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Conserved domains on  [gi|1958773961|ref|XP_038964955|]
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contactin-associated protein-like 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 296-439 6.48e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.37  E-value: 6.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 296 AASFPNPSsYLHFSTFQGE-TSADISFYFKTLIPRGV--FLENLGNTDFIKLELKSSTeVSFSFDvgNGPVEIVVRSPSP 372
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGR-LVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958773961 373 LNDDQWHRVTAERNVKQASLQVDRLPqQIRKAPTEGHTRLELYSQLFVGGAGG---------QQGFLGCIRSLRMN 439
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEdlkspglpvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 552-684 9.16e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 9.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 552 FSTTKAPCILLYVSSLTTDFLAVLVKpTGNLQIRYNLGGtrEPFNIDVDHRNMANGQPHSVNITRHEKTIILKLDHYPAA 631
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELV-NGRLVLRYDLGS--GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958773961 632 GYHLPSSSDtIFNSPKSLFLGKVIETgkiDQEIHKYNTPGFTGCLSRVQFNHI 684
Cdd:pfam02210  78 SSLPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 94-130 1.69e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 53.72  E-value: 1.69e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958773961  94 SCEAYKHLGQTSN--YYWIDPDGSGPLGPLKVYCNMTED 130
Cdd:NF040941    1 SCWEILQAGPSAPsgVYWIDPDGMGGLAPFQVYCDMTTD 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 51-86 5.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 5.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958773961  51 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYSGATC 86
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
4.1m smart00294
putative band 4.1 homologues' binding motif;
779-797 1.02e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.02e-05
                           10
                   ....*....|....*....
gi 1958773961  779 LIRYMFRHKGTYHTNEAKG 797
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 463-488 6.25e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958773961 463 CTSYgaNCENGGKCIEKYHGYSCDCS 488
Cdd:pfam00008   1 CAPN--PCSNGGTCVDTPGGYTCICP 24
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 296-439 6.48e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.37  E-value: 6.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 296 AASFPNPSsYLHFSTFQGE-TSADISFYFKTLIPRGV--FLENLGNTDFIKLELKSSTeVSFSFDvgNGPVEIVVRSPSP 372
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGR-LVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958773961 373 LNDDQWHRVTAERNVKQASLQVDRLPqQIRKAPTEGHTRLELYSQLFVGGAGG---------QQGFLGCIRSLRMN 439
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEdlkspglpvSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
318-441 1.68e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 1.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961  318 DISFYFKTLIPRGV--FLENLGNTDFIKLELKSSTeVSFSFDVGNGPVEIVVrSPSPLNDDQWHRVTAERNVKQASLQVD 395
Cdd:smart00282   1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGR-LVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958773961  396 RLPQQIRKAPtEGHTRLELYSQLFVGGAGGQQ---------GFLGCIRSLRMNGV 441
Cdd:smart00282  79 GGNRVSGESP-GGLTILNLDGPLYLGGLPEDLklpplpvtpGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 323-441 3.78e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.82  E-value: 3.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 323 FKTLIPRGVFLEN-LGNTDFIKLELKSSTeVSFSFDVGNGPVEIVVrSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQI 401
Cdd:pfam02210   1 FRTRQPNGLLLYAgGGGSDFLALELVNGR-LVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958773961 402 RKAPTEGHTrLELYSQLFVGGAGG---------QQGFLGCIRSLRMNGV 441
Cdd:pfam02210  79 SLPPGESLL-LNLNGPLYLGGLPPllllpalpvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 552-684 9.16e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 9.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 552 FSTTKAPCILLYVSSLTTDFLAVLVKpTGNLQIRYNLGGtrEPFNIDVDHRNMANGQPHSVNITRHEKTIILKLDHYPAA 631
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELV-NGRLVLRYDLGS--GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958773961 632 GYHLPSSSDtIFNSPKSLFLGKVIETgkiDQEIHKYNTPGFTGCLSRVQFNHI 684
Cdd:pfam02210  78 SSLPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
547-683 9.64e-25

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.11  E-value: 9.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961  547 QIHFSFSTTKAPCILLYVSSL-TTDFLAVLVKpTGNLQIRYNLGGTrePFNIDVDHRNMANGQPHSVNITRHEKTIILKL 625
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELR-DGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958773961  626 DHYPAAGYHLPSSSdTIFNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFNH 683
Cdd:smart00282  78 DGGNRVSGESPGGL-TILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 545-682 1.78e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 94.41  E-value: 1.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 545 QEQIHFSFSTTKAPCILLYVSS-LTTDFLAVLVKpTGNLQIRYNLGgtREPFNIDVDHRnMANGQPHSVNITRHEKTIIL 623
Cdd:cd00110    21 RLSISFSFRTTSPNGLLLYAGSqNGGDFLALELE-DGRLVLRYDLG--SGSLVLSSKTP-LNDGQWHSVSVERNGRSVTL 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958773961 624 KLDHYPAAgYHLPSSSDTIFNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFN 682
Cdd:cd00110    97 SVDGERVV-ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 94-130 1.69e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 53.72  E-value: 1.69e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958773961  94 SCEAYKHLGQTSN--YYWIDPDGSGPLGPLKVYCNMTED 130
Cdd:NF040941    1 SCWEILQAGPSAPsgVYWIDPDGMGGLAPFQVYCDMTTD 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 51-86 5.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 5.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958773961  51 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYSGATC 86
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
4.1m smart00294
putative band 4.1 homologues' binding motif;
779-797 1.02e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.02e-05
                           10
                   ....*....|....*....
gi 1958773961  779 LIRYMFRHKGTYHTNEAKG 797
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 54-85 8.19e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 8.19e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1958773961  54 CVPNHCEHGGKCSQTWDSFKCTCDEtGYSGAT 85
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
51-86 1.16e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958773961   51 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYS-GATC 86
Cdd:smart00179   2 IDECASGNpCQNGGTCVNTVGSYRCECPP-GYTdGRNC 38
COLFI pfam01410
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 105-128 5.46e-03

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 460199  Cd Length: 233  Bit Score: 39.25  E-value: 5.46e-03
                          10        20
                  ....*....|....*....|....
gi 1958773961 105 SNYYWIDPDGSGPLGPLKVYCNMT 128
Cdd:pfam01410  45 SGEYWIDPNQGCTRDAIKVFCNFE 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 463-488 6.25e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958773961 463 CTSYgaNCENGGKCIEKYHGYSCDCS 488
Cdd:pfam00008   1 CAPN--PCSNGGTCVDTPGGYTCICP 24
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 296-439 6.48e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.37  E-value: 6.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 296 AASFPNPSsYLHFSTFQGE-TSADISFYFKTLIPRGV--FLENLGNTDFIKLELKSSTeVSFSFDvgNGPVEIVVRSPSP 372
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGR-LVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958773961 373 LNDDQWHRVTAERNVKQASLQVDRLPqQIRKAPTEGHTRLELYSQLFVGGAGG---------QQGFLGCIRSLRMN 439
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEdlkspglpvSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
318-441 1.68e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 1.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961  318 DISFYFKTLIPRGV--FLENLGNTDFIKLELKSSTeVSFSFDVGNGPVEIVVrSPSPLNDDQWHRVTAERNVKQASLQVD 395
Cdd:smart00282   1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGR-LVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958773961  396 RLPQQIRKAPtEGHTRLELYSQLFVGGAGGQQ---------GFLGCIRSLRMNGV 441
Cdd:smart00282  79 GGNRVSGESP-GGLTILNLDGPLYLGGLPEDLklpplpvtpGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 323-441 3.78e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.82  E-value: 3.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 323 FKTLIPRGVFLEN-LGNTDFIKLELKSSTeVSFSFDVGNGPVEIVVrSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQI 401
Cdd:pfam02210   1 FRTRQPNGLLLYAgGGGSDFLALELVNGR-LVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958773961 402 RKAPTEGHTrLELYSQLFVGGAGG---------QQGFLGCIRSLRMNGV 441
Cdd:pfam02210  79 SLPPGESLL-LNLNGPLYLGGLPPllllpalpvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 552-684 9.16e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 9.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 552 FSTTKAPCILLYVSSLTTDFLAVLVKpTGNLQIRYNLGGtrEPFNIDVDHRNMANGQPHSVNITRHEKTIILKLDHYPAA 631
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELV-NGRLVLRYDLGS--GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958773961 632 GYHLPSSSDtIFNSPKSLFLGKVIETgkiDQEIHKYNTPGFTGCLSRVQFNHI 684
Cdd:pfam02210  78 SSLPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
547-683 9.64e-25

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.11  E-value: 9.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961  547 QIHFSFSTTKAPCILLYVSSL-TTDFLAVLVKpTGNLQIRYNLGGTrePFNIDVDHRNMANGQPHSVNITRHEKTIILKL 625
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELR-DGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958773961  626 DHYPAAGYHLPSSSdTIFNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFNH 683
Cdd:smart00282  78 DGGNRVSGESPGGL-TILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 545-682 1.78e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 94.41  E-value: 1.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 545 QEQIHFSFSTTKAPCILLYVSS-LTTDFLAVLVKpTGNLQIRYNLGgtREPFNIDVDHRnMANGQPHSVNITRHEKTIIL 623
Cdd:cd00110    21 RLSISFSFRTTSPNGLLLYAGSqNGGDFLALELE-DGRLVLRYDLG--SGSLVLSSKTP-LNDGQWHSVSVERNGRSVTL 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958773961 624 KLDHYPAAgYHLPSSSDTIFNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFN 682
Cdd:cd00110    97 SVDGERVV-ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
Laminin_G_1 pfam00054
Laminin G domain;
323-444 6.15e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 83.52  E-value: 6.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 323 FKTLIPRGVFLENLGNT--DFIKLELKSStEVSFSFDVGNGPVeiVVRSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQ 400
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTerDFLALELRDG-RLEVSYDLGSGAA--VVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958773961 401 IRKAPTEGHTRLELYSQLFVGGAGG----------QQGFLGCIRSLRMNGVTLD 444
Cdd:pfam00054  78 TGESPLGATTDLDVDGPLYVGGLPSlgvkkrrlaiSPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
552-683 2.99e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.87  E-value: 2.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958773961 552 FSTTKAPCILLYVSSLT-TDFLAV-LVKptGNLQIRYNLGGTRE----PFNIDvdhrnmaNGQPHSVNITRHEKTIILKL 625
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTeRDFLALeLRD--GRLEVSYDLGSGAAvvrsGDKLN-------DGKWHSVELERNGRSGTLSV 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958773961 626 DHYPAAGYHLPSSSDTIFNSPKSLFLGKVieTGKIDQEIHKYNTPGFTGCLSRVQFNH 683
Cdd:pfam00054  72 DGEARPTGESPLGATTDLDVDGPLYVGGL--PSLGVKKRRLAISPSFDGCIRDVIVNG 127
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 94-130 1.69e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 53.72  E-value: 1.69e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958773961  94 SCEAYKHLGQTSN--YYWIDPDGSGPLGPLKVYCNMTED 130
Cdd:NF040941    1 SCWEILQAGPSAPsgVYWIDPDGMGGLAPFQVYCDMTTD 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 51-86 5.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 5.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958773961  51 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYSGATC 86
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
4.1m smart00294
putative band 4.1 homologues' binding motif;
779-797 1.02e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.02e-05
                           10
                   ....*....|....*....
gi 1958773961  779 LIRYMFRHKGTYHTNEAKG 797
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 54-85 8.19e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 8.19e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1958773961  54 CVPNHCEHGGKCSQTWDSFKCTCDEtGYSGAT 85
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
51-86 1.16e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958773961   51 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYS-GATC 86
Cdd:smart00179   2 IDECASGNpCQNGGTCVNTVGSYRCECPP-GYTdGRNC 38
COLFI pfam01410
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 105-128 5.46e-03

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 460199  Cd Length: 233  Bit Score: 39.25  E-value: 5.46e-03
                          10        20
                  ....*....|....*....|....
gi 1958773961 105 SNYYWIDPDGSGPLGPLKVYCNMT 128
Cdd:pfam01410  45 SGEYWIDPNQGCTRDAIKVFCNFE 68
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 56-86 5.47e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 5.47e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1958773961  56 PNHCEHGGKCSQTWDSFKCTCDEtGYSGA-TC 86
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVCPP-GYTGDrSC 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 463-488 6.25e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 1958773961 463 CTSYgaNCENGGKCIEKYHGYSCDCS 488
Cdd:pfam00008   1 CAPN--PCSNGGTCVDTPGGYTCICP 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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