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Conserved domains on  [gi|1958676522|ref|XP_038948073|]
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alpha-L-iduronidase isoform X2 [Rattus norvegicus]

Protein Classification

6-phospho-beta-glucosidase; DMT family transporter( domain architecture ID 10472212)

6-phospho-beta-glucosidase catalyzes the conversion of 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate| DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-525 0e+00

Glycosyl hydrolases family 39;


:

Pssm-ID: 426141  Cd Length: 472  Bit Score: 708.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522  29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITASRKSSGQG 106
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAYRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 107 LIYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFEDKQQVFEWKDLVSLLARRYIGKYGLTNVSKWN 176
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 177 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 256
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 257 DYISLH---KKGAGSSIAILEQEVAV------VEQIQQLFPKFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 327
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 328 QHQNLLFANSSSSMRYILLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEvlk 407
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAE--- 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 408 agaVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTSDDTHIHPNDSIPVILHLRGvPPGLELVYVVLYLDNQLSSPYSAW 487
Cdd:pfam01229 359 ---VSDSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1958676522 488 QHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLT 525
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
 
Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-525 0e+00

Glycosyl hydrolases family 39;


Pssm-ID: 426141  Cd Length: 472  Bit Score: 708.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522  29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITASRKSSGQG 106
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAYRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 107 LIYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFEDKQQVFEWKDLVSLLARRYIGKYGLTNVSKWN 176
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 177 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 256
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 257 DYISLH---KKGAGSSIAILEQEVAV------VEQIQQLFPKFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 327
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 328 QHQNLLFANSSSSMRYILLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEvlk 407
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAE--- 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 408 agaVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTSDDTHIHPNDSIPVILHLRGvPPGLELVYVVLYLDNQLSSPYSAW 487
Cdd:pfam01229 359 ---VSDSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1958676522 488 QHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLT 525
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
16-540 1.35e-36

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 143.52  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522  16 AFLASPLALAETPYLVRVDAARPLRPLLPFWRSTGfcpplphDQADQY----DLSWDQQLNLAYIGAVPHsgieqVRIHW 91
Cdd:COG3664     4 TLLGPLAAAAPPPVAITVDLAKVAGPMKPLWAWFG-------YDEPNYtymkDGKKLLSEGAGLSPVFRY-----IRFHG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522  92 LL--DLITASRKSSGqGLIYNFTHLDAFLDLLMENQLLP----GF---ELMGSPSGYF---------TDFEdkqqvfEWK 153
Cdd:COG3664    72 LFhdDMGVYREDADG-NPVYNFTYVDKIFDFLLELGMKPfvelGFmpeALASGPQTVFwwkgnvtppKDYA------KWA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 154 DLVSLLARRYIGKYGLTNVSKWNFETWNEPDHHDFdnVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSfhplPRSPM 233
Cdd:COG3664   145 DLVRAFVRHLIDRYGIDEVRSWYFEVWNEPNLSGF--WKGTQEEYFKLYDYTARAVKSVDPRLRVGGPATA----GGAAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 234 cW--SLLGHCAngtnfftgEVGVRLDYISLHKKGAGSSI---------AILEQEVAVVEQIQQlfPKFKDTPIYNDEADp 302
Cdd:COG3664   219 -WlpDFLEHCA--------KNGVPVDFVSTHAYGTDPGFdgqlsmnpdAVLRDVEKVRKLIAA--SAFPNLPLHITEWN- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 303 lVGWSLPQPWRADVTYAALVVKVIAQHQNLlfANSsssmryillsndnaflsyhpypFSQRTLTARF--QVNNTHPPH-- 378
Cdd:COG3664   287 -TSYTPRDPYHDTAFYAAYIAKSLKRAGDL--ADS----------------------MSYWTFSDIFeeAGPPTQPFHgg 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 379 -----VQLLRKPVLTVMGLMALLDGEQLwaevlkagAVLDSNhtvgVLASThHPEGpseawRTTVLIYTSDDTHIHPNDS 453
Cdd:COG3664   342 fgllnTNGIKKPVYHAFRMLNRLGGERL--------AVGDDD----AVATR-DDDG-----RVAVLVWNYHDDDPAGPAR 403

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 454 iPVILHLRGVPPGleLVYVVLY-LDNQLSSPYSAWQHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLTLYRKLPV 532
Cdd:COG3664   404 -TVELTLTGLPAG--KYRLTVYrVDEEHGNAYAAWLEMGSPQQPTREQIAELKAAAELQTSPEVVVVADGKLTLDLTLPR 480


                  ....*...
gi 1958676522 533 PSLMLVHL 540
Cdd:COG3664   481 NSVVLIEL 488
 
Name Accession Description Interval E-value
Glyco_hydro_39 pfam01229
Glycosyl hydrolases family 39;
29-525 0e+00

Glycosyl hydrolases family 39;


Pssm-ID: 426141  Cd Length: 472  Bit Score: 708.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522  29 YLVRVDAARPLRPLLPFWRST-GFCPPLPHDQADqydlsWDQQLNLAYigavPHSGIEQVRIH-WLLDLITASRKSSGQG 106
Cdd:pfam01229   1 VKIKVDAARDLRKLTPFWRSCvGFCPPLPALQAD-----WDQQLNLAY----PHIGFEYVRGHgWLLDDITAYRESVDQG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 107 LIYNFTHLDAFLDLLMENQLLPGFEL--------MGSPSGYF--TDFEDKQQVFEWKDLVSLLARRYIGKYGLTNVSKWN 176
Cdd:pfam01229  72 LFYNFTHIDRILDLLLENGLLPFFELgfmpkrlaSGTPTVFFweGNFTPPKQYEEWKNLVSLLARHYIGRYGLDEVSKWN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 177 FETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSFHPLPRspmcwSLLGHCANGTnfftgevgVRL 256
Cdd:pfam01229 152 FETWNEPNLKDFDWVDMTEQEYFNLYKACAEAIKEVSPNLKVGGPADSFDPWIR-----SLLEFCYNGN--------VPL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 257 DYISLH---KKGAGSSIAILEQEVAV------VEQIQQLFPKFKDTPIYNDEADPlvGWSLPQPWRADVTYAALVVKVIA 327
Cdd:pfam01229 219 DFISLHaysKKGAGSSILILEEEMASeymlneVKQVRELIPEFPDLPVYNTEANP--SWSPPQPWHDDPTYAAYVVKVIA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 328 QHQNLLFANSSSSMRYILLSNDNAFLSYHpypfsqrtltARFQVNNTHPphvqlLRKPVLTVMGLMALLDGEQLWAEvlk 407
Cdd:pfam01229 297 QHQDLPDANSYWTFRDVFEENDNAFLSFH----------GGFGLNNTHP-----IPKPVLTAFKLLALLDGEQLWAE--- 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 408 agaVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTSDDTHIHPNDSIPVILHLRGvPPGLELVYVVLYLDNQLSSPYSAW 487
Cdd:pfam01229 359 ---VSDSNHTVGVIASRHDPSGALIAWNEIVLIYSSDDTTAHPDKEYPVTLRLNG-PVGFKLVYIKLMIDEDHGNPWGTW 434

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1958676522 488 QHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLT 525
Cdd:pfam01229 435 QHMGRPVFPSKEQIRRLRDAEKPKAEAPRPFPADGRLT 472
XynB COG3664
Beta-xylosidase [Carbohydrate transport and metabolism];
16-540 1.35e-36

Beta-xylosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442881  Cd Length: 490  Bit Score: 143.52  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522  16 AFLASPLALAETPYLVRVDAARPLRPLLPFWRSTGfcpplphDQADQY----DLSWDQQLNLAYIGAVPHsgieqVRIHW 91
Cdd:COG3664     4 TLLGPLAAAAPPPVAITVDLAKVAGPMKPLWAWFG-------YDEPNYtymkDGKKLLSEGAGLSPVFRY-----IRFHG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522  92 LL--DLITASRKSSGqGLIYNFTHLDAFLDLLMENQLLP----GF---ELMGSPSGYF---------TDFEdkqqvfEWK 153
Cdd:COG3664    72 LFhdDMGVYREDADG-NPVYNFTYVDKIFDFLLELGMKPfvelGFmpeALASGPQTVFwwkgnvtppKDYA------KWA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 154 DLVSLLARRYIGKYGLTNVSKWNFETWNEPDHHDFdnVSMTTQGFLNYYDACSEGLRIASPTLRLGGPGDSfhplPRSPM 233
Cdd:COG3664   145 DLVRAFVRHLIDRYGIDEVRSWYFEVWNEPNLSGF--WKGTQEEYFKLYDYTARAVKSVDPRLRVGGPATA----GGAAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 234 cW--SLLGHCAngtnfftgEVGVRLDYISLHKKGAGSSI---------AILEQEVAVVEQIQQlfPKFKDTPIYNDEADp 302
Cdd:COG3664   219 -WlpDFLEHCA--------KNGVPVDFVSTHAYGTDPGFdgqlsmnpdAVLRDVEKVRKLIAA--SAFPNLPLHITEWN- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 303 lVGWSLPQPWRADVTYAALVVKVIAQHQNLlfANSsssmryillsndnaflsyhpypFSQRTLTARF--QVNNTHPPH-- 378
Cdd:COG3664   287 -TSYTPRDPYHDTAFYAAYIAKSLKRAGDL--ADS----------------------MSYWTFSDIFeeAGPPTQPFHgg 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 379 -----VQLLRKPVLTVMGLMALLDGEQLwaevlkagAVLDSNhtvgVLASThHPEGpseawRTTVLIYTSDDTHIHPNDS 453
Cdd:COG3664   342 fgllnTNGIKKPVYHAFRMLNRLGGERL--------AVGDDD----AVATR-DDDG-----RVAVLVWNYHDDDPAGPAR 403

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676522 454 iPVILHLRGVPPGleLVYVVLY-LDNQLSSPYSAWQHMGQPVFPSAEQFRQMRMVEDPVAEAPRPFPARGRLTLYRKLPV 532
Cdd:COG3664   404 -TVELTLTGLPAG--KYRLTVYrVDEEHGNAYAAWLEMGSPQQPTREQIAELKAAAELQTSPEVVVVADGKLTLDLTLPR 480


                  ....*...
gi 1958676522 533 PSLMLVHL 540
Cdd:COG3664   481 NSVVLIEL 488
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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