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Conserved domains on  [gi|1958768716|ref|XP_038963217|]
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leucine-rich repeat and guanylate kinase domain-containing protein isoform X13 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-369 4.83e-31

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 118.74  E-value: 4.83e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 200 FSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLP-IKVLSVSNNQIETITGLEE 278
Cdd:cd21340     9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVnLKKLYLGGNRISVVEGLEN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 279 LKA------------------------------LQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEI-EYIENLP 327
Cdd:cd21340    89 LTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWP 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958768716 328 ILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEK 369
Cdd:cd21340   169 SLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER 210
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 416-448 1.79e-05

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd00071:

Pssm-ID: 450170  Cd Length: 137  Bit Score: 44.45  E-value: 1.79e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958768716 416 MLILTGPEACGKRELAHRLCRQFSTYFRYGACH 448
Cdd:cd00071     1 LIVLSGPSGVGKSTLLKRLLEEFDPNFGFSVSH 33
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-184 3.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 3.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 129 RNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCV----SCMPYLLELNASQNRLTT 184
Cdd:cd21340   123 RVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCK 182
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-369 4.83e-31

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 118.74  E-value: 4.83e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 200 FSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLP-IKVLSVSNNQIETITGLEE 278
Cdd:cd21340     9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVnLKKLYLGGNRISVVEGLEN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 279 LKA------------------------------LQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEI-EYIENLP 327
Cdd:cd21340    89 LTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWP 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958768716 328 ILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEK 369
Cdd:cd21340   169 SLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-340 2.61e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 2.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716  96 NLEDEYDGVLREENVADALDGLGWSGRGTEQVYRNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDL-SCVSCMPYLLE 174
Cdd:COG4886    61 LLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 175 LNASQNRLTTF-FNFKPPQNLKqKVDFSSNQISEM-YDLSAYHTLTQLILDNNEIEEI-TGLEKCISLTHLSLAGNRITT 251
Cdd:COG4886   141 LDLSNNQLTDLpEPLGNLTNLK-SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 252 I-KGLGTLP-IKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSeIEYIENLPIL 329
Cdd:COG4886   220 LpEPLANLTnLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGL 298

                         250
                  ....*....|.
gi 1958768716 330 RVLNLLRNPIQ 340
Cdd:COG4886   299 NSLLLLLLLLN 309
LRR_9 pfam14580
Leucine-rich repeat;
242-376 3.71e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.48  E-value: 3.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 242 LSLAGNRITTIKGLG-TL-PIKVLSVSNNQIETITGLEELKALQNLDLSHNQISSL-HGLENH-DLLEVINLEDNKIKEL 317
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLdQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEAlPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768716 318 SEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKY 376
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMF 162
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
217-344 1.15e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 217 LTQLILDNNEI----EEITGlekciSLTHLSLAGNRITTIKGlgTLP--IKVLSVSNNQIETITglEEL-KALQNLDLSH 289
Cdd:PRK15370  201 ITTLILDNNELkslpENLQG-----NIKTLYANSNQLTSIPA--TLPdtIQEMELSINRITELP--ERLpSALQSLDLFH 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768716 290 NQISSLHglEN-HDLLEVINLEDNKIKELSeieyiENLPI-LRVLNLLRNPIQTKPE 344
Cdd:PRK15370  272 NKISCLP--ENlPEELRYLSVYDNSIRTLP-----AHLPSgITHLNVQSNSLTALPE 321
GMPK cd00071
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), ...
 416-448 1.79e-05

Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.


Pssm-ID: 238026  Cd Length: 137  Bit Score: 44.45  E-value: 1.79e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958768716 416 MLILTGPEACGKRELAHRLCRQFSTYFRYGACH 448
Cdd:cd00071     1 LIVLSGPSGVGKSTLLKRLLEEFDPNFGFSVSH 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-184 3.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 3.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 129 RNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCV----SCMPYLLELNASQNRLTT 184
Cdd:cd21340   123 RVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCK 182
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-167 4.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 4.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958768716 129 RNLNLSHCELIDVSILSGYVHLQKLNLSGN-RIEDLSCVS 167
Cdd:pfam12799   4 EVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-369 4.83e-31

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 118.74  E-value: 4.83e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 200 FSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLP-IKVLSVSNNQIETITGLEE 278
Cdd:cd21340     9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVnLKKLYLGGNRISVVEGLEN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 279 LKA------------------------------LQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEI-EYIENLP 327
Cdd:cd21340    89 LTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWP 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958768716 328 ILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEK 369
Cdd:cd21340   169 SLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-340 2.61e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 2.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716  96 NLEDEYDGVLREENVADALDGLGWSGRGTEQVYRNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDL-SCVSCMPYLLE 174
Cdd:COG4886    61 LLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 175 LNASQNRLTTF-FNFKPPQNLKqKVDFSSNQISEM-YDLSAYHTLTQLILDNNEIEEI-TGLEKCISLTHLSLAGNRITT 251
Cdd:COG4886   141 LDLSNNQLTDLpEPLGNLTNLK-SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTD 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 252 I-KGLGTLP-IKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSeIEYIENLPIL 329
Cdd:COG4886   220 LpEPLANLTnLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGL 298

                         250
                  ....*....|.
gi 1958768716 330 RVLNLLRNPIQ 340
Cdd:COG4886   299 NSLLLLLLLLN 309
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
129-364 7.82e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 7.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 129 RNLNLSHCELIDVSI-LSGYVHLQKLNLSGNRIEDLSC-VSCMPYLLELNASQNRLTTF-FNFKPPQNLKqKVDFSSNQI 205
Cdd:COG4886   162 KSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLE-TLDLSNNQL 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 206 SEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLPIKVLSVSNNQIETITGLEELKALQNL 285
Cdd:COG4886   241 TDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768716 286 DLSHNQISSLHGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKI 364
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR_9 pfam14580
Leucine-rich repeat;
242-376 3.71e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.48  E-value: 3.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 242 LSLAGNRITTIKGLG-TL-PIKVLSVSNNQIETITGLEELKALQNLDLSHNQISSL-HGLENH-DLLEVINLEDNKIKEL 317
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLdQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEAlPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768716 318 SEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKY 376
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
171-360 3.70e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 3.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 171 YLLELNASQNRLTTFFNFKPPQNLKQKVDFSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRIT 250
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 251 TIKGLGTLP-IKVLSVSNNQietitGLEELKALQNLDLSHNQISSL-HGLENHDLLEVINLEDNKIKELSeiEYIENLPI 328
Cdd:COG4886    88 GLTDLGDLTnLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLP--EPLGNLTN 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1958768716 329 LRVLNLLRNPIQTKPEywffVIFMLLRLTELD 360
Cdd:COG4886   161 LKSLDLSNNQLTDLPE----ELGNLTNLKELD 188
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
131-337 7.32e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 7.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 131 LNLSHCELIDVSI-LSGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNRLTTFFNFKPPQNLkQKVDFSSNQISEMy 209
Cdd:COG4886   210 LDLSGNQLTDLPEpLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL-KTLDLSNNQLTDL- 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 210 DLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLPIKVLSVSNNQIETITGLEELkalqNLDLSH 289
Cdd:COG4886   288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN----LLSLLL 363

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1958768716 290 NQISSLHGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRN 337
Cdd:COG4886   364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 132-344 2.05e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.34  E-value: 2.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 132 NLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCVScmpyLLELNASQNRLTTF-------------FNFKPPQNLKQ-- 196
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEE----LAEALTQNTTVTTLwlkrnpigdegaeILAEALKGNKSlt 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 197 KVDFSSNQISE------MYDLSAYHTLTQLILDNNEIEE------ITGLEKCISLTHLSLAGNRITT------IKGL-GT 257
Cdd:COG5238   240 TLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLqGN 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 258 LPIKVLSVSNNQIET------ITGLEELKALQNLDLSHNQISS------LHGLENHDLLEVINLEDNKIKELSEIEYIEN 325
Cdd:COG5238   320 KTLHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIGKQGAEALIDA 399

                         250       260
                  ....*....|....*....|.
gi 1958768716 326 LPI--LRVLNLLRNPIQTKPE 344
Cdd:COG5238   400 LQTnrLHTLILDGNLIGAEAQ 420
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 126-339 1.01e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 126 QVYRNLNLSHCElIDVSILSGYVHLQKL--NLSGNRIEDlscVSCMPYLLELNASQNRLTTFFNFKPPQNLK-QKVDFSS 202
Cdd:COG5238   114 TPPPDLRRIMAK-TLEDSLILYLALPRRinLIQVLKDPL---GGNAVHLLGLAARLGLLAAISMAKALQNNSvETVYLGC 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 203 NQISEMYD------LSAYHTLTQLILDNNEIEE------ITGLEKCISLTHLSLAGNRITT--IKGLGTL-----PIKVL 263
Cdd:COG5238   190 NQIGDEGIeelaeaLTQNTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGDegVIALAEAlknntTVETL 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 264 SVSNNQIET------ITGLEELKALQNLDLSHNQISS------LHGLENHDLLEVINLEDNKIKELSEIEYIENL---PI 328
Cdd:COG5238   270 YLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALqenTT 349

                         250
                  ....*....|.
gi 1958768716 329 LRVLNLLRNPI 339
Cdd:COG5238   350 LHSLDLSDNQI 360
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
217-344 1.15e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 217 LTQLILDNNEI----EEITGlekciSLTHLSLAGNRITTIKGlgTLP--IKVLSVSNNQIETITglEEL-KALQNLDLSH 289
Cdd:PRK15370  201 ITTLILDNNELkslpENLQG-----NIKTLYANSNQLTSIPA--TLPdtIQEMELSINRITELP--ERLpSALQSLDLFH 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768716 290 NQISSLHglEN-HDLLEVINLEDNKIKELSeieyiENLPI-LRVLNLLRNPIQTKPE 344
Cdd:PRK15370  272 NKISCLP--ENlPEELRYLSVYDNSIRTLP-----AHLPSgITHLNVQSNSLTALPE 321
GMPK cd00071
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), ...
 416-448 1.79e-05

Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.


Pssm-ID: 238026  Cd Length: 137  Bit Score: 44.45  E-value: 1.79e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958768716 416 MLILTGPEACGKRELAHRLCRQFSTYFRYGACH 448
Cdd:cd00071     1 LIVLSGPSGVGKSTLLKRLLEEFDPNFGFSVSH 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 260-300 3.16e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 3.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958768716 260 IKVLSVSNNQIETITGLEELKALQNLDLSHN-QISSLHGLEN 300
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
282-339 3.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768716 282 LQNLDLSHNQISSLH-----GLENhdlLEVINLEDNKIKELSEIEyIENLPILRVLNLLRNPI 339
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgafkGLSN---LKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-184 3.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 3.79e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 129 RNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCV----SCMPYLLELNASQNRLTT 184
Cdd:cd21340   123 RVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCK 182
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-252 8.60e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 8.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 150 LQKLNLSGNRIEDLSCVSCMPYLLELNAsqnrlttffnfkppqnlkqkvdfSSNQISEMydlsayhtltqlildnNEIEE 229
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDA-----------------------SNNQISDL----------------EELLD 162

                          90       100
                  ....*....|....*....|...
gi 1958768716 230 ItgLEKCISLTHLSLAGNRITTI 252
Cdd:cd21340   163 L--LSSWPSLRELDLTGNPVCKK 183
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 196-339 9.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 9.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 196 QKVDFSSNQISE-----MYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLS-------LAGNRITtikGLGTLPI-KV 262
Cdd:cd00116    84 QELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpaleklvLGRNRLE---GASCEALaKA 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 263 LSVsnnqietITGLEELKALQNlDLSHNQISSL-HGLENHDLLEVINLEDNKI-----KELSEIeyIENLPILRVLNLLR 336
Cdd:cd00116   161 LRA-------NRDLKELNLANN-GIGDAGIRALaEGLKANCNLEVLDLNNNGLtdegaSALAET--LASLKSLEVLNLGD 230


                  ...
gi 1958768716 337 NPI 339
Cdd:cd00116   231 NNL 233
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 238-278 1.84e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958768716 238 SLTHLSLAGNRITTIKGLGTLP-IKVLSVS-NNQIETITGLEE 278
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPnLETLDLSgNNKITDLSDLAN 44
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 154-293 5.79e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 154 NLSGnRIEDLSCVscMPYLLELNASQNRlttFFNFKP----PQNLKqKVDFSSNQISEMY--DLSAYHTLTQLILDNNEI 227
Cdd:PLN00113  439 NLQG-RINSRKWD--MPSLQMLSLARNK---FFGGLPdsfgSKRLE-NLDLSRNQFSGAVprKLGSLSELMQLKLSENKL 511

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768716 228 E-EITG-LEKCISLTHLSLAGNRITtikglGTLPikvlsvsnnqietiTGLEELKALQNLDLSHNQIS 293
Cdd:PLN00113  512 SgEIPDeLSSCKKLVSLDLSHNQLS-----GQIP--------------ASFSEMPVLSQLDLSQNQLS 560
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 217-255 7.58e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 7.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958768716 217 LTQLILDNNEIEEITGLEKCISLTHLSLAGN-RITTIKGL 255
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 280-321 8.12e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 8.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958768716 280 KALQNLDLSHNQISSLHGLENHDLLEVINLEDN-KIKELSEIE 321
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-334 2.43e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 107 EENVADALDGLGWSGRGTEqvyrnLNLSHCELIDV------SILSGYVhLQKLNLSGNRIEDL-------SCVSCMPYLL 173
Cdd:cd00116    67 PRGLQSLLQGLTKGCGLQE-----LDLSDNALGPDgcgvleSLLRSSS-LQELKLNNNGLGDRglrllakGLKDLPPALE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 174 ELNASQNRLTtffnfkppqnlkqkvDFSSNQISEmyDLSAYHTLTQLILDNNEIEE--ITGLekCISLTHLSLagnritt 251
Cdd:cd00116   141 KLVLGRNRLE---------------GASCEALAK--ALRANRDLKELNLANNGIGDagIRAL--AEGLKANCN------- 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768716 252 ikglgtlpIKVLSVSNNQIETITG------LEELKALQNLDLSHNQISSLHGLENHDL-------LEVINLEDNKIKEL- 317
Cdd:cd00116   195 --------LEVLDLNNNGLTDEGAsalaetLASLKSLEVLNLGDNNLTDAGAAALASAllspnisLLTLSLSCNDITDDg 266

                         250
                  ....*....|....*....
gi 1958768716 318 --SEIEYIENLPILRVLNL 334
Cdd:cd00116   267 akDLAEVLAEKESLLELDL 285
LRR_8 pfam13855
Leucine rich repeat;
261-314 4.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768716 261 KVLSVSNNQIETITG--LEELKALQNLDLSHNQISSLHGLENHDL--LEVINLEDNKI 314
Cdd:pfam13855   4 RSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLpsLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-167 4.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 4.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958768716 129 RNLNLSHCELIDVSILSGYVHLQKLNLSGN-RIEDLSCVS 167
Cdd:pfam12799   4 EVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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