NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958643930|ref|XP_038961853|]
View 

ankyrin repeat domain-containing protein 42 isoform X5 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12789823)

ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  17176038

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-179 3.42e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.77  E-value: 3.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  21 TADSIHLAAMEGHLHCFKFLLSRVNsavqALKAFNDNGENVLDLAHRFLKQNIVQFIQGAeyeGSHLDDQDDLAF-PGHV 99
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGA----DINAKDDGGNTLLHAAARNGDLEIVKLLLEA---GADVNARDKDGEtPLHL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 100 AAFKGDLEMLKKLIDDGvINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 179
Cdd:COG0666   127 AAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
PHA02874 super family cl31515
ankyrin repeat protein; Provisional
 66-303 2.08e-06

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA02874:

Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  66 HRFLKQNIVQFIQGAEYEGSHLDDQDDLA-FPGHVAAFKGDLEMLKKLIDDGVInLNERDENGSTPMHKAAGQGHIDCLQ 144
Cdd:PHA02874  129 HYAIKKGDLESIKMLFEYGADVNIEDDNGcYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIK 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 145 WLVEMGadSNITNKAGERPSDVAKRFAH-LAAVKLLEGLQKYEIDDIEG------------DKNHISFFIRHgvegstda 211
Cdd:PHA02874  208 LLIDHG--NHIMNKCKNGFTPLHNAIIHnRSAIELLINNASINDQDIDGstplhhainppcDIDIIDILLYH-------- 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 212 KDDLSLSESDKANARMRAHKKIVELRQLLEIAESNF--KHLGGITEEDLKQKKELLESKKT---ITELQEQLayERLRRE 286
Cdd:PHA02874  278 KADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVliKEADKLKDSDFLEHIEIKDNKEFsdfIKECNEEI--EDMKKT 355

                         250
                  ....*....|....*..
gi 1958643930 287 KLECQLDEYRVEVNQLK 303
Cdd:PHA02874  356 KCGCDKNIFDLCLIRIK 372
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-179 3.42e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.77  E-value: 3.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  21 TADSIHLAAMEGHLHCFKFLLSRVNsavqALKAFNDNGENVLDLAHRFLKQNIVQFIQGAeyeGSHLDDQDDLAF-PGHV 99
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGA----DINAKDDGGNTLLHAAARNGDLEIVKLLLEA---GADVNARDKDGEtPLHL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 100 AAFKGDLEMLKKLIDDGvINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 179
Cdd:COG0666   127 AAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-157 3.62e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 3.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  25 IHLAAMEGHLHCFKFLLSRVNSAvqalKAFNDNGENVLdlahrflkqnivqfiqgaeyegshlddqddlafpgHVAAFKG 104
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA----NLQDKNGRTAL-----------------------------------HLAAKNG 41

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958643930 105 DLEMLKKLIDDGVINLnerDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITN 157
Cdd:pfam12796  42 HLEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 25-179 5.10e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 5.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  25 IHLAAME--GHLHCFKFLLSRvNSAVQALkafNDNGENVLdlaHRFLKQNivqfiqgaeyegshlddqddlafpghvaaf 102
Cdd:PHA03100  110 LLYAISKksNSYSIVEYLLDN-GANVNIK---NSDGENLL---HLYLESN------------------------------ 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 103 KGDLEMLKKLIDDGV---------------INLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVA 167
Cdd:PHA03100  153 KIDLKILKLLIDKGVdinaknrvnyllsygVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232

                         170
                  ....*....|..
gi 1958643930 168 KRFAHLAAVKLL 179
Cdd:PHA03100  233 ILNNNKEIFKLL 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 66-303 2.08e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  66 HRFLKQNIVQFIQGAEYEGSHLDDQDDLA-FPGHVAAFKGDLEMLKKLIDDGVInLNERDENGSTPMHKAAGQGHIDCLQ 144
Cdd:PHA02874  129 HYAIKKGDLESIKMLFEYGADVNIEDDNGcYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIK 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 145 WLVEMGadSNITNKAGERPSDVAKRFAH-LAAVKLLEGLQKYEIDDIEG------------DKNHISFFIRHgvegstda 211
Cdd:PHA02874  208 LLIDHG--NHIMNKCKNGFTPLHNAIIHnRSAIELLINNASINDQDIDGstplhhainppcDIDIIDILLYH-------- 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 212 KDDLSLSESDKANARMRAHKKIVELRQLLEIAESNF--KHLGGITEEDLKQKKELLESKKT---ITELQEQLayERLRRE 286
Cdd:PHA02874  278 KADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVliKEADKLKDSDFLEHIEIKDNKEFsdfIKECNEEI--EDMKKT 355

                         250
                  ....*....|....*..
gi 1958643930 287 KLECQLDEYRVEVNQLK 303
Cdd:PHA02874  356 KCGCDKNIFDLCLIRIK 372
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 126-155 2.59e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.59e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643930  126 NGSTPMHKAAGQGHIDCLQWLVEMGADSNI 155
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-179 3.42e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.77  E-value: 3.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  21 TADSIHLAAMEGHLHCFKFLLSRVNsavqALKAFNDNGENVLDLAHRFLKQNIVQFIQGAeyeGSHLDDQDDLAF-PGHV 99
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLAAGA----DINAKDDGGNTLLHAAARNGDLEIVKLLLEA---GADVNARDKDGEtPLHL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 100 AAFKGDLEMLKKLIDDGvINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 179
Cdd:COG0666   127 AAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
20-179 7.58e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 7.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  20 ETADSIHLAAMEGHLHCFKFLLSRVNSAVQALKAFNDNGENVLDLAHRFLKQNIVQFIQGAEYEGSHLDDQDDLAFpgHV 99
Cdd:COG0666    16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLL--HA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 100 AAFKGDLEMLKKLIDDGvINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 179
Cdd:COG0666    94 AARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-157 3.62e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 3.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  25 IHLAAMEGHLHCFKFLLSRVNSAvqalKAFNDNGENVLdlahrflkqnivqfiqgaeyegshlddqddlafpgHVAAFKG 104
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA----NLQDKNGRTAL-----------------------------------HLAAKNG 41

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958643930 105 DLEMLKKLIDDGVINLnerDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITN 157
Cdd:pfam12796  42 HLEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-147 3.55e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.67  E-value: 3.55e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958643930  98 HVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLV 147
Cdd:pfam13637   6 HAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-179 9.66e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 9.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  41 LSRVNSAVQALKAFNDNGENVLDLAHRFLKQNIVQFIQGAEYEGSHLDDQDDLAFPGHVAAFKGDLEMLKKLIDDGVINL 120
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958643930 121 NERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 179
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
Ank_5 pfam13857
Ankyrin repeats (many copies);
112-167 4.77e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.96  E-value: 4.77e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958643930 112 LIDDGVINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVA 167
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
127-179 3.28e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 3.28e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958643930 127 GSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 179
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 25-179 5.10e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 5.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  25 IHLAAME--GHLHCFKFLLSRvNSAVQALkafNDNGENVLdlaHRFLKQNivqfiqgaeyegshlddqddlafpghvaaf 102
Cdd:PHA03100  110 LLYAISKksNSYSIVEYLLDN-GANVNIK---NSDGENLL---HLYLESN------------------------------ 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 103 KGDLEMLKKLIDDGV---------------INLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVA 167
Cdd:PHA03100  153 KIDLKILKLLIDKGVdinaknrvnyllsygVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232

                         170
                  ....*....|..
gi 1958643930 168 KRFAHLAAVKLL 179
Cdd:PHA03100  233 ILNNNKEIFKLL 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 98-179 3.05e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  98 HVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVK 177
Cdd:PHA02874  129 HYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207


                  ..
gi 1958643930 178 LL 179
Cdd:PHA02874  208 LL 209
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 98-195 3.05e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  98 HVAAfKGDLEMLKKLIDDGViNLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVK 177
Cdd:PTZ00322   88 QLAA-SGDAVGARILLTGGA-DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                          90
                  ....*....|....*...
gi 1958643930 178 LLEGlqkYEIDDIEGDKN 195
Cdd:PTZ00322  166 LLSR---HSQCHFELGAN 180
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 66-303 2.08e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  66 HRFLKQNIVQFIQGAEYEGSHLDDQDDLA-FPGHVAAFKGDLEMLKKLIDDGVInLNERDENGSTPMHKAAGQGHIDCLQ 144
Cdd:PHA02874  129 HYAIKKGDLESIKMLFEYGADVNIEDDNGcYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIK 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 145 WLVEMGadSNITNKAGERPSDVAKRFAH-LAAVKLLEGLQKYEIDDIEG------------DKNHISFFIRHgvegstda 211
Cdd:PHA02874  208 LLIDHG--NHIMNKCKNGFTPLHNAIIHnRSAIELLINNASINDQDIDGstplhhainppcDIDIIDILLYH-------- 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 212 KDDLSLSESDKANARMRAHKKIVELRQLLEIAESNF--KHLGGITEEDLKQKKELLESKKT---ITELQEQLayERLRRE 286
Cdd:PHA02874  278 KADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVliKEADKLKDSDFLEHIEIKDNKEFsdfIKECNEEI--EDMKKT 355

                         250
                  ....*....|....*..
gi 1958643930 287 KLECQLDEYRVEVNQLK 303
Cdd:PHA02874  356 KCGCDKNIFDLCLIRIK 372
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 126-158 1.44e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 1.44e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958643930 126 NGSTPMHKAAGQ-GHIDCLQWLVEMGADSNITNK 158
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 100-187 9.24e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 9.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930 100 AAFKGDLEMLKKLIDDGvINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADsnitnkagerpSDVAKRFAHLAAVKLL 179
Cdd:PLN03192  629 AAKRNDLTAMKELLKQG-LNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD-----------VDKANTDDDFSPTELR 696


                  ....*...
gi 1958643930 180 EGLQKYEI 187
Cdd:PLN03192  697 ELLQKREL 704
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 126-155 2.18e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 2.18e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958643930 126 NGSTPMHKAAGQGHIDCLQWLVEMGADSNI 155
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 126-155 2.59e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.59e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958643930  126 NGSTPMHKAAGQGHIDCLQWLVEMGADSNI 155
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 106-179 1.23e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 1.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643930 106 LEMLKKLIDDGViNLNERDENGSTPMHK-AAGQG-HIDCLQWLVEMGADSNITNKAGERPSDVAKRF--AHLAAVKLL 179
Cdd:PHA03095   97 LDVIKLLIKAGA-DVNAKDKVGRTPLHVyLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSrnANVELLRLL 173
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 107-179 1.24e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.33  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958643930 107 EMLKKLIDDGvINLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLL 179
Cdd:PHA02874  105 DMIKTILDCG-IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
Ank_2 pfam12796
Ankyrin repeats (3 copies);
131-195 1.48e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 1.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958643930 131 MHKAAGQGHIDCLQWLVEMGADSNITNKAGERPSDVAKRFAHLAAVKLLegLQKYEIDDIEGDKN 195
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDNGRT 63
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-77 3.90e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.25  E-value: 3.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958643930  10 SNPGPSKSCRETAdsIHLAAMEGHLHCFKFLLSRVNSAVQalkafnDNGENVLDLAHRFLKQNIVQFI 77
Cdd:pfam12796  21 ADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHADVNLK------DNGRTALHYAARSGHLEIVKLL 80
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-134 5.83e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 5.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958643930  98 HVAAFKGDLEMLKKLIDDGViNLNERDENGSTPMHKA 134
Cdd:pfam13857  21 HVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1-160 6.39e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 38.05  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930   1 MKDHTTPGVSNPGpskscreTADSIHLAAMEGHLHCFKFLLsrvNSAVQALKAFNDNGENVLDLAHRFLKQNIVQFI--Q 78
Cdd:PHA02875   55 MKHGAIPDVKYPD-------IESELHDAVEEGDVKAVEELL---DLGKFADDVFYKDGMTPLHLATILKKLDIMKLLiaR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643930  79 GAEYEGSHLDDQDDLafpgHVAAFKGDLEMLKKLIDDGVInLNERDENGSTPMHKAAGQGHIDCLQWLVEMGADSNITNK 158
Cdd:PHA02875  125 GADPDIPNTDKFSPL----HLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGK 199


                  ..
gi 1958643930 159 AG 160
Cdd:PHA02875  200 NG 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH