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Conserved domains on  [gi|1958763150|ref|XP_038961436|]
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actin-related protein 5 isoform X1 [Rattus norvegicus]

Protein Classification

acetate and sugar kinases/Hsc70/actin family protein( domain architecture ID 99298)

acetate and sugar kinases/Hsc70/actin (ASKHA) family protein catalyzes phosphoryl transfer from ATP to their respective substrates

CATH:  3.30.420.40
Gene Ontology:  GO:0000166
PubMed:  8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
 1-424 7.96e-127

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


:

Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 371.52  E-value: 7.96e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   1 MMSELLFECYRIPKVAYGIDSLFSFYHNMPKNALSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLL 80
Cdd:cd10211   111 LMSELLFECYGVPSVAYGIDSLFSYYHNQPQGDPSDGLVISSGYSTTHVIPVLNGRLDLSQCKRINLGGFHATDYLQRLL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  81 QLKYPGHLAAITLSRMEEILQEHSYIAEDYAAELQKWRCPDYYENNVHKMQLPFsskllgstltaeekqerrqqqlrrlq 160
Cdd:cd10211   191 QLKYPTHPSAITLSRAEELVHEHCYVAEDYDEELKKWEDPEYYEENVRKIQLPF-------------------------- 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 161 elnarrreeklqldqerlerllyvqelledgqmdqfhkalielnmdspeelqsyiqkltlaveqakqkilqaeanlevdv 240
Cdd:cd10211       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 241 vdskpetpdleplepsledvenindfeplfseetpevekpqvtttvqpvfnlaayhqlfvgterirapeiifqpsligee 320
Cdd:cd10211       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 321 qaGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDH 400
Cdd:cd10211   245 --GLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEKELRAIRPFGSPFNVVRAKDPVLDAWRGAAKWALDS 322

                         410       420
                  ....*....|....*....|....
gi 1958763150 401 lEDSGAWVTRKDYEEKGGEYLKEH 424
Cdd:cd10211   323 -TFEKVWITKQEYEEKGGEYLKEH 345
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 193-414 4.13e-06

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd10212:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 424  Bit Score: 48.95  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 193 MDQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQAEANLEVDVVDSKPETPdleplepsLEDVENINdFEPLfse 272
Cdd:cd10212   226 IQQFKSTMLQVSEKDLFELERYYKEQADIYAKQQEQLKQMDQQLQYTALTGSPNNP--------LVQKKNFL-FKPL--- 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 273 etpeveKPQVTTTVQPVFNLAAYhqlfvgterirapeiIFQPSLIGEE---QAGIAETLHYVLDRYPKAVQDTLVQNVFL 349
Cdd:cd10212   294 ------NKTLTLDLKECYQFAEY---------------LFKPQLISDKfspEDGLGPLMAKSVKKAPEQVYSLLLTNVII 352

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 350 TGGNVMYPGMKARVEKELLEMRPFQ--SSFQVQLASNPVLDAWYGARDWALDHLEDSGAWVTRKDYE 414
Cdd:cd10212   353 TGSTSLIEGMEQRIIKELSIRFPQYklTTFANQVMMDRKIQGWLGALTMANLPSWSLGKWYSKEDYE 419
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
 1-424 7.96e-127

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 371.52  E-value: 7.96e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   1 MMSELLFECYRIPKVAYGIDSLFSFYHNMPKNALSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLL 80
Cdd:cd10211   111 LMSELLFECYGVPSVAYGIDSLFSYYHNQPQGDPSDGLVISSGYSTTHVIPVLNGRLDLSQCKRINLGGFHATDYLQRLL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  81 QLKYPGHLAAITLSRMEEILQEHSYIAEDYAAELQKWRCPDYYENNVHKMQLPFsskllgstltaeekqerrqqqlrrlq 160
Cdd:cd10211   191 QLKYPTHPSAITLSRAEELVHEHCYVAEDYDEELKKWEDPEYYEENVRKIQLPF-------------------------- 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 161 elnarrreeklqldqerlerllyvqelledgqmdqfhkalielnmdspeelqsyiqkltlaveqakqkilqaeanlevdv 240
Cdd:cd10211       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 241 vdskpetpdleplepsledvenindfeplfseetpevekpqvtttvqpvfnlaayhqlfvgterirapeiifqpsligee 320
Cdd:cd10211       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 321 qaGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDH 400
Cdd:cd10211   245 --GLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEKELRAIRPFGSPFNVVRAKDPVLDAWRGAAKWALDS 322

                         410       420
                  ....*....|....*....|....
gi 1958763150 401 lEDSGAWVTRKDYEEKGGEYLKEH 424
Cdd:cd10211   323 -TFEKVWITKQEYEEKGGEYLKEH 345
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 2-417 8.83e-31

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 122.37  E-value: 8.83e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150    2 MSELLFECYRIPKVAYGIDSLFSFYHNMpknaLSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLq 81
Cdd:smart00268 114 ILEIMFETFNFPALYIAIQAVLSLYASG----RTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITDYLKELL- 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   82 lkypghlaaitlsrmEEILQEHSYIAEDYAAelqkwrcpdyyennvhkmqlpfsskllgstltaeekqerrqqqlrrlqe 161
Cdd:smart00268 189 ---------------SERGYQFNSSAEFEIV------------------------------------------------- 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  162 lnarrREEKlqldqerlERLLYVQElledgqmdqfhkalielnmDSPEELQSYiqkltlaveqakqkilqaeanlevdvv 241
Cdd:smart00268 205 -----REIK--------EKLCYVAE-------------------DFEKEMKLA--------------------------- 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  242 dskpetpdlEPLEPSLEDVENindfeplfseetpevekpqvtttvqpvFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQ 321
Cdd:smart00268 226 ---------RESSESSKLEKT---------------------------YELPDGNTIKVGNERFRIPEILFSPELIGLEQ 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  322 AGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWA-LDH 400
Cdd:smart00268 270 KGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIAPPERKYSVWLGGSILAsLST 349

                          410
                   ....*....|....*..
gi 1958763150  401 LEDSgaWVTRKDYEEKG 417
Cdd:smart00268 350 FEDM--WITKKEYEESG 364
Actin pfam00022
Actin;
295-417 3.54e-19

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 89.29  E-value: 3.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 295 YHQLFvGTERIRAPEIIFQPSLIGEEQA--------GIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKE 366
Cdd:pfam00022 267 STIIL-GAERFRVPEILFNPSLIGSESElpppqtavGIPELIVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKE 345

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 367 LleMRPFQSSFQVQLASNPVLD-----AWYGARDWA-LDHLEDSgaWVTRKDYEEKG 417
Cdd:pfam00022 346 L--AQLAPPGVKVKIIAPGNTVerrysAWIGGSILAsLGTFQQM--WVSKQEYEEHG 398
PTZ00281 PTZ00281
actin; Provisional
 276-425 7.84e-16

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 78.97  E-value: 7.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 276 EVEKPQVTTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVM 355
Cdd:PTZ00281  227 EMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTM 306

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958763150 356 YPGMKARVEKELLEMRPfqSSFQVQLASNP--VLDAWYGARDWA-LDHLEDsgAWVTRKDYEEKGGEYLKEHC 425
Cdd:PTZ00281  307 FPGIADRMNKELTALAP--STMKIKIIAPPerKYSVWIGGSILAsLSTFQQ--MWISKEEYDESGPSIVHRKC 375
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
 193-414 4.13e-06

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 48.95  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 193 MDQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQAEANLEVDVVDSKPETPdleplepsLEDVENINdFEPLfse 272
Cdd:cd10212   226 IQQFKSTMLQVSEKDLFELERYYKEQADIYAKQQEQLKQMDQQLQYTALTGSPNNP--------LVQKKNFL-FKPL--- 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 273 etpeveKPQVTTTVQPVFNLAAYhqlfvgterirapeiIFQPSLIGEE---QAGIAETLHYVLDRYPKAVQDTLVQNVFL 349
Cdd:cd10212   294 ------NKTLTLDLKECYQFAEY---------------LFKPQLISDKfspEDGLGPLMAKSVKKAPEQVYSLLLTNVII 352

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 350 TGGNVMYPGMKARVEKELLEMRPFQ--SSFQVQLASNPVLDAWYGARDWALDHLEDSGAWVTRKDYE 414
Cdd:cd10212   353 TGSTSLIEGMEQRIIKELSIRFPQYklTTFANQVMMDRKIQGWLGALTMANLPSWSLGKWYSKEDYE 419
COG5277 COG5277
Actin-related protein [Cytoskeleton];
303-415 4.20e-05

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 45.55  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 303 ERIRAPEIIFQPSLIGEE----------------------QAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMY---P 357
Cdd:COG5277   279 ERFLIGEILFNPNHEGFEsyiqqgrlriedavigdvvlygEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpP 358

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 358 GMK-------ARVEKELLEMRPfQSSFQVQLASNPVLDAWYGARDWALDhLEDSGAW--VTRKDYEE 415
Cdd:COG5277   359 GLEdvavdsvTRVQIELSELAP-ELKVNVRLVSDPQYSVWKGAIIYGYA-LPFSVKWswITKEGWYF 423
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
 1-424 7.96e-127

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 371.52  E-value: 7.96e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   1 MMSELLFECYRIPKVAYGIDSLFSFYHNMPKNALSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLL 80
Cdd:cd10211   111 LMSELLFECYGVPSVAYGIDSLFSYYHNQPQGDPSDGLVISSGYSTTHVIPVLNGRLDLSQCKRINLGGFHATDYLQRLL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  81 QLKYPGHLAAITLSRMEEILQEHSYIAEDYAAELQKWRCPDYYENNVHKMQLPFsskllgstltaeekqerrqqqlrrlq 160
Cdd:cd10211   191 QLKYPTHPSAITLSRAEELVHEHCYVAEDYDEELKKWEDPEYYEENVRKIQLPF-------------------------- 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 161 elnarrreeklqldqerlerllyvqelledgqmdqfhkalielnmdspeelqsyiqkltlaveqakqkilqaeanlevdv 240
Cdd:cd10211       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 241 vdskpetpdleplepsledvenindfeplfseetpevekpqvtttvqpvfnlaayhqlfvgterirapeiifqpsligee 320
Cdd:cd10211       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 321 qaGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDH 400
Cdd:cd10211   245 --GLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEKELRAIRPFGSPFNVVRAKDPVLDAWRGAAKWALDS 322

                         410       420
                  ....*....|....*....|....
gi 1958763150 401 lEDSGAWVTRKDYEEKGGEYLKEH 424
Cdd:cd10211   323 -TFEKVWITKQEYEEKGGEYLKEH 345
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
 2-417 6.94e-34

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 131.13  E-value: 6.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   2 MSELLFECYripkvayGIDSLF-------SFYHNMPKNALSSG------LVISSGYQCTHILPVLEGRLDAKNCKRINLG 68
Cdd:cd10210   108 MDEIVFEEY-------GFQSLYrttaaalSAFAYLADSEQSSSsssqccLVVDSGFSFTHIVPFFDGKPVKRAVRRIDVG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  69 GSQAAGYLQRLLQLKYpghlaaITLSR----MEEILQEHSYIAEDYAAELQKwrcpdyyennvhkmqlpfsskllgstlt 144
Cdd:cd10210   181 GKLLTNYLKEIISYRQ------LNVMDetylVNQIKEDLCFVSTDFYEDLEI---------------------------- 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 145 aeekqerrqqqlrrlqelnARRREEKLQLDQErlerllYVqelLEDGQmDQFHKALIELNMDSPEELQSYIQKLTLaveq 224
Cdd:cd10210   227 -------------------AKKKGKENTIRRD------YV---LPDYT-TSKRGYVRDPEEPNRGKLKEDEQVLRL---- 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 225 akqkilqaeanlevdvvdskpetpdleplepsledvenindfeplfseetpevekpqvtttvqpvfnlaayhqlfvGTER 304
Cdd:cd10210   274 ----------------------------------------------------------------------------NNER 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 305 IRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASN 384
Cdd:cd10210   278 FTVPELLFHPSDIGIQQAGIAEAIVQSINACPEELQPLLYANIVLTGGNALFPGFRERLEAELRSLAPDDYDVNVTLPED 357

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1958763150 385 PVLDAWYGARDWALDHlEDSGAWVTRKDYEEKG 417
Cdd:cd10210   358 PITYAWEGGSLLAQSP-EFEELAVTRAEYEEHG 389
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 2-417 8.83e-31

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 122.37  E-value: 8.83e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150    2 MSELLFECYRIPKVAYGIDSLFSFYHNMpknaLSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLq 81
Cdd:smart00268 114 ILEIMFETFNFPALYIAIQAVLSLYASG----RTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITDYLKELL- 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   82 lkypghlaaitlsrmEEILQEHSYIAEDYAAelqkwrcpdyyennvhkmqlpfsskllgstltaeekqerrqqqlrrlqe 161
Cdd:smart00268 189 ---------------SERGYQFNSSAEFEIV------------------------------------------------- 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  162 lnarrREEKlqldqerlERLLYVQElledgqmdqfhkalielnmDSPEELQSYiqkltlaveqakqkilqaeanlevdvv 241
Cdd:smart00268 205 -----REIK--------EKLCYVAE-------------------DFEKEMKLA--------------------------- 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  242 dskpetpdlEPLEPSLEDVENindfeplfseetpevekpqvtttvqpvFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQ 321
Cdd:smart00268 226 ---------RESSESSKLEKT---------------------------YELPDGNTIKVGNERFRIPEILFSPELIGLEQ 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  322 AGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWA-LDH 400
Cdd:smart00268 270 KGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIAPPERKYSVWLGGSILAsLST 349

                          410
                   ....*....|....*..
gi 1958763150  401 LEDSgaWVTRKDYEEKG 417
Cdd:smart00268 350 FEDM--WITKKEYEESG 364
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 300-417 3.26e-20

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 91.86  E-value: 3.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 300 VGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPfqSSFQV 379
Cdd:cd13397   243 IGSERFRCPEALFRPSLIGREAPGIHKLVYNSIMKCDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAP--SSTKV 320

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958763150 380 QLASNPvlDAWYGArdW-------ALDHLEDsgAWVTRKDYEEKG 417
Cdd:cd13397   321 KVIAPP--ERKYSV--WiggsilaSLSTFKS--MWITRAEYDEFG 359
Actin pfam00022
Actin;
295-417 3.54e-19

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 89.29  E-value: 3.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 295 YHQLFvGTERIRAPEIIFQPSLIGEEQA--------GIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKE 366
Cdd:pfam00022 267 STIIL-GAERFRVPEILFNPSLIGSESElpppqtavGIPELIVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKE 345

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 367 LleMRPFQSSFQVQLASNPVLD-----AWYGARDWA-LDHLEDSgaWVTRKDYEEKG 417
Cdd:pfam00022 346 L--AQLAPPGVKVKIIAPGNTVerrysAWIGGSILAsLGTFQQM--WVSKQEYEEHG 398
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 2-83 3.62e-16

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 77.92  E-value: 3.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   2 MSELLFECYRIPKVAYGIDSLFSFYHNmpknALSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLQ 81
Cdd:cd10169    66 LAEILFETFNVPSLYIANQAVLSLYAS----GRTTGLVVDSGEGVTHIVPVYEGYVLPHAVRRLDIGGRDLTDYLAKLLR 141


                  ..
gi 1958763150  82 LK 83
Cdd:cd10169   142 EK 143
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 319-417 5.65e-16

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 77.53  E-value: 5.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 319 EEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWA- 397
Cdd:cd10169   161 EKLCGLHELIYDSIMKCDIDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLAPSSVKVKVIAPPERKYSAWIGGSILAs 240

                          90       100
                  ....*....|....*....|
gi 1958763150 398 LDHLEDSgaWVTRKDYEEKG 417
Cdd:cd10169   241 LSTFQQM--WITKEEYEEHG 258
PTZ00281 PTZ00281
actin; Provisional
 276-425 7.84e-16

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 78.97  E-value: 7.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 276 EVEKPQVTTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVM 355
Cdd:PTZ00281  227 EMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTM 306

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958763150 356 YPGMKARVEKELLEMRPfqSSFQVQLASNP--VLDAWYGARDWA-LDHLEDsgAWVTRKDYEEKGGEYLKEHC 425
Cdd:PTZ00281  307 FPGIADRMNKELTALAP--STMKIKIIAPPerKYSVWIGGSILAsLSTFQQ--MWISKEEYDESGPSIVHRKC 375
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
 276-417 1.01e-15

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 78.56  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 276 EVEKPQVTTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVM 355
Cdd:cd10224   221 EMQTAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMEAAGIHETTYNSIMKCDVDIRKDLYANIVLSGGTTM 300

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958763150 356 YPGMKARVEKELLEMRPfqSSFQVQLASNP--VLDAWYGARDWA-LDHLEDsgAWVTRKDYEEKG 417
Cdd:cd10224   301 FPGIADRMQKEITALAP--STMKIKIVAPPerKYSVWIGGSILAsLSTFQQ--MWISKQEYDESG 361
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
 300-422 4.57e-15

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 76.45  E-value: 4.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 300 VGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEM--------- 370
Cdd:cd10220   247 VGGERFEAPEALFQPHLIDVEGPGIAELLFNTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIKQLylervlkgd 326

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958763150 371 RPFQSSFQVQLASNP-----------VLDawygardwalDHLEDSGA-WVTRKDYEEKGGEYLK 422
Cdd:cd10220   327 TERLSKFKIRIEDPPrrkhmvflggaVLA----------DIMKDKDEfWITRQEYEEQGVRVLD 380
PTZ00004 PTZ00004
actin-2; Provisional
 300-417 2.51e-14

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 74.42  E-value: 2.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 300 VGTERIRAPEIIFQPSLIGEEQA-GIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQ 378
Cdd:PTZ00004  252 VGSERFRCPEALFQPSLIGKEEPpGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIK 331

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958763150 379 VQLASNPVLDAWYGARDWA-LDHLEDsgAWVTRKDYEEKG 417
Cdd:PTZ00004  332 VVAPPERKYSVWIGGSILSsLPTFQQ--MWVTKEEYDESG 369
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 296-417 2.72e-14

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 74.00  E-value: 2.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 296 HQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPfqs 375
Cdd:cd10214   241 HLITIGKERFRCPEMLFNPSLIGSKQPGLHTLTMNSLNKCDANLKKDLAKNILLCGGSTMFDGFPDRFQKELSKLCP--- 317

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958763150 376 sfqvqlASNPVLDA--------WYG----ARDWALDHLedsgaWVTRKDYEEKG 417
Cdd:cd10214   318 ------NDNPIVAAsperkysvWTGgsilASLKSFQQL-----WVRRREYEERG 360
PTZ00452 PTZ00452
actin; Provisional
 298-425 8.29e-14

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 72.87  E-value: 8.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 298 LFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSF 377
Cdd:PTZ00452  248 LTIKSQKFRCSEILFQPKLIGLEVAGIHHLAYSSIKKCDLDLRQELCRNIVLSGGTTLFPGIANRLSNELTNLVPSQLKI 327

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958763150 378 QVQLASNPVLDAWYGARDWALDHLEDSgAWVTRKDYEEKGGEYLKEHC 425
Cdd:PTZ00452  328 QVAAPPDRRFSAWIGGSIQCTLSTQQP-QWIKRQEYDEQGPSIVHRKC 374
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
 272-417 7.84e-13

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 69.50  E-value: 7.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 272 EETPEVEKPQVTTtvqpvFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTG 351
Cdd:cd10216   223 EEKLEEEKTEKAQ-----YTLPDGSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLVDSIQKSDLDLRKTLYSNIVLSG 297

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 352 GNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWA-LDHLEDsgAWVTRKDYEEKG 417
Cdd:cd10216   298 GSTLFKGFGDRLLSEVKKLAPKDVKIRISAPPERLYSTWIGGSILAsLSTFKK--MWVSKKEYEEDG 362
PTZ00466 PTZ00466
actin-like protein; Provisional
 297-417 1.04e-11

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 66.12  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 297 QLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSS 376
Cdd:PTZ00466  252 QILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLNEIRKFAPKDIT 331

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958763150 377 FQVQLASNPVLDAWYGARDWA-LDHLEDsgAWVTRKDYEEKG 417
Cdd:PTZ00466  332 IRISAPPERKFSTFIGGSILAsLATFKK--IWISKQEFDEYG 371
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 295-417 1.22e-08

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 56.81  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 295 YHQLFvGTERIRAPEIIFQPSLIGEEQAGIAETLHY------VLDrypkAVQ--D-----TLVQNVFLTGGNVMYPGMKA 361
Cdd:cd13395   281 YNIEF-GAERFKIPELLFDPSLVKGIPAPPSEGNELlglpqlVYT----SIGscDvdirpELYGNVVLTGGNSLLPGFTD 355

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763150 362 RVEKELLEMRPFQSSFQVqLASNPVLD----AWYGardwaldhledsG-----------AWVTRKDYEEKG 417
Cdd:cd13395   356 RLNRELSEKAPGSLKLKI-LASGNTVErrfsSWIG------------GsilaslgsfqqMWISKQEYEEHG 413
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
 300-417 6.48e-08

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 54.32  E-value: 6.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 300 VGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELL-----EMRPFq 374
Cdd:cd10209   227 VGKERYCVGEALFRPSILGIEEYGIVEQLVRAVSTSPSENRRQLLENIVLCGGTSSVPGLEARLQKEIRllsspSSRPA- 305

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958763150 375 ssfqvqLASNPvldawygarDWALDHLEDSGAW----------------VTRKDYEEKG 417
Cdd:cd10209   306 ------LVKPP---------EYMPENTLRYSAWiggailakvvfpqnqhVTKADYDETG 349
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
 3-117 7.13e-07

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 51.27  E-value: 7.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   3 SELLFECYRIPKVAYGIDSLFSFY------HNMPKNALSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYL 76
Cdd:PTZ00280  122 AEIMFETFNVKGLYIAVQAVLALRaswtskKAKELGGTLTGTVIDSGDGVTHVIPVVDGYVIGSSIKHIPLAGRDITNFI 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958763150  77 QRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYAAELQKW 117
Cdd:PTZ00280  202 QQMLRERGEPIPAEDILLLAQRIKEKYCYVAPDIAKEFEKY 242
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
 193-414 4.13e-06

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 48.95  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 193 MDQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQAEANLEVDVVDSKPETPdleplepsLEDVENINdFEPLfse 272
Cdd:cd10212   226 IQQFKSTMLQVSEKDLFELERYYKEQADIYAKQQEQLKQMDQQLQYTALTGSPNNP--------LVQKKNFL-FKPL--- 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 273 etpeveKPQVTTTVQPVFNLAAYhqlfvgterirapeiIFQPSLIGEE---QAGIAETLHYVLDRYPKAVQDTLVQNVFL 349
Cdd:cd10212   294 ------NKTLTLDLKECYQFAEY---------------LFKPQLISDKfspEDGLGPLMAKSVKKAPEQVYSLLLTNVII 352

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 350 TGGNVMYPGMKARVEKELLEMRPFQ--SSFQVQLASNPVLDAWYGARDWALDHLEDSGAWVTRKDYE 414
Cdd:cd10212   353 TGSTSLIEGMEQRIIKELSIRFPQYklTTFANQVMMDRKIQGWLGALTMANLPSWSLGKWYSKEDYE 419
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
 300-417 1.61e-05

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 46.77  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 300 VGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDR-YPKAVQ--DTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSS 376
Cdd:cd13396   210 LSNERFKTGEILFQPGLGGMRAMGLHQAVALCMDHcALVHSQgdDGWFKTIVLSGGSACLPGLSERLERELRKLLPKSLS 289

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958763150 377 FQVQLASNP--VLDAWYGARdwALDHLED-SGAW-VTRKDYEEKG 417
Cdd:cd13396   290 EGIRIIPPPlgPDSAWQGAK--LISNLSNfPDGWcITKKQFRNKP 332
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
 300-417 1.87e-05

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 46.65  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 300 VGTERIRAPEIIFQPSLIGEE-QAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEK------------- 365
Cdd:PTZ00280  268 VGYERFLGPEMFFHPEIFSSEwTTPLPEVVDDAIQSCPIDCRRPLYKNIVLSGGSTMFKGFDKRLQRdvrkrvdrrlkka 347

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958763150 366 -ELLEMRPFQSSFQVQLASNPV--LDAWYGARDWALDHlEDSGAWVTRKDYEEKG 417
Cdd:PTZ00280  348 eELSGGKLKPIPIDVNVVSHPRqrYAVWYGGSMLASSP-EFEKVCHTKAEYDEYG 401
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
 35-116 3.98e-05

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 45.61  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150  35 SSGLVISSGYQCTHILPVLEGR-LDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILqehSYIAEDYAAE 113
Cdd:cd13396   115 TSGIVVNIGFRVTTIVPVYRGRvMHDIGVEVVGQGALRLTGFLKELMQQNGIRFPSLYTVRTIKEKL---CYVAEDYEAE 191


                  ...
gi 1958763150 114 LQK 116
Cdd:cd13396   192 LAK 194
COG5277 COG5277
Actin-related protein [Cytoskeleton];
303-415 4.20e-05

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 45.55  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 303 ERIRAPEIIFQPSLIGEE----------------------QAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMY---P 357
Cdd:COG5277   279 ERFLIGEILFNPNHEGFEsyiqqgrlriedavigdvvlygEMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpP 358

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763150 358 GMK-------ARVEKELLEMRPfQSSFQVQLASNPVLDAWYGARDWALDhLEDSGAW--VTRKDYEE 415
Cdd:COG5277   359 GLEdvavdsvTRVQIELSELAP-ELKVNVRLVSDPQYSVWKGAIIYGYA-LPFSVKWswITKEGWYF 423
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
 1-116 1.93e-04

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 43.71  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150   1 MMSELLFECYRIPKVAYGIDSLFSFYHNMPKNALS----SGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYL 76
Cdd:cd10221   119 YTAEIMFETFNVPGLYIAVQAVLALAASWTSRKVGertlTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFI 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958763150  77 QRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYAAELQK 116
Cdd:cd10221   199 QQLLREREEGIPPEDSLEVAKRIKERYCYVCPDIVKEFAK 238
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
 300-417 5.56e-04

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 42.17  E-value: 5.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763150 300 VGTERIRAPEIIFQPSLIGEE-QAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPG--------MKARVEK----- 365
Cdd:cd10221   265 VGYERFLAPEIFFNPEIASSDfTTPLPEVVDQVIQSCPIDTRRGLYKNIVLSGGSTMFKDfgrrlqrdVKRIVDArlkas 344

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958763150 366 -ELLEMRPFQSSFQVQLASNP-----VldaWYGARDWALDHlEDSGAWVTRKDYEEKG 417
Cdd:cd10221   345 eELSGGKLKPKPIDVNVISHPmqryaV---WFGGSMLASTP-EFYTVCHTKAEYEEYG 398
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
 33-83 5.35e-03

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 38.77  E-value: 5.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958763150  33 ALSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLQLK 83
Cdd:cd10207   118 GIRTALVVDCGYRETRVLPVYEGVPLLSAWQSTPLGGKALHKRLKKLLLEH 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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