAM 163
Cdd:NF038229  179 LLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRPWARYLGEIPHDAMGALYRRADVVLNNSLFEGMANALLEAM 258

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958670650 164 DLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTYQRL 237
Cdd:NF038229  259 ALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQLLQDPALRRRLGRPGRQLVRERYSPEREAEAYLRL 332
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 12-238 2.14e-30

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 115.71  E-value: 2.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  12 VAFTEAMKDTAEVQWPHATGKIFVqsqgiatIPNA-DFNWNTFLQQSEIDQSADDLhIFLVICGLRPVKDPLYLVDAFSE 90
Cdd:cd03801   145 IAVSEALRDELRALGGIPPEKIVV-------IPNGvDLERFSPPLRRKLGIPPDRP-VLLFVGRLSPRKGVDLLLEALAK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  91 WHQETPNVYMVIVGPEvDPVFTREVKDRVRRASGVRLIREMCQEDLHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVL 170
Cdd:cd03801   217 LLRRGPDVRLVIVGGD-GPLRAELEELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVV 295

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 171 ARNIPGNSAVVEHGVTGLLFS--NPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTYQRLI 238
Cdd:cd03801   296 ATDVGGLPEVVEDGEGGLVVPpdDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 136-241 9.11e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 86.97  E-value: 9.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 136 LHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLF--SNPQEFIQLAKRLVSDPALEKEI 213
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRLLEDPELRRRL 93

                          90       100
                  ....*....|....*....|....*...
gi 1958670650 214 VTNGREYVRTHHSWQVERDTYQRLIGKL 241
Cdd:COG0438    94 GEAARERAEERFSWEAIAERLLALYEEL 121
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 68-219 2.46e-20

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 84.25  E-value: 2.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  68 IFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVGPEvdpvftrEVKDRVRRASGVRLIREMCQ-------EDLHAVV 140
Cdd:pfam00534   4 IILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDG-------EEEKRLKKLAEKLGLGDNVIflgfvsdEDLPELL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 141 KSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLF--SNPQEFIQLAKRLVSDPALEKEIVTNGR 218
Cdd:pfam00534  77 KIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENAR 156


                  .
gi 1958670650 219 E 219
Cdd:pfam00534 157 K 157
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 29-226 1.24e-18

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 83.41  E-value: 1.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  29 ATGKIFVQSQGIATIPNADFNWNTFlQQSEIDQSADDLHIFLVicG-LRPVKDPLYLVDAFSEWHQETPNVYMVIVGP-E 106
Cdd:cd03808   154 AIKKGIIKKKKTVLIPGSGVDLDRF-QYSPESLPSEKVVFLFV--ArLLKDKGIDELIEAAKILKKKGPNVRFLLVGDgE 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 107 VDPVFTREVKDRVRRAS----GVRliremcqEDLHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVE 182
Cdd:cd03808   231 LENPSEILIEKLGLEGRieflGFR-------SDVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVI 303

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958670650 183 HGVTGLLFsNPQEFIQLAK---RLVSDPALEKEIVTNGREYVRTHHS 226
Cdd:cd03808   304 DGVNGFLV-PPGDVEALADaieKLIEDPELRKEMGEAARKRVEEKFD 349
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 71-237 1.04e-16

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 78.13  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  71 VICG---LRPVKDPLYLVDAFSEWHQETPNVYMVIVGPEVdpvfTREVKDRVRRASG----VRLIREmcQEDLHAVVKSC 143
Cdd:cd03807   192 VIGIvgrLHPVKDHSDLLRAAALLVETHPDLRLLLVGRGP----ERPNLERLLLELGledrVHLLGE--RSDVPALLPAM 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 144 FALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGvTGLLFS--NPQEFIQLAKRLVSDPALEKEIVTNGREYV 221
Cdd:cd03807   266 DIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDG-TGFLVPagDPQALADAIRALLEDPEKRARLGRAARERI 344

                         170
                  ....*....|....*.
gi 1958670650 222 RTHHSWQVERDTYQRL 237
Cdd:cd03807   345 ANEFSIDAMVRRYETL 360
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
76-206 8.44e-16

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 71.77  E-value: 8.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  76 RPVKDPLYLVDAFSEWHQETPNVYMVIVGPEVDpvftREVKDRVRR-ASGVRLIREMcqEDLHAVVKSCFALVNSSVSEG 154
Cdd:pfam13692  12 PNVKGVDYLLEAVPLLRKRDNDVRLVIVGDGPE----EELEELAAGlEDRVIFTGFV--EDLAELLAAADVFVLPSLYEG 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958670650 155 MSAAILEAMDLEVPVLARNIPGNSAVVeHGVTGLLFS--NPQEFIQLAKRLVSD 206
Cdd:pfam13692  86 FGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLVPpgDPEALAEAILRLLED 138
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 32-211 5.02e-15

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 73.16  E-value: 5.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  32 KIFVQSQGIA---------------TIPNAdFNWNTFLQQSEIDQSADDLHIFLVIC-G-LRPVKDPLYLVDAFSEWHQE 94
Cdd:cd03811   138 KIVCVSKGIKedlirlgpsppekieVIYNP-IDIDRIRALAKEPILNEPEDGPVILAvGrLDPQKGHDLLIEAFAKLRKK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  95 TPNVYMVIVGpevdpvftrevkDRVRRASGVRLIREM----------CQEDLHAVVKSCFALVNSSVSEGMSAAILEAMD 164
Cdd:cd03811   217 YPDVKLVILG------------DGPLREELEKLAKELglaerviflgFQSNPYPYLKKADLFVLSSRYEGFPNVLLEAMA 284

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1958670650 165 LEVPVLARNIPGNSAVVEHGVTGLLF--SNPQEFIQLAKRLVSDPALEK 211
Cdd:cd03811   285 LGTPVVSTDCPGPREILDDGENGLLVpdGDAAALAGILAALLQKKLDAA 333
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 35-228 1.98e-14

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 71.63  E-value: 1.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  35 VQSQGIATIPNA--DFNWNTFLQQSEIDQSADDLHIFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVG-------P 105
Cdd:cd03809   159 VPPEKIVVIPLGvdPSFFPPESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVGgkgwedeE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 106 EVDPVFTREVKDRVRRASGVRliremcQEDLHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPgnsAVVEhgV 185
Cdd:cd03809   239 LLDLVKKLGLGGRVRFLGYVS------DEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNIS---VLPE--V 307

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958670650 186 TG---LLFS--NPQEFIQLAKRLVSDPALEKEIVTNGREYVRtHHSWQ 228
Cdd:cd03809   308 AGdaaLYFDplDPESIADAILRLLEDPSLREELIRKGLERAK-KFSWE 354
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 75-232 1.32e-12

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 66.25  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  75 LRPVKDPLYLVDAFSEWHQETPNVYMVIVG--PEVDPvFTREVKDRVRRAsGVRLIREMCQEDLHAVVKSCFALVNSSVS 152
Cdd:cd03798   209 LIPRKGIDLLLEAFARLAKARPDVVLLIVGdgPLREA-LRALAEDLGLGD-RVTFTGRLPHEQVPAYYRACDVFVLPSRH 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 153 EGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFS--NPQEFIQLAKRLVSDPALEKEiVTNGREYVRTHHSWQVE 230
Cdd:cd03798   287 EGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVPpgDADALAAALRRALAEPYLREL-GEAARARVAERFSWVKA 365


                  ..
gi 1958670650 231 RD 232
Cdd:cd03798   366 AD 367
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 75-228 1.39e-12

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 66.50  E-value: 1.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  75 LRPVKDPLYLVDAFSEWHQETPNVYMVIV-GPEVDP---------VFTREVK--DRVRRASGVRliremcQEDLHAVVKS 142
Cdd:cd03800   229 LDPRKGIDTLVRAFAQLPELRELANLVLVgGPSDDPlsmdreelaELAEELGliDRVRFPGRVS------RDDLPELYRA 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 143 CFALVNSSVSE--GMSAaiLEAMDLEVPVLARNIPGNSAVVEHGVTGLLFsNPQEFIQLA---KRLVSDPALEKEIVTNG 217
Cdd:cd03800   303 ADVFVVPSLYEpfGLTA--IEAMACGTPVVATAVGGLQDIVRDGRTGLLV-DPHDPEALAaalRRLLDDPALWQRLSRAG 379

                         170
                  ....*....|.
gi 1958670650 218 REYVRTHHSWQ 228
Cdd:cd03800   380 LERARAHYTWE 390
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 68-190 4.26e-12

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 63.96  E-value: 4.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  68 IFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVGPEVDPVFTREVKDRVRRASGVRLIREMCQ-EDLHAVVKSCFAL 146
Cdd:cd01635   112 DKVSVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDdEVLELLLAAADVF 191

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958670650 147 VNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLF 190
Cdd:cd01635   192 VLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 68-224 5.70e-12

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 64.65  E-value: 5.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  68 IFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVG-PEVDPVFTREVKDRVRRASGV-RLIREMCQEDLHAVVkSCF- 144
Cdd:cd03792   199 YILQVARFDPSKDPLGVIDAYKLFKRRAEEPQLVICGhGAVDDPEGSVVYEEVMEYAGDdHDIHVLRLPPSDQEI-NALq 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 145 ----ALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLAKRLVSDPALEKEIVTNGREY 220
Cdd:cd03792   278 raatVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAVRILRLLTDPELRRKMGLAAREH 357


                  ....
gi 1958670650 221 VRTH 224
Cdd:cd03792   358 VRDN 361
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 84-237 2.20e-11

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 62.68  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  84 LVDAFSEWHQEtPNVYMVIVG--PEvdpvfTREVKDRVRR---ASGVRLIREMCQEDLHAVVKSCFALVNSSVSEGMSAA 158
Cdd:cd03817   219 LLRAFAELKKE-PNIKLVIVGdgPE-----REELKELARElglADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLV 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 159 ILEAMDLEVPVLARNIPGNSAVVEHGVTGLLF-SNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTYQRL 237
Cdd:cd03817   293 YLEAMAAGLPVVAAKDPAASELVEDGENGFLFePNDETLAEKLLHLRENLELLRKLSKNAEISAREFAFAKSVEKLYEEV 372
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 76-224 1.52e-10

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 60.44  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  76 RPVKDPLYLVDAFSEWHQETP-NVYMVIVGPEVDPVF--TRE--VKDRVRRASGVRLIREMCQedlhavVKSCFALVNSS 150
Cdd:cd04962   206 RPVKRIDDVVRVFARVRRKIPaKLLLVGDGPERVPAEelARElgVEDRVLFLGKQDDVEELLS------IADLFLLPSEK 279

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958670650 151 VSEGMSAaiLEAMDLEVPVLARNIPGNSAVVEHGVTGLLFsNPQEFIQLAKRLVS---DPALEKEIVTNGREYVRTH 224
Cdd:cd04962   280 ESFGLAA--LEAMACGVPVVSSNAGGIPEVVKHGETGFLS-DVGDVDAMAKSALSileDDELYNRMGRAARKRAAER 353
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 40-219 1.85e-10

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 60.06  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  40 IATIPNA----DFNWNTFlqQSEIDQSADDLHIFLV-ICG-LRPVKDPLYLVDAFSEWHQEtPNVYMVIVGPEvdpvftr 113
Cdd:cd03819   152 IRVIPNGvdtdRFPPEAE--AEERAQLGLPEGKPVVgYVGrLSPEKGWLLLVDAAAELKDE-PDFRLLVAGDG------- 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 114 EVKDRVRRASGVRLIREMCQ-----EDLHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGL 188
Cdd:cd03819   222 PERDEIRRLVERLGLRDRVTftgfrEDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGL 301

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958670650 189 LFSNPQ--EFIQLAKRLVSDPALEKEIVTNGRE 219
Cdd:cd03819   302 LVPPGDaeALADAIRAAKLLPEAREKLQAAAAL 334
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 83-225 2.38e-10

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 59.77  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  83 YLVDAFSEWHQETPNVYMVIVGpevDPVFTREVKDRVRRASGVRLIREMCQEDLHAVVKSCFALVNSSV------SEGMS 156
Cdd:cd05844   206 VLIEAFRRLAARHPTARLVIAG---DGPLRPALQALAAALGRVRFLGALPHAEVQDWMRRAEIFCLPSVtaasgdSEGLG 282

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958670650 157 AAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSnPQEFIQLAKR---LVSDPALEKEIVTNGREYVRTHH 225
Cdd:cd05844   283 IVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVP-EGDVDALADAlqaLLADRALADRMGGAARAFVCEQF 353
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 68-224 2.31e-09

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 56.90  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  68 IFLVICGLRPVKDPLYLVDAFsewhQETpNVYMVIVG--PEVDPVFTREVKDRVRRasgVRLIREMCQEDLHAVVKSCFA 145
Cdd:cd03795   193 IFLFIGRLVYYKGLDYLIEAA----QYL-NYPIVIGGegPLKPDLEAQIELNLLDN---VKFLGRVDDEEKVIYLHLCDV 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 146 LVNSSV--SEGMSAAILEAMDLEVPVLARNIP-GNSAVVEHGVTGLLF--SNPQEFIQLAKRLVSDPALEKEIVTNGREY 220
Cdd:cd03795   265 FVFPSVlrSEAFGIVLLEAMMCGKPVISTNIGtGVPYVNNNGETGLVVppKDPDALAEAIDKLLSDEELRESYGENAKKR 344


                  ....
gi 1958670650 221 VRTH 224
Cdd:cd03795   345 FEEL 348
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 84-234 4.86e-09

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 55.81  E-value: 4.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  84 LVDAFSEwHQETPNVYMVIVGPEVDPvftREVKDRVRRA--SGVRLIREMCQEDLHAVVKSC-FALVNSSVSEGMSAAI- 159
Cdd:cd03794   235 LLEAAER-LKRRPDIRFLFVGDGDEK---ERLKELAKARglDNVTFLGRVPKEEVPELLSAAdVGLVPLKDNPANRGSSp 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 160 ---LEAMDLEVPVLARNIPGNSAVVEHGVTGLLF--SNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTY 234
Cdd:cd03794   311 sklFEYMAAGKPILASDDGGSDLAVEINGCGLVVepGDPEALADAILELLDDPELRRAMGENGRELAEEKFSREKLADRL 390
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 1-227 1.64e-08

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 54.30  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650   1 MGKVLEEArFAVAFTeAMKDTAEVQWPHATGKIFVqsqgiatIPNADF--NWNTFLQQSEIDQSADDLHIFLVICGLRPV 78
Cdd:cd03821   146 ERRNLNNA-ALVHFT-SEQEADELRRFGLEPPIAV-------IPNGVDipEFDPGLRDRRKHNGLEDRRIILFLGRIHPK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  79 KDPLYLVDAFSEWHQETPNVYMVIVGPEvDPVFTREVKDRVRRASGVR-LIREMC-QEDLHAVVKS--CFALvnSSVSEG 154
Cdd:cd03821   217 KGLDLLIRAARKLAEQGRDWHLVIAGPD-DGAYPAFLQLQSSLGLGDRvTFTGPLyGEAKWALYASadLFVL--PSYSEN 293

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958670650 155 MSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLAKRLVSDPALEKEIVTNGREYV--RTHHSW 227
Cdd:cd03821   294 FGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEALRDPADRKRLGEMARRARqvEENFSW 368
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 40-209 6.35e-08

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 52.24  E-value: 6.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  40 IATIPNAdFNWNTFLQQSEIDQsaddlHIFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVGpevdpvftrevkDRV 119
Cdd:cd03820   161 VVVIPNP-LSFPSEEPSTNLKS-----KRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYG------------DGP 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 120 RRASGVRLIREMCQED---LHAVVK---------SCFALvnSSVSEGMSAAILEAMDLEVPVLARNIP-GNSAVVEHGVT 186
Cdd:cd03820   223 EREELEKLIDKLGLEDrvkLLGPTKniaeeyansSIFVL--SSRYEGFPMVLLEAMAYGLPIISFDCPtGPSEIIEDGEN 300

                         170       180
                  ....*....|....*....|....*.
gi 1958670650 187 GLLFsNPQEFIQLAK---RLVSDPAL 209
Cdd:cd03820   301 GLLV-PNGDVDALAEallRLMEDEEL 325
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 40-237 1.06e-07

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 51.95  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  40 IATIPNAdFNWNTFLQQSEIDQSADDLHIFLVicgLR--PVKDPLYLVDAFSEWHQETPNVYMVIVGPEV-DPVFTREVK 116
Cdd:cd03813   269 TRVIPNG-IDIQRFAPAREERPEKEPPVVGLV---GRvvPIKDVKTFIRAFKLVRRAMPDAEGWLIGPEDeDPEYAQECK 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 117 DRVRRASGVRLIREMCQEDLHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVE-----HGVTGLLF- 190
Cdd:cd03813   345 RLVASLGLENKVKFLGFQNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELIYgaddaLGQAGLVVp 424

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958670650 191 -SNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQVERDTYQRL 237
Cdd:cd03813   425 pADPEALAEALIKLLRDPELRQAFGEAGRKRVEKYYTLEGMIDSYRKL 472
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
147-228 1.22e-07

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 48.37  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 147 VNSSVSEGMSAA-ILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHH 225
Cdd:pfam13524   3 LNPSRRPDSPNMrVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYLLEHPEERRAIAAAGRERVLAEH 82


                  ...
gi 1958670650 226 SWQ 228
Cdd:pfam13524  83 TYA 85
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 68-227 1.43e-07

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 51.53  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  68 IFLVICGLRPVKDPLYLVDAFSEWHQETPnVYMVIVG------------PEVdpVFTREVKDrvrrasgvrliremcqED 135
Cdd:cd03814   200 LLLYVGRLAPEKNLEALLDADLPLAASPP-VRLVVVGdgparaeleargPDV--IFTGFLTG----------------EE 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 136 LHAVVKSCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFS--NPQEFIQLAKRLVSDPALEKEI 213
Cdd:cd03814   261 LARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEpgDAAAFAAALRALLEDPELRRRM 340

                         170
                  ....*....|....
gi 1958670650 214 VTNGREYVRThHSW 227
Cdd:cd03814   341 AARARAEAER-YSW 353
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 64-221 2.37e-07

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 50.91  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  64 DDLHIFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVGpevDPVFTREVKDRVRRasgVRLIREMCQEDLHAVVKS- 142
Cdd:cd04951   186 NDEFVILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAG---DGPLRNELERLICN---LNLVDRVILLGQISNISEy 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 143 -----CFALvnSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLAKRLVSDPALEKEIVTNG 217
Cdd:cd04951   260 ynaadLFVL--SSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVVPVSDPQLLAEKIKEIFDMSDEERDILGNK 337


                  ....
gi 1958670650 218 REYV 221
Cdd:cd04951   338 NEYI 341
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 68-241 7.09e-07

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 49.25  E-value: 7.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  68 IFLVICGLRPVKDPLYLVDAFSEWHQEtPNVYMVIVGPevDPVFTREVKDRVRrasGVRLIREmcQEDLHAVVKSCFALV 147
Cdd:cd03825   197 LFGAESVTKPRKGFDELIEALKLLATK-DDLLLVVFGK--NDPQIVILPFDII---SLGYIDD--DEQLVDIYSAADLFV 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 148 NSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSN--PQEFIQLAKRLVSDPALEKEIVTNGREYVRTHH 225
Cdd:cd03825   269 HPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPgdVQALAEAIEWLLANPKERESLGERARALAENHF 348

                         170
                  ....*....|....*.
gi 1958670650 226 SWQVERDTYQRLIGKL 241
Cdd:cd03825   349 DQRVQAQRYLELYKDL 364
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 147-200 1.33e-06

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 48.61  E-value: 1.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958670650 147 VNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEFIQLA 200
Cdd:cd04946   309 VNVSESEGIPVSIMEAISFGIPVIATNVGGTREIVENETNGLLLDKDPTPNEIV 362
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
40-228 7.93e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 46.32  E-value: 7.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  40 IATIPNA------DFNwNTFLQQSEIDQSADDLHIFLVicG-LRPVKDPLYLVDAFSEWHQETPNVYMVIVGpevDPV-- 110
Cdd:PRK15484  163 ISIVPNGfcletyQSN-PQPNLRQQLNISPDETVLLYA--GrISPDKGILLLMQAFEKLATAHSNLKLVVVG---DPTas 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 111 -------FTREVKDRVRRAsGVRLIREMCQ--EDLHAVVK-SCFALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAV 180
Cdd:PRK15484  237 skgekaaYQKKVLEAAKRI-GDRCIMLGGQppEKMHNYYPlADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEF 315

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958670650 181 VEHGVTGLLFSNP---QEFIQLAKRLVSDPALEkEIVTNGREYVRTHHSWQ 228
Cdd:PRK15484  316 VLEGITGYHLAEPmtsDSIISDINRTLADPELT-QIAEQAKDFVFSKYSWE 365
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 32-205 2.53e-05

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 44.60  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  32 KIFVQSQGIATIPNADFNWNTFlqqSEIDQSADDlHIFLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVGpevdpvf 111
Cdd:cd04949   130 ERFNKYPPIFTIPVGYVDQLDT---AESNHERKS-NKIITISRLAPEKQLDHLIEAVAKAVKKVPEITLDIYG------- 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 112 trevkdrvrRASGVRLIREMcQEDLHA--VVK---------SCFA----LVNSSVSEGMSAAILEAMDLEVPVLARNIP- 175
Cdd:cd04949   199 ---------YGEEREKLKKL-IEELHLedNVFlkgyhsnldQEYQdaylSLLTSQMEGFGLTLMEAIGHGLPVVSYDVKy 268

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958670650 176 GNSAVVEHGVTGLLFsnPQEFIQ-LAKRLVS 205
Cdd:cd04949   269 GPSELIEDGENGYLI--EKNNIDaLADKIIE 297
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 118-241 3.75e-05

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 44.20  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 118 RVRRASGVRLIREMCQEDLHAVVKSCFALVNSSV-SEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFSNPQEF 196
Cdd:cd03802   215 EPLPGPRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEM 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958670650 197 IQLAKRLvsdPALEKEIVtngREYVRTHHSWQVERDTYQRLIGKL 241
Cdd:cd03802   295 AEAIANI---DRIDRAAC---RRYAEDRFSAARMADRYEALYRKV 333
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
188-228 8.42e-05

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 43.00  E-value: 8.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958670650 188 LLFSNPQEFIQLAKRLVSDPALEKEIVTNGREYVRTHHSWQ 228
Cdd:COG4641   249 LVFRDGEELAEKLRYLLADPEERRAIAEAGRRRVLAEHTYA 289
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 125-225 2.10e-04

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 41.67  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 125 VRLIREMCQEDLHAVVKSCFALVNSSVS------EGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFsnPQEFIQ 198
Cdd:cd03799   233 VKLLGWKPQEEIIEILDEADIFIAPSVTaadgdqDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLV--PERDAE 310

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958670650 199 -LAKR---LVSDPALEKEIVTNGREYVRTHH 225
Cdd:cd03799   311 aIAEKltyLIEHPAIWPEMGKAGRARVEEEY 341
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 160-221 3.68e-04

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 41.04  E-value: 3.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958670650 160 LEAMDLEVPVLARNIPGNSAVVEHGVTGLLF-SNPQEFIQLAKRLVSDPALEKEIVTNGREYV 221
Cdd:cd03805   317 LEAMYAGKPVIACNSGGPLETVVEGVTGFLCePTPEAFAEAMLKLANDPDLADRMGAAGRKRV 379
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 75-239 1.83e-03

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 38.91  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  75 LRPVKDPLYLVDAFSEWHQETPNVYMVIVGpEVDPVFTREVKDRVRRASGVRLIREM---------CQEDLHAVVKSC-- 143
Cdd:cd03822   196 IGPGKGLEILLEALPELKAEFPDVRLVIAG-ELHPSLARYEGERYRKAAIEELGLQDhvdfhnnflPEEEVPRYISAAdv 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 144 FALVNSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVeHGVTGLL--FSNPQEFIQLAKRLVSDPALEKEIVTNGREYV 221
Cdd:cd03822   275 VVLPYLNTEQSSSGTLSYAIACGKPVISTPLRHAEELL-ADGRGVLvpFDDPSAIAEAILRLLEDDERRQAIAERAYAYA 353

                         170
                  ....*....|....*...
gi 1958670650 222 RThHSWQVERDTYQRLIG 239
Cdd:cd03822   354 RA-MTWESIADRYLRLFN 370
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 69-230 2.86e-03

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 38.46  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650  69 FLVICGLRPVKDPLYLVDAFSEWHQETPNVYMVIVGPEVDPVFTrEVKDRVRRASGVRliremcQEDLHAVVKSC-FALV 147
Cdd:cd03823   194 FGYIGRLTEEKGIDLLVEAFKRLPREDIELVIAGHGPLSDERQI-EGGRRIAFLGRVP------TDDIKDFYEKIdVLVV 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670650 148 NSSVSEGMSAAILEAMDLEVPVLARNIPGNSAVVEHGVTGLLFS--NPQEFIQLAKRLVSDPALEKEIVTNGREyvRTHH 225
Cdd:cd03823   267 PSIWPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLFApgDAEDLAAAMRRLLTDPALLERLRAGAEP--PRST 344


                  ....*
gi 1958670650 226 SWQVE 230
Cdd:cd03823   345 ESQAE 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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