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Conserved domains on  [gi|1958680934|ref|XP_038949568|]
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telomerase protein component 1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1006-1464 1.56e-63

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.86  E-value: 1.56e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1006 AFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSLyLS 1085
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1086 PALSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVAVSALVWlSPsvlvsgaeDGSLhgwmlrrnslqslwls 1165
Cdd:COG2319     80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SP--------DGKT---------------- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1166 svcqkpvlglaasqefLASASEDFTVRLWPrqlltqphaVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCW 1245
Cdd:COG2319    135 ----------------LASGSADGTVRLWD---------LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1246 DVKVAQaplLIHTFSScHRDWITGCTWTKD-NILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVV--AVEEHIVSVS 1322
Cdd:COG2319    190 DLATGK---LLRTLTG-HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfsPDGRLLASGS 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1323 RDGTLKVWDRQ-GVELTSIPAHSGPISQCAAAleprPAGQpgselLVVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAA 1401
Cdd:COG2319    266 ADGTVRLWDLAtGELLRTLTGHSGGVNSVAFS----PDGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958680934 1402 AASEASGLLLT-SDNSSVRLWQIPKEADDTCKPRSSAVITAVAWAPDGSLVVSGNEAGELTLWQ 1464
Cdd:COG2319    337 AFSPDGKTLASgSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 837-1112 4.16e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 4.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  837 TAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISSFAFLSDTALFLTT-FDGLLELWDLQHGCWVFQTKAH 915
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECVRTLTGH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  916 QYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYT-HPKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKE 994
Cdd:cd00200     93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  995 LGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGR 1074
Cdd:cd00200    173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1958680934 1075 PRGCLgSLYLSPALSVALNPDGDQVAVGYRGDGIKIYR 1112
Cdd:cd00200    253 CVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 321-496 4.77e-32

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 123.57  E-value: 4.77e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  321 RLSLVIGQAGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAfnllRRLCTHLHQKLGEPSALPSTYRGLVW 400
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  401 ELQQKLLlksaqwlqpgqtlvLIIDGADKLVDHNGQ---------LISDWIPKSLPRRVHLVLSVSSDSG--LGETLQQS 469
Cdd:pfam05729   77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142

                          170       180
                   ....*....|....*....|....*..
gi 1958680934  470 QsayVVALGSLVPSSRAQLVREELALY 496
Cdd:pfam05729  143 R---YLEVRGFSESDRKQYVRKYFSDE 166
DUF5920 super family cl44764
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ...
 2-46 3.07e-22

Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.


The actual alignment was detected with superfamily member pfam19334:

Pssm-ID: 466045  Cd Length: 203  Bit Score: 96.38  E-value: 3.07e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958680934    2 FIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGP 46
Cdd:pfam19334  157 FIAERGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSP 201
DUF4062 pfam13271
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ...
 59-167 1.60e-16

Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.


:

Pssm-ID: 463823  Cd Length: 78  Bit Score: 75.71  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934   59 RLFISSTFRDMHGERDLLMRSVLpalqarafphRISLHAIdlrwGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGY 138
Cdd:pfam13271    1 KVFISSTFYDLKEEREALIEALL----------ELGHIPV----GMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66

                           90       100
                   ....*....|....*....|....*....
gi 1958680934  139 TPpsydlpdhphfhwtqryPSGRSVTEME 167
Cdd:pfam13271   67 ID-----------------PDGISYTELE 78
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1006-1464 1.56e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.86  E-value: 1.56e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1006 AFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSLyLS 1085
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1086 PALSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVAVSALVWlSPsvlvsgaeDGSLhgwmlrrnslqslwls 1165
Cdd:COG2319     80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SP--------DGKT---------------- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1166 svcqkpvlglaasqefLASASEDFTVRLWPrqlltqphaVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCW 1245
Cdd:COG2319    135 ----------------LASGSADGTVRLWD---------LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1246 DVKVAQaplLIHTFSScHRDWITGCTWTKD-NILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVV--AVEEHIVSVS 1322
Cdd:COG2319    190 DLATGK---LLRTLTG-HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfsPDGRLLASGS 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1323 RDGTLKVWDRQ-GVELTSIPAHSGPISQCAAAleprPAGQpgselLVVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAA 1401
Cdd:COG2319    266 ADGTVRLWDLAtGELLRTLTGHSGGVNSVAFS----PDGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958680934 1402 AASEASGLLLT-SDNSSVRLWQIPKEADDTCKPRSSAVITAVAWAPDGSLVVSGNEAGELTLWQ 1464
Cdd:COG2319    337 AFSPDGKTLASgSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1129-1422 4.15e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.92  E-value: 4.15e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1129 VSALVWLSPS-VLVSGAEDGSLHGW------MLRRNSLQSLWLSSV--CqkpvlglaASQEFLASASEDFTVRLWPrqll 1199
Cdd:cd00200     12 VTCVAFSPDGkLLATGSGDGTIKVWdletgeLLRTLKGHTGPVRDVaaS--------ADGTYLASGSSDKTIRLWD---- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1200 tqphaVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKVAQaplLIHTFsSCHRDWITGCTWTKDNILI 1279
Cdd:cd00200     80 -----LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTL-RGHTDWVNSVAFSPDGTFV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1280 SCSS-DGSVGLWNPEAGQQLGQFPGHQSAVSAVVAV--EEHIVSVSRDGTLKVWD-RQGVELTSIPAHSGPISQCAAAle 1355
Cdd:cd00200    151 ASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDlSTGKCLGTLRGHENGVNSVAFS-- 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958680934 1356 prpagqpGSELLVVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAAAASEASGLLLT-SDNSSVRLWQ 1422
Cdd:cd00200    229 -------PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASgSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 837-1112 4.16e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 4.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  837 TAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISSFAFLSDTALFLTT-FDGLLELWDLQHGCWVFQTKAH 915
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECVRTLTGH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  916 QYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYT-HPKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKE 994
Cdd:cd00200     93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  995 LGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGR 1074
Cdd:cd00200    173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1958680934 1075 PRGCLgSLYLSPALSVALNPDGDQVAVGYRGDGIKIYR 1112
Cdd:cd00200    253 CVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 321-496 4.77e-32

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 123.57  E-value: 4.77e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  321 RLSLVIGQAGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAfnllRRLCTHLHQKLGEPSALPSTYRGLVW 400
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  401 ELQQKLLlksaqwlqpgqtlvLIIDGADKLVDHNGQ---------LISDWIPKSLPRRVHLVLSVSSDSG--LGETLQQS 469
Cdd:pfam05729   77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142

                          170       180
                   ....*....|....*....|....*..
gi 1958680934  470 QsayVVALGSLVPSSRAQLVREELALY 496
Cdd:pfam05729  143 R---YLEVRGFSESDRKQYVRKYFSDE 166
DUF5920 pfam19334
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ...
 2-46 3.07e-22

Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.


Pssm-ID: 466045  Cd Length: 203  Bit Score: 96.38  E-value: 3.07e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958680934    2 FIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGP 46
Cdd:pfam19334  157 FIAERGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSP 201
DUF4062 pfam13271
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ...
 59-167 1.60e-16

Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.


Pssm-ID: 463823  Cd Length: 78  Bit Score: 75.71  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934   59 RLFISSTFRDMHGERDLLMRSVLpalqarafphRISLHAIdlrwGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGY 138
Cdd:pfam13271    1 KVFISSTFYDLKEEREALIEALL----------ELGHIPV----GMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66

                           90       100
                   ....*....|....*....|....*....
gi 1958680934  139 TPpsydlpdhphfhwtqryPSGRSVTEME 167
Cdd:pfam13271   67 ID-----------------PDGISYTELE 78
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1210-1246 1.52e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.52e-09
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958680934  1210 CAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWD 1246
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 1182-1356 1.86e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.22  E-value: 1.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1182 LASASEDFTVRLW--PRQLLTQ---PHAVEelpcaaeLRGHEGPVCCCSFSPDGR-ILATAGRDRNLLCWDVKVAQAPLL 1255
Cdd:PTZ00421    91 LFTASEDGTIMGWgiPEEGLTQnisDPIVH-------LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEV 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1256 IhtfsSCHRDWITGCTWTKD-NILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVS--AVVAVEEHIV-----SVSRDGTL 1327
Cdd:PTZ00421   164 I----KCHSDQITSLEWNLDgSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIitlgcSKSQQRQI 239

                          170       180
                   ....*....|....*....|....*....
gi 1958680934 1328 KVWDRQGVEltsIPAHSGPISQCAAALEP 1356
Cdd:PTZ00421   240 MLWDTRKMA---SPYSTVDLDQSSALFIP 265
WD40 pfam00400
WD domain, G-beta repeat;
1210-1246 2.57e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 2.57e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958680934 1210 CAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWD 1246
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 913-944 1.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 1.55e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958680934   913 KAHQYQITGCCLSPDRRLLATVCLGGYVKLWD 944
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 319-430 3.31e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 41.31  E-value: 3.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  319 HGRLSLVIGQAGQGKTAFLASLVSALkvPDQPNVAPFVFFHFSAArpdqclafNLLRRLCTHLHqklgePSALPSTYRGL 398
Cdd:COG3267     42 GGGFVVLTGEVGTGKTTLLRRLLERL--PDDVKVAYIPNPQLSPA--------ELLRAIADELG-----LEPKGASKADL 106

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958680934  399 VWELQQKLLLKSAQwlqpGQTLVLIIDGADKL 430
Cdd:COG3267    107 LRQLQEFLLELAAA----GRRVVLIIDEAQNL 134
WD40 pfam00400
WD domain, G-beta repeat;
913-944 3.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 3.35e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958680934  913 KAHQYQITGCCLSPDRRLLATVCLGGYVKLWD 944
Cdd:pfam00400    8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1006-1464 1.56e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.86  E-value: 1.56e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1006 AFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSLyLS 1085
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1086 PALSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVAVSALVWlSPsvlvsgaeDGSLhgwmlrrnslqslwls 1165
Cdd:COG2319     80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SP--------DGKT---------------- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1166 svcqkpvlglaasqefLASASEDFTVRLWPrqlltqphaVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCW 1245
Cdd:COG2319    135 ----------------LASGSADGTVRLWD---------LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1246 DVKVAQaplLIHTFSScHRDWITGCTWTKD-NILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVV--AVEEHIVSVS 1322
Cdd:COG2319    190 DLATGK---LLRTLTG-HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfsPDGRLLASGS 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1323 RDGTLKVWDRQ-GVELTSIPAHSGPISQCAAAleprPAGQpgselLVVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAA 1401
Cdd:COG2319    266 ADGTVRLWDLAtGELLRTLTGHSGGVNSVAFS----PDGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958680934 1402 AASEASGLLLT-SDNSSVRLWQIPKEADDTCKPRSSAVITAVAWAPDGSLVVSGNEAGELTLWQ 1464
Cdd:COG2319    337 AFSPDGKTLASgSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
965-1424 1.42e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.78  E-value: 1.42e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  965 FHPEGQVVATGNWSGIVTFFQADGLKVTKELGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGV 1044
Cdd:COG2319      2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1045 STVLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSlYLSPALSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQE 1124
Cdd:COG2319     82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1125 LNVAVSALVWlSPsvlvsgaeDGSLhgwmlrrnslqslwlssvcqkpvlglaasqefLASASEDFTVRLWprqlltqphA 1204
Cdd:COG2319    161 HSGAVTSVAF-SP--------DGKL--------------------------------LASGSDDGTVRLW---------D 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1205 VEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVkvaQAPLLIHTFSScHRDWITGCTWTKDN-ILISCSS 1283
Cdd:COG2319    191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL---ATGKLLRTLTG-HSGSVRSVAFSPDGrLLASGSA 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1284 DGSVGLWNPEAGQQLGQFPGHQSAVSAVV--AVEEHIVSVSRDGTLKVWDRQ-GVELTSIPAHSGPISQCAAAleprPAG 1360
Cdd:COG2319    267 DGTVRLWDLATGELLRTLTGHSGGVNSVAfsPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFS----PDG 342

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958680934 1361 QpgselLVVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAAAASEASGLLLT-SDNSSVRLWQIP 1424
Cdd:COG2319    343 K-----TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASgSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
824-1248 3.82e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 215.93  E-value: 3.82e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  824 GQQSLSLPISSSPTAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISSFAFLSDTALFLTT-FDGLLELWD 902
Cdd:COG2319     27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAsADGTVRLWD 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  903 LQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYT-HPKSLNCITFHPEGQVVATGNWSGIV 981
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  982 TFFQADGLKVTKELGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGE 1061
Cdd:COG2319    187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1062 DGKAQLWSGFLGRPRGCLGSlYLSPALSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVAVSALVWlSPsvlv 1141
Cdd:COG2319    267 DGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SP---- 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1142 sgaeDGslhgwmlrrnslqslwlssvcqkpvlglaasqEFLASASEDFTVRLWPrqlltqphaVEELPCAAELRGHEGPV 1221
Cdd:COG2319    341 ----DG--------------------------------KTLASGSDDGTVRLWD---------LATGELLRTLTGHTGAV 375

                          410       420
                   ....*....|....*....|....*..
gi 1958680934 1222 CCCSFSPDGRILATAGRDRNLLCWDVK 1248
Cdd:COG2319    376 TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
840-1334 9.64e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.78  E-value: 9.64e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  840 AFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISSFAFLSDTALFLTT-FDGLLELWDLQHGCWVFQTKAHQYQ 918
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGaGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  919 ITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYT-HPKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKELGG 997
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  998 PGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVStvlflhaggrfltagedgkaqlwsgflgrprg 1077
Cdd:COG2319    161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR-------------------------------- 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1078 clgslylspalSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVAVSALVWlSPsvlvsgaeDGSLhgwmlrrn 1157
Cdd:COG2319    209 -----------SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF-SP--------DGRL-------- 260

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1158 slqslwlssvcqkpvlglaasqefLASASEDFTVRLWprqlltqphAVEELPCAAELRGHEGPVCCCSFSPDGRILATAG 1237
Cdd:COG2319    261 ------------------------LASGSADGTVRLW---------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1238 RDRNLLCWDVKVAQaplLIHTFSScHRDWITGCTWTKD-NILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVV--AV 1314
Cdd:COG2319    308 DDGTVRLWDLATGK---LLRTLTG-HTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAfsPD 383

                          490       500
                   ....*....|....*....|
gi 1958680934 1315 EEHIVSVSRDGTLKVWDRQG 1334
Cdd:COG2319    384 GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1129-1422 4.15e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.92  E-value: 4.15e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1129 VSALVWLSPS-VLVSGAEDGSLHGW------MLRRNSLQSLWLSSV--CqkpvlglaASQEFLASASEDFTVRLWPrqll 1199
Cdd:cd00200     12 VTCVAFSPDGkLLATGSGDGTIKVWdletgeLLRTLKGHTGPVRDVaaS--------ADGTYLASGSSDKTIRLWD---- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1200 tqphaVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKVAQaplLIHTFsSCHRDWITGCTWTKDNILI 1279
Cdd:cd00200     80 -----LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTL-RGHTDWVNSVAFSPDGTFV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1280 SCSS-DGSVGLWNPEAGQQLGQFPGHQSAVSAVVAV--EEHIVSVSRDGTLKVWD-RQGVELTSIPAHSGPISQCAAAle 1355
Cdd:cd00200    151 ASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDlSTGKCLGTLRGHENGVNSVAFS-- 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958680934 1356 prpagqpGSELLVVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAAAASEASGLLLT-SDNSSVRLWQ 1422
Cdd:cd00200    229 -------PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASgSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1132-1542 1.38e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 1.38e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1132 LVWLSPSVLVSGAEDGSLHGWMLRRNSLQSLWLSSVCQKPVLGLAASQEFLASASEDFTVRLWPRQLLTqphaveelpCA 1211
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA---------LL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1212 AELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVkvaQAPLLIHTFSScHRDWITGCTWTKD-NILISCSSDGSVGLW 1290
Cdd:COG2319     72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL---ATGLLLRTLTG-HTGAVRSVAFSPDgKTLASGSADGTVRLW 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1291 NPEAGQQLGQFPGHQSAVSAVV--AVEEHIVSVSRDGTLKVWD-RQGVELTSIPAHSGPISQCAAAleprPAGQpgselL 1367
Cdd:COG2319    148 DLATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK-----L 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1368 VVTVGLDGATKLWHPLLVCQIHTLQGHSGPVTAAAASEASGLLLT-SDNSSVRLWQIPKEADDTCKPRSSAVITAVAWAP 1446
Cdd:COG2319    219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASgSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1447 DGSLVVSGNEAGELTLW--QKAQAVATARAP-GRVSDLIWcSANAFFVLSANEN--VSEWQVELRKgstctnfrlyLKRV 1521
Cdd:COG2319    299 DGKLLASGSDDGTVRLWdlATGKLLRTLTGHtGAVRSVAF-SPDGKTLASGSDDgtVRLWDLATGE----------LLRT 367

                          410       420
                   ....*....|....*....|.
gi 1958680934 1522 LQEDLGVLTGMALAPDGQSLI 1542
Cdd:COG2319    368 LTGHTGAVTSVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1210-1494 8.56e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 8.56e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1210 CAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKVAQaplLIHTFSScHRDWITGCTWTKDNI-LISCSSDGSVG 1288
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKG-HTGPVRDVAASADGTyLASGSSDKTIR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1289 LWNPEAGQQLGQFPGHQSAVSAVVAVEEH--IVSVSRDGTLKVWD-RQGVELTSIPAHSGPISQCAAaleprpagqPGSE 1365
Cdd:cd00200     77 LWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAF---------SPDG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1366 LLVVTVGLDGATKLWHP-LLVCqIHTLQGHSGPVTAAAASEASGLLLT-SDNSSVRLWQIPKEA-DDTCKPRSSAViTAV 1442
Cdd:cd00200    148 TFVASSSQDGTIKLWDLrTGKC-VATLTGHTGEVNSVAFSPDGEKLLSsSSDGTIKLWDLSTGKcLGTLRGHENGV-NSV 225

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958680934 1443 AWAPDGSLVVSGNEAGELTLW--QKAQAVATARAP-GRVSDLIWcSANAFFVLSA 1494
Cdd:cd00200    226 AFSPDGYLLASGSEDGTIRVWdlRTGECVQTLSGHtNSVTSLAW-SPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 956-1331 2.93e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.33  E-value: 2.93e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  956 HPKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKELGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLA 1035
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1036 AFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSlYLSPALSVALNPDGDqvavgyrgdgikiyriss 1115
Cdd:cd00200     88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGT------------------ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1116 gpqeaqcqelnvavsalvwlspsvlvsgaedgslhgwmlrrnslqslwlssvcqkpvlglaasqeFLASASEDFTVRLWp 1195
Cdd:cd00200    149 -----------------------------------------------------------------FVASSSQDGTIKLW- 162

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1196 rqlltqphAVEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKVAQaplLIHTFSScHRDWITGCTWTKD 1275
Cdd:cd00200    163 --------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRG-HENGVNSVAFSPD 230

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958680934 1276 N-ILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVVAVEE--HIVSVSRDGTLKVWD 1331
Cdd:cd00200    231 GyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 837-1112 4.16e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 4.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  837 TAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISSFAFLSDTALFLTT-FDGLLELWDLQHGCWVFQTKAH 915
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECVRTLTGH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  916 QYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYT-HPKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKE 994
Cdd:cd00200     93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  995 LGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGR 1074
Cdd:cd00200    173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1958680934 1075 PRGCLgSLYLSPALSVALNPDGDQVAVGYRGDGIKIYR 1112
Cdd:cd00200    253 CVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 321-496 4.77e-32

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 123.57  E-value: 4.77e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  321 RLSLVIGQAGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAfnllRRLCTHLHQKLGEPSALPSTYRGLVW 400
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  401 ELQQKLLlksaqwlqpgqtlvLIIDGADKLVDHNGQ---------LISDWIPKSLPRRVHLVLSVSSDSG--LGETLQQS 469
Cdd:pfam05729   77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142

                          170       180
                   ....*....|....*....|....*..
gi 1958680934  470 QsayVVALGSLVPSSRAQLVREELALY 496
Cdd:pfam05729  143 R---YLEVRGFSESDRKQYVRKYFSDE 166
DUF5920 pfam19334
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ...
 2-46 3.07e-22

Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.


Pssm-ID: 466045  Cd Length: 203  Bit Score: 96.38  E-value: 3.07e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958680934    2 FIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGP 46
Cdd:pfam19334  157 FIAERGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSP 201
DUF4062 pfam13271
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ...
 59-167 1.60e-16

Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.


Pssm-ID: 463823  Cd Length: 78  Bit Score: 75.71  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934   59 RLFISSTFRDMHGERDLLMRSVLpalqarafphRISLHAIdlrwGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGY 138
Cdd:pfam13271    1 KVFISSTFYDLKEEREALIEALL----------ELGHIPV----GMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66

                           90       100
                   ....*....|....*....|....*....
gi 1958680934  139 TPpsydlpdhphfhwtqryPSGRSVTEME 167
Cdd:pfam13271   67 ID-----------------PDGISYTELE 78
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1210-1246 1.52e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.52e-09
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1958680934  1210 CAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWD 1246
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 1182-1356 1.86e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.22  E-value: 1.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1182 LASASEDFTVRLW--PRQLLTQ---PHAVEelpcaaeLRGHEGPVCCCSFSPDGR-ILATAGRDRNLLCWDVKVAQAPLL 1255
Cdd:PTZ00421    91 LFTASEDGTIMGWgiPEEGLTQnisDPIVH-------LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEV 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1256 IhtfsSCHRDWITGCTWTKD-NILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVS--AVVAVEEHIV-----SVSRDGTL 1327
Cdd:PTZ00421   164 I----KCHSDQITSLEWNLDgSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIitlgcSKSQQRQI 239

                          170       180
                   ....*....|....*....|....*....
gi 1958680934 1328 KVWDRQGVEltsIPAHSGPISQCAAALEP 1356
Cdd:PTZ00421   240 MLWDTRKMA---SPYSTVDLDQSSALFIP 265
WD40 pfam00400
WD domain, G-beta repeat;
1210-1246 2.57e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 2.57e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958680934 1210 CAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWD 1246
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1255-1291 9.67e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 9.67e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1958680934  1255 LIHTFSsCHRDWITGCTWTKD-NILISCSSDGSVGLWN 1291
Cdd:smart00320    4 LLKTLK-GHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 913-944 1.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 1.55e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958680934   913 KAHQYQITGCCLSPDRRLLATVCLGGYVKLWD 944
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 1089-1291 3.57e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 3.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1089 SVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQELNVA-------VSALVWLS--PSVLVSGAEDGSLHGWMLRRNSL 1159
Cdd:PLN00181   488 AIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVelasrskLSGICWNSyiKSQVASSNFEGVVQVWDVARSQL 567

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934 1160 QSLWLSSvcQKPVLGL---AASQEFLASASEDFTVRLWPrqlLTQPHAVEELPCAAElrghegpVCCCSFSPD-GRILAT 1235
Cdd:PLN00181   568 VTEMKEH--EKRVWSIdysSADPTLLASGSDDGSVKLWS---INQGVSIGTIKTKAN-------ICCVQFPSEsGRSLAF 635

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958680934 1236 AGRDRNLLCWDVKVAQAPLLIHTfssCHRDWITGCTWTKDNILISCSSDGSVGLWN 1291
Cdd:PLN00181   636 GSADHKVYYYDLRNPKLPLCTMI---GHSKTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1295-1331 4.62e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 4.62e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1958680934  1295 GQQLGQFPGHQSAVSAVV--AVEEHIVSVSRDGTLKVWD 1331
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1295-1331 5.75e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.75e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958680934 1295 GQQLGQFPGHQSAVSAVV--AVEEHIVSVSRDGTLKVWD 1331
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAfsPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1387-1421 1.11e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.11e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958680934  1387 QIHTLQGHSGPVTAAAASEASGLLLT-SDNSSVRLW 1421
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASgSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
1255-1291 1.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958680934 1255 LIHTFSsCHRDWITGCTWTKD-NILISCSSDGSVGLWN 1291
Cdd:pfam00400    3 LLKTLE-GHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 319-430 3.31e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 41.31  E-value: 3.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  319 HGRLSLVIGQAGQGKTAFLASLVSALkvPDQPNVAPFVFFHFSAArpdqclafNLLRRLCTHLHqklgePSALPSTYRGL 398
Cdd:COG3267     42 GGGFVVLTGEVGTGKTTLLRRLLERL--PDDVKVAYIPNPQLSPA--------ELLRAIADELG-----LEPKGASKADL 106

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958680934  399 VWELQQKLLLKSAQwlqpGQTLVLIIDGADKL 430
Cdd:COG3267    107 LRQLQEFLLELAAA----GRRVVLIIDEAQNL 134
WD40 pfam00400
WD domain, G-beta repeat;
913-944 3.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 3.35e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958680934  913 KAHQYQITGCCLSPDRRLLATVCLGGYVKLWD 944
Cdd:pfam00400    8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
1387-1421 4.04e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 4.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958680934 1387 QIHTLQGHSGPVTAAAASEASGLLLT-SDNSSVRLW 1421
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASgSDDGTVKVW 38
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 306-439 4.62e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 39.79  E-value: 4.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  306 RLLQDTVQQLMLPHGRLSLVIGQAGQGKTAFLASLVSALkVPDQPNVAPFVFFHFSAARP--DQCLAFNLLRRLCTH--- 380
Cdd:pfam13191   10 EQLLDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRAL-ERDGGYFLRGKCDENLPYSPllEALTREGLLRQLLDEles 88

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958680934  381 ---------LHQKLGEPSALPSTYRGLVWELQQKLLLKSAqwlQPGQTLVLIIDGADKLVDHNGQLIS 439
Cdd:pfam13191   89 slleawraaLLEALAPVPELPGDLAERLLDLLLRLLDLLA---RGERPLVLVLDDLQWADEASLQLLA 153
AAA_22 pfam13401
AAA domain;
319-430 7.08e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.48  E-value: 7.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958680934  319 HGRLSLVIGQAGQGKTAFLASLVSALKVPDqpnvAPFVFFhfsaarpdQCLAFNLLRRLCTHLHQKLGEPSALPSTYRGL 398
Cdd:pfam13401    4 GAGILVLTGESGTGKTTLLRRLLEQLPEVR----DSVVFV--------DLPSGTSPKDLLRALLRALGLPLSGRLSKEEL 71

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958680934  399 VWELQQKLllksaqwLQPGQTLVLIIDGADKL 430
Cdd:pfam13401   72 LAALQQLL-------LALAVAVVLIIDEAQHL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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