NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958746883|ref|XP_038953754|]
View 

core-binding factor subunit beta isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CBF_beta super family cl03529
Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription ...
 2-113 1.18e-58

Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.


The actual alignment was detected with superfamily member pfam02312:

Pssm-ID: 396750  Cd Length: 166  Bit Score: 178.71  E-value: 1.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746883   2 AFVATGTNLSLQFFPASWQGEQRQTPsREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQQE 81
Cdd:pfam02312  56 AFVATGTNLQLQFEPNQTSGTQYHTP-GEECDFEKEPGKVHLKSRFIMNGVCVKWRGWIDLERLDGVGCLEFDEERAKIE 134

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958746883  82 DALAQQAFEEARRRTREFEDRDRSHREEMEAR 113
Cdd:pfam02312 135 DAVLREQIERYNQRLREFEERQRGYREEEEAA 166
 
Name Accession Description Interval E-value
CBF_beta pfam02312
Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription ...
 2-113 1.18e-58

Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.


Pssm-ID: 396750  Cd Length: 166  Bit Score: 178.71  E-value: 1.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746883   2 AFVATGTNLSLQFFPASWQGEQRQTPsREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQQE 81
Cdd:pfam02312  56 AFVATGTNLQLQFEPNQTSGTQYHTP-GEECDFEKEPGKVHLKSRFIMNGVCVKWRGWIDLERLDGVGCLEFDEERAKIE 134

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958746883  82 DALAQQAFEEARRRTREFEDRDRSHREEMEAR 113
Cdd:pfam02312 135 DAVLREQIERYNQRLREFEERQRGYREEEEAA 166
 
Name Accession Description Interval E-value
CBF_beta pfam02312
Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription ...
 2-113 1.18e-58

Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.


Pssm-ID: 396750  Cd Length: 166  Bit Score: 178.71  E-value: 1.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958746883   2 AFVATGTNLSLQFFPASWQGEQRQTPsREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQQE 81
Cdd:pfam02312  56 AFVATGTNLQLQFEPNQTSGTQYHTP-GEECDFEKEPGKVHLKSRFIMNGVCVKWRGWIDLERLDGVGCLEFDEERAKIE 134

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958746883  82 DALAQQAFEEARRRTREFEDRDRSHREEMEAR 113
Cdd:pfam02312 135 DAVLREQIERYNQRLREFEERQRGYREEEEAA 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH