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Conserved domains on  [gi|1988899995|ref|XP_039496597|]
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eukaryotic translation initiation factor 4 gamma 1 isoform X1 [Drosophila santomea]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
932-1180 8.02e-48

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 170.24  E-value: 8.02e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  932 RRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVidermesenksnl 1011
Cdd:pfam02854    2 KKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPT------------- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1012 aHFRNALLDKTEQEFTQNVSqstaKEKKLQPIVDKIKkctdanekaeleaileeeerkirrrsgGTVRFIGELFKISMLT 1091
Cdd:pfam02854   69 -DFGIHLLNRLQEEFEKRFE----LEENEQGNRRRRL---------------------------GLVRFLGELYKFGLLT 116
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1092 GKIIYSCIDTLLNPH-------SEDMLECLCKLLTTVGAKFEktpvnskDPSRCYSLEKSITRMQAIasKTDKDGGKVSS 1164
Cdd:pfam02854  117 EKILFECLKELLSSLtkedlkrDLFNLECLLTLLTTIGKLLE-------NEKLPKLMDQFLDEIQKY--VLSKDDPKLSS 187
                          250
                   ....*....|....*.
gi 1988899995 1165 RVRFMLQDVIDLRKNK 1180
Cdd:pfam02854  188 RLRFMLQDLIELRKNK 203
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
1692-1823 3.15e-32

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 122.78  E-value: 3.15e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1692 KHVKNVIDHIEHLLKEGTTPDCIIDYSNGNIMVVDKLFiRGLTETLSNFSIHY--KENSYKLESETFQKFCIPVLQRYID 1769
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYAS-PGFVRALMTAVLKYaiEEKSLPEKEKALLEKYAPLLQKYLD 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1988899995 1770 SNEDHQLECLYTMQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQ 1823
Cdd:cd11559     80 DDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDP 133
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
1490-1605 1.69e-22

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 94.26  E-value: 1.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1490 IKSVVSEMIDlSAASKAVTPVVVSCIK--QIPEkLRCSFIYYILTDYLHLanvGKQYRRYLSIVVSQLIQQNYISVDHLR 1567
Cdd:pfam02847    1 LKRKIFLILE-EYLSSGDYDEAARCLLklGLPS-QHHEVVKVLIECALEE---SKTYREFYGLLLERLCEFNLISTKQFE 75
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1988899995 1568 LAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILT 1605
Cdd:pfam02847   76 KGFWRVLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
238-581 2.31e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 52.27  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  238 STPNAPRGASGGATRHVHVQPMYSQPlhqnmvlQQYTQYNPRQQTFPTSHLQYAP---AP-MPYYQYQYVPTLQQQPPHT 313
Cdd:pfam17823   98 SEPATREGAADGAASRALAAAASSSP-------SSAAQSLPAAIAALPSEAFSAPraaACrANASAAPRAAIAAASAPHA 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  314 RSAVTVNTNVNVGNNlqpvQSGPNGPLPGPGATSSQLQLLT----------STVQPGASTVMGVGG-----PGSTMGQVG 378
Cdd:pfam17823  171 ASPAPRTAASSTTAA----SSTTAASSAPTTAASSAPATLTpargistaatATGHPAAGTALAAVGnsspaAGTVTAAVG 246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  379 VPPMVGVGVMPASVQpqSVQPASRRrhqhrLQIIDPTTKKnilddFDKTKSNTDNDFSDQVISTNTPATvlsEGPIRIPQ 458
Cdd:pfam17823  247 TVTPAALATLAAAAG--TVASAAGT-----INMGDPHARR-----LSPAKHMPSDTMARNPAAPMGAQA---QGPIIQVS 311
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  459 QDSFGINTSSQGSESMTNASYSPIESTPISRSDVGQTPIVSAMSDAPSVEILPTPQRGRSKKIPIMSPKN---------- 528
Cdd:pfam17823  312 TDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTTqpspllptqg 391
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1988899995  529 --------VSESIAAPITDETDDAGSTPISGA-----TKETMQPNFPHQNLHISESPKQKQTVSNT 581
Cdd:pfam17823  392 aagpgillAPEQVATEATAGTASAGPTPRSSGdpktlAMASCQLSTQGQYLVVTTDPLTPALVDKM 457
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
932-1180 8.02e-48

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 170.24  E-value: 8.02e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  932 RRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVidermesenksnl 1011
Cdd:pfam02854    2 KKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPT------------- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1012 aHFRNALLDKTEQEFTQNVSqstaKEKKLQPIVDKIKkctdanekaeleaileeeerkirrrsgGTVRFIGELFKISMLT 1091
Cdd:pfam02854   69 -DFGIHLLNRLQEEFEKRFE----LEENEQGNRRRRL---------------------------GLVRFLGELYKFGLLT 116
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1092 GKIIYSCIDTLLNPH-------SEDMLECLCKLLTTVGAKFEktpvnskDPSRCYSLEKSITRMQAIasKTDKDGGKVSS 1164
Cdd:pfam02854  117 EKILFECLKELLSSLtkedlkrDLFNLECLLTLLTTIGKLLE-------NEKLPKLMDQFLDEIQKY--VLSKDDPKLSS 187
                          250
                   ....*....|....*.
gi 1988899995 1165 RVRFMLQDVIDLRKNK 1180
Cdd:pfam02854  188 RLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
931-1180 6.64e-42

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 152.90  E-value: 6.64e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995   931 VRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVkvidermesenksn 1010
Cdd:smart00543    1 EKKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKN-------------- 66
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1011 lAHFRNALLDKTEQEFTQNVsqstaKEKKLQPIVDKIkkctdanekaeleaileeeerkirrrsgGTVRFIGELFKISML 1090
Cdd:smart00543   67 -PDFGSLLLERLQEEFEKGL-----ESEEESDKQRRL----------------------------GLVRFLGELYNFQVL 112
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1091 TGKIIYSCIDTLLNPH-------SEDMLECLCKLLTTVGAKFEktpvNSKDPSRcysLEKSITRMQAIasKTDKDGGKVS 1163
Cdd:smart00543  113 TSKIILELLKELLNDLtkldpprSDFSVECLLSLLPTCGKDLE----REKSPKL---LDEILERLQDY--LLKKDKTELS 183
                           250
                    ....*....|....*..
gi 1988899995  1164 SRVRFMLQDVIDLRKNK 1180
Cdd:smart00543  184 SRLRFMLELLIELRKNK 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
1692-1823 3.15e-32

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 122.78  E-value: 3.15e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1692 KHVKNVIDHIEHLLKEGTTPDCIIDYSNGNIMVVDKLFiRGLTETLSNFSIHY--KENSYKLESETFQKFCIPVLQRYID 1769
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYAS-PGFVRALMTAVLKYaiEEKSLPEKEKALLEKYAPLLQKYLD 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1988899995 1770 SNEDHQLECLYTMQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQ 1823
Cdd:cd11559     80 DDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDP 133
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1762-1844 2.13e-25

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 101.21  E-value: 2.13e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1762 PVLQRYIDSNEDHQLECLYTMQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQSAGKGVAVKSLNPFFNSL 1841
Cdd:smart00515    1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTWL 80

                    ...
gi 1988899995  1842 LND 1844
Cdd:smart00515   81 QEA 83
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
1490-1605 1.69e-22

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 94.26  E-value: 1.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1490 IKSVVSEMIDlSAASKAVTPVVVSCIK--QIPEkLRCSFIYYILTDYLHLanvGKQYRRYLSIVVSQLIQQNYISVDHLR 1567
Cdd:pfam02847    1 LKRKIFLILE-EYLSSGDYDEAARCLLklGLPS-QHHEVVKVLIECALEE---SKTYREFYGLLLERLCEFNLISTKQFE 75
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1988899995 1568 LAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILT 1605
Cdd:pfam02847   76 KGFWRVLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
1488-1605 1.63e-20

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 88.46  E-value: 1.63e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1488 KLIKSVVSEmidlsAASKAVTPVVVSCIKQIPEK-LRCSFIYYILTDYLHLanvGKQYRRYLSIVVSQLIQQNYISVDHL 1566
Cdd:smart00544    3 KKIFLIIEE-----YLSSGDTDEAVHCLLELKLPeQHHEVVKVLLTCALEE---KRTYREMYSVLLSRLCQANVISTKQF 74
                            90       100       110
                    ....*....|....*....|....*....|....*....
gi 1988899995  1567 RLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILT 1605
Cdd:smart00544   75 EKGFWRLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
1775-1845 6.96e-07

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 48.29  E-value: 6.96e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1988899995 1775 QLECLYTMQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQSAGKGVAV-KSLNPFFNSLLNDE 1845
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEKGMKKVrKQAKPFVEWLEEAE 72
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
238-581 2.31e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 52.27  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  238 STPNAPRGASGGATRHVHVQPMYSQPlhqnmvlQQYTQYNPRQQTFPTSHLQYAP---AP-MPYYQYQYVPTLQQQPPHT 313
Cdd:pfam17823   98 SEPATREGAADGAASRALAAAASSSP-------SSAAQSLPAAIAALPSEAFSAPraaACrANASAAPRAAIAAASAPHA 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  314 RSAVTVNTNVNVGNNlqpvQSGPNGPLPGPGATSSQLQLLT----------STVQPGASTVMGVGG-----PGSTMGQVG 378
Cdd:pfam17823  171 ASPAPRTAASSTTAA----SSTTAASSAPTTAASSAPATLTpargistaatATGHPAAGTALAAVGnsspaAGTVTAAVG 246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  379 VPPMVGVGVMPASVQpqSVQPASRRrhqhrLQIIDPTTKKnilddFDKTKSNTDNDFSDQVISTNTPATvlsEGPIRIPQ 458
Cdd:pfam17823  247 TVTPAALATLAAAAG--TVASAAGT-----INMGDPHARR-----LSPAKHMPSDTMARNPAAPMGAQA---QGPIIQVS 311
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  459 QDSFGINTSSQGSESMTNASYSPIESTPISRSDVGQTPIVSAMSDAPSVEILPTPQRGRSKKIPIMSPKN---------- 528
Cdd:pfam17823  312 TDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTTqpspllptqg 391
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1988899995  529 --------VSESIAAPITDETDDAGSTPISGA-----TKETMQPNFPHQNLHISESPKQKQTVSNT 581
Cdd:pfam17823  392 aagpgillAPEQVATEATAGTASAGPTPRSSGdpktlAMASCQLSTQGQYLVVTTDPLTPALVDKM 457
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
932-1180 8.02e-48

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 170.24  E-value: 8.02e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  932 RRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVidermesenksnl 1011
Cdd:pfam02854    2 KKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPT------------- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1012 aHFRNALLDKTEQEFTQNVSqstaKEKKLQPIVDKIKkctdanekaeleaileeeerkirrrsgGTVRFIGELFKISMLT 1091
Cdd:pfam02854   69 -DFGIHLLNRLQEEFEKRFE----LEENEQGNRRRRL---------------------------GLVRFLGELYKFGLLT 116
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1092 GKIIYSCIDTLLNPH-------SEDMLECLCKLLTTVGAKFEktpvnskDPSRCYSLEKSITRMQAIasKTDKDGGKVSS 1164
Cdd:pfam02854  117 EKILFECLKELLSSLtkedlkrDLFNLECLLTLLTTIGKLLE-------NEKLPKLMDQFLDEIQKY--VLSKDDPKLSS 187
                          250
                   ....*....|....*.
gi 1988899995 1165 RVRFMLQDVIDLRKNK 1180
Cdd:pfam02854  188 RLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
931-1180 6.64e-42

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 152.90  E-value: 6.64e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995   931 VRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVkvidermesenksn 1010
Cdd:smart00543    1 EKKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKN-------------- 66
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1011 lAHFRNALLDKTEQEFTQNVsqstaKEKKLQPIVDKIkkctdanekaeleaileeeerkirrrsgGTVRFIGELFKISML 1090
Cdd:smart00543   67 -PDFGSLLLERLQEEFEKGL-----ESEEESDKQRRL----------------------------GLVRFLGELYNFQVL 112
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1091 TGKIIYSCIDTLLNPH-------SEDMLECLCKLLTTVGAKFEktpvNSKDPSRcysLEKSITRMQAIasKTDKDGGKVS 1163
Cdd:smart00543  113 TSKIILELLKELLNDLtkldpprSDFSVECLLSLLPTCGKDLE----REKSPKL---LDEILERLQDY--LLKKDKTELS 183
                           250
                    ....*....|....*..
gi 1988899995  1164 SRVRFMLQDVIDLRKNK 1180
Cdd:smart00543  184 SRLRFMLELLIELRKNK 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
1692-1823 3.15e-32

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 122.78  E-value: 3.15e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1692 KHVKNVIDHIEHLLKEGTTPDCIIDYSNGNIMVVDKLFiRGLTETLSNFSIHY--KENSYKLESETFQKFCIPVLQRYID 1769
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYAS-PGFVRALMTAVLKYaiEEKSLPEKEKALLEKYAPLLQKYLD 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1988899995 1770 SNEDHQLECLYTMQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQ 1823
Cdd:cd11559     80 DDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDP 133
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1762-1844 2.13e-25

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 101.21  E-value: 2.13e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1762 PVLQRYIDSNEDHQLECLYTMQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQSAGKGVAVKSLNPFFNSL 1841
Cdd:smart00515    1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTWL 80

                    ...
gi 1988899995  1842 LND 1844
Cdd:smart00515   81 QEA 83
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
1490-1605 1.69e-22

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 94.26  E-value: 1.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995 1490 IKSVVSEMIDlSAASKAVTPVVVSCIK--QIPEkLRCSFIYYILTDYLHLanvGKQYRRYLSIVVSQLIQQNYISVDHLR 1567
Cdd:pfam02847    1 LKRKIFLILE-EYLSSGDYDEAARCLLklGLPS-QHHEVVKVLIECALEE---SKTYREFYGLLLERLCEFNLISTKQFE 75
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1988899995 1568 LAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILT 1605
Cdd:pfam02847   76 KGFWRVLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
1488-1605 1.63e-20

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 88.46  E-value: 1.63e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  1488 KLIKSVVSEmidlsAASKAVTPVVVSCIKQIPEK-LRCSFIYYILTDYLHLanvGKQYRRYLSIVVSQLIQQNYISVDHL 1566
Cdd:smart00544    3 KKIFLIIEE-----YLSSGDTDEAVHCLLELKLPeQHHEVVKVLLTCALEE---KRTYREMYSVLLSRLCQANVISTKQF 74
                            90       100       110
                    ....*....|....*....|....*....|....*....
gi 1988899995  1567 RLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILT 1605
Cdd:smart00544   75 EKGFWRLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
1775-1845 6.96e-07

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 48.29  E-value: 6.96e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1988899995 1775 QLECLYTMQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKDQSAGKGVAV-KSLNPFFNSLLNDE 1845
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEKGMKKVrKQAKPFVEWLEEAE 72
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
238-581 2.31e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 52.27  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  238 STPNAPRGASGGATRHVHVQPMYSQPlhqnmvlQQYTQYNPRQQTFPTSHLQYAP---AP-MPYYQYQYVPTLQQQPPHT 313
Cdd:pfam17823   98 SEPATREGAADGAASRALAAAASSSP-------SSAAQSLPAAIAALPSEAFSAPraaACrANASAAPRAAIAAASAPHA 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  314 RSAVTVNTNVNVGNNlqpvQSGPNGPLPGPGATSSQLQLLT----------STVQPGASTVMGVGG-----PGSTMGQVG 378
Cdd:pfam17823  171 ASPAPRTAASSTTAA----SSTTAASSAPTTAASSAPATLTpargistaatATGHPAAGTALAAVGnsspaAGTVTAAVG 246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  379 VPPMVGVGVMPASVQpqSVQPASRRrhqhrLQIIDPTTKKnilddFDKTKSNTDNDFSDQVISTNTPATvlsEGPIRIPQ 458
Cdd:pfam17823  247 TVTPAALATLAAAAG--TVASAAGT-----INMGDPHARR-----LSPAKHMPSDTMARNPAAPMGAQA---QGPIIQVS 311
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1988899995  459 QDSFGINTSSQGSESMTNASYSPIESTPISRSDVGQTPIVSAMSDAPSVEILPTPQRGRSKKIPIMSPKN---------- 528
Cdd:pfam17823  312 TDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTTqpspllptqg 391
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1988899995  529 --------VSESIAAPITDETDDAGSTPISGA-----TKETMQPNFPHQNLHISESPKQKQTVSNT 581
Cdd:pfam17823  392 aagpgillAPEQVATEATAGTASAGPTPRSSGdpktlAMASCQLSTQGQYLVVTTDPLTPALVDKM 457
YppG pfam14179
YppG-like protein; The YppG-like protein family includes the B. subtilis YppG protein, which ...
254-311 1.88e-03

YppG-like protein; The YppG-like protein family includes the B. subtilis YppG protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.


Pssm-ID: 372950 [Multi-domain]  Cd Length: 101  Bit Score: 39.41  E-value: 1.88e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1988899995  254 VHVQPMYSQPLHQNMVLQQYTQYNPRQqtfptshlQYAPAPMPYYQYQYVPTLQQQPP 311
Cdd:pfam14179    5 SQPYPYFSQQVYQQPVQPQYPPFAPQQ--------YMPQPPMPYMNPYPKQQPQQQQP 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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