|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
448-1285 |
2.43e-167 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 520.50 E-value: 2.43e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 448 GSYPDMHS-------SSASSPVPDRAPEPNST----LVPTPTAAQPAKV--AKPFGYgYPTLQPAYQNAAapPTTAHPSG 514
Cdd:COG5028 7 GVYPQAQSqvhtgaaSSKKSARPHRAYANFSAgqmgMPPYTTPPLQQQSrrQIDQAA-TAMHNTGANNPA--PSVMSPAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 515 PAYSGYPQQYPGvhqlssglgGLSLQSSPQPES-LRPVNL--TQEKNI----LPATPIWAPVPNLSAELSKLNCSPDSFR 587
Cdd:COG5028 84 QSQQKFSSPYGG---------SMADGTAPKPTNpLVPVDLfeDQPPPIsdlfLPPPPIVPPLTTNFVGSEQSNCSPKYVR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 588 CTLTSIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVP 662
Cdd:COG5028 155 STMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNICRSKNDVP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 663 EEFlYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPG-D 739
Cdd:COG5028 235 EGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNfD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 740 SRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFINTRETHSALGP 818
Cdd:COG5028 314 PRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 819 ALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvhHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYS 898
Cdd:COG5028 393 ALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDLFLTSEDYI 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 899 DLASLACMSKYSAGCIFYYPSFHSThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLA 978
Cdd:COG5028 466 DVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFS 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 979 NINPDAGFAVQLSIEESLAdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVS 1058
Cdd:COG5028 545 TMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALN 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1059 SSLSDARDALVNAVVDPLSAYSSAVSSVPRSTLTA-PSSLKLLPLYVLALLKQKAFRTGtSTRLDDRVYAMCQMKSQPLV 1137
Cdd:COG5028 624 SSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALNRLTSLPLK 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1138 HLMKMIHPNLYRIDRLTDEGAIHVNDRVVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWIGKGCDSNFIENVLGYPDFGS 1217
Cdd:COG5028 703 QLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSD 781
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958750089 1218 IPQKMTHLPELDTLPSERTRSFVTWLRDSRP-LSPVLHVVKD--ESPARTDFFQHLVEDRTEAALSYYEFL 1285
Cdd:COG5028 782 IPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
701-944 |
1.36e-130 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 400.50 E-value: 1.36e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 701 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 779
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 780 TPDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 859
Cdd:cd01479 81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 860 STKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHsTHNPSQAEKLQKDLKRY 939
Cdd:cd01479 161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239
|
....*
gi 1958750089 940 LTRKI 944
Cdd:cd01479 240 LTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
701-940 |
6.40e-107 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 337.30 E-value: 6.40e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 701 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 780
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 781 PDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 857
Cdd:pfam04811 81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 858 RSSTKVVHHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSTHnpsQAEKLQKDL 936
Cdd:pfam04811 161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237
|
....
gi 1958750089 937 KRYL 940
Cdd:pfam04811 238 QRYF 241
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
668-1294 |
9.97e-34 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 142.14 E-value: 9.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 668 NPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTVLCQSL---LENLdKLPgd 739
Cdd:PTZ00395 921 NLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP-- 988
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 740 sRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNM 805
Cdd:PTZ00395 989 -QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSV 1067
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 806 FINTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVHHLgpatdFYKKLALDCSG 883
Cdd:PTZ00395 1068 STTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYA 1142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 884 QQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIFYYPSFhsthnpsqaeKLQKDLKR-YL-------TRKIGFEAVMRIR 953
Cdd:PTZ00395 1143 FNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENF----------LWQKDYKEiYMnimdtltSEDIAYCCELKLR 1212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 954 CTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRIRVHTLCLPVV 1029
Cdd:PTZ00395 1213 YSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLT 1292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1030 SSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDPLSAYSSAVSSVPRST-----LTAPSSLKLLPLYV 1104
Cdd:PTZ00395 1293 SSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAILFSYRINCASSahsgqLILPDTLKLLPLFT 1366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1105 LALLKQKAfrTGTSTRLDDRVYAMCQMKSQPLVHLMKMIHPNLY--RIDRLTDE-GAIHVNDRVVpQPPLQKLSAEKLTR 1181
Cdd:PTZ00395 1367 SSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKIYS 1443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1182 EGAFLMDCGSVFYIWIGKGCDSNFIENVLgypdfGSIP-QKMTHLPELDTLPS----ERTRSFVTWLRDSRPLSPVLhVV 1256
Cdd:PTZ00395 1444 NGIYLLDACTHFYLYFGFHSDANFAKEIV-----GDIPtEKNAHELNLTDTPNaqkvQRIIKNLSRIHHFNKYVPLV-MV 1517
|
650 660 670
....*....|....*....|....*....|....*...
gi 1958750089 1257 KDESPARTDFFQHLVEDRTEAALSYYEFLIHVQQQVCK 1294
Cdd:PTZ00395 1518 APKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2-483 |
6.54e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 6.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 2 SAPAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQmqvpsgyglPHQNYMAPSGHYSQGPGKMTSLPLDNQCENYYS 81
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP---------PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQ 2681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 82 RPY-TAPTQNVGTPSSANQPGAQlmyGRGPSAPHMGASMPGPFQGAPASASHSYPSASQPYSSlgnrYSSPATYSATASV 160
Cdd:PHA03247 2682 RPRrRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP----PAVPAGPATPGGP 2754
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 161 ASQGYPSTCSHyPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARPLKESYSGPSTAVAYPSRPPPPPSQHQQQQ 240
Cdd:PHA03247 2755 ARPARPPTTAG-PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 241 QQQQQQQQQSHSGYSSLPWSGpGLPPAQDSLIRNqmgslaiPNSHPAINVADSLSCPITENVQPPKPSSVVATVLPGPSS 320
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGG-SVAPGGDVRRRP-------PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 321 TRMPPAPSHPVGPVPSAPPPPEQMQTKVR---------FPVPSHAGCGKWRPVNRDPGLWGTYIGRM---RERPPekfan 388
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPppprpqpplAPTTDPAGAGEPSGAVPQPWLGALVPGRVavpRFRVP----- 2980
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 389 kgmQYGDYVNNQASSTPTPLSSASDDEEEEDEDEEAGVDSSSTTSSASPLPNSYDALEGGS-----YPDMHSSSASSPVP 463
Cdd:PHA03247 2981 ---QPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDadslfDSDSERSDLEALDP 3057
|
490 500
....*....|....*....|
gi 1958750089 464 DrAPEPNSTLVPTPTAAQPA 483
Cdd:PHA03247 3058 L-PPEPHDPFAHEPDPATPE 3076
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
110-495 |
8.75e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 8.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 110 PSAPHMGASMPGPFQGAPASASHSYPSASQPYSSLGNRYSSPATYSATASVASQGYPStcSHYPISTVSNVVYP-NVSYP 188
Cdd:pfam03154 187 PPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPS--PHPPLQPMTQPPPPsQVSPQ 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 189 SLPASEPYGQMftsqsaPPPARPLKesySGPSTaVAYPSRPPPPPSQHQQQQQQQQQQQQQSHSGYSSlpwSGPGLPPAQ 268
Cdd:pfam03154 265 PLPQPSLHGQM------PPMPHSLQ---TGPSH-MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ---QRIHTPPSQ 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 269 DSLIRNQ-------------MGSLAIPNSHPAINVADSLSCPITENVQPPKPSSVVATVLPGPS-------STRMPPA-- 326
Cdd:pfam03154 332 SQLQSQQppreqplppaplsMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPAlkplsslSTHHPPSah 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 327 PSHPVGPVPSAPPPPEQMQTKVRFPVPSHAGCGKWRPVNrdpglwgtyiGRMRERPPEK-FANKGMQYGDYVNNQASSTP 405
Cdd:pfam03154 412 PPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPT----------SGLHQVPSQSpFPQHPFVPGGPPPITPPSGP 481
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 406 TPLSSASDDEEEEDEDEEAGVDSSSTTSSASPLPNSYDALEGgsyPDMHSSSASSPVPDRAPEPNSTLVPTPT-AAQPAK 484
Cdd:pfam03154 482 PTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEA---LDEAEEPESPPPPPRSPSPEPTVVNTPShASQSAR 558
|
410
....*....|.
gi 1958750089 485 VAKPFGYGYPT 495
Cdd:pfam03154 559 FYKHLDRGYNS 569
|
|
| GEL |
smart00262 |
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ... |
1160-1201 |
9.43e-03 |
|
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.
Pssm-ID: 214590 [Multi-domain] Cd Length: 90 Bit Score: 36.89 E-value: 9.43e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1958750089 1160 HVNDRVVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIGKGC 1201
Cdd:smart00262 4 RVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
448-1285 |
2.43e-167 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 520.50 E-value: 2.43e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 448 GSYPDMHS-------SSASSPVPDRAPEPNST----LVPTPTAAQPAKV--AKPFGYgYPTLQPAYQNAAapPTTAHPSG 514
Cdd:COG5028 7 GVYPQAQSqvhtgaaSSKKSARPHRAYANFSAgqmgMPPYTTPPLQQQSrrQIDQAA-TAMHNTGANNPA--PSVMSPAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 515 PAYSGYPQQYPGvhqlssglgGLSLQSSPQPES-LRPVNL--TQEKNI----LPATPIWAPVPNLSAELSKLNCSPDSFR 587
Cdd:COG5028 84 QSQQKFSSPYGG---------SMADGTAPKPTNpLVPVDLfeDQPPPIsdlfLPPPPIVPPLTTNFVGSEQSNCSPKYVR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 588 CTLTSIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVP 662
Cdd:COG5028 155 STMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNICRSKNDVP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 663 EEFlYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPG-D 739
Cdd:COG5028 235 EGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNfD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 740 SRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFINTRETHSALGP 818
Cdd:COG5028 314 PRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 819 ALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvhHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYS 898
Cdd:COG5028 393 ALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDLFLTSEDYI 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 899 DLASLACMSKYSAGCIFYYPSFHSThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLA 978
Cdd:COG5028 466 DVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFS 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 979 NINPDAGFAVQLSIEESLAdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVS 1058
Cdd:COG5028 545 TMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALN 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1059 SSLSDARDALVNAVVDPLSAYSSAVSSVPRSTLTA-PSSLKLLPLYVLALLKQKAFRTGtSTRLDDRVYAMCQMKSQPLV 1137
Cdd:COG5028 624 SSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALNRLTSLPLK 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1138 HLMKMIHPNLYRIDRLTDEGAIHVNDRVVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWIGKGCDSNFIENVLGYPDFGS 1217
Cdd:COG5028 703 QLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSD 781
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958750089 1218 IPQKMTHLPELDTLPSERTRSFVTWLRDSRP-LSPVLHVVKD--ESPARTDFFQHLVEDRTEAALSYYEFL 1285
Cdd:COG5028 782 IPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
701-944 |
1.36e-130 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 400.50 E-value: 1.36e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 701 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 779
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 780 TPDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 859
Cdd:cd01479 81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 860 STKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHsTHNPSQAEKLQKDLKRY 939
Cdd:cd01479 161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239
|
....*
gi 1958750089 940 LTRKI 944
Cdd:cd01479 240 LTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
701-940 |
6.40e-107 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 337.30 E-value: 6.40e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 701 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 780
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 781 PDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 857
Cdd:pfam04811 81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 858 RSSTKVVHHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSTHnpsQAEKLQKDL 936
Cdd:pfam04811 161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237
|
....
gi 1958750089 937 KRYL 940
Cdd:pfam04811 238 QRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
701-938 |
9.54e-104 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 328.44 E-value: 9.54e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 701 PQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 780
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 781 PDSLLVNLYESKELIKDLLNALPNMF--INTRETHSALGPALQAAFKLMSPT--GGRVSVFQTQLPSLGAGLLQSREDPN 856
Cdd:cd01468 81 PDRFLVPLSECKKVIHDLLEQLPPMFwpVPTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 857 QRSSTKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSthnPSQAEKLQKDL 936
Cdd:cd01468 161 PIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQA---PNDGSKFKQDL 237
|
..
gi 1958750089 937 KR 938
Cdd:cd01468 238 QR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
668-1294 |
9.97e-34 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 142.14 E-value: 9.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 668 NPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTVLCQSL---LENLdKLPgd 739
Cdd:PTZ00395 921 NLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP-- 988
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 740 sRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNM 805
Cdd:PTZ00395 989 -QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSV 1067
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 806 FINTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVHHLgpatdFYKKLALDCSG 883
Cdd:PTZ00395 1068 STTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYA 1142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 884 QQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIFYYPSFhsthnpsqaeKLQKDLKR-YL-------TRKIGFEAVMRIR 953
Cdd:PTZ00395 1143 FNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENF----------LWQKDYKEiYMnimdtltSEDIAYCCELKLR 1212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 954 CTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRIRVHTLCLPVV 1029
Cdd:PTZ00395 1213 YSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLT 1292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1030 SSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDPLSAYSSAVSSVPRST-----LTAPSSLKLLPLYV 1104
Cdd:PTZ00395 1293 SSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAILFSYRINCASSahsgqLILPDTLKLLPLFT 1366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1105 LALLKQKAfrTGTSTRLDDRVYAMCQMKSQPLVHLMKMIHPNLY--RIDRLTDE-GAIHVNDRVVpQPPLQKLSAEKLTR 1181
Cdd:PTZ00395 1367 SSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKIYS 1443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1182 EGAFLMDCGSVFYIWIGKGCDSNFIENVLgypdfGSIP-QKMTHLPELDTLPS----ERTRSFVTWLRDSRPLSPVLhVV 1256
Cdd:PTZ00395 1444 NGIYLLDACTHFYLYFGFHSDANFAKEIV-----GDIPtEKNAHELNLTDTPNaqkvQRIIKNLSRIHHFNKYVPLV-MV 1517
|
650 660 670
....*....|....*....|....*....|....*...
gi 1958750089 1257 KDESPARTDFFQHLVEDRTEAALSYYEFLIHVQQQVCK 1294
Cdd:PTZ00395 1518 APKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
945-1029 |
3.00e-33 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 123.42 E-value: 3.00e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 945 GFEAVMRIRCTKGLSMHTFHGNFFVRS-TDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRIRVHT 1023
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*.
gi 1958750089 1024 LCLPVV 1029
Cdd:pfam08033 81 VALPVT 86
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
584-1063 |
2.11e-22 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 104.19 E-value: 2.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 584 DSFRCTLTSIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSfIDQRR--WKCNLCYRVNDV 661
Cdd:COG5047 10 DGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCH-IDERNqsWICPFCNQRNTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 662 PEEflYNPLTRSYGEPhkRPEVQNSTVEFIASsdymlRPPQ-PAVYLFVLDVshnAVEAGYLTVLCQSLLENLDKLPGDS 740
Cdd:COG5047 89 PPQ--YRDISNANLPL--ELLPQSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 741 RtrIGFMTFDSTIHF----------------------YNLQE--GLSQPQMLIV--SDIDDVFLPTPDSLLVNLYESKEL 794
Cdd:COG5047 157 L--VGLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGfeSKISGIGQFASSRFLLPTQQCEFK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 795 IKDLLNAL-PNMF--INTRETHSALGPALQAAFKLMSPT----GGRVSVFQTQLPSLGAGLLQSRE--DP---NQRSSTK 862
Cdd:COG5047 235 LLNILEQLqPDPWpvPAGKRPLRCTGSALNIASSLLEQCfpnaGCHIVLFAGGPCTVGPGTVVSTElkEPmrsHHDIESD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 863 VVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSTHNPSQAEK-LQKDLKRYLt 941
Cdd:COG5047 315 SAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRiFNRDSEGYL- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 942 rKIGFEAVMRIRCTKGLSMHTFHGN---------------FFVRSTDLLSLANINPDAGFAVQLSIEESLADTS------ 1000
Cdd:COG5047 394 -KMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALYFEIALGAASGSaqrpae 472
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958750089 1001 -LVCFQTalLYTSSKGERRIRVHTLCLPVVSSLADV-YAGVDVQAAICLLANMAVDRSVSSSLSD 1063
Cdd:COG5047 473 aYIQFIT--TYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIAAFKAETEDIID 535
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
1040-1141 |
1.82e-18 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 81.78 E-value: 1.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 1040 DVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDPLSA-YSSAVSSVPRSTLTAPSSLKLLPLYVLALLKQKAFRTGTS 1118
Cdd:pfam04815 1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAyRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNS 80
|
90 100
....*....|....*....|...
gi 1958750089 1119 TRLDDRVYAMCQMKSQPLVHLMK 1141
Cdd:pfam04815 81 SPSDERAYARHLLLSLPVEELLL 103
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
628-664 |
1.12e-15 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 71.71 E-value: 1.12e-15
10 20 30
....*....|....*....|....*....|....*...
gi 1958750089 628 IVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVPEE 664
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
584-1068 |
4.57e-14 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 77.29 E-value: 4.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 584 DSFRCTLTSIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIvRCRSCRTYINPF--VSFiDQRRWKCNLCYRVNDV 661
Cdd:PLN00162 10 DGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 662 PeeflynpltRSY---GEPHKRPEV--QNSTVEFiASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTvlcQSLLENLDKL 736
Cdd:PLN00162 88 P---------PHYssiSETNLPAELfpQYTTVEY-TLPPGSGGAPSPPVFVFVVDTCMIEEELGALK---SALLQAIALL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 737 PGDSrtRIGFMTFDSTIHFYNL------------------------QEGLS----QPQMLIVSDIDDVFLPTP-DSLLVN 787
Cdd:PLN00162 155 PENA--LVGLITFGTHVHVHELgfsecsksyvfrgnkevskdqileQLGLGgkkrRPAGGGIAGARDGLSSSGvNRFLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 788 LYESKELIKDLLNALPNMFINTRETHSAL---GPALQAAFKLM---SP-TGGRVSVFqTQLPS-LGAGLLQSREDPNQRS 859
Cdd:PLN00162 233 ASECEFTLNSALEELQKDPWPVPPGHRPArctGAALSVAAGLLgacVPgTGARIMAF-VGGPCtEGPGAIVSKDLSEPIR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 860 STK-----VVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSthnpsqaEKLQK 934
Cdd:PLN00162 312 SHKdldkdAAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGH-------SVFKD 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 935 DLKRYLTR------KIGFEAVMRIRCTKGL----------SMH----------TFHGNffvrsTDLLSLANINPDAGFAV 988
Cdd:PLN00162 385 SLRRVFERdgegslGLSFNGTFEVNCSKDVkvqgaigpcaSLEkkgpsvsdteIGEGG-----TTAWKLCGLDKKTSLAV 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 989 --QLSIEESLADTSL---VCFQTALLYTSSKGERRIRVHTLCLPVV--SSLADVYAGVDVQAAICLLANMAVDRSVSssl 1061
Cdd:PLN00162 460 ffEVANSGQSNPQPPgqqFFLQFLTRYQHSNGQTRLRVTTVTRRWVegSSSEELVAGFDQEAAAVVMARLASHKMET--- 536
|
....*..
gi 1958750089 1062 SDARDAL 1068
Cdd:PLN00162 537 EEEFDAT 543
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
1165-1240 |
1.26e-09 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 55.78 E-value: 1.26e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958750089 1165 VVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIGKGcdSNFIENVLGYPDFGSIP-QKMTHLPELDTLP-SERTRSFV 1240
Cdd:pfam00626 1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDdDERFPLPEVIRVPqGKEPARFL 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2-483 |
6.54e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 6.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 2 SAPAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQmqvpsgyglPHQNYMAPSGHYSQGPGKMTSLPLDNQCENYYS 81
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP---------PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQ 2681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 82 RPY-TAPTQNVGTPSSANQPGAQlmyGRGPSAPHMGASMPGPFQGAPASASHSYPSASQPYSSlgnrYSSPATYSATASV 160
Cdd:PHA03247 2682 RPRrRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP----PAVPAGPATPGGP 2754
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 161 ASQGYPSTCSHyPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARPLKESYSGPSTAVAYPSRPPPPPSQHQQQQ 240
Cdd:PHA03247 2755 ARPARPPTTAG-PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 241 QQQQQQQQQSHSGYSSLPWSGpGLPPAQDSLIRNqmgslaiPNSHPAINVADSLSCPITENVQPPKPSSVVATVLPGPSS 320
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGG-SVAPGGDVRRRP-------PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 321 TRMPPAPSHPVGPVPSAPPPPEQMQTKVR---------FPVPSHAGCGKWRPVNRDPGLWGTYIGRM---RERPPekfan 388
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPppprpqpplAPTTDPAGAGEPSGAVPQPWLGALVPGRVavpRFRVP----- 2980
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 389 kgmQYGDYVNNQASSTPTPLSSASDDEEEEDEDEEAGVDSSSTTSSASPLPNSYDALEGGS-----YPDMHSSSASSPVP 463
Cdd:PHA03247 2981 ---QPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDadslfDSDSERSDLEALDP 3057
|
490 500
....*....|....*....|
gi 1958750089 464 DrAPEPNSTLVPTPTAAQPA 483
Cdd:PHA03247 3058 L-PPEPHDPFAHEPDPATPE 3076
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
121-570 |
3.36e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 121 GPFQGAPASASHSYPSASQPYSSLGNRYSSPAtysATASVASQGYPstcshyPISTVSNV-VYPNVSYPSLPASEPYGQM 199
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA---VTSRARRPDAP------PQSARPRApVDDRGDPRGPAPPSPLPPD 2620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 200 FTSQSAPPPA-RPLKESYSGPSTAVAYPSRPPPPPSQHQQQQQQQQQQQQQSHSGYSSLP--WSGPGLPPAQDSLirnqm 276
Cdd:PHA03247 2621 THAPDPPPPSpSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqrPRRRAARPTVGSL----- 2695
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 277 GSLAIPNSHPainvadslscPITENVQPPKPSSVVATVLPGPSSTRMPPAPSHpvgpvpsappppeqmqtkvrfPVPSHA 356
Cdd:PHA03247 2696 TSLADPPPPP----------PTPEPAPHALVSATPLPPGPAAARQASPALPAA---------------------PAPPAV 2744
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 357 GCGKWRPVNRDPglwgtyigrmRERPPekfankgmqygdyvnnqasSTPTPLSSASDDEEEededeeAGVDSSSTTSSAS 436
Cdd:PHA03247 2745 PAGPATPGGPAR----------PARPP-------------------TTAGPPAPAPPAAPA------AGPPRRLTRPAVA 2789
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 437 PLPNSYDALEGGSYPDMHSSSASSPVPDRAPEPN-STLVPTPTAAQPAKVAKPFGYGYPTLQPAYQNA------------ 503
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASpAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApggdvrrrppsr 2869
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958750089 504 AAPPTTAHPSGPAYSGYPQQYPGVHQLSSGLGGLSLQSSPQPESLRPVnLTQEKNILPATPIWAPVP 570
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP-QPQPQPPPPPQPQPPPPP 2935
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
448-608 |
5.47e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 448 GSYPDMHSSSASSPVPDRAPEPNSTLVPTPTAAQPAKVAKPfgygYPTLQPAyqNAAAPPTTAHPSGPAYSGYPQQYPGv 527
Cdd:PHA03247 2693 GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP----ALPAAPA--PPAVPAGPATPGGPARPARPPTTAG- 2765
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 528 hqLSSGLGGLSLQSSPQPESLRPVNLTQEKNILPATPIWAPVPNLSAELSKLNCSPDSFRCTLTSIPQTQALLNKAKLPL 607
Cdd:PHA03247 2766 --PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843
|
.
gi 1958750089 608 G 608
Cdd:PHA03247 2844 G 2844
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
3-211 |
7.00e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.74 E-value: 7.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 3 APAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQMQVPSGyglPHQNYMAPSGHYSQGPGKMTSLPLDNQCENYYSR 82
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAG---AAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG 665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 83 PYTAPTQNVGTPSSANQPGAQLMYGRGPSAPHMGASMPGPFQGAPASASHSYPSASQpysslgnrySSPATYSATASVAS 162
Cdd:PRK07764 666 GDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPP---------QAAQGASAPSPAAD 736
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1958750089 163 QGYPstcshyPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARP 211
Cdd:PRK07764 737 DPVP------LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
110-495 |
8.75e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 8.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 110 PSAPHMGASMPGPFQGAPASASHSYPSASQPYSSLGNRYSSPATYSATASVASQGYPStcSHYPISTVSNVVYP-NVSYP 188
Cdd:pfam03154 187 PPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPS--PHPPLQPMTQPPPPsQVSPQ 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 189 SLPASEPYGQMftsqsaPPPARPLKesySGPSTaVAYPSRPPPPPSQHQQQQQQQQQQQQQSHSGYSSlpwSGPGLPPAQ 268
Cdd:pfam03154 265 PLPQPSLHGQM------PPMPHSLQ---TGPSH-MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ---QRIHTPPSQ 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 269 DSLIRNQ-------------MGSLAIPNSHPAINVADSLSCPITENVQPPKPSSVVATVLPGPS-------STRMPPA-- 326
Cdd:pfam03154 332 SQLQSQQppreqplppaplsMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPAlkplsslSTHHPPSah 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 327 PSHPVGPVPSAPPPPEQMQTKVRFPVPSHAGCGKWRPVNrdpglwgtyiGRMRERPPEK-FANKGMQYGDYVNNQASSTP 405
Cdd:pfam03154 412 PPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPT----------SGLHQVPSQSpFPQHPFVPGGPPPITPPSGP 481
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750089 406 TPLSSASDDEEEEDEDEEAGVDSSSTTSSASPLPNSYDALEGgsyPDMHSSSASSPVPDRAPEPNSTLVPTPT-AAQPAK 484
Cdd:pfam03154 482 PTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEA---LDEAEEPESPPPPPRSPSPEPTVVNTPShASQSAR 558
|
410
....*....|.
gi 1958750089 485 VAKPFGYGYPT 495
Cdd:pfam03154 559 FYKHLDRGYNS 569
|
|
| GEL |
smart00262 |
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ... |
1160-1201 |
9.43e-03 |
|
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.
Pssm-ID: 214590 [Multi-domain] Cd Length: 90 Bit Score: 36.89 E-value: 9.43e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1958750089 1160 HVNDRVVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIGKGC 1201
Cdd:smart00262 4 RVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
|
|
| |
