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Conserved domains on  [gi|1958749072|ref|XP_038957637|]
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leukocyte surface antigen CD53 isoform X1 [Rattus norvegicus]

Protein Classification

tetraspanin family protein( domain architecture ID 548)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886|GO:0097197
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 3-81 2.86e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03164:

Pssm-ID: 351888 [Multi-domain]  Cd Length: 86  Bit Score: 138.77  E-value: 2.86e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072   3 KKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGPPSSCPSGA---DVQGCYKKGQAWFHSNFLY 79
Cdd:cd03164     5 KKLNNYVKEGLTDSLEQYHKDNNTSEAWDMIQSNLQCCGINGTTDWGSGVPSSCCSSDteyKVEGCYKKLKNWFESNFLY 84


                  ..
gi 1958749072  80 IG 81
Cdd:cd03164    85 TG 86
 
Name Accession Description Interval E-value
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 3-81 2.86e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 138.77  E-value: 2.86e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072   3 KKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGPPSSCPSGA---DVQGCYKKGQAWFHSNFLY 79
Cdd:cd03164     5 KKLNNYVKEGLTDSLEQYHKDNNTSEAWDMIQSNLQCCGINGTTDWGSGVPSSCCSSDteyKVEGCYKKLKNWFESNFLY 84


                  ..
gi 1958749072  80 IG 81
Cdd:cd03164    85 TG 86
Tetraspanin pfam00335
Tetraspanin family;
1-103 2.95e-10

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 54.63  E-value: 2.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072   1 MKKKINTLVAEGLNDSIQHYHSD-----NSTRMAWDFIQSQLQCCGvngssdwisgppsscpsgadvqGCYKKGQAWFHS 75
Cdd:pfam00335  98 YRDKLSGLLSNWLKKSLEDGYRDwldlySCLNSALDSLQSEFGCCG----------------------GCKEKLLEWLRK 155

                          90       100
                  ....*....|....*....|....*...
gi 1958749072  76 NFLYIGIVTICVCVIQVLGMSFALTLNC 103
Cdd:pfam00335 156 NLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 3-81 2.86e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 138.77  E-value: 2.86e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072   3 KKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGPPSSCPSGA---DVQGCYKKGQAWFHSNFLY 79
Cdd:cd03164     5 KKLNNYVKEGLTDSLEQYHKDNNTSEAWDMIQSNLQCCGINGTTDWGSGVPSSCCSSDteyKVEGCYKKLKNWFESNFLY 84


                  ..
gi 1958749072  80 IG 81
Cdd:cd03164    85 TG 86
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 1-76 6.51e-20

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 77.16  E-value: 6.51e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072   1 MKKKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISG---PPSSCPSGADV--------QGCYKKG 69
Cdd:cd03127     3 YRDQLESLVSDTLNDAWDEYYVDDDFQEAMDALQSTFECCGVNGPTDYLDLrllVPSSCCKGTDGncglnlytEGCLEKL 82


                  ....*..
gi 1958749072  70 QAWFHSN 76
Cdd:cd03127    83 VDFLRSN 89
Tetraspanin pfam00335
Tetraspanin family;
1-103 2.95e-10

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 54.63  E-value: 2.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072   1 MKKKINTLVAEGLNDSIQHYHSD-----NSTRMAWDFIQSQLQCCGvngssdwisgppsscpsgadvqGCYKKGQAWFHS 75
Cdd:pfam00335  98 YRDKLSGLLSNWLKKSLEDGYRDwldlySCLNSALDSLQSEFGCCG----------------------GCKEKLLEWLRK 155

                          90       100
                  ....*....|....*....|....*...
gi 1958749072  76 NFLYIGIVTICVCVIQVLGMSFALTLNC 103
Cdd:pfam00335 156 NLKIIGAGVIALGVIQLLGIILACCLCC 183
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 13-76 5.48e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 51.98  E-value: 5.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072  13 LNDSIQHYHSDN--STRMAWDFIQSQLQCCGVNGSSDW--ISGP---PSSC------------PSGADVQGCYKKGQAWF 73
Cdd:cd03165    15 LKEGLELYGTRNnrGLTNAWDITQTEFRCCGVTNYTDWyeVLGEnrvPDSCcqedsqdcgrnpTELWWKTGCYEKVQQWL 94


                  ...
gi 1958749072  74 HSN 76
Cdd:cd03165    95 VDN 97
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 2-56 5.85e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 49.40  E-value: 5.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958749072   2 KKKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGP-------PSSC 56
Cdd:cd03166     4 RDKVMSEFNDSFNQMISNYNKTNDFRKILDRMQKDLKCCGANNYTDWENIPsldtdsvPDSC 65
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 17-77 1.81e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 45.84  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072  17 IQHYHS--DNSTRM-AWDFIQSQLQCCGVNGSSDWISG-----------PPSSCPSGADV-------------------- 62
Cdd:cd03160    20 IQNYGGnpENKTAEeAWDYVQFQLQCCGWTGPQDWTDNsliknsseplyPCSCCNSSATAdsprpskgfceapasldwpv 99

                          90
                  ....*....|....*..
gi 1958749072  63 --QGCYKKGQAWFHSNF 77
Cdd:cd03160   100 yqEGCMEKLQSWLNENL 116
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 5-68 7.21e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 43.89  E-value: 7.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749072   5 INTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGP-------PSSC------------------PSG 59
Cdd:cd03161     7 IKGTFLRTYNEAVSNYNGDDERSDAVDTVQRTLHCCGVENYTDWLNSPyflekgiPLSCcknrsdcspqdlknltkaATK 86


                  ....*....
gi 1958749072  60 ADVQGCYKK 68
Cdd:cd03161    87 VYQQGCFTL 95
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 2-48 8.41e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 43.88  E-value: 8.41e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958749072   2 KKKINTLVAEGLNDSIQH-YHSDNSTRM--AWDFIQSQLQCCGVNGSSDW 48
Cdd:cd03155     4 YQQLEDELKESLKRTMQEnYGQSGEEALtlTVDELQQEFKCCGSNNYTDW 53
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 19-49 1.48e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 43.29  E-value: 1.48e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958749072  19 HYHSDNST----RMAWDFIQSQLQCCGVNGSSDWI 49
Cdd:cd03156    20 NYGNYNSTgdaiTSTWNRVMIELKCCGVNGPTDFV 54
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 4-56 3.66e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 42.41  E-value: 3.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958749072   4 KINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGP----------PSSC 56
Cdd:cd03163     7 KVEDELNPSIDKVFNKYNGTNAESRAVDYLQRQLQCCGIHNYTDWENTPwfkesknnsvPLSC 69
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 2-48 5.49e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 39.21  E-value: 5.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958749072   2 KKKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDW 48
Cdd:cd03158     4 SNQTIDLLEENIRKAIVHYYDDLDLQNIIDFVQKEFKCCGGDDYRDW 50
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 11-48 1.35e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 38.56  E-value: 1.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958749072  11 EGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDW 48
Cdd:cd03159    13 EFLNNNIRAYRDDIDLQNLIDFLQEYWQCCGARGPDDW 50
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 12-65 4.18e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 37.06  E-value: 4.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958749072  12 GLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGPPSSCpSGADVQGC 65
Cdd:cd03167    14 TLRLAIAHYQDDPDLRFLIDQVQLGLQCCGASSYQDWQQNLYFNC-SSPGVQAC 66
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 11-56 1.55e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 35.09  E-value: 1.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958749072  11 EGLNDSIQH-----YHSDNSTRMAWDFIQSQLQCCG-VNGSSDWISGPPSSC 56
Cdd:cd03154    13 NELKEKNTKllsllGQNAKSVKKSLEKFQKELKCCGlVNGADDWGNDIPASC 64
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 27-58 3.83e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


Pssm-ID: 239410  Cd Length: 103  Bit Score: 34.13  E-value: 3.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958749072  27 RMAWDFIQSQLQCCGVNGSSDWIS-----GPPSSCPS 58
Cdd:cd03157    32 THAWNSFQTEFKCCGVIYFTDWLEmtemeWPPDSCCS 68
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 1-48 5.58e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 34.33  E-value: 5.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958749072   1 MKKKINTLVAEGLNDSIQHYHSDNSTRMAW-----DFIQSQLQCCGVNGSSDW 48
Cdd:cd03162     3 MRGSLEESLKTGLKNAMKFYKDTDTPGRCFlkktiDMLQIEFQCCGNNGYRDW 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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