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Conserved domains on  [gi|1958807854|ref|XP_038955842|]
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N-alpha-acetyltransferase 10 isoform X5 [Rattus norvegicus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 28-122 6.85e-17

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 71.01  E-value: 6.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854  28 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 107
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96

                          90
                  ....*....|....*
gi 1958807854 108 SLHVRKSNRAALHLY 122
Cdd:pfam00583  97 FLEVAADNLAAIALY 111
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 28-122 6.85e-17

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 71.01  E-value: 6.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854  28 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 107
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96

                          90
                  ....*....|....*
gi 1958807854 108 SLHVRKSNRAALHLY 122
Cdd:pfam00583  97 FLEVAADNLAAIALY 111
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 54-122 9.15e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 59.67  E-value: 9.15e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807854  54 GYVLAKMEEDPDdvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLY 122
Cdd:COG0456     1 GFALLGLVDGGD---EAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALY 65
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-110 2.69e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 52.66  E-value: 2.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807854  42 SYIAEDEnGKIVGYVLAKMEEDPDDvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLH 110
Cdd:cd04301     1 FLVAEDD-GEIVGFASLSPDGSGGD--TAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 39-122 2.21e-06

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 44.15  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854  39 PQLSYIAEDeNGKIVGYVLAKMeedpdDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKyVSLHVRKSNRAA 118
Cdd:PRK03624   44 PSLFLVAEV-GGEVVGTVMGGY-----DGHRGWAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPK-INLQVREDNDAV 116


                  ....
gi 1958807854 119 LHLY 122
Cdd:PRK03624  117 LGFY 120
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 28-122 6.85e-17

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 71.01  E-value: 6.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854  28 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 107
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96

                          90
                  ....*....|....*
gi 1958807854 108 SLHVRKSNRAALHLY 122
Cdd:pfam00583  97 FLEVAADNLAAIALY 111
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 54-122 9.15e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 59.67  E-value: 9.15e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807854  54 GYVLAKMEEDPDdvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLY 122
Cdd:COG0456     1 GFALLGLVDGGD---EAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALY 65
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
3-117 4.48e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 59.33  E-value: 4.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854   3 IRNARPEDLMNMQHCNLLCLPENYQMKY-YFYHGLSWPQLSYIAEDeNGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSH 81
Cdd:COG3153     1 IRPATPEDAEAIAALLRAAFGPGREAELvDRLREDPAAGLSLVAED-DGEIVGHVALSPVDIDGEGPALLLGPLAVDPEY 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958807854  82 RRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRA 117
Cdd:COG3153    80 RGQGIGRALMRAALEAARER-GARAVVLLGDPSLLP 114
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-110 2.69e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 52.66  E-value: 2.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807854  42 SYIAEDEnGKIVGYVLAKMEEDPDDvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLH 110
Cdd:cd04301     1 FLVAEDD-GEIVGFASLSPDGSGGD--TAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 1-122 4.33e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 51.15  E-value: 4.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854   1 MNIRNARPEDLMNMQHcnlLCLPENYQMKYYFYhglswpqlsYIAEdENGKIVGYV-LAKMEEDpddvpHGHITSLAVKR 79
Cdd:COG1246     1 MTIRPATPDDVPAILE---LIRPYALEEEIGEF---------WVAE-EDGEIVGCAaLHPLDED-----LAELRSLAVHP 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958807854  80 SHRRLGLAQKLMDQA-SRAmiENFNAKYVSLHvrkSNRAALHLY 122
Cdd:COG1246    63 DYRGRGIGRRLLEALlAEA--RELGLKRLFLL---TTSAAIHFY 101
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-122 6.11e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.76  E-value: 6.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854  43 YIAEDeNGKIVGYVLAKMEEDPDDVPHGHItslAVKRSHRRLGLAQKLMDQASRAMienfNAKYVSLHVRKSNRAALHLY 122
Cdd:pfam13508   6 FVAED-DGKIVGFAALLPLDDEGALAELRL---AVHPEYRGQGIGRALLEAAEAAA----KEGGIKLLELETTNRAAAFY 77
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-122 8.40e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 50.76  E-value: 8.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854   1 MNIRNARPEDLMNMQHCNLLCLPENY-----------QMKYYFYHGLSWPQLSYIAEdENGKIVGYVLAKMEEDPDDVPH 69
Cdd:COG1247     2 MTIRPATPEDAPAIAAIYNEAIAEGTatfeteppseeEREAWFAAILAPGRPVLVAE-EDGEVVGFASLGPFRPRPAYRG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958807854  70 GHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLY 122
Cdd:COG1247    81 TAEESIYVDPDARGRGIGRALLEALIERARAR-GYRRLVAVVLADNEASIALY 132
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
56-122 6.13e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 46.83  E-value: 6.13e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807854  56 VLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKSNRAALHLY 122
Cdd:COG3393     2 LVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALAR-GARTPFLYVDADNPAARRLY 67
PRK03624 PRK03624
putative acetyltransferase; Provisional
 39-122 2.21e-06

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 44.15  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854  39 PQLSYIAEDeNGKIVGYVLAKMeedpdDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKyVSLHVRKSNRAA 118
Cdd:PRK03624   44 PSLFLVAEV-GGEVVGTVMGGY-----DGHRGWAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPK-INLQVREDNDAV 116


                  ....
gi 1958807854 119 LHLY 122
Cdd:PRK03624  117 LGFY 120
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
48-112 2.07e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 41.32  E-value: 2.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807854  48 ENGKIVGY--VLakmeedPDDVPHGHITSLAVKRSHRRLGLAQKLMdQASRAMIENFNAKYVSLHVR 112
Cdd:COG2153    41 DDGELVATarLL------PPGDGEAKIGRVAVLPEYRGQGLGRALM-EAAIEEARERGARRIVLSAQ 100
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 68-132 5.69e-05

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 39.24  E-value: 5.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807854  68 PHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnfNAKYVSLHVRKSNRAALHLYSNtLNFQSYR 132
Cdd:pfam08445  20 PGGELGALQTLPEHRRRGLGSRLVAALARGIAE--RGITPFAVVVAGNTPSRRLYEK-LGFRKID 81
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 47-110 1.13e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 39.18  E-value: 1.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807854  47 DENGKIVGYVLAKMeedpddvpHGHITSLAVKRSHRRLGLAQKLMDQA-SRAMIENFNAKYVSLH 110
Cdd:pfam13673  37 FEGGQIVGVIALRD--------RGHISLLFVDPDYQGQGIGKALLEAVeDYAEKDGIKLSELTVN 93
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 44-122 2.43e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 38.83  E-value: 2.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807854  44 IAEDENGKIVGYVLAkMEEDPDDvPHGHItSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRAALHLY 122
Cdd:COG1670    65 IEDKEDGELIGVVGL-YDIDRAN-RSAEI-GYWLAPAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVL 140
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
44-122 7.96e-04

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 37.60  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854  44 IAEDENGKIVGYVLAKMEEDPDdvphGHITSLAVKRSHRRLGLAQKLMdQASRAMIENFNAKyvSLHV--RKSNRAALHL 121
Cdd:PRK10975  105 LLRDASGQIQGFVTLRELNDTD----ARIGLLAVFPGAQGRGIGARLM-QAALNWCQARGLT--RLRVatQMGNLAALRL 177


                  .
gi 1958807854 122 Y 122
Cdd:PRK10975  178 Y 178
Eis COG4552
Predicted acetyltransferase [General function prediction only];
67-101 4.34e-03

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 35.64  E-value: 4.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958807854  67 VPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEN 101
Cdd:COG4552    70 VPMAGITGVAVAPEHRRRGVARALLREALAELRER 104
Acetyltransf_13 pfam13880
ESCO1/2 acetyl-transferase;
77-99 7.61e-03

ESCO1/2 acetyl-transferase;


Pssm-ID: 464015  Cd Length: 69  Bit Score: 33.22  E-value: 7.61e-03
                          10        20
                  ....*....|....*....|...
gi 1958807854  77 VKRSHRRLGLAQKLMDQASRAMI 99
Cdd:pfam13880  12 VSPSHRRKGIATRLLDAARSNFI 34
PRK07757 PRK07757
N-acetyltransferase;
1-94 7.96e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 34.40  E-value: 7.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807854   1 MNIRNARPEDLMNMQhcNLLclpenyqmKYYFYHGLSWPQ-LSYIAE--------DENGKIVGYV-LAKMEEDpddvpHG 70
Cdd:PRK07757    2 MEIRKARLSDVKAIH--ALI--------NVYAKKGLMLPRsLDELYEnirdfyvaEEEGEIVGCCaLHILWED-----LA 66

                          90       100
                  ....*....|....*....|....
gi 1958807854  71 HITSLAVKRSHRRLGLAQKLMDQA 94
Cdd:PRK07757   67 EIRSLAVSEDYRGQGIGRMLVEAC 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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