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Conserved domains on  [gi|1958709997|ref|XP_038951739|]
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acyl-CoA-binding domain-containing protein 5 isoform X9 [Rattus norvegicus]

Protein Classification

acyl-CoA-binding protein( domain architecture ID 10087334)

acyl-CoA-binding protein binds acyl-CoA esters and may play a role in housekeeping and/or trafficking

CATH:  1.20.80.10
Gene Ontology:  GO:0000062
PubMed:  16018771
SCOP:  4000745

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 45-132 1.57e-40

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


:

Pssm-ID: 238248  Cd Length: 85  Bit Score: 140.54  E-value: 1.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958709997  45 ETRFEAAVKVIQSLPKNgsfqPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEM 124
Cdd:cd00435     2 QEEFEAAAEKVKKLKTK----PSNEEKLQLYSLYKQATVGDCNTERPGMFDLKGRAKWDAWNSLKGMSKEDAMKAYIAKV 77


                  ....*...
gi 1958709997 125 KKIIETMP 132
Cdd:cd00435    78 EELIAKYA 85
 
Name Accession Description Interval E-value
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 45-132 1.57e-40

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 140.54  E-value: 1.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958709997  45 ETRFEAAVKVIQSLPKNgsfqPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEM 124
Cdd:cd00435     2 QEEFEAAAEKVKKLKTK----PSNEEKLQLYSLYKQATVGDCNTERPGMFDLKGRAKWDAWNSLKGMSKEDAMKAYIAKV 77


                  ....*...
gi 1958709997 125 KKIIETMP 132
Cdd:cd00435    78 EELIAKYA 85
ACBP pfam00887
Acyl CoA binding protein;
45-122 3.32e-35

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 126.17  E-value: 3.32e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958709997  45 ETRFEAAVKVIQSLPKngsfQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVE 122
Cdd:pfam00887   1 EEKFEAAAEFVKKLKS----KPSNEEKLELYGLYKQATVGDCNTPRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74
ACB COG4281
Acyl-CoA-binding protein [Lipid transport and metabolism];
45-128 5.01e-27

Acyl-CoA-binding protein [Lipid transport and metabolism];


Pssm-ID: 443422  Cd Length: 87  Bit Score: 104.16  E-value: 5.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958709997  45 ETRFEAAVKVIQSLPKngsfQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEM 124
Cdd:COG4281     5 QAAFEAAVARVKTLTE----RPDNDTLLKLYALYKQATEGDVTGKRPGMTDFVGRAKYDAWAQLKGMSKDEAMQQYIDLV 80


                  ....
gi 1958709997 125 KKII 128
Cdd:COG4281    81 NSLL 84
PTZ00458 PTZ00458
acyl CoA binding protein; Provisional
 48-127 2.55e-12

acyl CoA binding protein; Provisional


Pssm-ID: 185637  Cd Length: 90  Bit Score: 62.53  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958709997  48 FEAAVKVIQSLPKNGSFqpTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKI 127
Cdd:PTZ00458    5 FEECVSFINSLPKTVNL--SVEIKLDLYKYYKQSTVGNCNIKEPSMFKYQDRKKYEAWKSIENLNREDAKKRYVEIVTEL 82
 
Name Accession Description Interval E-value
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 45-132 1.57e-40

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 140.54  E-value: 1.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958709997  45 ETRFEAAVKVIQSLPKNgsfqPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEM 124
Cdd:cd00435     2 QEEFEAAAEKVKKLKTK----PSNEEKLQLYSLYKQATVGDCNTERPGMFDLKGRAKWDAWNSLKGMSKEDAMKAYIAKV 77


                  ....*...
gi 1958709997 125 KKIIETMP 132
Cdd:cd00435    78 EELIAKYA 85
ACBP pfam00887
Acyl CoA binding protein;
45-122 3.32e-35

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 126.17  E-value: 3.32e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958709997  45 ETRFEAAVKVIQSLPKngsfQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVE 122
Cdd:pfam00887   1 EEKFEAAAEFVKKLKS----KPSNEEKLELYGLYKQATVGDCNTPRPGMFDFKGKAKWDAWKKLGGMSKEEAMAKYVE 74
ACB COG4281
Acyl-CoA-binding protein [Lipid transport and metabolism];
45-128 5.01e-27

Acyl-CoA-binding protein [Lipid transport and metabolism];


Pssm-ID: 443422  Cd Length: 87  Bit Score: 104.16  E-value: 5.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958709997  45 ETRFEAAVKVIQSLPKngsfQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEM 124
Cdd:COG4281     5 QAAFEAAVARVKTLTE----RPDNDTLLKLYALYKQATEGDVTGKRPGMTDFVGRAKYDAWAQLKGMSKDEAMQQYIDLV 80


                  ....
gi 1958709997 125 KKII 128
Cdd:COG4281    81 NSLL 84
PTZ00458 PTZ00458
acyl CoA binding protein; Provisional
 48-127 2.55e-12

acyl CoA binding protein; Provisional


Pssm-ID: 185637  Cd Length: 90  Bit Score: 62.53  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958709997  48 FEAAVKVIQSLPKNGSFqpTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKI 127
Cdd:PTZ00458    5 FEECVSFINSLPKTVNL--SVEIKLDLYKYYKQSTVGNCNIKEPSMFKYQDRKKYEAWKSIENLNREDAKKRYVEIVTEL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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