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Conserved domains on  [gi|1958652499|ref|XP_038956385|]
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zinc finger protein 418-like isoform X2 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 2.98e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.98e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958652499  34 CVTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENFTLISSL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-730 1.04e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 328 RPFECLKCGKAFVCHSSLLRHQRTHTGEWPYECSDCGRLFRQ--IVSLITHQRTHTTEKPYKCgqceksfSHKATLTVHQ 405
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLN-------SKSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 406 RVHTGEKPYHYEACGKSFSQSSGLN---NHSKIHTGEKPYECGECGL--CFRQRATLMKHLRTHTSERPYecRECGKFFK 480
Cdd:COG5048   105 ASSSSLSSSSSNSNDNNLLSSHSLPpssRDPQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSLHPPLPAN--SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 481 QYFYLIKHRRIHTTTEFYEYEQCVKSYTQKAtLIRHQRVHTGESPYKCEECGKAFEYKSRLNRHQRTHTgerPYECAKCG 560
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 561 KFFRERYDLAEHQKIH----------TKAKPYHCDQCGKCFSRGADLVKHQR--VHTGE--RPYTCGE--CGKTFRRSTH 624
Cdd:COG5048   259 ESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 625 LVQHRRIHTGEKPYHC--EACGKSFSQSS-----GLINHSKIHTGEKPYKC--GECGLCFRQRATLMKHLRTHTSERPYE 695
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1958652499 696 CR--ECGKFFKQYFYLIEHRRIHTTNEFYECEQFGKS 730
Cdd:COG5048   419 CKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
580-892 7.08e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 7.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 580 KPYHCDQCGKCFSRGADLVKHQRVHTGERPYTCG--ECGKTFRRSTHLVQHRRIHTGEKPYHCEA-CGKSFSQSSGLINH 656
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 657 SKIHTGEKPYKCGECGLCFRQRATLMKHLRTHTSERPYECRECGKFF---KQYFYLIEHRRIHttnefyecEQFGKSYTQ 733
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntPQSNSLHPPLPAN--------SLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 734 KTTLIRHQRVHTGESPYKCEECGKAYEYKSRLNRHQRTHTGErPYECAKCGKFFRERYDLAEHQKIHTKEKPYHCDQCGK 813
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 814 CFSRGADLVIHQRVHTDER-------PYTCGECGKTFRRSTHLVQHRR--IHTGE--KPYHC--EACGKSFSQSSGLINH 880
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330
                  ....*....|..
gi 1958652499 881 SKIHTGEKPYKC 892
Cdd:COG5048   343 ILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-311 3.04e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|...
gi 1958652499 289 LRIHQRRHTGEKPYKCGECGKSF 311
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 2.98e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.98e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958652499  34 CVTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENFTLISSL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
35-87 5.12e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 5.12e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499   35 VTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENFTLISSLVYRY-------KAEAEEKTC 87
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVpkpdlisQLEQGEEPW 60
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-72 4.41e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 4.41e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958652499  35 VTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENF-TLIS 72
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYeNLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-730 1.04e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 328 RPFECLKCGKAFVCHSSLLRHQRTHTGEWPYECSDCGRLFRQ--IVSLITHQRTHTTEKPYKCgqceksfSHKATLTVHQ 405
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLN-------SKSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 406 RVHTGEKPYHYEACGKSFSQSSGLN---NHSKIHTGEKPYECGECGL--CFRQRATLMKHLRTHTSERPYecRECGKFFK 480
Cdd:COG5048   105 ASSSSLSSSSSNSNDNNLLSSHSLPpssRDPQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSLHPPLPAN--SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 481 QYFYLIKHRRIHTTTEFYEYEQCVKSYTQKAtLIRHQRVHTGESPYKCEECGKAFEYKSRLNRHQRTHTgerPYECAKCG 560
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 561 KFFRERYDLAEHQKIH----------TKAKPYHCDQCGKCFSRGADLVKHQR--VHTGE--RPYTCGE--CGKTFRRSTH 624
Cdd:COG5048   259 ESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 625 LVQHRRIHTGEKPYHC--EACGKSFSQSS-----GLINHSKIHTGEKPYKC--GECGLCFRQRATLMKHLRTHTSERPYE 695
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1958652499 696 CR--ECGKFFKQYFYLIEHRRIHTTNEFYECEQFGKS 730
Cdd:COG5048   419 CKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
580-892 7.08e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 7.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 580 KPYHCDQCGKCFSRGADLVKHQRVHTGERPYTCG--ECGKTFRRSTHLVQHRRIHTGEKPYHCEA-CGKSFSQSSGLINH 656
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 657 SKIHTGEKPYKCGECGLCFRQRATLMKHLRTHTSERPYECRECGKFF---KQYFYLIEHRRIHttnefyecEQFGKSYTQ 733
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntPQSNSLHPPLPAN--------SLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 734 KTTLIRHQRVHTGESPYKCEECGKAYEYKSRLNRHQRTHTGErPYECAKCGKFFRERYDLAEHQKIHTKEKPYHCDQCGK 813
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 814 CFSRGADLVIHQRVHTDER-------PYTCGECGKTFRRSTHLVQHRR--IHTGE--KPYHC--EACGKSFSQSSGLINH 880
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330
                  ....*....|..
gi 1958652499 881 SKIHTGEKPYKC 892
Cdd:COG5048   343 ILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
848-873 8.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958652499 848 HLVQHRRIHTGEKPYHCEACGKSFSQ 873
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 8.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958652499 624 HLVQHRRIHTGEKPYHCEACGKSFSQ 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-311 3.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|...
gi 1958652499 289 LRIHQRRHTGEKPYKCGECGKSF 311
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 2.98e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.98e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958652499  34 CVTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENFTLISSL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
35-87 5.12e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 5.12e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499   35 VTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENFTLISSLVYRY-------KAEAEEKTC 87
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVpkpdlisQLEQGEEPW 60
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-72 4.41e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 4.41e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958652499  35 VTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENF-TLIS 72
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYeNLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-730 1.04e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 328 RPFECLKCGKAFVCHSSLLRHQRTHTGEWPYECSDCGRLFRQ--IVSLITHQRTHTTEKPYKCgqceksfSHKATLTVHQ 405
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLN-------SKSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 406 RVHTGEKPYHYEACGKSFSQSSGLN---NHSKIHTGEKPYECGECGL--CFRQRATLMKHLRTHTSERPYecRECGKFFK 480
Cdd:COG5048   105 ASSSSLSSSSSNSNDNNLLSSHSLPpssRDPQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSLHPPLPAN--SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 481 QYFYLIKHRRIHTTTEFYEYEQCVKSYTQKAtLIRHQRVHTGESPYKCEECGKAFEYKSRLNRHQRTHTgerPYECAKCG 560
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 561 KFFRERYDLAEHQKIH----------TKAKPYHCDQCGKCFSRGADLVKHQR--VHTGE--RPYTCGE--CGKTFRRSTH 624
Cdd:COG5048   259 ESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 625 LVQHRRIHTGEKPYHC--EACGKSFSQSS-----GLINHSKIHTGEKPYKC--GECGLCFRQRATLMKHLRTHTSERPYE 695
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1958652499 696 CR--ECGKFFKQYFYLIEHRRIHTTNEFYECEQFGKS 730
Cdd:COG5048   419 CKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
580-892 7.08e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 7.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 580 KPYHCDQCGKCFSRGADLVKHQRVHTGERPYTCG--ECGKTFRRSTHLVQHRRIHTGEKPYHCEA-CGKSFSQSSGLINH 656
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 657 SKIHTGEKPYKCGECGLCFRQRATLMKHLRTHTSERPYECRECGKFF---KQYFYLIEHRRIHttnefyecEQFGKSYTQ 733
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntPQSNSLHPPLPAN--------SLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 734 KTTLIRHQRVHTGESPYKCEECGKAYEYKSRLNRHQRTHTGErPYECAKCGKFFRERYDLAEHQKIHTKEKPYHCDQCGK 813
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 814 CFSRGADLVIHQRVHTDER-------PYTCGECGKTFRRSTHLVQHRR--IHTGE--KPYHC--EACGKSFSQSSGLINH 880
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330
                  ....*....|..
gi 1958652499 881 SKIHTGEKPYKC 892
Cdd:COG5048   343 ILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-882 3.36e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 3.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 498 YEYEQCVKSYTQKATLIRHQRVHTGESPYKCEECGKAFEYKSRLN--RHQRTHTGERPYECAKCG---KFFRERYDLAE- 571
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLplsNSKASSSSLSSs 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 572 ----------------HQKIHTKAKPYH------CDQCGKCFSRGADLVKHQ-RVHTGERPYTCGECGKTFRRSTHlvqH 628
Cdd:COG5048   114 ssnsndnnllsshslpPSSRDPQLPDLLsisnlrNNPLPGNNSSSVNTPQSNsLHPPLPANSLSKDPSSNLSLLIS---S 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 629 RRIHTGEKPYHCEACGKSFSQSSGLINHSKIHTgEKPYKCGECGLCFRQRATLMKHLRTHTSERPYECRECGKFFK---- 704
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptas 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 705 ------QYFYLIEHRRIHTtneFYECEQFGKSYTQKTTLIRHQR--VHTGES--PYKCEE--CGKAYEYKSRLNRHQRTH 772
Cdd:COG5048   270 sqssspNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 773 TGERPYEC-------AKCGKFFRERYDLAEHQKIHTKEKPYHCDQCGKCFSRGADLVI--HQRVHTDERP--YTCGECGK 841
Cdd:COG5048   347 TSISPAKEkllnsssKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPynCKNPPCSK 426

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1958652499 842 TFRRSTHLVQHRRIHTGEKPYHCEACgKSFSQSSGLINHSK 882
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-658 1.26e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 271 NRPYECHVCGKWFGQKATLRIHQRRHTGEKPYKCG--ECGKSFCQISKLSEHCRVHSGERPFECLKCG---KAFVCHSSL 345
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 346 lrhqRTHTGEWPYECSDCGRLFRQIVSLITHQRTHTTEKPYKC---------GQCEKSFSHKATLTVH---------QRV 407
Cdd:COG5048   111 ----SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssVNTPQSNSLHPPLPANslskdpssnLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 408 HTGEKPYHYEACGKSFSQSS------GLNNHSKIHTGEKPYECGECGLCFRQRATLMKHLRTHTSERPYECRECGKFFK- 480
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSssysipSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLp 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 481 ---------QYFYLIKHRRIhttTEFYEYEQCVKSYTQKATLIRHQR--VHTGES--PYKCEE--CGKAFEYKSRLNRHQ 545
Cdd:COG5048   267 tassqssspNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652499 546 RTHTGERPYEC-------AKCGKFFRERYDLAEHQKIHTKAKPYHCD--QCGKCFSRGADLVKHQRVHTGERP--YTCGE 614
Cdd:COG5048   344 LLHTSISPAKEkllnsssKFSPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1958652499 615 CGKTFRRSTHLVQHRRIHTGEKPYHCEACgKSFSQSSGLINHSK 658
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
848-873 8.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958652499 848 HLVQHRRIHTGEKPYHCEACGKSFSQ 873
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 8.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958652499 624 HLVQHRRIHTGEKPYHCEACGKSFSQ 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
830-880 2.34e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 2.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958652499 830 DERPYTCGECGKTFRRSTHLVQHRRIHTGEKPYHCEACGKSFSQSSGLINH 880
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-481 2.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|....*
gi 1958652499 457 LMKHLRTHTSERPYECRECGKFFKQ 481
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
681-705 2.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|....*
gi 1958652499 681 LMKHLRTHTSERPYECRECGKFFKQ 705
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-537 2.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|....*
gi 1958652499 513 LIRHQRVHTGESPYKCEECGKAFEY 537
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-311 3.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|...
gi 1958652499 289 LRIHQRRHTGEKPYKCGECGKSF 311
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
792-817 3.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.33e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958652499 792 DLAEHQKIHTKEKPYHCDQCGKCFSR 817
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-563 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....
gi 1958652499 540 RLNRHQRTHTGERPYECAKCGKFF 563
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
764-787 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....
gi 1958652499 764 RLNRHQRTHTGERPYECAKCGKFF 787
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
737-761 9.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|....*
gi 1958652499 737 LIRHQRVHTGESPYKCEECGKAYEY 761
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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