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Conserved domains on  [gi|1958784479|ref|XP_038968777|]
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neurexin-1 isoform X47 [Rattus norvegicus]

Protein Classification

neurexin-3( domain architecture ID 11129565)

neurexin-3 is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion, and may also mediate intracellular signaling

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 117-235 1.28e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 1.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784479 117 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 196
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958784479 197 RYPAGRQLtIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 235
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
4.1m smart00294
putative band 4.1 homologues' binding motif;
380-398 1.24e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 41.74  E-value: 1.24e-05
                           10
                   ....*....|....*....
gi 1958784479  380 MYKYRNRDEGSYHVDESRN 398
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
 360-395 5.03e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 460035  Cd Length: 63  Bit Score: 35.45  E-value: 5.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958784479 360 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 395
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 117-235 1.28e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 1.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784479 117 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 196
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958784479 197 RYPAGRQLtIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 235
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 86-234 1.63e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.95  E-value: 1.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784479  86 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 165
Cdd:cd00110     1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784479 166 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLtIFNSQATIIIGGKEQG---------QPFQGQLSGLYYN 234
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSA-LLNLDGPLYLGGLPEDlkspglpvsPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
112-235 4.23e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.23e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784479  112 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 190
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958784479  191 SWPVIERYPAGrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 235
Cdd:smart00282  80 GNRVSGESPGG--LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNLKVNG 131
4.1m smart00294
putative band 4.1 homologues' binding motif;
380-398 1.24e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 41.74  E-value: 1.24e-05
                           10
                   ....*....|....*....
gi 1958784479  380 MYKYRNRDEGSYHVDESRN 398
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
 360-395 5.03e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 35.45  E-value: 5.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958784479 360 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 395
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 117-235 1.28e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 1.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784479 117 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 196
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958784479 197 RYPAGRQLtIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 235
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 86-234 1.63e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.95  E-value: 1.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784479  86 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 165
Cdd:cd00110     1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784479 166 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLtIFNSQATIIIGGKEQG---------QPFQGQLSGLYYN 234
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSA-LLNLDGPLYLGGLPEDlkspglpvsPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
112-235 4.23e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.23e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784479  112 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 190
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958784479  191 SWPVIERYPAGrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 235
Cdd:smart00282  80 GNRVSGESPGG--LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
117-190 1.08e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.70  E-value: 1.08e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958784479 117 FSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDiAIEESNAIINDGKYHVVRFTRSGGNATLQVD 190
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVD 72
4.1m smart00294
putative band 4.1 homologues' binding motif;
380-398 1.24e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 41.74  E-value: 1.24e-05
                           10
                   ....*....|....*....
gi 1958784479  380 MYKYRNRDEGSYHVDESRN 398
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
 360-395 5.03e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 35.45  E-value: 5.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958784479 360 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 395
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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