NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958763417|ref|XP_038961570|]
View 

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X5 [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-139 1.30e-97

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23978:

Pssm-ID: 480271  Cd Length: 229  Bit Score: 283.28  E-value: 1.30e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWGPPNKMQKPQGSLL-RVIQRAGLAFPNMEAY 79
Cdd:cd23978    31 MNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWGPPNKMQKDGKSNLfRIIQRASMTFPNMSAF 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417  80 AVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSGP 139
Cdd:cd23978   111 VVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYGMVPPNYCSKR 170
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 1-139 1.30e-97

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 283.28  E-value: 1.30e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWGPPNKMQKPQGSLL-RVIQRAGLAFPNMEAY 79
Cdd:cd23978    31 MNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWGPPNKMQKDGKSNLfRIIQRASMTFPNMSAF 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417  80 AVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSGP 139
Cdd:cd23978   111 VVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYGMVPPNYCSKR 170
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 1-134 4.03e-12

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 63.40  E-value: 4.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVV-AHSSVFRVLRKPQEFVNRTPETVFIFwgPPNKMQkpqgSLL---RVIQRAGLAFPNM 76
Cdd:pfam00777  73 CNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEFVL--VPFKGR----DLLwlpAFLTKGNVSRSLR 146

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958763417  77 EAYAVSQARMQQFDDLFR-------GETGKDREKSHSW----LSTGWFTMVIAVELCDHVHVYGMVPPD 134
Cdd:pfam00777 147 VLYTLKEVKIPVDPDKVLflhpdflRYVANFWLRSHGLkgrrPSTGLLMLSLALHLCDEVSLYGFGPFL 215
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 1-139 1.30e-97

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 283.28  E-value: 1.30e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWGPPNKMQKPQGSLL-RVIQRAGLAFPNMEAY 79
Cdd:cd23978    31 MNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWGPPNKMQKDGKSNLfRIIQRASMTFPNMSAF 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417  80 AVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSGP 139
Cdd:cd23978   111 VVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYGMVPPNYCSKR 170
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 1-139 5.05e-70

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 213.26  E-value: 5.05e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKP-QEFVNRTPETVFIFWGPPNKMQKPQGSLLRVIQRAGLAFPNMEAY 79
Cdd:cd23965    31 MNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAiLLLAGTRAPTVVVFWGPETKMNKDGAGKYNLLRSLSKKYPDVEFY 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417  80 AVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSGP 139
Cdd:cd23965   111 SLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVYGMVPENYCREH 170
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 1-139 4.11e-59

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 186.23  E-value: 4.11e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWGPPNKMQKP-QGSLLRVIQRAGLAFPNMEAY 79
Cdd:cd23976    45 MNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLNVSQGTVFIFWGPSNYMRRDgKGLVYNNLQLMNQILPKLKVY 124

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417  80 AVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSGP 139
Cdd:cd23976   125 TITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTMIIALELCDRINVYGMVPPDFCRDP 184
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 1-137 4.34e-46

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 152.32  E-value: 4.34e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWGPPNKM-QKPQGSLLRVIQRAGLAFPNMEAY 79
Cdd:cd23977    31 MNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWGPERNMdRDGGGKTYRALLTLAKMYPHLQVY 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958763417  80 AVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCS 137
Cdd:cd23977   111 TLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYGMVSDSYCR 168
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 1-136 2.61e-44

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 147.77  E-value: 2.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWGPPNKMQKP-QGSLLRVIQRAGLAFPNMEAY 79
Cdd:cd23975    31 MNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWGPFRNMRKDgKGIVYNMLKKAVESYPQAKIY 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763417  80 AVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYC 136
Cdd:cd23975   111 VTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYGMINDTYC 167
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-130 5.13e-19

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 80.87  E-value: 5.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTP---ETVFIFWGPPNKMQKpqgsllRVIQRAGLafPNME 77
Cdd:cd19952    28 FNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPleeEVVLILSRAAAADFK------RLKRRKKR--HDNA 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763417  78 AYAVS---QARMQQFDDLFRGETGKDrEKSHSWLSTGWFTMVIAVELCDHVHVYGM 130
Cdd:cd19952   100 VLLLTdpaPDLLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDLYGF 154
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 1-129 1.61e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 67.67  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFRVL------RKPQEFVNRTPETV-FIFWGPPNKMQKPQGSLLRVIQRAGLAF 73
Cdd:cd23963    93 CNLPPIKGFEKDVGRKTNLTTLNPSILKRRYnslkknRDRDKFLNRLKEYNgSILWYPKFSFKSSTNLLLKAARALKKNG 172

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958763417  74 PNME---AYAVSQARMQQFddlfRGETGKDRekshsWLSTGWFTMVIAVELCDHVHVYG 129
Cdd:cd23963   173 LNLTvvySNPEHFLAVQKF----WKRRGLEK-----RPSTGLYLVSLALTFCDEIHLYG 222
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 1-134 4.03e-12

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 63.40  E-value: 4.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVV-AHSSVFRVLRKPQEFVNRTPETVFIFwgPPNKMQkpqgSLL---RVIQRAGLAFPNM 76
Cdd:pfam00777  73 CNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEFVL--VPFKGR----DLLwlpAFLTKGNVSRSLR 146

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958763417  77 EAYAVSQARMQQFDDLFR-------GETGKDREKSHSW----LSTGWFTMVIAVELCDHVHVYGMVPPD 134
Cdd:pfam00777 147 VLYTLKEVKIPVDPDKVLflhpdflRYVANFWLRSHGLkgrrPSTGLLMLSLALHLCDEVSLYGFGPFL 215
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 1-129 3.14e-10

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 57.30  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFR-------------VLRKPQEFV-------NRTPETVFIFWG--------PP 52
Cdd:cd23967    32 MNDAPVKGYEKDVGSKTTFRMFYPESAFRdpeeydsdwllvlVPFKSMDLLwlqavikGKKPNGKGGFWKkiatsvpkPP 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958763417  53 NKMQ--KPQgsllrVIQRAGlafpnmeayavsqarmqqfDDLfrGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 129
Cdd:cd23967   112 KKIRilNPY-----ILQEAA-------------------FDL--IGLPMNGKQGKNVPTTGIIAIVMALHYCDEVDIAG 164
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 2-132 4.79e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 54.84  E-value: 4.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   2 NDAPTTGYSADVGNKTTFRVVAHssvfRVLRKPQEFVNRTP---ETVFIFWGPP-------NKMQKPQGSLLRVIQRAGL 71
Cdd:cd23986    80 NSAPTRGYEKDVGNKTTIRIINS----QILTNPNHHFIDSSlykDVILVAWDPApysanlhKWYKKPDYNLFTPYVQYRK 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763417  72 AFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVP 132
Cdd:cd23986   156 RNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP--SSGFIGILIMMSMCREVHVYEYIP 214
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 1-133 7.98e-09

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 54.20  E-value: 7.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAH----SSVFRVLRKPqEFVNrtpETVFIfWGP-------PNKMQKPQGSLLRVIQRA 69
Cdd:cd23968    75 FNDAPTKGFEKDVGSKTTLRLINSqilsKPEFNFLTDP-LYRN---VTLLV-WDPssynvnlEKWYKKPDFDFFPNYIKY 149

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763417  70 GLAFPNMEAYaVSQARM--QQFDDLFRGETGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVPP 133
Cdd:cd23968   150 RRRHPEEPFY-LIDPRFlwRLWDILQEYTPEKIKPNPP---SSGFIGIVLMLHLCDWVDVYEYVPS 211
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 2-132 1.47e-07

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 50.48  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   2 NDAPTTGYSADVGNKTTFRVVaHSSVfrVLRKPQEFVNRT--PETVFIFWGP-------PNKMQKPQGSLLRVIQRAGLA 72
Cdd:cd23985    76 NGAPTAGFQQDVGTKTTIRLI-NSQL--VTTEKHKFLKDSlyNEGILIVWDPapyhsdiPEWYKNPDYNFFENYKTYRRL 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763417  73 FPNMEAYaVSQARMQ-QFDDLFRGETGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVP 132
Cdd:cd23985   153 NPNQPFY-ILHPQMQwELWDIIQENSPEEIQPNPP--SSGMLGIILMMTLCDQVDVYEFLP 210
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 1-129 5.29e-06

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 45.51  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSVFR-------------VLRKPQ------EFVNRTPETVFIFW-GPPNKMQ-KP- 58
Cdd:cd23984    32 MNNGPVIGYENDVGKRTTFRLCYPESIFSdpshydpnttvvlIPFKPHdlrwllDLLMGKKVSAKGFWkKPALNLIyKPn 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763417  59 QGSLL--RVIQRAG---LAFPnmeayavsqarmQQFDdlfrgetgKDREKSHSwlSTGWFTMVIAVELCDHVHVYG 129
Cdd:cd23984   112 QIRILnpFILRIAAyelLHFP------------KRFP--------KEKKPKHP--TTGIIAITLALHICNEVHIAG 165
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 1-130 3.29e-05

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 43.42  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAhssvfrvlrkPQEFVNRTPETVFI---FwgppnkmqKPQGsllrvIQRAGLAFPNME 77
Cdd:cd23966   107 MNKAPTKGFEKDVGSKTTHHFMY----------PESAVDLDPGVHLVlvpF--------KVLD-----LQWLISALTTGE 163

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958763417  78 ---AYavsqARMQQFDDLfrgetgkDREK-----------SH-SWL-------STGWFTMVIAVELCDHVHVYGM 130
Cdd:cd23966   164 itrTY----TPVKRFIKA-------DKDKvlvinpafikyVHdNWTehhgrypSTGFLALIFALHICDEVSVFGF 227
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 1-134 1.49e-04

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 41.19  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVV----AHSS-----------VFrVLRKPQEF------VNRTPETVFIFWGPPNKMQKPQ 59
Cdd:cd23982    32 LNDAPVRGFEKDVGSKTTIRLFypesAQFDpgiendpdtllVL-VPFKPLDFywlyeiLSNEKRVRKGFWKQPPRIWDAN 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958763417  60 GSLLRVIqraglafpNMEAYAVSQARMQQFddlfrgeTGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVPPD 134
Cdd:cd23982   111 PKQIRIL--------NPYYTYVAATKLLQV-------PGQRKKKQKP--TTGLLAITLALHLCDEVHIAGFGYPD 168
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 1-129 1.05e-03

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 39.09  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRVVAHSSvFRVLRKPQEFVNRTPETVFIFW-------GPPNKMQKPQGSLLRVIQRAGLAF 73
Cdd:cd23980   111 MNKAPTEGFEADVGSKTTHHFVYPES-FRELAQNVSMILVPFKTLDLEWvisatttGTISHTYVPVPRKIKVKKEKILIY 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763417  74 -PNMEAYAvsqarmqqFDDLFRGEtGKdrekshsWLSTGWFTMVIAVELCDHVHVYG 129
Cdd:cd23980   190 hPAFIKYV--------FDRWLQGH-GR-------YPSTGILSVIFSLHVCDEVDLYG 230
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 1-21 1.23e-03

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 38.57  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|.
gi 1958763417   1 MNDAPTTGYSADVGNKTTFRV 21
Cdd:cd23983    32 LNNAPVQGYSQDVGNKTTIRM 52
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 108-132 1.62e-03

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 38.39  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958763417 108 LSTGwFTMV-IAVELCDHVHVYGMVP 132
Cdd:cd23971   200 LSTG-LMLVsAALELCENVHLYGFWP 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH