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Conserved domains on  [gi|1958675969|ref|XP_038947852|]
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kelch-like protein 5 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 3-108 2.98e-80

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


:

Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 243.05  E-value: 2.98e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90       100
                  ....*....|....*....|....*.
gi 1958675969  83 EQRQKDLSKLLAYIRLPLLAPQFLAD 108
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106
PHA03098 super family cl33709
kelch-like protein; Provisional
 7-429 1.51e-75

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 245.45  E-value: 1.51e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQ 86
Cdd:PHA03098  108 NNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKY 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969  87 KDLSKLLAYIRLPLLAPQFLADMENNALFRDDiecqklimeamKYHLLPERRPMLQSPRTK------PRKSTVGTLFAVG 160
Cdd:PHA03098  188 KDICLILKVLRITFLSEEGIKKLKRWKLRIKK-----------KKIVFNKRCIKIIYSKKYnlnkilPRSSTFGSIIYIH 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 161 GMDSTKGATSIEKYDLRTNMWTPVANMNgrRLQFGVAVLDDKLYVVGGRDG-LKTLNTVECYNPKTKTWSVMPPMSTHRH 239
Cdd:PHA03098  257 ITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKnNLSVNSVVSYDTKTKSWNKVPELIYPRK 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 240 GLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPH 318
Cdd:PHA03098  335 NPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLN 414

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 319 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGhdapTSNLTSRLS-DCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKL 397
Cdd:PHA03098  415 TNKWSKGSPLPISHYGGCAIYHDGKIYVIGG----ISYIDNIKVyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKI 490

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1958675969 398 YAVGGYDGQTYLNIVEAYDPQTNEWTQVAPLC 429
Cdd:PHA03098  491 YVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
 
Name Accession Description Interval E-value
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 3-108 2.98e-80

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 243.05  E-value: 2.98e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90       100
                  ....*....|....*....|....*.
gi 1958675969  83 EQRQKDLSKLLAYIRLPLLAPQFLAD 108
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106
PHA03098 PHA03098
kelch-like protein; Provisional
 7-429 1.51e-75

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 245.45  E-value: 1.51e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQ 86
Cdd:PHA03098  108 NNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKY 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969  87 KDLSKLLAYIRLPLLAPQFLADMENNALFRDDiecqklimeamKYHLLPERRPMLQSPRTK------PRKSTVGTLFAVG 160
Cdd:PHA03098  188 KDICLILKVLRITFLSEEGIKKLKRWKLRIKK-----------KKIVFNKRCIKIIYSKKYnlnkilPRSSTFGSIIYIH 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 161 GMDSTKGATSIEKYDLRTNMWTPVANMNgrRLQFGVAVLDDKLYVVGGRDG-LKTLNTVECYNPKTKTWSVMPPMSTHRH 239
Cdd:PHA03098  257 ITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKnNLSVNSVVSYDTKTKSWNKVPELIYPRK 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 240 GLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPH 318
Cdd:PHA03098  335 NPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLN 414

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 319 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGhdapTSNLTSRLS-DCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKL 397
Cdd:PHA03098  415 TNKWSKGSPLPISHYGGCAIYHDGKIYVIGG----ISYIDNIKVyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKI 490

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1958675969 398 YAVGGYDGQTYLNIVEAYDPQTNEWTQVAPLC 429
Cdd:PHA03098  491 YVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
148-416 9.52e-64

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 206.93  E-value: 9.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 148 PRKSTV-----GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNG-RRLQFGVAVLDDKLYVVGGRDG----LKTLNT 217
Cdd:COG3055    12 PRSEAAaalldGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 218 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL-SGK 296
Cdd:COG3055    92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGK 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 297 LYAVGGRDGSSclksvecfdpHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPTSNltsrlsdcVERYDPKTDMWT 376
Cdd:COG3055   172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958675969 377 AVASMSISRDAVGVCLLGDKLYAVGGYDGQ----TYLNIVEAYD 416
Cdd:COG3055   234 ALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrtPLVTSAEVYD 277
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 9-108 8.11e-43

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 146.15  E-value: 8.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   9 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQKD 88
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|
gi 1958675969  89 LSKLLAYIRLPLLAPQFLAD 108
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLN 100
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 9-108 1.51e-36

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 129.38  E-value: 1.51e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969    9 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQKD 88
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 1958675969   89 LSKLLAYIRLPLLAPQFLAD 108
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 190-235 1.09e-15

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 70.72  E-value: 1.09e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958675969 190 RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMS 235
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
296-342 1.12e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 70.67  E-value: 1.12e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958675969  296 KLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNG 342
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 3-108 2.98e-80

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 243.05  E-value: 2.98e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90       100
                  ....*....|....*....|....*.
gi 1958675969  83 EQRQKDLSKLLAYIRLPLLAPQFLAD 108
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 3-108 2.35e-77

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 235.69  E-value: 2.35e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18444     1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                          90       100
                  ....*....|....*....|....*.
gi 1958675969  83 EQRQKDLSKLLAYIRLPLLAPQFLAD 108
Cdd:cd18444    81 PERKKHLAKLLALIRLPLLTPQFLAD 106
PHA03098 PHA03098
kelch-like protein; Provisional
 7-429 1.51e-75

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 245.45  E-value: 1.51e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQ 86
Cdd:PHA03098  108 NNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKY 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969  87 KDLSKLLAYIRLPLLAPQFLADMENNALFRDDiecqklimeamKYHLLPERRPMLQSPRTK------PRKSTVGTLFAVG 160
Cdd:PHA03098  188 KDICLILKVLRITFLSEEGIKKLKRWKLRIKK-----------KKIVFNKRCIKIIYSKKYnlnkilPRSSTFGSIIYIH 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 161 GMDSTKGATSIEKYDLRTNMWTPVANMNgrRLQFGVAVLDDKLYVVGGRDG-LKTLNTVECYNPKTKTWSVMPPMSTHRH 239
Cdd:PHA03098  257 ITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKnNLSVNSVVSYDTKTKSWNKVPELIYPRK 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 240 GLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPH 318
Cdd:PHA03098  335 NPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLN 414

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 319 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGhdapTSNLTSRLS-DCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKL 397
Cdd:PHA03098  415 TNKWSKGSPLPISHYGGCAIYHDGKIYVIGG----ISYIDNIKVyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKI 490

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1958675969 398 YAVGGYDGQTYLNIVEAYDPQTNEWTQVAPLC 429
Cdd:PHA03098  491 YVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 3-108 8.87e-67

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 208.62  E-value: 8.87e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18510     1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                          90       100
                  ....*....|....*....|....*.
gi 1958675969  83 EQRQKDLSKLLAYIRLPLLAPQFLAD 108
Cdd:cd18510    81 QNRQKDLGMLLSYIRLPLLPPQLLAD 106
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
148-416 9.52e-64

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 206.93  E-value: 9.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 148 PRKSTV-----GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNG-RRLQFGVAVLDDKLYVVGGRDG----LKTLNT 217
Cdd:COG3055    12 PRSEAAaalldGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 218 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL-SGK 296
Cdd:COG3055    92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGK 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 297 LYAVGGRDGSSclksvecfdpHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPTSNltsrlsdcVERYDPKTDMWT 376
Cdd:COG3055   172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958675969 377 AVASMSISRDAVGVCLLGDKLYAVGGYDGQ----TYLNIVEAYD 416
Cdd:COG3055   234 ALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrtPLVTSAEVYD 277
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
181-441 8.16e-63

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 204.23  E-value: 8.16e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 181 WTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMST-HRHGLGVAVLEGPMYAVGG---- 255
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGftga 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 256 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 335
Cdd:COG3055    83 NPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 336 GVTT-WNGLLYAIGGHDAPTSNLTsrlsdcverydpktdmWTAVASMSISRDAVGVCLLGDKLYAVGGYDGqtYLNIVEA 414
Cdd:COG3055   163 AAAVlPDGKILVIGGRNGSGFSNT----------------WTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEA 224

                         250       260
                  ....*....|....*....|....*..
gi 1958675969 415 YDPQTNEWTQVAPLCLGRAGACVVTVK 441
Cdd:COG3055   225 YDPATNTWTALGELPTPRHGHAAVLTD 251
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 4-108 1.65e-61

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 194.85  E-value: 1.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90       100
                  ....*....|....*....|....*
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQFLAD 108
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLPPQLLAD 106
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 4-116 6.31e-54

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 175.50  E-value: 6.31e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQFLAD-MENNALFR 116
Cdd:cd18445    81 NRKEHLAELLEHVRLPLLSPEYLVQrVEEEELIK 114
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 4-138 4.70e-50

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 166.42  E-value: 4.70e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYHLLPERR 138
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDvVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 9-108 8.11e-43

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 146.15  E-value: 8.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   9 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQKD 88
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|
gi 1958675969  89 LSKLLAYIRLPLLAPQFLAD 108
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLN 100
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 4-132 7.54e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 142.09  E-value: 7.54e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYH 132
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQrVEEETLVKNSSACKDYLIEAMKYH 130
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
274-440 5.11e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 141.83  E-value: 5.11e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 274 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMS-KRRGGVGVTTWNGLLYAIGGHDA 352
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 353 PTSNLTSrLSDcVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQTYLNIVEAYDPQTNEWTQVAPLCLGR 432
Cdd:COG3055    82 ANPSSTP-LND-VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159


                  ....*...
gi 1958675969 433 AGACVVTV 440
Cdd:COG3055   160 DHLAAAVL 167
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 4-108 4.59e-38

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 133.59  E-value: 4.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90       100
                  ....*....|....*....|....*
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQFLAD 108
Cdd:cd18457    81 NREEYLPELLSKVRLPLLRPQFLTD 105
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 4-132 2.15e-37

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 132.88  E-value: 2.15e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYH 132
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQtVEEEALIKNNNTCKDFLIEAMKYH 130
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 9-108 1.51e-36

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 129.38  E-value: 1.51e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969    9 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQKD 88
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 1958675969   89 LSKLLAYIRLPLLAPQFLAD 108
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 3-101 9.34e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 124.85  E-value: 9.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18459     1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                          90
                  ....*....|....*....
gi 1958675969  83 EQRQKDLSKLLAYIRLPLL 101
Cdd:cd18459    81 QERRPHLPQVLQHVRLPLL 99
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 3-99 3.81e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 120.49  E-value: 3.81e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 1958675969  83 EQRQKDLSKLLAYIRLP 99
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 4-105 5.80e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 117.41  E-value: 5.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90       100
                  ....*....|....*....|..
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQF 105
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 5-106 5.31e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 104.03  E-value: 5.31e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   5 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 84
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 1958675969  85 RQKDLSKLLAYIRLPLLAPQFL 106
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 7-85 1.81e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 98.93  E-value: 1.81e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 85
Cdd:cd18480     4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 4-102 2.15e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 99.64  E-value: 2.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*....
gi 1958675969  84 QRQKDLSKLLAYIRLPLLA 102
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLLS 99
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 7-81 3.40e-25

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 98.25  E-value: 3.40e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHD 81
Cdd:cd18508     3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 3-93 4.74e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 98.13  E-value: 4.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18458     1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                          90
                  ....*....|.
gi 1958675969  83 EQRQKDLSKLL 93
Cdd:cd18458    81 ENRRQYLEALL 91
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 6-94 5.14e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 92.77  E-value: 5.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   6 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 85
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81


                  ....*....
gi 1958675969  86 QKDLSKLLA 94
Cdd:cd18455    82 KVHLKDLMS 90
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 4-106 1.14e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 92.15  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90       100
                  ....*....|....*....|...
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAPQFL 106
Cdd:cd18446    81 ERLPLLPRVLENVRLPLLDPWYF 103
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 4-81 1.25e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 91.13  E-value: 1.25e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI-RNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHD 81
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAkDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 4-103 1.76e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 85.93  E-value: 1.76e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18485     1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                          90       100
                  ....*....|....*....|
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAP 103
Cdd:cd18485    81 SRVQHLVELLKQVRLELVSP 100
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 6-106 3.56e-20

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 85.22  E-value: 3.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   6 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 85
Cdd:cd18466     3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                          90       100
                  ....*....|....*....|.
gi 1958675969  86 QKDLSKLLAYIRLPLLAPQFL 106
Cdd:cd18466    83 KKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 3-80 1.20e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 82.83  E-value: 1.20e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRH 80
Cdd:cd18463     1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 2-105 3.84e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 82.11  E-value: 3.84e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   2 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHD 81
Cdd:cd18469     1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                          90       100
                  ....*....|....*....|....
gi 1958675969  82 LEQRQKDLSKLLAYIRLPLLAPQF 105
Cdd:cd18469    81 PQARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 5-101 5.48e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 81.56  E-value: 5.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   5 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 84
Cdd:cd18515     1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                          90
                  ....*....|....*..
gi 1958675969  85 RQKDLSKLLAYIRLPLL 101
Cdd:cd18515    81 RHCYLSELLQTVRLALL 97
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 4-101 6.10e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 81.43  E-value: 6.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*...
gi 1958675969  84 QRQKDLSKLLAYIRLPLL 101
Cdd:cd18514    81 KRKDYLPELLRNVRLALL 98
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 5-101 1.07e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 81.00  E-value: 1.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   5 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 84
Cdd:cd18464     1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                          90
                  ....*....|....*..
gi 1958675969  85 RQKDLSKLLAYIRLPLL 101
Cdd:cd18464    81 RHEVLPELLRSVRLALL 97
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 4-99 2.33e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 77.21  E-value: 2.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|....*..
gi 1958675969  84 QRQKDLSKLLAY-IRLP 99
Cdd:cd18483    81 KREMHLPEIFAKcIRMP 97
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 7-101 6.10e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 75.95  E-value: 6.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQ 86
Cdd:cd18516     4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                          90
                  ....*....|....*
gi 1958675969  87 KDLSKLLAYIRLPLL 101
Cdd:cd18516    84 KALPVLLESIRFRLM 98
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 4-101 1.12e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 75.22  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*...
gi 1958675969  84 QRQKDLSKLLAYIRLPLL 101
Cdd:cd18460    81 HRQHFWPELLQHVRLPFV 98
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 8-100 3.53e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 74.00  E-value: 3.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   8 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQK 87
Cdd:cd18462     5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                          90
                  ....*....|...
gi 1958675969  88 DLSKLLAYIRLPL 100
Cdd:cd18462    85 CAYDLLSSIKLDL 97
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 3-100 3.66e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 73.55  E-value: 3.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   3 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDL 82
Cdd:cd18447     1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                          90
                  ....*....|....*...
gi 1958675969  83 EQRQKDLSKLLAYIRLPL 100
Cdd:cd18447    81 PNRQPYMVDILAKVRFPL 98
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 190-235 1.09e-15

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 70.72  E-value: 1.09e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958675969 190 RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMS 235
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
296-342 1.12e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 70.67  E-value: 1.12e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958675969  296 KLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNG 342
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
202-248 1.41e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 70.28  E-value: 1.41e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958675969  202 KLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 248
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 4-103 1.75e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 71.70  E-value: 1.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMnIPNEETILNALLTWVRHDLE 83
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90       100
                  ....*....|....*....|
gi 1958675969  84 QRQKDLSKLLAYIRLPLLAP 103
Cdd:cd18476    80 ARKGYIHDLFKKVRLQYVHP 99
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 8-80 1.98e-15

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 70.84  E-value: 1.98e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958675969   8 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRH 80
Cdd:cd18503     5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 4-101 3.30e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 71.03  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....*...
gi 1958675969  84 QRQKDLSKLLAYIRLPLL 101
Cdd:cd18477    81 NRQKALPTVFESIRFRLL 98
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 4-102 9.30e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 69.80  E-value: 9.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....*....
gi 1958675969  84 QRQKDLSKLLAYIRLPLLA 102
Cdd:cd18517    81 NRVKSLGEIFDCIRFRLMP 99
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 8-98 4.13e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 67.77  E-value: 4.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   8 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQK 87
Cdd:cd18479     5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                          90
                  ....*....|.
gi 1958675969  88 DLSKLLAYIRL 98
Cdd:cd18479    85 YLSSVLSQIRI 95
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 7-81 4.99e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 67.15  E-value: 4.99e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHD 81
Cdd:cd18474     4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 5-59 8.54e-14

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 65.37  E-value: 8.54e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958675969   5 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLAS 59
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 284-329 1.74e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 64.56  E-value: 1.74e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958675969 284 PRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMS 329
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PHA02790 PHA02790
Kelch-like protein; Provisional
 20-375 4.03e-13

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 70.84  E-value: 4.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969  20 GCTDLHKVAHNYTMEHFME----VIRNQEFVllpanEIAKLLASDDMNIPNEETILNALLTWVRhdleQRQKDLSKLLAY 95
Cdd:PHA02790  136 GLSNLLCHTKDFIAKHFLEleddIIDNFDYL-----SMKLILESDELNVPDEDYVVDFVIKWYM----KRRNRLGNLLLL 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969  96 I----RLPLLAPQFLadmeNNALFRddIECQKlIMEAMKYHLLPERRPMLQSPRTKPR---------KSTVG-TLFAVGG 161
Cdd:PHA02790  207 IknviRSNYLSPRGI----NNVKWI--LDCTK-IFHCDKQPRKSYKYPFIEYPMNMDQiidifhmctSTHVGeVVYLIGG 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 162 MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGgrdGLKTLNTVECYNPKTKTWSVMPPMSTHRHGL 241
Cdd:PHA02790  280 WMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVG---GLPNPTSVERWFHGDAAWVNMPSLLKPRCNP 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 242 GVAVLEGPMYAVGGHDGWSylNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGgrdgssclKSVECFDPHTNK 321
Cdd:PHA02790  357 AVASINNVIYVIGGHSETD--TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG--------RNAEFYCESSNT 426

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958675969 322 WTLCAQMSKRRGGVGVTTWNGLLYAIGGHdaptsnLTSRLSDCVERYDPKTDMW 375
Cdd:PHA02790  427 WTLIDDPIYPRDNPELIIVDNKLLLIGGF------YRGSYIDTIEVYNNRTYSW 474
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 4-95 5.31e-13

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 64.56  E-value: 5.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDD-MNIPNEETILNALLTWVRHDL 82
Cdd:cd18502     1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQeLESINERKLCQLVLEWVQRSI 80

                          90
                  ....*....|...
gi 1958675969  83 EQRQKDLSKLLAY 95
Cdd:cd18502    81 EEGGLDLDDLTEK 93
Kelch smart00612
Kelch domain;
251-295 8.85e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.58  E-value: 8.85e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958675969  251 YAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 295
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 385-428 1.12e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 62.24  E-value: 1.12e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958675969 385 RDAVGVCLLGDKLYAVGGYDGQTYLNIVEAYDPQTNEWTQVAPL 428
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
Kelch smart00612
Kelch domain;
396-440 1.39e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 61.81  E-value: 1.39e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958675969  396 KLYAVGGYDGQTYLNIVEAYDPQTNEWTQVAPLCLGRAGACVVTV 440
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch smart00612
Kelch domain;
156-201 2.43e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 58.34  E-value: 2.43e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958675969  156 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDD 201
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 237-282 2.93e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.01  E-value: 2.93e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958675969 237 HRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMS 282
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 4-78 4.88e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 58.55  E-value: 4.88e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWV 78
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
PLN02193 PLN02193
nitrile-specifier protein
 189-402 8.62e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.82  E-value: 8.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 189 GRRLQFGVAVLDDKLYVVGGRdglKTLNT-----VECYNPKTKTWSVMPPMST--HRHGLGVAVLE--GPMYAVGGHDGW 259
Cdd:PLN02193  164 GLRCSHGIAQVGNKIYSFGGE---FTPNQpidkhLYVFDLETRTWSISPATGDvpHLSCLGVRMVSigSTLYVFGGRDAS 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 260 SYLNTVERWDPQARQWNFVATMS---TPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKR---RG 333
Cdd:PLN02193  241 RQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSfsiRG 320

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958675969 334 GVGVTTWNGLLYAIGGHDAPTSnltsrlsDCVERYDPKTDMWTAVASMSI---SRDAVGVCLLGDKLYAVGG 402
Cdd:PLN02193  321 GAGLEVVQGKVWVVYGFNGCEV-------DDVHYYDPVQDKWTQVETFGVrpsERSVFASAAVGKHIVIFGG 385
PLN02193 PLN02193
nitrile-specifier protein
 149-302 1.66e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 62.67  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 149 RKSTVG-TLFAVGGMDSTKGATSIEKYDLRTNMW---TPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 224
Cdd:PLN02193  223 RMVSIGsTLYVFGGRDASRQYNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIV 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 225 TKTW---SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSyLNTVERWDPQARQWNFVATMS---TPRSTVGVAVLSGKLY 298
Cdd:PLN02193  303 DKKWfhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQVETFGvrpSERSVFASAAVGKHIV 381


                  ....
gi 1958675969 299 AVGG 302
Cdd:PLN02193  382 IFGG 385
PHA02713 PHA02713
hypothetical protein; Provisional
 174-303 5.24e-10

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 61.56  E-value: 5.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 174 YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYA 252
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYA 356

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958675969 253 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 303
Cdd:PHA02713  357 IGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGR 407
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 331-382 6.13e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.54  E-value: 6.13e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958675969 331 RRGGVGVTTWNGLLYAIGGHDAPTSnltsrlSDCVERYDPKTDMWTAVASMS 382
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQS------LNSVEVYDPETNTWSKLPSMP 46
PLN02193 PLN02193
nitrile-specifier protein
 174-323 1.20e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 59.97  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 174 YDLRTNMWT--------PVANMNGRRLqfgVAVlDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMS---THRHGLG 242
Cdd:PLN02193  198 FDLETRTWSispatgdvPHLSCLGVRM---VSI-GSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHS 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 243 VAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMS---TPRSTVGVAVLSGKLYAVGGRDGSScLKSVECFDPHT 319
Cdd:PLN02193  274 MAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGdsfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQ 352


                  ....
gi 1958675969 320 NKWT 323
Cdd:PLN02193  353 DKWT 356
Kelch smart00612
Kelch domain;
343-395 1.87e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 52.95  E-value: 1.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958675969  343 LLYAIGGHDaPTSNLTSrlsdcVERYDPKTDMWTAVASMSISRDAVGVCLLGD 395
Cdd:smart00612   1 KIYVVGGFD-GGQRLKS-----VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 8-98 3.59e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 53.73  E-value: 3.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   8 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDlEQRQK 87
Cdd:cd18470     5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                          90
                  ....*....|.
gi 1958675969  88 DLSKLLAYIRL 98
Cdd:cd18470    84 YAADLLSNIRF 94
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 4-87 5.32e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 53.04  E-value: 5.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLE 83
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....
gi 1958675969  84 QRQK 87
Cdd:cd18451    81 ERER 84
Kelch_6 pfam13964
Kelch motif;
191-234 2.27e-08

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 50.03  E-value: 2.27e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958675969 191 RLQFGVAVLDDKLYVVGGR-DGLKTLNTVECYNPKTKTWSVMPPM 234
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL 46
PHA02713 PHA02713
hypothetical protein; Provisional
 221-400 3.26e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 55.79  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 221 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD-GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYA 299
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYA 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 300 VGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG---HDAPTS---------NLTSRLSDCVER 367
Cdd:PHA02713  357 IGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrteHIDYTSvhhmnsidmEEDTHSSNKVIR 436

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958675969 368 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 400
Cdd:PHA02713  437 YDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 8-99 8.35e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 49.73  E-value: 8.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   8 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDlEQRQK 87
Cdd:cd18449     5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                          90
                  ....*....|..
gi 1958675969  88 DLSKLLAYIRLP 99
Cdd:cd18449    84 FAAKLMENIRFP 95
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 9-101 8.96e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 49.91  E-value: 8.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   9 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDlEQRQKD 88
Cdd:cd18465     6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRAS 84

                          90
                  ....*....|...
gi 1958675969  89 LSKLLAYIRLPLL 101
Cdd:cd18465    85 ASHVLCHIRFPLM 97
PLN02153 PLN02153
epithiospecifier protein
 189-380 1.89e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 52.68  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 189 GRRLQFGVAVLDDKLYVVGGRdgLKTLNTVE----CYNPKTKTWSVMPP------MSThrHGLGVAVLEGPMYAVGGHDG 258
Cdd:PLN02153   21 GPRCSHGIAVVGDKLYSFGGE--LKPNEHIDkdlyVFDFNTHTWSIAPAngdvprISC--LGVRMVAVGTKLYIFGGRDE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 259 WSYLNTVERWDPQARQWNFVATMST-----PRSTVGVAVLSGKLYAVGGRDGSSCLK------SVECFDPHTNKWtlcAQ 327
Cdd:PLN02153   97 KREFSDFYSYDTVKNEWTFLTKLDEeggpeARTFHSMASDENHVYVFGGVSKGGLMKtperfrTIEAYNIADGKW---VQ 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958675969 328 MS------KRRGGVGVTTWNGLLYAIGGHdaPTSNLTSRLSD----CVERYDPKTDMWTAVAS 380
Cdd:PLN02153  174 LPdpgenfEKRGGAGFAVVQGKIWVVYGF--ATSILPGGKSDyesnAVQFFDPASGKWTEVET 234
PLN02153 PLN02153
epithiospecifier protein
 149-302 2.19e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 52.68  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 149 RKSTVGT-LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGR-----RLQFGVAVLDDKLYVVGG--RDGLKT----LN 216
Cdd:PLN02153   80 RMVAVGTkLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvsKGGLMKtperFR 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 217 TVECYNPKTKTWSVMPPMSTH---RHGLGVAVLEGPMYAV---------GGHDGWSYlNTVERWDPQARQWNFVATMS-- 282
Cdd:PLN02153  160 TIEAYNIADGKWVQLPDPGENfekRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGak 238

                         170       180
                  ....*....|....*....|.
gi 1958675969 283 -TPRSTVGVAVLSGKLYAVGG 302
Cdd:PLN02153  239 pSARSVFAHAVVGKYIIIFGG 259
PLN02193 PLN02193
nitrile-specifier protein
 242-425 6.77e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 51.49  E-value: 6.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 242 GVAVLEGPMYAVGGH-------DGWSYLntverWDPQARQWNFV-ATMSTPR-STVGVAVLS--GKLYAVGGRDGSSCLK 310
Cdd:PLN02193  170 GIAQVGNKIYSFGGEftpnqpiDKHLYV-----FDLETRTWSISpATGDVPHlSCLGVRMVSigSTLYVFGGRDASRQYN 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 311 SVECFDPHTNKWTLCAQMSK---RRGGVGVTTWNGLLYAIGGHDAptsnlTSRLsDCVERYDPKTDMW----TAVASMSI 383
Cdd:PLN02193  245 GFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSA-----TARL-KTLDSYNIVDKKWfhcsTPGDSFSI 318

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958675969 384 sRDAVGVCLLGDKLYAVGGYDGqTYLNIVEAYDPQTNEWTQV 425
Cdd:PLN02193  319 -RGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQV 358
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 4-101 1.57e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 46.43  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRN--QEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHD 81
Cdd:cd18471     1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                          90       100
                  ....*....|....*....|
gi 1958675969  82 LeqRQKDLSKLLAYIRLPLL 101
Cdd:cd18471    81 C--RYQYMDELLQYVRFGLM 98
PLN02153 PLN02153
epithiospecifier protein
 144-323 1.58e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 144 PRTKPRKSTVG-TLFAVGGmdSTKGATSIEK----YDLRTNMWTpVANMNG---RRLQFGV--AVLDDKLYVVGGRDGLK 213
Cdd:PLN02153   22 PRCSHGIAVVGdKLYSFGG--ELKPNEHIDKdlyvFDFNTHTWS-IAPANGdvpRISCLGVrmVAVGTKLYIFGGRDEKR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 214 TLNTVECYNPKTKTWSVMPPMSTH-----RHGLGVAVLEGPMYAVGGHDGWSYLNTVER------WDPQARQWnfvATMS 282
Cdd:PLN02153   99 EFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGGLMKTPERfrtieaYNIADGKW---VQLP 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958675969 283 TP------RSTVGVAVLSGKLYAV---------GGRDGSSClKSVECFDPHTNKWT 323
Cdd:PLN02153  176 DPgenfekRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWT 230
PRK14131 PRK14131
N-acetylneuraminate epimerase;
316-439 2.97e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 49.24  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 316 DPHtNKWTLCAQM--SKRRGGVGVTTwNGLLYAIGGHDAPTSNLTSRLSDCVERYDPKTDMWTAVAS---MSISrDAVGV 390
Cdd:PRK14131   59 APS-KGWTKIAAFpgGPREQAVAAFI-DGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKLDTrspVGLA-GHVAV 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 391 CLLGDKLYAVGGY-----DG-------------------QTYLN----------IVEAYDPQTNEWTQ--VAPLcLGRAG 434
Cdd:PRK14131  136 SLHNGKAYITGGVnknifDGyfedlaaagkdktpkdkinDAYFDkkpedyffnkEVLSYDPSTNQWKNagESPF-LGTAG 214


                  ....*
gi 1958675969 435 ACVVT 439
Cdd:PRK14131  215 SAVVI 219
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 190-234 4.21e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 43.48  E-value: 4.21e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958675969 190 RRLQFGVAVLDDKLYVVGGRDGLK--TLNTVECYNPKTKTWSVMPPM 234
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGdlSSSDVLVYDPETNVWTEVPRL 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 154-188 4.27e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 4.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958675969 154 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMN 188
Cdd:pfam01344  12 GKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
385-428 5.95e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.09  E-value: 5.95e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958675969 385 RDAVGVCLLGDKLYAVGGYDGQ-TYLNIVEAYDPQTNEWTQVAPL 428
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEELPPL 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
189-234 8.01e-06

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 42.98  E-value: 8.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958675969 189 GRRLQFGVAVLDDKLYVVGGRDGL-KTLNTVECYNPKTKTWSVMPPM 234
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGSL 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
394-438 1.14e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 1.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958675969 394 GDKLYAVGGYD--GQTYLNIVEAYDPQTNEWTQVAPLCLGRAGACVV 438
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 7-97 1.71e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 43.26  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   7 SNCLGIRSFADAQGCTDLHKVAHNYTMEHF-MEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 85
Cdd:cd18482     4 SNCAGILKFADAFDNRELKSKALAFIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83

                          90
                  ....*....|..
gi 1958675969  86 QKDLSKLLAYIR 97
Cdd:cd18482    84 AASAAEVLKCVR 95
Kelch_6 pfam13964
Kelch motif;
284-332 4.12e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 4.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958675969 284 PRSTVGVAVLSGKLYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMSKRR 332
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PRK14131 PRK14131
N-acetylneuraminate epimerase;
167-255 5.17e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.39  E-value: 5.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 167 GATSIEKYDLRT--NMWTPVANMNG-RRLQFGVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVM---PPM 234
Cdd:PRK14131   48 AGTSWYKLDLNApsKGWTKIAAFPGgPREQAVAAFIDGKLYVFGGigktnSEGsPQVFDDVYKYDPKTNSWQKLdtrSPV 127

                          90       100
                  ....*....|....*....|.
gi 1958675969 235 STHRHgLGVAVLEGPMYAVGG 255
Cdd:PRK14131  128 GLAGH-VAVSLHNGKAYITGG 147
Kelch_4 pfam13418
Galactose oxidase, central domain;
386-428 1.59e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 1.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958675969 386 DAVGVCLLGDKLYAVGGYDGQ-TYLNIVEAYDPQTNEWTQVAPL 428
Cdd:pfam13418   4 YHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGSL 47
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 4-106 1.61e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 40.87  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   4 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI-RNQEFV-LLPAN--EIAKLLASDDMNIPNEETILNALLTWVR 79
Cdd:cd18473     1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLaSDADDAgLLELNleSLQAVLEADDIPRVKESRLLTLVLEWLN 80

                          90       100
                  ....*....|....*....|....*..
gi 1958675969  80 HDlEQRQKDLSKLLAYIRLPLLAPQFL 106
Cdd:cd18473    81 QD-ESRLAYANALLSRIRYGLVPVEEL 106
Kelch_6 pfam13964
Kelch motif;
337-385 2.01e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.86  E-value: 2.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958675969 337 VTTWNGLLYAIGGHDAPtsnltSRLSDCVERYDPKTDMWTAVASMSISR 385
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNA-----SPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 385-428 2.44e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 38.47  E-value: 2.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958675969 385 RDAVGVCLLGDKLYAVGGYDGQ--TYLNIVEAYDPQTNEWTQVAPL 428
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPRL 47
Kelch_6 pfam13964
Kelch motif;
237-285 4.59e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 4.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958675969 237 HRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWNFVATMSTPR 285
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 8-101 9.05e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 38.59  E-value: 9.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969   8 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWvRHDLEQRQK 87
Cdd:cd18461     5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEK 83

                          90       100
                  ....*....|....*....|
gi 1958675969  88 DL------SKLLAYIRLPLL 101
Cdd:cd18461    84 DQvslqepPKLLEAVRFPLM 103
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 284-328 9.59e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.93  E-value: 9.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958675969 284 PRSTVGVAVLSGKLYAVGGRDGSSCLKS--VECFDPHTNKWTLCAQM 328
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSsdVLVYDPETNVWTEVPRL 47
PHA02713 PHA02713
hypothetical protein; Provisional
 155-253 1.34e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.15  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 155 TLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD------GLKTLNTVEC-------- 220
Cdd:PHA02713  353 TIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehidytSVHHMNSIDMeedthssn 432

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958675969 221 ----YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAV 253
Cdd:PHA02713  433 kvirYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 14-78 2.13e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 36.79  E-value: 2.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958675969  14 SFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWV 78
Cdd:cd18493    10 QYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
PRK14131 PRK14131
N-acetylneuraminate epimerase;
197-302 4.08e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 39.23  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675969 197 AVLDDKLYVVGGRDGLK--TLNTvecyNPKTKTWSVM-----PPmsthRHGLGVAVLEGPMYAVGG-----HDGW-SYLN 263
Cdd:PRK14131   35 AIDNNTVYVGLGSAGTSwyKLDL----NAPSKGWTKIaafpgGP----REQAVAAFIDGKLYVFGGigktnSEGSpQVFD 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958675969 264 TVERWDPQARQWNFVATMStPRSTVGVAVLS---GKLYAVGG 302
Cdd:PRK14131  107 DVYKYDPKTNSWQKLDTRS-PVGLAGHVAVSlhnGKAYITGG 147
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 35-100 9.78e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 35.67  E-value: 9.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958675969  35 HFM-----EVIRNQEFVLLPANEIAKLLASDDMNIPnEETILNALLTWVRHDlEQRQKDLSKLLAYIRLPL 100
Cdd:cd14822    27 QFMdrnaqEVLSSEGFLTLSKSALKELLSRDSFCAP-EVDIFNAVRRWCEHN-PDSKEDAKEILEAVRLPL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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