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Conserved domains on  [gi|1976336895|ref|XP_039227733|]
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F-box/WD repeat-containing protein 5 [Drosophila yakuba]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
176-233 6.35e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 6.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSP-DGRTLASGSADGTVRLWD 400
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-238 4.26e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895  77 WDYESVKdrfdkvdKVIDLHGH---IIGMALSPDHRYLYVNTRpwpknyvitnplepppiaqeiD--IHVIDLMTLKRVG 151
Cdd:cd00200    78 WDLETGE-------CVRTLTGHtsyVSSVAFSPDGRILSSSSR---------------------DktIKVWDVETGKCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895 152 NmLRAHKAYTPStecffIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIK 230
Cdd:cd00200   130 T-LRGHTDWVNS-----VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSP-DGEKLLSSSSDGTIK 202


                  ....*...
gi 1976336895 231 VWRSRAKA 238
Cdd:cd00200   203 LWDLSTGK 210
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
176-233 6.35e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 6.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSP-DGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-238 4.26e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895  77 WDYESVKdrfdkvdKVIDLHGH---IIGMALSPDHRYLYVNTRpwpknyvitnplepppiaqeiD--IHVIDLMTLKRVG 151
Cdd:cd00200    78 WDLETGE-------CVRTLTGHtsyVSSVAFSPDGRILSSSSR---------------------DktIKVWDVETGKCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895 152 NmLRAHKAYTPStecffIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIK 230
Cdd:cd00200   130 T-LRGHTDWVNS-----VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSP-DGEKLLSSSSDGTIK 202


                  ....*...
gi 1976336895 231 VWRSRAKA 238
Cdd:cd00200   203 LWDLSTGK 210
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-237 3.50e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895 139 IHVIDLMTLKRVGNmLRAHK------AYTPSTECFfifldvceeyvASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVA 211
Cdd:cd00200   159 IKLWDLRTGKCVAT-LTGHTgevnsvAFSPDGEKL-----------LSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVA 226

                          90       100
                  ....*....|....*....|....*.
gi 1976336895 212 FNPrDSEMLVTTSDDYTIKVWRSRAK 237
Cdd:cd00200   227 FSP-DGYLLASGSEDGTIRVWDLRTG 251
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 203-232 4.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.11e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 1976336895  203 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:smart00320  11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
203-232 1.85e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.85e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1976336895 203 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:pfam00400  10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
176-233 6.35e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 6.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSP-DGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
176-233 1.07e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 1.07e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGSDDGTVRLWD 190
WD40 COG2319
WD40 repeat [General function prediction only];
177-232 2.11e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 2.11e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1976336895 177 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSP-DGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-238 4.26e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895  77 WDYESVKdrfdkvdKVIDLHGH---IIGMALSPDHRYLYVNTRpwpknyvitnplepppiaqeiD--IHVIDLMTLKRVG 151
Cdd:cd00200    78 WDLETGE-------CVRTLTGHtsyVSSVAFSPDGRILSSSSR---------------------DktIKVWDVETGKCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895 152 NmLRAHKAYTPStecffIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIK 230
Cdd:cd00200   130 T-LRGHTDWVNS-----VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSP-DGEKLLSSSSDGTIK 202


                  ....*...
gi 1976336895 231 VWRSRAKA 238
Cdd:cd00200   203 LWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
176-232 5.05e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 5.05e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSP-DGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
177-233 9.39e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 9.39e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1976336895 177 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
176-233 9.39e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 9.39e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
177-233 4.31e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 4.31e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1976336895 177 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:COG2319    92 LLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSP-DGKTLASGSADGTVRLWD 148
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-237 3.50e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1976336895 139 IHVIDLMTLKRVGNmLRAHK------AYTPSTECFfifldvceeyvASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVA 211
Cdd:cd00200   159 IKLWDLRTGKCVAT-LTGHTgevnsvAFSPDGEKL-----------LSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVA 226

                          90       100
                  ....*....|....*....|....*.
gi 1976336895 212 FNPrDSEMLVTTSDDYTIKVWRSRAK 237
Cdd:cd00200   227 FSP-DGYLLASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-232 7.25e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 7.25e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLW 78
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-233 1.05e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.05e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1976336895 177 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-232 4.43e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 4.43e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1976336895 176 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:cd00200    64 TYLASGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSP-DGRILSSSSRDKTIKVW 120
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 203-232 4.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.11e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 1976336895  203 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:smart00320  11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
203-232 1.85e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.85e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1976336895 203 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 232
Cdd:pfam00400  10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 203-233 3.00e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 3.00e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1976336895 203 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 233
Cdd:cd00200     8 HTGGVTCVAFSP-DGKLLATGSGDGTIKVWD 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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