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Conserved domains on  [gi|1958645250|ref|XP_038966897|]
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lysophospholipid acyltransferase 7 isoform X1 [Rattus norvegicus]

Protein Classification

membrane-bound O-acyltransferase family protein( domain architecture ID 326)

membrane-bound O-acyltransferase (MBOAT) family protein may be an integral transmembrane enzyme that modifies protective cell-surface polymers, catalyzing the transfer of an acetyl group from acetyl-CoA to its target substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MBOAT super family cl00738
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
8-431 3.35e-32

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


The actual alignment was detected with superfamily member PLN02332:

Pssm-ID: 445070  Cd Length: 465  Bit Score: 127.86  E-value: 3.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250   8 YLMVLLISIPVGFLFKKA-GPGLKRWGAAAVGLGLTLFTCGPHS-LHSLITILGTWALIQAQPCSCHALALAWTFSYLLF 85
Cdd:PLN02332   21 FLLCFVASIPLSALWRFIpSGTLRHLYAALSGAFLSYLSFGFSSnLHFVVPMIAGYLAMALARRRCGAITFLFAFAYLIY 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250  86 FRALSLLG---LPTPTPFTNAvQLLLTLKLVSLASEVQDlhlAQRKEmaSGFSKEPTLGLLPDVPSLMETLSYSYCYVGI 162
Cdd:PLN02332  101 CHVFYMSGdawKEGGIDFTGA-LMVLTLKVISCAMNYQD---GLLKE--EGLREAQKKNRLIQLPSLIEYLGYCLCCGSH 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 163 MTGPFFRYRTYLDWLE----------QPFPEAV-PSLRPLLRRAWpaplFGLLFLLSSHLFPLEAVREDAFYARPLPTRL 231
Cdd:PLN02332  175 LAGPVFEFRDYLDWTEgkglwdpnakGKCPSPYgATLRALLQAAI----CMGLYLYLTPQFPLSRFTEPDYQEWGFWHRF 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 232 FYMIPVFFAFRMRFYVAWIAAECGCIAAGFG--AYPVAAKARAGggptlqcpppsspeiaasleydYEAIRNIDCYGTDF 309
Cdd:PLN02332  251 GYQYMSGFTARWKYYFIWSISEAAIIISGLGfsGWDGEGKPKAK----------------------WDRAKNVDILGVEL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 310 CVRVRDGMRYWNMTVQWWLAQYIY-------KSAPFRSYVLrsawTMLLSAYWHGLHPGYYLSFMTIPLCLAAEGYLESa 382
Cdd:PLN02332  309 AKSAVQIPLVWNIQVSTWLRHYVYerlvpkgKKPGFFQLLA----TQTVSAVWHGLYPGYILFFVQSALMIAGSRVIYR- 383
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958645250 383 LRRHLSPGGQKA---WDWFHWFLKMRAYDYMCMGFVLLSMGDTLRYWASIYF 431
Cdd:PLN02332  384 WQQAIPPSMALArnlLVFINFLYTVLVLNYSCVGFMLLSLDETLAAYGSVYY 435
 
Name Accession Description Interval E-value
PLN02332 PLN02332
membrane bound O-acyl transferase (MBOAT) family protein
8-431 3.35e-32

membrane bound O-acyl transferase (MBOAT) family protein


Pssm-ID: 215190  Cd Length: 465  Bit Score: 127.86  E-value: 3.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250   8 YLMVLLISIPVGFLFKKA-GPGLKRWGAAAVGLGLTLFTCGPHS-LHSLITILGTWALIQAQPCSCHALALAWTFSYLLF 85
Cdd:PLN02332   21 FLLCFVASIPLSALWRFIpSGTLRHLYAALSGAFLSYLSFGFSSnLHFVVPMIAGYLAMALARRRCGAITFLFAFAYLIY 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250  86 FRALSLLG---LPTPTPFTNAvQLLLTLKLVSLASEVQDlhlAQRKEmaSGFSKEPTLGLLPDVPSLMETLSYSYCYVGI 162
Cdd:PLN02332  101 CHVFYMSGdawKEGGIDFTGA-LMVLTLKVISCAMNYQD---GLLKE--EGLREAQKKNRLIQLPSLIEYLGYCLCCGSH 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 163 MTGPFFRYRTYLDWLE----------QPFPEAV-PSLRPLLRRAWpaplFGLLFLLSSHLFPLEAVREDAFYARPLPTRL 231
Cdd:PLN02332  175 LAGPVFEFRDYLDWTEgkglwdpnakGKCPSPYgATLRALLQAAI----CMGLYLYLTPQFPLSRFTEPDYQEWGFWHRF 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 232 FYMIPVFFAFRMRFYVAWIAAECGCIAAGFG--AYPVAAKARAGggptlqcpppsspeiaasleydYEAIRNIDCYGTDF 309
Cdd:PLN02332  251 GYQYMSGFTARWKYYFIWSISEAAIIISGLGfsGWDGEGKPKAK----------------------WDRAKNVDILGVEL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 310 CVRVRDGMRYWNMTVQWWLAQYIY-------KSAPFRSYVLrsawTMLLSAYWHGLHPGYYLSFMTIPLCLAAEGYLESa 382
Cdd:PLN02332  309 AKSAVQIPLVWNIQVSTWLRHYVYerlvpkgKKPGFFQLLA----TQTVSAVWHGLYPGYILFFVQSALMIAGSRVIYR- 383
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958645250 383 LRRHLSPGGQKA---WDWFHWFLKMRAYDYMCMGFVLLSMGDTLRYWASIYF 431
Cdd:PLN02332  384 WQQAIPPSMALArnlLVFINFLYTVLVLNYSCVGFMLLSLDETLAAYGSVYY 435
COG5202 COG5202
Predicted membrane protein [Function unknown];
128-434 5.83e-29

Predicted membrane protein [Function unknown];


Pssm-ID: 227529  Cd Length: 512  Bit Score: 119.30  E-value: 5.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 128 KEMASGFSKEPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLE----QPFPEAV-------PSLRPLLRRAW 196
Cdd:COG5202   146 KEYSSDLTEHQKSRARRGTPTVLDFLSYIFFIPGLLLGPAFDYADFDSWLTcemfRSLMENPyerpkrpPNGKLALATFL 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 197 PAPLFGLLFLLSSHLFPLEAVREDAFYARPLPTRLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGaypvaakaragggp 276
Cdd:COG5202   226 KGLGWLILFQVGRISIPRKHLLEEDFPVRLLPMRWAYLYLFTFGNRIKYYFAWHFSHGSCILFGLG-------------- 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 277 tlQCPPPSSPEIAasleydYEAIRNIDCYGTDFCVRVRDGMRYWNMTVQWWLAQYIY-------KSAPFRSyvlrSAWTM 349
Cdd:COG5202   292 --YNGPDSTQKIR------WDRVRNIDFMKVELATNVKDLLEAWNMNTNKWLKNSVYlrvvkkgKKPGFWS----TLGTF 359
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 350 LLSAYWHGLHPGYYLSFMTiplcLAAEGYLESALRRHL----------SPGGQKAWDWFHWFLKMR-AYDYMCMGFVLLS 418
Cdd:COG5202   360 AISALWHGINPGYYLTFLS----LAASQTIVKENRRLLrpfflredgvTPLPSKSLYDVLGRIAMLlLTTYFSASFFLLS 435
                         330
                  ....*....|....*.
gi 1958645250 419 MGDTLRYWASIYFWVH 434
Cdd:COG5202   436 LKDSMYVWRSVYFAVH 451
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
122-419 1.45e-20

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 92.50  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 122 LHLAQRKEMASGFSKEPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPF----PEAVPSLRPLLRRAWP 197
Cdd:pfam03062  54 LLLFSYRPVSLSFRKLASAAALSQDPSLLEYLGYVFFYPGLLVGPIFSYSDYMSFPRDPLfrwlYYVKRNLAPALGALFL 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 198 APLFGLLFLLSSHLFPLEAVREDAFYARPLPTRLFYMIPVFFAFRMRFYVAWIAAECgciaagfgAYPVAAKARAGGGPT 277
Cdd:pfam03062 134 GLTYLILIQYLLSHLPDKDFSKFKFLSYAFLLRFSVIMRILLGLLWLFLLIFDFLGW--------LFAEGEDILFGLGFN 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 278 LQcpppsspeiaasleydyEAIRNIDCYGT-DFCVRVRDGMRYWNMTVQWWLAQYIYKsaPFRSYVLRSAW-----TMLL 351
Cdd:pfam03062 206 GW-----------------DRVAPENIYRCwENAVSFSEFWRAWNIPVHKWLKRYVYK--PLGKKGKLNKFlatlaTFLF 266
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958645250 352 SAYWHGLHPGYYLSFMTIPLCLAAEGYlesaLRRHLSPGGQKAWDWFHWFLKMRAYDYMCMGFVLLSM 419
Cdd:pfam03062 267 SAVWHGYYLGYLLWFVLRVLLLLAEKL----IRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALL 330
 
Name Accession Description Interval E-value
PLN02332 PLN02332
membrane bound O-acyl transferase (MBOAT) family protein
8-431 3.35e-32

membrane bound O-acyl transferase (MBOAT) family protein


Pssm-ID: 215190  Cd Length: 465  Bit Score: 127.86  E-value: 3.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250   8 YLMVLLISIPVGFLFKKA-GPGLKRWGAAAVGLGLTLFTCGPHS-LHSLITILGTWALIQAQPCSCHALALAWTFSYLLF 85
Cdd:PLN02332   21 FLLCFVASIPLSALWRFIpSGTLRHLYAALSGAFLSYLSFGFSSnLHFVVPMIAGYLAMALARRRCGAITFLFAFAYLIY 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250  86 FRALSLLG---LPTPTPFTNAvQLLLTLKLVSLASEVQDlhlAQRKEmaSGFSKEPTLGLLPDVPSLMETLSYSYCYVGI 162
Cdd:PLN02332  101 CHVFYMSGdawKEGGIDFTGA-LMVLTLKVISCAMNYQD---GLLKE--EGLREAQKKNRLIQLPSLIEYLGYCLCCGSH 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 163 MTGPFFRYRTYLDWLE----------QPFPEAV-PSLRPLLRRAWpaplFGLLFLLSSHLFPLEAVREDAFYARPLPTRL 231
Cdd:PLN02332  175 LAGPVFEFRDYLDWTEgkglwdpnakGKCPSPYgATLRALLQAAI----CMGLYLYLTPQFPLSRFTEPDYQEWGFWHRF 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 232 FYMIPVFFAFRMRFYVAWIAAECGCIAAGFG--AYPVAAKARAGggptlqcpppsspeiaasleydYEAIRNIDCYGTDF 309
Cdd:PLN02332  251 GYQYMSGFTARWKYYFIWSISEAAIIISGLGfsGWDGEGKPKAK----------------------WDRAKNVDILGVEL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 310 CVRVRDGMRYWNMTVQWWLAQYIY-------KSAPFRSYVLrsawTMLLSAYWHGLHPGYYLSFMTIPLCLAAEGYLESa 382
Cdd:PLN02332  309 AKSAVQIPLVWNIQVSTWLRHYVYerlvpkgKKPGFFQLLA----TQTVSAVWHGLYPGYILFFVQSALMIAGSRVIYR- 383
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958645250 383 LRRHLSPGGQKA---WDWFHWFLKMRAYDYMCMGFVLLSMGDTLRYWASIYF 431
Cdd:PLN02332  384 WQQAIPPSMALArnlLVFINFLYTVLVLNYSCVGFMLLSLDETLAAYGSVYY 435
COG5202 COG5202
Predicted membrane protein [Function unknown];
128-434 5.83e-29

Predicted membrane protein [Function unknown];


Pssm-ID: 227529  Cd Length: 512  Bit Score: 119.30  E-value: 5.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 128 KEMASGFSKEPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLE----QPFPEAV-------PSLRPLLRRAW 196
Cdd:COG5202   146 KEYSSDLTEHQKSRARRGTPTVLDFLSYIFFIPGLLLGPAFDYADFDSWLTcemfRSLMENPyerpkrpPNGKLALATFL 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 197 PAPLFGLLFLLSSHLFPLEAVREDAFYARPLPTRLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGaypvaakaragggp 276
Cdd:COG5202   226 KGLGWLILFQVGRISIPRKHLLEEDFPVRLLPMRWAYLYLFTFGNRIKYYFAWHFSHGSCILFGLG-------------- 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 277 tlQCPPPSSPEIAasleydYEAIRNIDCYGTDFCVRVRDGMRYWNMTVQWWLAQYIY-------KSAPFRSyvlrSAWTM 349
Cdd:COG5202   292 --YNGPDSTQKIR------WDRVRNIDFMKVELATNVKDLLEAWNMNTNKWLKNSVYlrvvkkgKKPGFWS----TLGTF 359
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 350 LLSAYWHGLHPGYYLSFMTiplcLAAEGYLESALRRHL----------SPGGQKAWDWFHWFLKMR-AYDYMCMGFVLLS 418
Cdd:COG5202   360 AISALWHGINPGYYLTFLS----LAASQTIVKENRRLLrpfflredgvTPLPSKSLYDVLGRIAMLlLTTYFSASFFLLS 435
                         330
                  ....*....|....*.
gi 1958645250 419 MGDTLRYWASIYFWVH 434
Cdd:COG5202   436 LKDSMYVWRSVYFAVH 451
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
122-419 1.45e-20

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 92.50  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 122 LHLAQRKEMASGFSKEPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPF----PEAVPSLRPLLRRAWP 197
Cdd:pfam03062  54 LLLFSYRPVSLSFRKLASAAALSQDPSLLEYLGYVFFYPGLLVGPIFSYSDYMSFPRDPLfrwlYYVKRNLAPALGALFL 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 198 APLFGLLFLLSSHLFPLEAVREDAFYARPLPTRLFYMIPVFFAFRMRFYVAWIAAECgciaagfgAYPVAAKARAGGGPT 277
Cdd:pfam03062 134 GLTYLILIQYLLSHLPDKDFSKFKFLSYAFLLRFSVIMRILLGLLWLFLLIFDFLGW--------LFAEGEDILFGLGFN 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645250 278 LQcpppsspeiaasleydyEAIRNIDCYGT-DFCVRVRDGMRYWNMTVQWWLAQYIYKsaPFRSYVLRSAW-----TMLL 351
Cdd:pfam03062 206 GW-----------------DRVAPENIYRCwENAVSFSEFWRAWNIPVHKWLKRYVYK--PLGKKGKLNKFlatlaTFLF 266
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958645250 352 SAYWHGLHPGYYLSFMTIPLCLAAEGYlesaLRRHLSPGGQKAWDWFHWFLKMRAYDYMCMGFVLLSM 419
Cdd:pfam03062 267 SAVWHGYYLGYLLWFVLRVLLLLAEKL----IRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALL 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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