Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.

                          10        20
                  ....*....|....*....|....
gi 1958645419   3 GECWDPDPHGRPDFGSILKQLEVI 26
Cdd:cd14148   235 EECWDPDPHGRPDFGSILKRLEDI 258

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).

                          10        20
                  ....*....|....*....|....
gi 1958645419   3 GECWDPDPHGRPDFGSILKQLEVI 26
Cdd:cd14148   235 EECWDPDPHGRPDFGSILKRLEDI 258

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645419  24 EVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKEL-----------RSREEELlrAAQEQRFQEEQlRRREQEL 92
Cdd:pfam03938   9 KILEESPEGKAAQAQLEKKFKKRQAELEAKQKELQKLYEELqkdgalleeerEEKEQEL--QKKEQELQQLQ-QKAQQEL 85

                          90
                  ....*....|
gi 1958645419  93 AEREMDIVER 102
Cdd:pfam03938  86 QKKQQELLQP 95

The Bin/Amphiphysin/Rvs (BAR) domain of Schizosaccharomyces pombe Meiotically Up-regulated Gene 137 protein and similar proteins; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions including organelle biogenesis, membrane trafficking or remodeling, and cell division and migration. This subfamily is composed predominantly of uncharacterized fungal proteins with similarity to Schizosaccharomyces pombe Meiotically Up-regulated Gene 137 protein (MUG137), which may play a role in meiosis and sporulation in fission yeast. MUG137 contains an N-terminal BAR domain and a C-terminal SH3 domain, similar to endophilins. Endophilins play roles in synaptic vesicle formation, virus budding, mitochondrial morphology maintenance, receptor-mediated endocytosis inhibition, and endosomal sorting. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645419  23 LEVIEQSaLFQMplESFHSLQEdwKLEIQHM-FDDLRTK---EKELRSREEELLRAAQeQRFQE--EQLRRREQELAERE 96
Cdd:cd07593   103 LANIERS-LAEM--KEYHSARK--KLESRRLaYDAALTKsqkAKKEDSRLEEELRRAK-AKYEEssEDVEARMVAIKESE 176

                          90
                  ....*....|....*
gi 1958645419  97 MDIVERELHLLMSQL 111
Cdd:cd07593   177 ADQYRDLTDLLDAEL 191

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).

                          10        20
                  ....*....|....*....|....
gi 1958645419   3 GECWDPDPHGRPDFGSILKQLEVI 26
Cdd:cd14148   235 EECWDPDPHGRPDFGSILKRLEDI 258

Uncharacterized protein, contains DUF3084 domain [Function unknown];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645419  13 RPDFGSILKQLEVIEQSALFQMplesfHSLQEdwklEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQEL 92
Cdd:COG4372    19 RPKTGILIAALSEQLRKALFEL-----DKLQE----ELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQL 89

                          90       100
                  ....*....|....*....|....*....
gi 1958645419  93 AEREMDIVERELHLlmSQLSQEKPRVRKR 121
Cdd:COG4372    90 QAAQAELAQAQEEL--ESLQEEAEELQEE 116

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.

                          10        20
                  ....*....|....*....|....*.
gi 1958645419   1 MSGECWDPDPHGRPDFGSILKQLEVI 26
Cdd:cd14147   242 LMADCWAQDPHRRPDFASILQQLEAL 267

phosphodiesterase; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645419  21 KQLEVIEQSALFQMPlESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRaaqeqrfQEEQLRRREQELAEREMDIV 100
Cdd:PRK12704   49 KEAEAIKKEALLEAK-EEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDR-------KLELLEKREEELEKKEKELE 120

                  ....*.
gi 1958645419 101 ERELHL 106
Cdd:PRK12704  121 QKQQEL 126

RNase Y N-terminal region;

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958645419  40 HSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQ--EQRfqEEQLRRREQELAEREMDIVERE 103
Cdd:pfam12072  63 HKLRAEAERELKERRNELQRQERRLLQKEETLDRKDEslEKK--EESLEKKEKELEAQQQQLEEKE 126

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958645419  34 MPLESFHSLQEdwklEIQHMFDD---LRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAE 94
Cdd:COG3074     1 MSLELLEELEA----KVQQAVDTielLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKT 60

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.

                          10        20
                  ....*....|....*....|...
gi 1958645419   4 ECWDPDPHGRPDFGSILKQLEVI 26
Cdd:cd14146   246 ECWEQDPHIRPSFALILEQLTAI 268

The Bin/Amphiphysin/Rvs (BAR) domain of Schizosaccharomyces pombe Meiotically Up-regulated Gene 137 protein and similar proteins; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions including organelle biogenesis, membrane trafficking or remodeling, and cell division and migration. This subfamily is composed predominantly of uncharacterized fungal proteins with similarity to Schizosaccharomyces pombe Meiotically Up-regulated Gene 137 protein (MUG137), which may play a role in meiosis and sporulation in fission yeast. MUG137 contains an N-terminal BAR domain and a C-terminal SH3 domain, similar to endophilins. Endophilins play roles in synaptic vesicle formation, virus budding, mitochondrial morphology maintenance, receptor-mediated endocytosis inhibition, and endosomal sorting. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645419  23 LEVIEQSaLFQMplESFHSLQEdwKLEIQHM-FDDLRTK---EKELRSREEELLRAAQeQRFQE--EQLRRREQELAERE 96
Cdd:cd07593   103 LANIERS-LAEM--KEYHSARK--KLESRRLaYDAALTKsqkAKKEDSRLEEELRRAK-AKYEEssEDVEARMVAIKESE 176

                          90
                  ....*....|....*
gi 1958645419  97 MDIVERELHLLMSQL 111
Cdd:cd07593   177 ADQYRDLTDLLDAEL 191

Uncharacterized protein, contains PD-(D/E)XK nuclease domain [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645419  42 LQEDW--------KLEIQHMFDDLRtkeKELRSREEELLRAAQEQRFQEEQLRR-REQELAERE----MDIVERELHLLM 108
Cdd:COG5493    16 LREDPefryavlgLLATKDGLEELL---ERLEKLEEQMRKWEEQLRKLEEEIKKlREQVRKLEEdvkrLEEQERKLEEAM 92

                          90       100
                  ....*....|....*....|
gi 1958645419 109 SQLSQEKPRVRKRKGNFKRS 128
Cdd:COG5493    93 AEHSELREELMKLIKRLERS 112

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958645419   24 EVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKEL------------RSREEELlrAAQEQRFQEEQlRRREQE 91
Cdd:smart00935   8 KILQESPAGKAAQKQLEKEFKKRQAELEKLEKELQKLKEKLqkdaatlseaarEKKEKEL--QKKVQEFQRKQ-QKLQQD 84

                           90
                   ....*....|.
gi 1958645419   92 LAEREMDIVER 102
Cdd:smart00935  85 LQKRQQEELQK 95

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958645419  28 QSALFQMPleSFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELlrAAQEQRFQEEQLRRREQELAEREMDI 99
Cdd:COG2825    32 QRILQESP--EGKAAQKKLEKEFKKRQAELQKLEKELQALQEKL--QKEAATLSEEERQKKERELQKKQQEL 99