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Conserved domains on  [gi|1958747600|ref|XP_038954019|]
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ribonucleoside-diphosphate reductase subunit M2-like [Rattus norvegicus]

Protein Classification

ribonucleoside-diphosphate reductase small subunit( domain architecture ID 10791385)

ribonucleoside-diphosphate reductase small subunit catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 71-390 0e+00

ribonucleoside-diphosphate reductase


:

Pssm-ID: 215272  Cd Length: 324  Bit Score: 623.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  71 EPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERF 150
Cdd:PLN02492    1 EPLLAENPDRFCMFPIKYPQIWEMYKKAEASFWTAEEVDLSADLKDWEKLTDDERHFISHVLAFFAASDGIVLENLAARF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 151 SQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIgDKEATYGERVVAFA 230
Cdd:PLN02492   81 MKEVQVPEARAFYGFQIAIENIHSEMYSLLLDTYIKDPKEKDRLFNAIETIPCVAKKADWALRWI-DSSASFAERLVAFA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 231 AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNAVRIEQEFLTEALP 310
Cdd:PLN02492  160 CVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEIVCEAVEIEKEFVCDALP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 311 VKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSN-----STENSFT 385
Cdd:PLN02492  240 CALVGMNADLMSQYIEFVADRLLVALGYEKVYNVVNPFDWMELISLQGKTNFFEKRVGEYQKAGVMSSlngggADNHVFS 319


                  ....*
gi 1958747600 386 LDADF 390
Cdd:PLN02492  320 LDEDF 324
 
Name Accession Description Interval E-value
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 71-390 0e+00

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 623.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  71 EPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERF 150
Cdd:PLN02492    1 EPLLAENPDRFCMFPIKYPQIWEMYKKAEASFWTAEEVDLSADLKDWEKLTDDERHFISHVLAFFAASDGIVLENLAARF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 151 SQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIgDKEATYGERVVAFA 230
Cdd:PLN02492   81 MKEVQVPEARAFYGFQIAIENIHSEMYSLLLDTYIKDPKEKDRLFNAIETIPCVAKKADWALRWI-DSSASFAERLVAFA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 231 AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNAVRIEQEFLTEALP 310
Cdd:PLN02492  160 CVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEIVCEAVEIEKEFVCDALP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 311 VKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSN-----STENSFT 385
Cdd:PLN02492  240 CALVGMNADLMSQYIEFVADRLLVALGYEKVYNVVNPFDWMELISLQGKTNFFEKRVGEYQKAGVMSSlngggADNHVFS 319


                  ....*
gi 1958747600 386 LDADF 390
Cdd:PLN02492  320 LDEDF 324
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
80-347 2.07e-156

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 441.17  E-value: 2.07e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  80 RFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEA 159
Cdd:pfam00268   1 RFNLNPIKYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 160 RCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSG 239
Cdd:pfam00268  81 RAFYGFQAFMENIHSESYSYILDTLGKDPEEIDELFNWIETNPALQKKAEWILKWYQDFDSDFLERLVAFAILEGIFFYS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 240 SFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLV-------HKPSEQRVKEIITNAVRIEQEFLTEALPVK 312
Cdd:pfam00268 161 GFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKeenpeleTKELKEEVYDLIKEAVELEKEFLDDALPVG 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1958747600 313 LIGMNCTLMKQYIEFVADRLMLELGFNKIFKVE-NP 347
Cdd:pfam00268 241 LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEvNP 276
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 81-356 1.05e-141

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 404.31  E-value: 1.05e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  81 FVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEAR 160
Cdd:cd01049     1 FNLNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 161 CFYGFQIAMENIHSEMYSLLIDTYIKDSkEREYLFNAIETMPCVKKKADWALRWIGD----KEATYGERVVAFAAVEGIF 236
Cdd:cd01049    81 AFYGFQAFMENIHSESYSYILDTLGKDE-ERDELFEAIETDPALKKKADWILRWYDNlddnTKESFAERLVAFAILEGIF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 237 FSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHK-------PSEQRVKEIITNAVRIEQEFLTEAL 309
Cdd:cd01049   160 FYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNEnpelfteEFKEEVYELIKEAVELEKEFARDLL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958747600 310 PVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKV--ENPFDFMENISL 356
Cdd:cd01049   240 PDGILGLNKEDMKQYIEYVANRRLENLGLEKLFNVedKNPFDWMELISD 288
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 69-377 5.65e-114

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 335.21  E-value: 5.65e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  69 EEEPLLRENP-RRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLV 147
Cdd:COG0208     1 LDEPIINGLTtNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 148 ERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDskeREYLFNAIETMPCVKKKADWALRWIGDKEATYG---- 223
Cdd:COG0208    81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLD---IDEIFNWIEENPALQKKAEFILKYYDDLGTRETkkdl 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 224 -ERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEQRVKEIIT 295
Cdd:COG0208   158 lKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINtireenpELFTEELKEEIYELLK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 296 NAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKV-ENPFDFMEN-ISLEGKTNFFEKRVGEYQRM 373
Cdd:COG0208   238 EAVELEKEYADDLFPDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGdVNPFPWMSEgLDLNKKTDFFETRVTEYQKG 317


                  ....
gi 1958747600 374 GVMS 377
Cdd:COG0208   318 GVES 321
 
Name Accession Description Interval E-value
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 71-390 0e+00

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 623.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  71 EPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERF 150
Cdd:PLN02492    1 EPLLAENPDRFCMFPIKYPQIWEMYKKAEASFWTAEEVDLSADLKDWEKLTDDERHFISHVLAFFAASDGIVLENLAARF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 151 SQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIgDKEATYGERVVAFA 230
Cdd:PLN02492   81 MKEVQVPEARAFYGFQIAIENIHSEMYSLLLDTYIKDPKEKDRLFNAIETIPCVAKKADWALRWI-DSSASFAERLVAFA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 231 AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNAVRIEQEFLTEALP 310
Cdd:PLN02492  160 CVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEIVCEAVEIEKEFVCDALP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 311 VKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSN-----STENSFT 385
Cdd:PLN02492  240 CALVGMNADLMSQYIEFVADRLLVALGYEKVYNVVNPFDWMELISLQGKTNFFEKRVGEYQKAGVMSSlngggADNHVFS 319


                  ....*
gi 1958747600 386 LDADF 390
Cdd:PLN02492  320 LDEDF 324
PTZ00211 PTZ00211
ribonucleoside-diphosphate reductase small subunit; Provisional
 64-390 0e+00

ribonucleoside-diphosphate reductase small subunit; Provisional


Pssm-ID: 240315 [Multi-domain]  Cd Length: 330  Bit Score: 599.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  64 TKPSIEEEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVN 143
Cdd:PTZ00211    5 MKENEEEEPLLKENPDRFVLFPIKYPDIWRMYKKAEASFWTAEEIDLGNDLKDWEKLNDGERHFIKHVLAFFAASDGIVL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 144 ENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIGDkEATYG 223
Cdd:PTZ00211   85 ENLAQRFMREVQVPEARCFYGFQIAMENIHSETYSLLIDTYITDEEEKDRLFHAIETIPAIKKKAEWAAKWINS-SNSFA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 224 ERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNAVRIEQE 303
Cdd:PTZ00211  164 ERLVAFAAVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYSHLKNKLPRERVQEIIKEAVEIERE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 304 FLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENS 383
Cdd:PTZ00211  244 FICDALPVDLIGMNSRLMAQYIEFVADRLLVALGVPKIYNSKNPFDWMDMISLQGKTNFFEKRVGEYQKAGVMAERTSKV 323


                  ....*..
gi 1958747600 384 FTLDADF 390
Cdd:PTZ00211  324 FSLDADF 330
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
80-347 2.07e-156

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 441.17  E-value: 2.07e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  80 RFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEA 159
Cdd:pfam00268   1 RFNLNPIKYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 160 RCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSG 239
Cdd:pfam00268  81 RAFYGFQAFMENIHSESYSYILDTLGKDPEEIDELFNWIETNPALQKKAEWILKWYQDFDSDFLERLVAFAILEGIFFYS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 240 SFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLV-------HKPSEQRVKEIITNAVRIEQEFLTEALPVK 312
Cdd:pfam00268 161 GFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKeenpeleTKELKEEVYDLIKEAVELEKEFLDDALPVG 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1958747600 313 LIGMNCTLMKQYIEFVADRLMLELGFNKIFKVE-NP 347
Cdd:pfam00268 241 LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEvNP 276
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 81-356 1.05e-141

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 404.31  E-value: 1.05e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  81 FVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEAR 160
Cdd:cd01049     1 FNLNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 161 CFYGFQIAMENIHSEMYSLLIDTYIKDSkEREYLFNAIETMPCVKKKADWALRWIGD----KEATYGERVVAFAAVEGIF 236
Cdd:cd01049    81 AFYGFQAFMENIHSESYSYILDTLGKDE-ERDELFEAIETDPALKKKADWILRWYDNlddnTKESFAERLVAFAILEGIF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 237 FSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHK-------PSEQRVKEIITNAVRIEQEFLTEAL 309
Cdd:cd01049   160 FYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNEnpelfteEFKEEVYELIKEAVELEKEFARDLL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958747600 310 PVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKV--ENPFDFMENISL 356
Cdd:cd01049   240 PDGILGLNKEDMKQYIEYVANRRLENLGLEKLFNVedKNPFDWMELISD 288
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 69-377 5.65e-114

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 335.21  E-value: 5.65e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  69 EEEPLLRENP-RRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLV 147
Cdd:COG0208     1 LDEPIINGLTtNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 148 ERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDskeREYLFNAIETMPCVKKKADWALRWIGDKEATYG---- 223
Cdd:COG0208    81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLD---IDEIFNWIEENPALQKKAEFILKYYDDLGTRETkkdl 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 224 -ERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEQRVKEIIT 295
Cdd:COG0208   158 lKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINtireenpELFTEELKEEIYELLK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 296 NAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKV-ENPFDFMEN-ISLEGKTNFFEKRVGEYQRM 373
Cdd:COG0208   238 EAVELEKEYADDLFPDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGdVNPFPWMSEgLDLNKKTDFFETRVTEYQKG 317


                  ....
gi 1958747600 374 GVMS 377
Cdd:COG0208   318 GVES 321
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 85-377 1.72e-48

ribonucleotide-diphosphate reductase subunit beta; Validated


Pssm-ID: 235968  Cd Length: 369  Bit Score: 168.25  E-value: 1.72e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  85 PIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWE---ALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARC 161
Cdd:PRK07209   53 PFKYKWAWEKYLAGCANHWMPQEVNMSRDIALWKspnGLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPECRQ 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 162 FYGFQIAMENIHSEMYSllidtYIKDS--KEREYLFNAIETMPCVKKKADWAL---RWIGDKEATYG---------ERVV 227
Cdd:PRK07209  133 YLLRQAFEEAIHTHAYQ-----YIVESlgLDEGEIFNMYHEVPSIRAKDEFLIpftRSLTDPNFKTGtpendqkllRNLI 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 228 AFAAV-EGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEQRVKEIITNAVR 299
Cdd:PRK07209  208 AFYCImEGIFFYVGFTQILSLGRQNKMTGIAEQYQYILRDESMHLNFGIDLINqiklenpHLWTAEFQAEIRELIKEAVE 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 300 IEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFK-VENPFDFM-ENISLEGKTNFFEKRVGEYQRMGVMS 377
Cdd:PRK07209  288 LEYRYARDTMPRGVLGLNASMFKDYLRFIANRRLQQIGLKPQYPgTENPFPWMsEMIDLKKEKNFFETRVIEYQTGGALS 367
nrdF PRK09614
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 85-390 9.17e-44

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 236591 [Multi-domain]  Cd Length: 324  Bit Score: 154.60  E-value: 9.17e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  85 PIEY---HDIWqmyKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARC 161
Cdd:PRK09614   16 KIEDpwdYEAW---KRLTANFWLPEEVPLSNDLKDWKKLSDEEKNLYTRVFGGLTLLDTLQNNNGMPNLMPDITTPEEEA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 162 FYGFQIAMENIHSEMYSLLIDTyIKDSKEREYLFNAIETMPCVKKKADWALRWIGD-KEATYGERVVAFAAVEGIFFSGS 240
Cdd:PRK09614   93 VLANIAFMEAVHAKSYSYIFST-LCSPEEIDEAFEWAEENPYLQKKADIIQDFYEPlKKKILRKAAVASVFLEGFLFYSG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 241 FASIFWLKKRGLMPGltfSNELIS---RDEGLHCDFACLMFKHLVHKPSE-------QRVKEIITNAVRIEQEFLTEALP 310
Cdd:PRK09614  172 FYYPLYLARQGKMTG---TAQIIRliiRDESLHGYYIGYLFQEGLEELPEleqeelkDEIYDLLYELYENEEAYTELLYD 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 311 VklIGmNCTLMKQYIEFVADRLMLELGFNKIF--KVENPFDFMENISLEG--KTNFFEKRVGEYQRMgvmsnSTENSFtl 386
Cdd:PRK09614  249 I--VG-LAEDVKKYIRYNANKRLMNLGLEPLFpeEEEVNPIWLNGLSNNAdeNHDFFEGKGTSYVKG-----ATEATE-- 318


                  ....
gi 1958747600 387 DADF 390
Cdd:PRK09614  319 DDDW 322
PRK12759 PRK12759
bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional
 85-381 6.78e-26

bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional


Pssm-ID: 139206 [Multi-domain]  Cd Length: 410  Bit Score: 107.80  E-value: 6.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  85 PIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWE--ALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCF 162
Cdd:PRK12759  102 PFNYPWAVDLTVKHEKAHWIEDEIDLSEDVTDWKngKITKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRNM 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 163 YGFQIAMENIHSEMYSLLIDTY-IKDSKereylFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF 241
Cdd:PRK12759  182 LGSFAAREGIHQRAYALLNDTLgLPDSE-----YHAFLEYKAMTDKIDFMMDADPTTRRGLGLCLAKTVFNEGVALFASF 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 242 ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEQRVKEIITNAVRIEQEFLTEALPVKLI 314
Cdd:PRK12759  257 AMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRiycqenpYIVDNEFKKEIYLMASKAVELEDRFIELAYELGTI 336

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958747600 315 -GMNCTLMKQYIEFVADRLMLELGFNKIFKVE-NPFDFMENIsLEG--KTNFFEKRVGEYQRMGVMSNSTE 381
Cdd:PRK12759  337 eGLKADEVKQYIRHITDRRLNQLGLKEIYNIEkNPLTWLEWI-LNGadHTNFFENRVTEYEVAGLTGSWDE 406
nrdF2 PRK13966
ribonucleotide-diphosphate reductase subunit beta; Provisional
 93-342 9.60e-09

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140022  Cd Length: 324  Bit Score: 56.27  E-value: 9.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  93 QMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNE-NLVERFSQEVQVTEARCFYGFQIaMEN 171
Cdd:PRK13966   26 EVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTvGAVSLIPDALTPHEEAVLTNIAF-MES 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 172 IHSEMYSLLIDTyIKDSKEREYLFNAIETMPCVKKKADWALRWIGDKEATygERVVAFAAVEG-IFFSGSFASIFWlKKR 250
Cdd:PRK13966  105 VHAKSYSQIFST-LCSTAEIDDAFRWSEENRNLQRKAEIVLQYYRGDEPL--KRKVASTLLESfLFYSGFYLPMYW-SSR 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 251 GLMPGLTFSNELISRDEGLHCDFACLMFKH---LVHKPSEQRVK--------EIITNAVRIEQEFLTEalpvklIGMNcT 319
Cdd:PRK13966  181 AKLTNTADMIRLIIRDEAVHGYYIGYKFQRglaLVDDVTRAELKdytyellfELYDNEVEYTQDLYDE------VGLT-E 253

                         250       260
                  ....*....|....*....|...
gi 1958747600 320 LMKQYIEFVADRLMLELGFNKIF 342
Cdd:PRK13966  254 DVKKFLRYNANKALMNLGYEALF 276
PRK13965 PRK13965
ribonucleotide-diphosphate reductase subunit beta; Provisional
 90-345 1.82e-08

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 184425 [Multi-domain]  Cd Length: 335  Bit Score: 55.55  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  90 DIWQmykKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIvnENLVERFSQ--EVQVTEARCFYGFQI 167
Cdd:PRK13965   37 EVWN---RVTQNFWLPEKVPVSNDLNSWRSLGEDWQQLITRTFTGLTLLDTV--QATVGDVAQipHSQTDHEQVIYTNFA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 168 AMENIHSEMYSLLIDTyIKDSKEREYLFNAIETMPCVKKKADWALR-WIGDKEAtygERVVAFAAVEGIFFSGSFASIFW 246
Cdd:PRK13965  112 FMVAIHARSYGTIFST-LCSSEQIEEAHEWVVSTESLQRRARVLIPyYTGDDPL---KSKVAAAMMPGFLLYGGFYLPFY 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 247 LKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNAVRIEQEFL-TEALPVKLIGMNCTLMKQYI 325
Cdd:PRK13965  188 LSARGKLPNTSDIIRLILRDKVIHNYYSGYKYQQKVARLSPEKQAEMKAFVFDLLYELIdLEKAYLRELYAGFDLAEDAI 267

                         250       260
                  ....*....|....*....|...
gi 1958747600 326 EFV---ADRLMLELGFNKIFKVE 345
Cdd:PRK13965  268 RFSlynAGKFLQNLGYESPFTEE 290
PRK08326 PRK08326
R2-like ligand-binding oxidase;
94-337 3.04e-08

R2-like ligand-binding oxidase;


Pssm-ID: 236242  Cd Length: 311  Bit Score: 54.62  E-value: 3.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  94 MYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVE---------RFSQEVQVT-----EA 159
Cdd:PRK08326   30 LFAKGNAKFWNPADIDFSRDAEDWEKLSDEERDYATRLCAQFIAGEEAVTLDIQPlisamaaegRLEDEMYLTqfafeEA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 160 RcfygfqiameniHSEMYSLLIDT---------YIKDSKEREYLFnaIETMPcvkkKADWALRwIGDKEATYGERVVAF- 229
Cdd:PRK08326  110 K------------HTEAFRRWFDAvgvtedlsvYTDDNPSYRQIF--YEELP----AALNRLS-TDPSPENQVRASVTYn 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 230 AAVEGIF-FSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLV------HKPSEQRVKEIITNAVR-IE 301
Cdd:PRK08326  171 HVVEGVLaETGYYAWRKICVTRGILPGLQELVRRIGDDERRHIAWGTYTCRRLVaaddsnWDVFEERMNELLPLALGlID 250

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1958747600 302 QEFLTEALPVKLIGMNCTLMkqyiEFVADRLMLELG 337
Cdd:PRK08326  251 EIFALYGDQIPFELSNDEFV----DYAADRGQRRLG 282
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 102-353 3.36e-08

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 54.97  E-value: 3.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 102 FWTAEEVDLSKDIQHWEALKPDERH-FISHvLAFFAASDGI----VN------------ENLVERFSqevqvtearcfyg 164
Cdd:PRK09101   48 FWRPEEVDVSRDRIDYQALPEHEKHiFISN-LKYQTLLDSIqgrsPNvallplvsipelETWIETWS------------- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 165 FQiamENIHSEMYSLLIDTYIKDSKEreyLFNAIETMPCVKKKA---------------DWALRWIGD-----KEATYGE 224
Cdd:PRK09101  114 FS---ETIHSRSYTHIIRNIVNDPSV---VFDDIVTNEEILKRAkdissyyddliemtsYYHLLGEGThtvngKTVTVSL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 225 R---------VVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHL-----------VHK 284
Cdd:PRK09101  188 RelkkklylcLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLMrsgkddpemaeIAE 267

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958747600 285 PSEQRVKEIITNAVRIEQEFlTEAL--PVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVE-NPFDFMEN 353
Cdd:PRK09101  268 ECKQECYDLFVQAAEQEKEW-ADYLfkDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRsNPIPWINA 338
RNRR2_Rv0233_like cd07911
Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Rv0233 is a Mycobacterium ...
 93-337 4.07e-08

Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Rv0233 is a Mycobacterium tuberculosis ribonucleotide reductase R2 protein with a heterodinuclear manganese/iron-carboxylate cofactor located in its metal center. The Rv0233-like family may represent a structural/functional counterpart of the evolutionary ancestor of the RNRR2's (Ribonucleotide Reductase, R2/beta subunit) and the bacterial multicomponent monooxygenases. RNRR2s belong to a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in prokaryotes and archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites.


Pssm-ID: 153120  Cd Length: 280  Bit Score: 53.89  E-value: 4.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  93 QMYKKAEA-SFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVE---------RFSQEVQVT----- 157
Cdd:cd07911    11 KLFEKGKRkGFWNPADIDFSQDREDWEQLSEEERDLALRLCAGFIAGEEAVTLDLLPlmmamaaegRLEEEMYLTqflfe 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 158 EARcfygfqiameniHSEMYSLLID---------TYIKDSKER---EYLFNAIEtmpcvKKKADWALRWIGDKEATYGER 225
Cdd:cd07911    91 EAK------------HTDFFRRWLDavgvsddlsDLHTAVYREpfyEALPYAEL-----RLYLDASPAAQVRASVTYNMI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 226 VVAFAAVEGIFfsgSFASIfwLKKRGLMPGLTFSNELISRDEGLHCDFAC-LMFKHLVHKPS-----EQRVKEIITNAVR 299
Cdd:cd07911   154 VEGVLAETGYY---AWRTI--CEKRGILPGMQEGIRRLGDDESRHIAWGTfTCRRLVAADDAnwdvfEERMNELVPHALG 228

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1958747600 300 IEQEfLTEALPVKLIGMNCTLMKQYiefVADRLMLELG 337
Cdd:cd07911   229 LIDE-IFELYDEMPFGLDPDELMQY---AVDQFQRRLG 262
nrdF1 PRK13967
ribonucleotide-diphosphate reductase subunit beta; Provisional
 93-270 2.86e-06

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140023  Cd Length: 322  Bit Score: 48.57  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600  93 QMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASD-GIVNENLVERFSQEVQVTEARCFYGFQIaMEN 171
Cdd:PRK13967   24 QVWERLTGNFWLPEKIPLSNDLASWQTLSSTEQQTTIRVFTGLTLLDtAQATVGAVAMIDDAVTPHEEAVLTNMAF-MES 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958747600 172 IHSEMYSLLIDTyIKDSKEREYLFNAIETMPCVKKKADWALRWIGDKEATygERVVAFAAVEG-IFFSGSFASIFWlKKR 250
Cdd:PRK13967  103 VHAKSYSSIFST-LCSTKQIDDAFDWSEQNPYLQRKAQIIVDYYRGDDAL--KRKASSVMLESfLFYSGFYLPMYW-SSR 178

                         170       180
                  ....*....|....*....|
gi 1958747600 251 GLMPGLTFSNELISRDEGLH 270
Cdd:PRK13967  179 GKLTNTADLIRLIIRDEAVH 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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