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Conserved domains on  [gi|1958765949|ref|XP_038962447|]
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zinc finger protein 106 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 743-1020 4.71e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 4.71e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  743 GSFEGHQAAVNAIQIF--GNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVTHTSGKnsvLYTGSSDHTIRCYN 820
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  821 VKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFNIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 897
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  898 CTISVRDARNGLLLRTLEGHSKTVLCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 973
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1958765949  974 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 1020
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 743-1020 4.71e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 4.71e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  743 GSFEGHQAAVNAIQIF--GNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVTHTSGKnsvLYTGSSDHTIRCYN 820
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  821 VKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFNIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 897
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  898 CTISVRDARNGLLLRTLEGHSKTVLCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 973
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1958765949  974 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 1020
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
745-1021 8.35e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 8.35e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  745 FEGHQAAVNAIQIF--GNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYNVK 822
Cdd:COG2319    116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  823 TRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFNIKNNKRQEIFECHGPRaVSCLATAQEGarKLLVVGSYD 897
Cdd:COG2319    193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  898 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 973
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958765949  974 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1021
Cdd:COG2319    348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 778-820 8.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 8.46e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958765949   778 SRKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYN 820
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
779-820 7.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 7.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958765949  779 RKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYN 820
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 743-1020 4.71e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 4.71e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  743 GSFEGHQAAVNAIQIF--GNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVTHTSGKnsvLYTGSSDHTIRCYN 820
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  821 VKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFNIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 897
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  898 CTISVRDARNGLLLRTLEGHSKTVLCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 973
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1958765949  974 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 1020
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
745-1021 8.35e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 8.35e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  745 FEGHQAAVNAIQIF--GNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYNVK 822
Cdd:COG2319    116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  823 TRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFNIKNNKRQEIFECHGPRaVSCLATAQEGarKLLVVGSYD 897
Cdd:COG2319    193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  898 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 973
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958765949  974 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1021
Cdd:COG2319    348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 744-984 1.21e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 1.21e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  744 SFEGHQAAVNAIQI--FGNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVTHtsgKNSVLYTGSSDHTIRCYNV 821
Cdd:cd00200     46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDV 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  822 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFNIKNNKRQEIFECHgPRAVSCLATAQEGARklLVVGSY 896
Cdd:cd00200    123 ETGKCLTTLRGhTDWVNSV--AFspdgTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEK--LLSSSS 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  897 DCTISVRDARNGLLLRTLEGHSKTVLCMKV--VNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMV 972
Cdd:cd00200    198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLA 277

                          250
                   ....*....|..
gi 1958765949  973 TACLDKFVRVYE 984
Cdd:cd00200    278 SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
744-987 6.93e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 6.93e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  744 SFEGHQAAVNAIQIF--GNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYNV 821
Cdd:COG2319    157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF---SPDGKLLASGSADGTVRLWDL 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  822 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFNIKNNKRQEIFEcHGPRAVSCLATAQEGarKLLVVGSY 896
Cdd:COG2319    234 ATGKLLRTLTGhSGSVRSV--AFspdgRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGSD 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  897 DCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 972
Cdd:COG2319    309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLA 388

                          250
                   ....*....|....*
gi 1958765949  973 TACLDKFVRVYELQS 987
Cdd:COG2319    389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 781-1020 1.40e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 1.40e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  781 CVGVFEGHISKVNCLlvtHTSGKNSVLYTGSSDHTIRCYNVKTRECMEQLQLE----DRVLCLHNRwRTLYAGLANGTVV 856
Cdd:cd00200      1 LRRTLKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpvRDVAASADG-TYLASGSSDKTIR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  857 TFNIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKV--VNDLVFSG 934
Cdd:cd00200     77 LWDLETGECVRTLTGH-TSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  935 SSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--V 1010
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDgyL 233

                          250
                   ....*....|
gi 1958765949 1011 IYTGCYDGSI 1020
Cdd:cd00200    234 LASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
748-1021 3.25e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 3.25e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  748 HQAAVNAIQIFGNSLYTCSADTTVRVYNLVSRKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYNVKTRECM 827
Cdd:COG2319     37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF---SPDGRLLASASADGTVRLWDLATGLLL 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  828 EQLQ-LEDRVLCLhnRW----RTLYAGLANGTVVTFNIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISV 902
Cdd:COG2319    114 RTLTgHTGAVRSV--AFspdgKTLASGSADGTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDG--KLLASGSDDGTVRL 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  903 RDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDK 978
Cdd:COG2319    189 WDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADG 268

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1958765949  979 FVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1021
Cdd:COG2319    269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVR 313
WD40 COG2319
WD40 repeat [General function prediction only];
872-1021 6.47e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 6.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765949  872 HGPRAVSCLATAQEGARklLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGE 949
Cdd:COG2319     34 GLAAAVASLAASPDGAR--LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGL 111

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958765949  950 LVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1021
Cdd:COG2319    112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 778-820 8.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 8.46e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958765949   778 SRKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYN 820
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
779-820 7.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 7.69e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958765949  779 RKCVGVFEGHISKVNCLLVthtSGKNSVLYTGSSDHTIRCYN 820
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 744-775 4.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 4.09e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958765949   744 SFEGHQAAVNAIQIFGNS--LYTCSADTTVRVYN 775
Cdd:smart00320    7 TLKGHTGPVTSVAFSPDGkyLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
743-775 8.59e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 8.59e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958765949  743 GSFEGHQAAVNAIQI--FGNSLYTCSADTTVRVYN 775
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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