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Conserved domains on  [gi|1958654872|ref|XP_038957306|]
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protein prune homolog 2 isoform X14 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BNIP2 pfam12496
Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; This domain family is found in ...
2778-2889 1.44e-42

Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.


:

Pssm-ID: 463609  Cd Length: 135  Bit Score: 152.92  E-value: 1.44e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958654872 2778 RRIKLTAPNINLSLDQSEGSILS-------DDNLDSpDEIDINVDELDTPDEADSFEYPGH------EDPM----ANRSS 2840
Cdd:pfam12496    1 KRKRLVAPELSLSLDQSEDSFLSaflspspDDFSDT-DDLDINVDDLETPSDSDSLEFPENgnelewEDDLprlgRGSGP 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958654872 2841 GQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVIEPYRRVISHG 2889
Cdd:pfam12496   80 SEAAESLPQYTAEDEVDDSgRRWRTFRIGEQEHRIDMKVIEPYKRVLSHG 129
DHHA2 pfam02833
DHHA2 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ...
214-277 4.80e-05

DHHA2 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus.


:

Pssm-ID: 460719  Cd Length: 124  Bit Score: 45.27  E-value: 4.80e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958654872  214 SQLSaqGLSLEQTMLKDLKELSDGEIKVAISTVNMTLEDCLLH--SNITSDLKAFTDKFGFDVLIL 277
Cdd:pfam02833    6 SDLS--GLSAEEILRKDYKEFTMGGVKVGISQVETVDEEWLLErkDELLAALEKFAERKGLDLLVL 69
 
Name Accession Description Interval E-value
BNIP2 pfam12496
Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; This domain family is found in ...
2778-2889 1.44e-42

Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.


Pssm-ID: 463609  Cd Length: 135  Bit Score: 152.92  E-value: 1.44e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958654872 2778 RRIKLTAPNINLSLDQSEGSILS-------DDNLDSpDEIDINVDELDTPDEADSFEYPGH------EDPM----ANRSS 2840
Cdd:pfam12496    1 KRKRLVAPELSLSLDQSEDSFLSaflspspDDFSDT-DDLDINVDDLETPSDSDSLEFPENgnelewEDDLprlgRGSGP 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958654872 2841 GQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVIEPYRRVISHG 2889
Cdd:pfam12496   80 SEAAESLPQYTAEDEVDDSgRRWRTFRIGEQEHRIDMKVIEPYKRVLSHG 129
DHHA2 pfam02833
DHHA2 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ...
214-277 4.80e-05

DHHA2 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus.


Pssm-ID: 460719  Cd Length: 124  Bit Score: 45.27  E-value: 4.80e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958654872  214 SQLSaqGLSLEQTMLKDLKELSDGEIKVAISTVNMTLEDCLLH--SNITSDLKAFTDKFGFDVLIL 277
Cdd:pfam02833    6 SDLS--GLSAEEILRKDYKEFTMGGVKVGISQVETVDEEWLLErkDELLAALEKFAERKGLDLLVL 69
 
Name Accession Description Interval E-value
BNIP2 pfam12496
Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; This domain family is found in ...
2778-2889 1.44e-42

Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.


Pssm-ID: 463609  Cd Length: 135  Bit Score: 152.92  E-value: 1.44e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958654872 2778 RRIKLTAPNINLSLDQSEGSILS-------DDNLDSpDEIDINVDELDTPDEADSFEYPGH------EDPM----ANRSS 2840
Cdd:pfam12496    1 KRKRLVAPELSLSLDQSEDSFLSaflspspDDFSDT-DDLDINVDDLETPSDSDSLEFPENgnelewEDDLprlgRGSGP 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958654872 2841 GQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVIEPYRRVISHG 2889
Cdd:pfam12496   80 SEAAESLPQYTAEDEVDDSgRRWRTFRIGEQEHRIDMKVIEPYKRVLSHG 129
DHHA2 pfam02833
DHHA2 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ...
214-277 4.80e-05

DHHA2 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus.


Pssm-ID: 460719  Cd Length: 124  Bit Score: 45.27  E-value: 4.80e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958654872  214 SQLSaqGLSLEQTMLKDLKELSDGEIKVAISTVNMTLEDCLLH--SNITSDLKAFTDKFGFDVLIL 277
Cdd:pfam02833    6 SDLS--GLSAEEILRKDYKEFTMGGVKVGISQVETVDEEWLLErkDELLAALEKFAERKGLDLLVL 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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