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Conserved domains on  [gi|1958644994|ref|XP_038966019|]
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terminal nucleotidyltransferase 4A isoform X2 [Rattus norvegicus]

Protein Classification

nucleotidyltransferase domain-containing protein( domain architecture ID 1001423)

nucleotidyltransferase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRF4 super family cl34961
DNA polymerase sigma [Replication, recombination and repair];
2-295 3.53e-66

DNA polymerase sigma [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG5260:

Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 222.34  E-value: 3.53e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994   2 SPCPEEAAMRREVVKRIETVVKDLWPSADVQIFGSFSTGLYLPTSDIDLVV-----FGKWERPPLQLLEQALRKHNVAEp 76
Cdd:COG5260    69 APSDEELKRRKALLEKLRTLLKKEFPDADLKVFGSTETGLALPKSDIDLCIisdprGYKETRNAGSLASHLFKKNLAKE- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  77 csIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSL 156
Cdd:COG5260   148 --VVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTI 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 157 ILMAISFLQLHP---RID--------ARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSgyRP 225
Cdd:COG5260   226 SCMVLSFLQMHPpflFFDngllsplkYNKNIDNLGVLFDDFFELYGKSFNYSLVVLSINSGDFYLPKYEKGWLKPS--KP 303

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958644994 226 SMLCIEDPLL-PGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRDS-ESTLGRIIKVTQEVIDYR 295
Cdd:COG5260   304 NSLSIQDPGTdRNNDISAVSFNIKDIKAAFIRAFELLSNKLFTLTSAIKHDAYgLLIEFNEASYSNTSRSLK 375
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 370-473 4.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 370 IDSDTPPCTT--PSVYQFSLQAPTTlMAGLPTALPVPSSKPQPAASRTLIMTTNnqtrVTIPPP---TLGVAPVPCRQAG 444
Cdd:pfam05109 420 IFSKAPESTTtsPTLNTTGFAAPNT-TTGLPSSTHVPTNLTAPASTGPTVSTAD----VTSPTPagtTSGASPVTPSPSP 494

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958644994 445 VDGTTSLKAvHNVTSPAIPSASPNP-LSSP 473
Cdd:pfam05109 495 RDNGTESKA-PDMTSPTSAVTTPTPnATSP 523
 
Name Accession Description Interval E-value
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
2-295 3.53e-66

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 222.34  E-value: 3.53e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994   2 SPCPEEAAMRREVVKRIETVVKDLWPSADVQIFGSFSTGLYLPTSDIDLVV-----FGKWERPPLQLLEQALRKHNVAEp 76
Cdd:COG5260    69 APSDEELKRRKALLEKLRTLLKKEFPDADLKVFGSTETGLALPKSDIDLCIisdprGYKETRNAGSLASHLFKKNLAKE- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  77 csIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSL 156
Cdd:COG5260   148 --VVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTI 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 157 ILMAISFLQLHP---RID--------ARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSgyRP 225
Cdd:COG5260   226 SCMVLSFLQMHPpflFFDngllsplkYNKNIDNLGVLFDDFFELYGKSFNYSLVVLSINSGDFYLPKYEKGWLKPS--KP 303

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958644994 226 SMLCIEDPLL-PGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRDS-ESTLGRIIKVTQEVIDYR 295
Cdd:COG5260   304 NSLSIQDPGTdRNNDISAVSFNIKDIKAAFIRAFELLSNKLFTLTSAIKHDAYgLLIEFNEASYSNTSRSLK 375
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 10-121 8.68e-39

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 137.69  E-value: 8.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  10 MRREVVKRIETVVKDLWPSADVQIFGSFSTGLYLPTSDIDLVVFG----KWERPPLQLLEQALRKHNvaEPCSIKVLDKA 85
Cdd:cd05402     1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGpnhrVDREDFLRKLAKLLKKSG--EVVEVEPIINA 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958644994  86 TVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYM 121
Cdd:cd05402    79 RVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
 178-238 5.84e-19

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 80.69  E-value: 5.84e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958644994 178 NLGMLLVEFFELYGRNFNYLKTGIRIKEGGaYIAKEEIMKAMTSGYRPSMLCIEDPLLPGN 238
Cdd:pfam03828   1 SLGELLIGFFEYYGREFDYENVVISIRTGG-ILSKKEKGWLRNEGRRPFLLCIEDPFDLDN 60
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 370-473 4.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 370 IDSDTPPCTT--PSVYQFSLQAPTTlMAGLPTALPVPSSKPQPAASRTLIMTTNnqtrVTIPPP---TLGVAPVPCRQAG 444
Cdd:pfam05109 420 IFSKAPESTTtsPTLNTTGFAAPNT-TTGLPSSTHVPTNLTAPASTGPTVSTAD----VTSPTPagtTSGASPVTPSPSP 494

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958644994 445 VDGTTSLKAvHNVTSPAIPSASPNP-LSSP 473
Cdd:pfam05109 495 RDNGTESKA-PDMTSPTSAVTTPTPnATSP 523
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 378-477 7.70e-04

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 40.76  E-value: 7.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 378 TTPSVYQFSLQAPTTlMAGLPTALPVPSSKPQPAASRTLIMTTNNQTRVtipPPTLGVAPVPCRQAGVDGTTSLKAVHNV 457
Cdd:cd21441    65 TSPTAVSSSPVSMTA-SASPSSSSSSSSSSSRPASSPTVITSVSSASSV---PTVLTPGPLVASASGVGGQQFLHIIHPV 140

                          90       100
                  ....*....|....*....|
gi 1958644994 458 tspaiPSASPNPLSSPHLYH 477
Cdd:cd21441   141 -----PPSSPMNLQSNKLSH 155
 
Name Accession Description Interval E-value
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
2-295 3.53e-66

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 222.34  E-value: 3.53e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994   2 SPCPEEAAMRREVVKRIETVVKDLWPSADVQIFGSFSTGLYLPTSDIDLVV-----FGKWERPPLQLLEQALRKHNVAEp 76
Cdd:COG5260    69 APSDEELKRRKALLEKLRTLLKKEFPDADLKVFGSTETGLALPKSDIDLCIisdprGYKETRNAGSLASHLFKKNLAKE- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  77 csIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSL 156
Cdd:COG5260   148 --VVVVSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTI 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 157 ILMAISFLQLHP---RID--------ARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSgyRP 225
Cdd:COG5260   226 SCMVLSFLQMHPpflFFDngllsplkYNKNIDNLGVLFDDFFELYGKSFNYSLVVLSINSGDFYLPKYEKGWLKPS--KP 303

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958644994 226 SMLCIEDPLL-PGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRDS-ESTLGRIIKVTQEVIDYR 295
Cdd:COG5260   304 NSLSIQDPGTdRNNDISAVSFNIKDIKAAFIRAFELLSNKLFTLTSAIKHDAYgLLIEFNEASYSNTSRSLK 375
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 10-121 8.68e-39

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 137.69  E-value: 8.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  10 MRREVVKRIETVVKDLWPSADVQIFGSFSTGLYLPTSDIDLVVFG----KWERPPLQLLEQALRKHNvaEPCSIKVLDKA 85
Cdd:cd05402     1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGpnhrVDREDFLRKLAKLLKKSG--EVVEVEPIINA 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958644994  86 TVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYM 121
Cdd:cd05402    79 RVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
 178-238 5.84e-19

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 80.69  E-value: 5.84e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958644994 178 NLGMLLVEFFELYGRNFNYLKTGIRIKEGGaYIAKEEIMKAMTSGYRPSMLCIEDPLLPGN 238
Cdd:pfam03828   1 SLGELLIGFFEYYGREFDYENVVISIRTGG-ILSKKEKGWLRNEGRRPFLLCIEDPFDLDN 60
NTP_transf_2 pfam01909
Nucleotidyltransferase domain; Members of this family belong to a large family of ...
 15-124 6.24e-14

Nucleotidyltransferase domain; Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.


Pssm-ID: 396474  Cd Length: 91  Bit Score: 67.44  E-value: 6.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  15 VKRIETVVKDLWPSADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEqalrkhnvaepcsikvldkaTVPIIKLTD 94
Cdd:pfam01909   1 LRKLREILKELFPVAEVVLFGSYARGTALPGSDIDLLVVFPEPVEEERLLK--------------------LAKIIKELE 60

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958644994  95 QETEVKVDISFNMETGV-RAAEFIKNYMKKY 124
Cdd:pfam01909  61 ELLGLEVDLVTREKIEFpLVKIDILEERILL 91
MJ0604 COG1708
Predicted nucleotidyltransferase, MJ0604 family [General function prediction only];
12-87 6.48e-05

Predicted nucleotidyltransferase, MJ0604 family [General function prediction only];


Pssm-ID: 441314  Cd Length: 95  Bit Score: 41.94  E-value: 6.48e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958644994  12 REVVKRIETVVKDLWPSADVQIFGSFSTGLYLPTSDIDL-VVFGKWERPP--LQLLEQALRKhnVAEPCSIKVLDKATV 87
Cdd:COG1708     6 RELLEEIVEALRRGPEVAAVYLFGSYARGDARPDSDIDLlVVVDDPPLPDerLELLADLLRE--LGLPVDLVVLTPAEL 82
NT_KNTase_like cd05403
Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, ...
 12-102 1.80e-04

Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.


Pssm-ID: 143393  Cd Length: 93  Bit Score: 40.48  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  12 REVVKRIETVVKDLWpsadvqIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLE-QALRKHNVAEPCSIKVLDKATVPII 90
Cdd:cd05403     8 LEILRELLGGVEKVY------LFGSYARGDARPDSDIDLLVIFDDPLDPLELARlLEELELLLGRPVDLVVLNALELELL 81

                          90
                  ....*....|..
gi 1958644994  91 KLTDQETEVKVD 102
Cdd:cd05403    82 LRILIEGEGIYL 93
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 370-473 4.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 370 IDSDTPPCTT--PSVYQFSLQAPTTlMAGLPTALPVPSSKPQPAASRTLIMTTNnqtrVTIPPP---TLGVAPVPCRQAG 444
Cdd:pfam05109 420 IFSKAPESTTtsPTLNTTGFAAPNT-TTGLPSSTHVPTNLTAPASTGPTVSTAD----VTSPTPagtTSGASPVTPSPSP 494

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958644994 445 VDGTTSLKAvHNVTSPAIPSASPNP-LSSP 473
Cdd:pfam05109 495 RDNGTESKA-PDMTSPTSAVTTPTPnATSP 523
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 378-477 7.70e-04

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 40.76  E-value: 7.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994 378 TTPSVYQFSLQAPTTlMAGLPTALPVPSSKPQPAASRTLIMTTNNQTRVtipPPTLGVAPVPCRQAGVDGTTSLKAVHNV 457
Cdd:cd21441    65 TSPTAVSSSPVSMTA-SASPSSSSSSSSSSSRPASSPTVITSVSSASSV---PTVLTPGPLVASASGVGGQQFLHIIHPV 140

                          90       100
                  ....*....|....*....|
gi 1958644994 458 tspaiPSASPNPLSSPHLYH 477
Cdd:cd21441   141 -----PPSSPMNLQSNKLSH 155
NT_2-5OAS_ClassI-CCAase cd05400
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class ...
 6-103 7.72e-04

Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; In vertebrates, 2-5OASs are induced by interferon during the innate immune response to protect against RNA virus infections. In the presence of an RNA activator, 2-5OASs catalyze the oligomerization of ATP into 2-5A. 2-5A activates endoribonuclease L, which leads to degradation of the viral RNA. 2-5OASs are also implicated in cell growth control, differentiation, and apoptosis. This family includes human OAS1, -2, -3, and OASL. CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This class I group includes the archaeal Sulfolobus shibatae and Archeoglobus fulgidus CCA-adding enzymes. It belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this family.


Pssm-ID: 143390 [Multi-domain]  Cd Length: 143  Bit Score: 40.08  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994   6 EEAAMRREVVKRIETVVKDL-WPSADVQIFGSFSTGLYL-PTSDIDLVVF---GKWERPP-----LQLLEQALRKHnvaE 75
Cdd:cd05400     4 EAKERYREIREALKESLSELaGRVAEVFLQGSYARGTALrGDSDIDLVVVlpdDTSFAEYgpaelLDELGEALKEY---Y 80

                          90       100
                  ....*....|....*....|....*...
gi 1958644994  76 PCSIKVldKATVPIIKLTDQETEVKVDI 103
Cdd:cd05400    81 GANEEV--KAQHRSVTVKFKGQGFHVDV 106
MJ0435 COG1669
Predicted nucleotidyltransferase MJ0435 [General function prediction only];
10-65 1.58e-03

Predicted nucleotidyltransferase MJ0435 [General function prediction only];


Pssm-ID: 441275  Cd Length: 96  Bit Score: 37.97  E-value: 1.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994  10 MRRE-VVKRIETVVKDLWPSADVQ---IFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLE 65
Cdd:COG1669     1 MNREeILEILREVIEELAERYGVSrlgLFGSVARGEAREDSDIDLLVEFDEPTSLFDLFE 60
Polbeta pfam18765
Polymerase beta, Nucleotidyltransferase; A member of the nucleotidyltransferase fold found in ...
 33-91 6.50e-03

Polymerase beta, Nucleotidyltransferase; A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.


Pssm-ID: 465859  Cd Length: 93  Bit Score: 35.97  E-value: 6.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958644994  33 IFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLE--QALRKHNVAEPCSIKVLDKATVPIIK 91
Cdd:pfam18765  18 LFGSRAKGDAREDSDIDLAVLYDEKLDFEELLElaSELEDILLLRKVDLVDLNKAPPVLAH 78
PAP_central pfam04928
Poly(A) polymerase central domain; The central domain of Poly(A) polymerase shares structural ...
 5-92 6.96e-03

Poly(A) polymerase central domain; The central domain of Poly(A) polymerase shares structural similarity with the allosteric activity domain of ribonucleotide reductase R1, which comprises a four-helix bundle and a three-stranded mixed beta- sheet. Even though the two enzymes bind ATP, the ATP-recognition motifs are different.


Pssm-ID: 461486 [Multi-domain]  Cd Length: 344  Bit Score: 38.65  E-value: 6.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644994   5 PEEAAMRREVVKRIETVVKDL-----------WPSADVQI-----FGSFSTGLYLPTSDID-LVVFGK--WERPPLQLLE 65
Cdd:pfam04928  35 EEETQKREEVLGKLNKLVKEFvkrvskekglpESVAKEAGgkiftFGSYRLGVHGPGSDIDtLCVVPKhvTREDFFTSFL 114

                          90       100
                  ....*....|....*....|....*...
gi 1958644994  66 QALRKH-NVAEPCSIkvlDKATVPIIKL 92
Cdd:pfam04928 115 EMLRERpEVTELTAV---PDAFVPVIKF 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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