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Conserved domains on  [gi|2006382824|ref|XP_039926827|]
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rho GTPase-activating protein 22 isoform X5 [Hirundo rustica]

Protein Classification

PH domain-containing protein; PH domain-containing RhoGEF family protein( domain architecture ID 10351259)

Pleckstrin homology (PH) domain-containing protein may be involved in targeting a protein to the appropriate cellular location or interacting with a binding partner; similar to the PH region of pleckstrin homology domain-containing family A member 2 (PLEKHA2/TAAP2) that binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2)| PH domain-containing RhoGEF family protein may function as a guanine nucleotide exchange factor; similar to Homo sapiens pleckstrin homology domain-containing family G member 4B and Danio rerio quattro

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
58-256 9.50e-138

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 399.12  E-value: 9.50e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  58 GIFGQRLEDTVQYERKYGQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASL 137
Cdd:cd04390     1 GVFGQRLEDTVAYERKFGPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 138 LKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLAT 217
Cdd:cd04390    81 LKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLAT 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2006382824 218 VFGPNILRPKMEDPVTMMEGTSLVQHLMTVLISEQGRIF 256
Cdd:cd04390   161 VFGPNILRPKVEDPATIMEGTPQIQQLMTVMISKHEPLF 199
PH-like super family cl17171
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
15-58 1.22e-26

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


The actual alignment was detected with superfamily member cd13378:

Pssm-ID: 473070  Cd Length: 116  Bit Score: 104.64  E-value: 1.22e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2006382824  15 GGAGDREKMPVNHEAFLLMANSQNEMEDWVKAIRRVIWAPFGGG 58
Cdd:cd13378    73 GGAGDREKVPMNHEAFLLMANSQSDMEDWVKAIRRVIWAPFGGG 116
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
511-583 1.46e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2006382824 511 RALQSLVVELKTELSKQRTEY---ETSIKRIEETSADLRNQVVRLEEELDQER--KKYTMLEIKLRNSERAREDAEKR 583
Cdd:COG1579    34 AELEDELAALEARLEAAKTELedlEKEIKRLELEIEEVEARIKKYEEQLGNVRnnKEYEALQKEIESLKRRISDLEDE 111
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
58-256 9.50e-138

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 399.12  E-value: 9.50e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  58 GIFGQRLEDTVQYERKYGQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASL 137
Cdd:cd04390     1 GVFGQRLEDTVAYERKFGPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 138 LKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLAT 217
Cdd:cd04390    81 LKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLAT 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2006382824 218 VFGPNILRPKMEDPVTMMEGTSLVQHLMTVLISEQGRIF 256
Cdd:cd04390   161 VFGPNILRPKVEDPATIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
80-227 3.94e-59

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 194.30  E-value: 3.94e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKP-LFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDF 158
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2006382824 159 LSCGQLlsKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPK 227
Cdd:pfam00620  81 IEAAKL--PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
80-252 3.84e-58

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.87  E-value: 3.84e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824   80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKP-LFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDF 158
Cdd:smart00324   4 PIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPdLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEF 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  159 LSCGQLLSKDEGEgtQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMEDPVTMMEgT 238
Cdd:smart00324  84 IEAAKLEDETERL--RALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASLKD-I 160
                          170
                   ....*....|....
gi 2006382824  239 SLVQHLMTVLISEQ 252
Cdd:smart00324 161 RHQNTVIEFLIENA 174
PH_RhoGAP2 cd13378
Rho GTPase activating protein 2 Pleckstrin homology (PH) domain; RhoGAP2 (also called RhoGap22 ...
15-58 1.22e-26

Rho GTPase activating protein 2 Pleckstrin homology (PH) domain; RhoGAP2 (also called RhoGap22 or ArhGap22) are involved in cell polarity, cell morphology and cytoskeletal organization. They activate a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt, and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues resulting in regulation of cell motility. Members here contain an N-terminal PH domain followed by a RhoGAP domain and either a BAR or TATA Binding Protein (TBP) Associated Factor 4 (TAF4) domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 241529  Cd Length: 116  Bit Score: 104.64  E-value: 1.22e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2006382824  15 GGAGDREKMPVNHEAFLLMANSQNEMEDWVKAIRRVIWAPFGGG 58
Cdd:cd13378    73 GGAGDREKVPMNHEAFLLMANSQSDMEDWVKAIRRVIWAPFGGG 116
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
511-583 1.46e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2006382824 511 RALQSLVVELKTELSKQRTEY---ETSIKRIEETSADLRNQVVRLEEELDQER--KKYTMLEIKLRNSERAREDAEKR 583
Cdd:COG1579    34 AELEDELAALEARLEAAKTELedlEKEIKRLELEIEEVEARIKKYEEQLGNVRnnKEYEALQKEIESLKRRISDLEDE 111
PH pfam00169
PH domain; PH stands for pleckstrin homology.
26-51 4.69e-03

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 37.16  E-value: 4.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 2006382824  26 NHEAFLLMANSQNEMEDWVKAIRRVI 51
Cdd:pfam00169  79 GKRTYLLQAESEEERKDWIKAIQSAI 104
THOC7 pfam05615
Tho complex subunit 7; The Tho complex is involved in transcription elongation and mRNA export ...
499-583 5.67e-03

Tho complex subunit 7; The Tho complex is involved in transcription elongation and mRNA export from the nucleus.


Pssm-ID: 461692 [Multi-domain]  Cd Length: 135  Bit Score: 37.63  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 499 PAAASRDSVQCSRALQSLVVEL--------KTEL-----SKQRTEYETSIKRIEETSADLRNQVVRLEEELDQE------ 559
Cdd:pfam05615  32 CNSLDSTPEEIQALREDLLLDLaafelsieKSQLlaeanERERENYEAEKEEIEEEIEAVREEIEELKERLEEAkrtrkn 111
                          90       100
                  ....*....|....*....|....
gi 2006382824 560 RKKYTmLEIKLRNSERAREDAEKR 583
Cdd:pfam05615 112 REEYD-ALAEKINENPSREETEKQ 134
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
492-593 5.87e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 5.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  492 SSSEQSDPAAASRDSVQCSRALQSLVVELkTELSKQRTEY-------ETSIKRIEETSADLRNQVVRLEEELDQER---- 560
Cdd:TIGR02168  728 ISALRKDLARLEAEVEQLEERIAQLSKEL-TELEAEIEELeerleeaEEELAEAEAEIEELEAQIEQLKEELKALReald 806
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2006382824  561 ---KKYTMLEIKLRNSERAREDAEKRNYLLQKEMEE 593
Cdd:TIGR02168  807 elrAELTLLNEEAANLRERLESLERRIAATERRLED 842
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
511-584 5.90e-03

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 36.39  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 511 RALQSLVVELKTELSKQRTEyetsIKRIEETSADLRNQVVRLEEELDQERKKYTMLEIKLR-----NSE-------RARE 578
Cdd:cd22887     7 QELEKRLAELEAELASLEEE----IKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRklqeeNDElverwmaKKQQ 82

                  ....*.
gi 2006382824 579 DAEKRN 584
Cdd:cd22887    83 EADKMN 88
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
58-256 9.50e-138

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 399.12  E-value: 9.50e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  58 GIFGQRLEDTVQYERKYGQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASL 137
Cdd:cd04390     1 GVFGQRLEDTVAYERKFGPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 138 LKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLAT 217
Cdd:cd04390    81 LKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLAT 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2006382824 218 VFGPNILRPKMEDPVTMMEGTSLVQHLMTVLISEQGRIF 256
Cdd:cd04390   161 VFGPNILRPKVEDPATIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
80-251 4.09e-64

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 208.31  E-value: 4.09e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFL 159
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 160 SCGQLLSKDEGEgtQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMEDPVTMMEGTS 239
Cdd:cd00159    81 ELAKIEDEEERI--EALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEDIKK 158
                         170
                  ....*....|..
gi 2006382824 240 LVQhLMTVLISE 251
Cdd:cd00159   159 LNE-IVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
80-227 3.94e-59

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 194.30  E-value: 3.94e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKP-LFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDF 158
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2006382824 159 LSCGQLlsKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPK 227
Cdd:pfam00620  81 IEAAKL--PDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
80-252 3.84e-58

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.87  E-value: 3.84e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824   80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKP-LFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDF 158
Cdd:smart00324   4 PIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPdLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEF 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  159 LSCGQLLSKDEGEgtQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMEDPVTMMEgT 238
Cdd:smart00324  84 IEAAKLEDETERL--RALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEVASLKD-I 160
                          170
                   ....*....|....
gi 2006382824  239 SLVQHLMTVLISEQ 252
Cdd:smart00324 161 RHQNTVIEFLIENA 174
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
59-256 5.05e-44

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 156.08  E-value: 5.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  59 IFGQRLEDTVqyeRKYGQRLApLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCG--EKPLFDSNTDVHTVAS 136
Cdd:cd04386     4 VFGTPLEEHL---KRTGREIA-LPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfSLPLDEFYSDPHAVAS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 137 LLKLYLRELPEPVIPFAKYEDFLSCGQLlsKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLA 216
Cdd:cd04386    80 ALKSYLRELPDPLLTYNLYEDWVQAANK--PDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIA 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2006382824 217 TVFGPNILRPKMEDPVTMMEGTSLVQHLMTV--LISEQGRIF 256
Cdd:cd04386   158 IVLAPNLLWAKNEGSLAEMAAGTSVHVVAIVelIISHADWFF 199
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
59-249 3.59e-42

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 150.31  E-value: 3.59e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  59 IFG---QRLEDTVQYERKygqrlAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVA 135
Cdd:cd04393     2 VFGvplQELQQAGQPENG-----VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 136 SLLKLYLRELPEPVIPFAKYEDFLSCGQLLSKdEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNL 215
Cdd:cd04393    77 SLLRLFLQELPEGLIPASLQIRLMQLYQDYNG-EDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENL 155
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2006382824 216 ATVFGPNI--LRPKMEDpvtmMEGTSLVQHLMTVLI 249
Cdd:cd04393   156 AAVFGPDVfhVYTDVED----MKEQEICSRIMAKLL 187
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
60-256 3.05e-41

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 148.25  E-value: 3.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVqyERKYGQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLK 139
Cdd:cd04404     6 FGVSLQFLK--EKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 140 LYLRELPEPVIPFAKYEDFLSCGQLLSKDEGEGTQELvkqVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVF 219
Cdd:cd04404    84 TFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQL---LQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVF 160
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2006382824 220 GPNILRPKmeDPVTMMEGTSLVQHLMTVLISEQGRIF 256
Cdd:cd04404   161 GPNLLWAK--DASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
60-224 2.05e-37

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 137.53  E-value: 2.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVQYErkygQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCG-------EKPLFDSntDVH 132
Cdd:cd04398     1 FGVPLEDLILRE----GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDplnvlliSPEDYES--DIH 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 133 TVASLLKLYLRELPEPVIPFAKYEDFLSCGQllSKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSV 212
Cdd:cd04398    75 SVASLLKLFFRELPEPLLTKALSREFIEAAK--IEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSV 152
                         170
                  ....*....|..
gi 2006382824 213 QNLATVFGPNIL 224
Cdd:cd04398   153 NNLAIIWGPTLM 164
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
80-250 2.00e-36

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 134.73  E-value: 2.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFL 159
Cdd:cd04382    18 PALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEFM 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 160 SCGQLLSKDEGEgtQELVKQVKNLPQANYNLLKYICKFLDEVqAHSSINKMSVQNLATVFGPNILRPKMEDP--VTMMEG 237
Cdd:cd04382    98 EAAEILDEDNSR--AALYQAISELPQPNRDTLAFLILHLQRV-AQSPECKMDINNLARVFGPTIVGYSVPNPdpMTILQD 174
                         170
                  ....*....|...
gi 2006382824 238 TSLVQHLMTVLIS 250
Cdd:cd04382   175 TVRQPRVVERLLE 187
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
60-235 1.01e-35

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 132.91  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDT-VQYERKYgqrlAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCG--EKPLFDSN-TDVHTVA 135
Cdd:cd04395     2 FGVPLDDCpPSSENPY----VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgfDIDLQDPRwRDVNVVS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 136 SLLKLYLRELPEPVIPFAKYEDFLSCGQLlsKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNL 215
Cdd:cd04395    78 SLLKSFFRKLPEPLFTNELYPDFIEANRI--EDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNL 155
                         170       180
                  ....*....|....*....|...
gi 2006382824 216 ATVFGPNILRP---KMEDPVTMM 235
Cdd:cd04395   156 AIVFGPTLVRTsddNMETMVTHM 178
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
80-256 1.88e-34

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 129.17  E-value: 1.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDC-GEKPLFDSNT--DVHTVASLLKLYLRELPEPVIPFAKYE 156
Cdd:cd04372    17 PMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISATVypDINVITGALKLYFRDLPIPVITYDTYP 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 157 DFLSCGQLLSKDEgegTQELVKQ-VKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMEDPVTMM 235
Cdd:cd04372    97 KFIDAAKISNPDE---RLEAVHEaLMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSALTTL 173
                         170       180
                  ....*....|....*....|.
gi 2006382824 236 EGTSLVQHLMTVLISEQGRIF 256
Cdd:cd04372   174 NDMRYQILIVQLLITNEDVLF 194
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
59-223 6.00e-34

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 127.86  E-value: 6.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  59 IFGQRLEDTVQYE-RKYGQRLAPLLVEQCVDFI-RERGLTEEGLFRMPGQANLVKDLQDSFDC-GEKPLFDSNT--DVHT 133
Cdd:cd04400     1 IFGSPLEEAVELSsHKYNGRDLPSVVYRCIEYLdKNRAIYEEGIFRLSGSASVIKQLKERFNTeYDVDLFSSSLypDVHT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 134 VASLLKLYLRELPEPVIPFAKYEDFLSCGQLLSkDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQ 213
Cdd:cd04400    81 VAGLLKLYLRELPTLILGGELHNDFKRLVEENH-DRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLR 159
                         170
                  ....*....|..
gi 2006382824 214 NLATVFGP--NI 223
Cdd:cd04400   160 NVCIVFSPtlNI 171
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
60-246 2.25e-33

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 125.97  E-value: 2.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVQYERKygqrLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDS--NTDVHTVASL 137
Cdd:cd04403     1 FGCHLEALCQRENS----TVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDskWEDIHVITGA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 138 LKLYLRELPEPVIPFAKYEDFLSCGQL-LSKDEGEGTQELVKQvknLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLA 216
Cdd:cd04403    77 LKLFFRELPEPLFPYSLFNDFVAAIKLsDYEQRVSAVKDLIKS---LPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLA 153
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2006382824 217 TVFGPNILRPKMED---PVTMMEGTSLVQHLMT 246
Cdd:cd04403   154 IVFGPTLLRPEQETgniAVHMVYQNQIVELILL 186
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
58-232 1.04e-31

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 121.37  E-value: 1.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  58 GIFGQRLEDTVQyerKYGQRLaPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFD--SNTDVHTVA 135
Cdd:cd04383     1 KLFNGSLEEYIQ---DSGQAI-PLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADdqNDHDINSVA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 136 SLLKLYLRELPEPVIPFAKYEDFLSCGQLlskdegEGTQELVKQVK----NLPQANYNLLKYICKFLDEVQAHSSINKMS 211
Cdd:cd04383    77 GVLKLYFRGLENPLFPKERFEDLMSCVKL------ENPTERVHQIReilsTLPRSVIIVMRYLFAFLNHLSQFSDENMMD 150
                         170       180
                  ....*....|....*....|..
gi 2006382824 212 VQNLATVFGPNILR-PKMEDPV 232
Cdd:cd04383   151 PYNLAICFGPTLMPvPEGQDQV 172
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
60-251 5.06e-31

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 119.47  E-value: 5.06e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVQYERKygqrlAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLK 139
Cdd:cd04377     1 FGVSLSSLTSEDRS-----VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 140 LYLRELPEPVIPFAKYEDFLSCGQLlsKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVF 219
Cdd:cd04377    76 QWLRELPEPLMTFELYENFLRAMEL--EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVF 153
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2006382824 220 GPNILR-PKMEDPVTMMEGTSLVQHLMTVLISE 251
Cdd:cd04377   154 APCILRcPDTADPLQSLQDVSKTTTCVETLIKE 186
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
80-241 1.25e-29

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 115.98  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGeKPLFD-SNTDVHTVASLLKLYLRELPEPVIPFAKYEDF 158
Cdd:cd04378    17 PFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENG-KDLVElSELSPHDISSVLKLFLRQLPEPLILFRLYNDF 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 159 LSCGQLLSKDEGEGTQ--------ELVKQVKNL----PQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRP 226
Cdd:cd04378    96 IALAKEIQRDTEEDKApntpievnRIIRKLKDLlrqlPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTLIRP 175
                         170
                  ....*....|....*.
gi 2006382824 227 KMED-PVTMmegTSLV 241
Cdd:cd04378   176 RPGDaDVSL---SSLV 188
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
60-249 1.39e-29

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 115.57  E-value: 1.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVQYER-KYGQRLAPLLVEQCVDFIRERGLTE-EGLFRMPGQANLVKDLQDSFDCGEKPLfdSNT-DVHTVAS 136
Cdd:cd04389     1 FGSSLEEIMDRQKeKYPELKLPWILTFLSEKVLALGGFQtEGIFRVPGDIDEVNELKLRVDQWDYPL--SGLeDPHVPAS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 137 LLKLYLRELPEPVIPFAKYEDFLscgqllskDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEV--QAHSSINKMSVQN 214
Cdd:cd04389    79 LLKLWLRELEEPLIPDALYQQCI--------SASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFaqPENVAHTKMDVSN 150
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2006382824 215 LATVFGPNILRPKMEDPVTMMEGTSLVQHLMTVLI 249
Cdd:cd04389   151 LAMVFAPNILRCTSDDPRVIFENTRKEMSFLRTLI 185
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
80-259 2.34e-29

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 115.23  E-value: 2.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFL 159
Cdd:cd04376    10 PRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAFI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 160 SCGQLLSKDEGEGTQELVKQvknLPQANYNLLKYICKFLDEVQAHS-----------SINKMSVQNLATVFGPNILR--- 225
Cdd:cd04376    90 GTALLEPDEQLEALQLLIYL---LPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPNLLHkqk 166
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2006382824 226 ---PKMEDPVTMMEGTSLVQHLMTVLISEQGRIFAVP 259
Cdd:cd04376   167 sgeREFVQASLRIEESTAIINVVQTMIDNYEELFMVS 203
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
80-251 4.10e-29

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 113.93  E-value: 4.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFL 159
Cdd:cd04407    16 PIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYNDFL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 160 SCGQLLSKDegEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILR-PKMEDPVTMMEGT 238
Cdd:cd04407    96 RAVELPEKQ--EQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLRcPDSSDPLTSMKDV 173
                         170
                  ....*....|...
gi 2006382824 239 SLVQHLMTVLISE 251
Cdd:cd04407   174 AKTTTCVEMLIKE 186
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
83-236 4.25e-27

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 109.02  E-value: 4.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  83 VEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSF------DCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYE 156
Cdd:cd04374    32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLLSLGldpktsTPGDVDLDNSEWEIKTITSALKTYLRNLPEPLMTYELHN 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 157 DFLSCGQllSKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMEDPVTMME 236
Cdd:cd04374   112 DFINAAK--SENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEETVAAIMD 189
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
60-249 4.57e-27

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 108.31  E-value: 4.57e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVQYERKYgqrlaPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDC-GEKPLFDSNTDVHTVASLL 138
Cdd:cd04373     1 FGVPLANVVTSEKPI-----PIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQdHNLDLVSKDFTVNAVAGAL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 139 KLYLRELPEPVIPFAKYEDFLSCGQLLskDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATV 218
Cdd:cd04373    76 KSFFSELPDPLIPYSMHLELVEAAKIN--DREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSIC 153
                         170       180       190
                  ....*....|....*....|....*....|.
gi 2006382824 219 FGPNILRPKMEDpVTMMEGTSLVQHLMTVLI 249
Cdd:cd04373   154 FWPTLMRPDFTS-MEALSATRIYQTIIETFI 183
PH_RhoGAP2 cd13378
Rho GTPase activating protein 2 Pleckstrin homology (PH) domain; RhoGAP2 (also called RhoGap22 ...
15-58 1.22e-26

Rho GTPase activating protein 2 Pleckstrin homology (PH) domain; RhoGAP2 (also called RhoGap22 or ArhGap22) are involved in cell polarity, cell morphology and cytoskeletal organization. They activate a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt, and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues resulting in regulation of cell motility. Members here contain an N-terminal PH domain followed by a RhoGAP domain and either a BAR or TATA Binding Protein (TBP) Associated Factor 4 (TAF4) domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 241529  Cd Length: 116  Bit Score: 104.64  E-value: 1.22e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2006382824  15 GGAGDREKMPVNHEAFLLMANSQNEMEDWVKAIRRVIWAPFGGG 58
Cdd:cd13378    73 GGAGDREKVPMNHEAFLLMANSQSDMEDWVKAIRRVIWAPFGGG 116
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
78-230 1.26e-26

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 107.32  E-value: 1.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  78 LAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFD--SNTDVHTVASLLKLYLRELPEPVIPFAKY 155
Cdd:cd04387    15 KVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVmlSEMDVNAIAGTLKLYFRELPEPLFTDELY 94
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2006382824 156 EDFlSCGQLLSkDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMED 230
Cdd:cd04387    95 PNF-AEGIALS-DPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKE 167
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
61-246 1.65e-26

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 106.62  E-value: 1.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  61 GQRLEDtvqyerkygQRLA----PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSF--DCGEKPLFDSNTDVHTV 134
Cdd:cd04385     2 GPALED---------QQLTdndiPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFrkDARSVQLREGEYTVHDV 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 135 ASLLKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEG-EGTQELVKQvknLPQANYNLLKYICKFLDEVQAHSSINKMSVQ 213
Cdd:cd04385    73 ADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERiARYKELIRR---LPPINRATLKVLIGHLYRVQKHSDENQMSVH 149
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2006382824 214 NLATVFGPNILRPKMEDPVTMMEGTSLVQHLMT 246
Cdd:cd04385   150 NLALVFGPTLFQTDEHSVGQTSHEVKVIEDLID 182
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
60-223 6.22e-26

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 104.82  E-value: 6.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVQYERKY-GQRLaPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDsNTDVHTVASLL 138
Cdd:cd04381     1 FGASLSLAVERSRCHdGIDL-PLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLE-EYEPPTVASLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 139 KLYLRELPEPVIP---FAKYEDflSCGQllsKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNL 215
Cdd:cd04381    79 KQYLRELPEPLLTkelMPRFEE--ACGR---PTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNI 153

                  ....*...
gi 2006382824 216 ATVFGPNI 223
Cdd:cd04381   154 SIVLSPTV 161
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
59-224 1.17e-25

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 105.57  E-value: 1.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  59 IFGQRLEDTVQYER-------------KYGQrlAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGE---K 122
Cdd:cd04396     1 VFGVSLEESLKYASvaisivdedgeqyVYGY--IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPdygK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 123 PLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDF---------------LSCGQLLSKDEGEGTQELVKQVKNLPQAN 187
Cdd:cd04396    79 SFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFrnplrkrprilqymkGRINEPLNTDIDQAIKEYRDLITRLPNLN 158
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2006382824 188 YNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNIL 224
Cdd:cd04396   159 RQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGIL 195
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
80-255 1.67e-25

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 104.50  E-value: 1.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFL 159
Cdd:cd04409    17 PFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEFI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 160 SC------------GQLLSKDEGEGTQELVKQV--------KNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVF 219
Cdd:cd04409    97 GLakesqhvnetqeAKKNSDKKWPNMCTELNRIllkskdllRQLPAPNYNTLQFLIVHLHRVSEQAEENKMSASNLGIIF 176
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2006382824 220 GPNILRPKMED-PVTMmegTSLVQHlmtvliSEQGRI 255
Cdd:cd04409   177 GPTLIRPRPTDaTVSL---SSLVDY------PHQARL 204
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
59-227 1.77e-25

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 104.12  E-value: 1.77e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  59 IFGQRLEDtvqYERKYGQRLaPLLVEQCVDFIRERGLTEeGLFRMPGQANLVKDLQDSFDCGEKP---LFDSNTDVHTVA 135
Cdd:cd04384     2 VFGCDLTE---HLLNSGQDV-PQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPdltKDVYIQDIHSVS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 136 SLLKLYLRELPEPVIPFAKYEDFLscgQLLSKDEGEGTQELVKQV-KNLPQANYNLLKYICKFLDEVQAHSSINKMSVQN 214
Cdd:cd04384    77 SLCKLYFRELPNPLLTYQLYEKFS---EAVSAASDEERLEKIHDViQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKN 153
                         170
                  ....*....|...
gi 2006382824 215 LATVFGPNILRPK 227
Cdd:cd04384   154 LAIVWAPNLLRSK 166
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
80-256 3.32e-25

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 103.15  E-value: 3.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDsNTDVHTVASLLKLYLRELPEPVIPFAKYEDFL 159
Cdd:cd04402    16 PKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLK-AEPVLLLASVLKDFLRNIPGSLLSSDLYEEWM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 160 ScgqLLSKDEGEGTQELVKQVKN-LPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPkmEDPVTM-MEG 237
Cdd:cd04402    95 S---ALDQENEEEKIAELQRLLDkLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWP--PASSELqNED 169
                         170
                  ....*....|....*....
gi 2006382824 238 TSLVQHLMTVLISEQGRIF 256
Cdd:cd04402   170 LKKVTSLVQFLIENCQEIF 188
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
80-259 3.93e-25

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 103.58  E-value: 3.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQA----NLVKDLQDSFDCGEKPLfdSNTDVHTVASLLKLYLRELPEPVIPFAKY 155
Cdd:cd04391    23 PLIFQKLINKLEERGLETEGILRIPGSAqrvkFLCQELEAKFYEGTFLW--DQVKQHDAASLLKLFIRELPQPLLTVEYL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 156 EDFLSCGQLLSKDEGegTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMEDPVTM- 234
Cdd:cd04391   101 PAFYSVQGLPSKKDQ--LQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAMIMAPNLFPPRGKHSKDNe 178
                         170       180       190
                  ....*....|....*....|....*....|
gi 2006382824 235 -----MEGTSLVQHLMTVLISEQGRIFAVP 259
Cdd:cd04391   179 slqeeVNMAAGCANIMRLLIRYQDLLWTVP 208
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
81-260 8.30e-25

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 102.17  E-value: 8.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  81 LLVEQCvDFIrERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLfdSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFLS 160
Cdd:cd04394    23 FLVDAC-TFL-LDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL--SSALPCDVAGLLKQFFRELPEPLLPYDLHEALLK 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 161 CgQLLSKDEgEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILrPKMED----PVTMME 236
Cdd:cd04394    99 A-QELPTDE-ERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLF-QSEEGgekmSSSTEK 175
                         170       180
                  ....*....|....*....|....
gi 2006382824 237 GTSLVQHLMTVLISEQGRIFAVPQ 260
Cdd:cd04394   176 RLRLQAAVVQTLIDNASNIGIVPD 199
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
73-234 1.07e-24

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 101.82  E-value: 1.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  73 KYGQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPF 152
Cdd:cd04408    10 RDFPEEVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 153 AKYEDFLSCGQLLSKDEGEGTQ------ELVKQVKNL----PQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPN 222
Cdd:cd04408    90 QLYDDFIALAKELQRDSEKAAEspsiveNIIRSLKELlgrlPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPT 169
                         170
                  ....*....|..
gi 2006382824 223 ILRPKMEDPVTM 234
Cdd:cd04408   170 LLRPLVGGDVSM 181
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
83-260 2.25e-23

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 98.30  E-value: 2.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  83 VEQCVDFIrERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNT-DVHTVASLLKLYLRELPEPVIPFAKYEDFLSC 161
Cdd:cd04392    13 IYQLIEYL-EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLTHAHYPAHLQI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 162 GQLLSKDEGEGTQELVKQVKN----------LPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPKMEDP 231
Cdd:cd04392    92 ADLCQFDEKGNKTSAPDKERLlealqlllllLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTP 171
                         170       180
                  ....*....|....*....|....*....
gi 2006382824 232 VTMMEGTSLVQHLMTVLISEQGRIFAVPQ 260
Cdd:cd04392   172 EDLHENAQKLNSIVTFMIKHSQKLFKAPA 200
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
60-230 6.38e-23

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 97.15  E-value: 6.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  60 FGQRLEDTVQYERkyGQRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPL---FDSNTDVHTVAS 136
Cdd:cd04379     1 FGVPLSRLVEREG--ESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVelsEELYPDINVITG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 137 LLKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEGEGTQELVKQVKN-LPQANYNLLKYICKFLDEVQAHSSINKMSVQNL 215
Cdd:cd04379    79 VLKDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDcLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNL 158
                         170
                  ....*....|....*
gi 2006382824 216 ATVFGPNILRPKMED 230
Cdd:cd04379   159 AVCFGPVLMFCSQEF 173
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
85-227 7.56e-21

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 91.25  E-value: 7.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  85 QCVDFIRERGLTEEGLFRMPGQ----ANLVKDLQDSFDCGeKPlFDSNTDVHTVASLLKLYLRELPEPVIPFAKYEDFLS 160
Cdd:cd04380    56 RLVDYLYTRGLAQEGLFEEPGLpsepGELLAEIRDALDTG-SP-FNSPGSAESVAEALLLFLESLPDPIIPYSLYERLLE 133
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2006382824 161 CGQLLSKDEgegtqelvKQV--KNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILRPK 227
Cdd:cd04380   134 AVANNEEDK--------RQVirISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLRDP 194
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
76-251 9.20e-21

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 90.06  E-value: 9.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  76 QRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKY 155
Cdd:cd04406    12 DRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELY 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 156 EDFLSCGQLlsKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILR-PKMEDPVTM 234
Cdd:cd04406    92 EEFLRAMGL--QERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRcPDTTDPLQS 169
                         170
                  ....*....|....*..
gi 2006382824 235 MEGTSLVQHLMTVLISE 251
Cdd:cd04406   170 VQDISKTTTCVELIVCE 186
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
80-259 1.97e-20

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 90.12  E-value: 1.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  80 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDCG--EKPLFDSNTDVHtVASLLKLYLRELPEPVIPFAKYED 157
Cdd:cd04397    28 PALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNptEVPDLSKENPVQ-LAALLKKFLRELPDPLLTFKLYRL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 158 FLSCGQLLSKDEGEGTQELVkqVKNLPQANYNLLKYICKFLDEVQAHSSI-----NKMSVQNLATVFGPNILRPKMEDPv 232
Cdd:cd04397   107 WISSQKIEDEEERKRVLHLV--YCLLPKYHRDTMEVLFSFLKWVSSFSHIdeetgSKMDIHNLATVITPNILYSKTDNP- 183
                         170       180
                  ....*....|....*....|....*..
gi 2006382824 233 TMMEGTSLVQHLMTVLISEQGRIFAVP 259
Cdd:cd04397   184 NTGDEYFLAIEAVNYLIENNEEFCEVP 210
PH_RhoGap24 cd13379
Rho GTPase activating protein 24 Pleckstrin homology (PH) domain; RhoGap24 (also called ...
17-58 2.34e-20

Rho GTPase activating protein 24 Pleckstrin homology (PH) domain; RhoGap24 (also called ARHGAP24, p73RhoGAp, and Filamin-A-associated RhoGAP) like other RhoGAPs are involved in cell polarity, cell morphology and cytoskeletal organization. They act as GTPase activators for the Rac-type GTPases by converting them to an inactive GDP-bound state and control actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity and are able to suppress RAC1 and CDC42 activity in vitro. Overexpression of these proteins induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Members here contain an N-terminal PH domain followed by a RhoGAP domain and either a BAR or TATA Binding Protein (TBP) Associated Factor 4 (TAF4) domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 241530  Cd Length: 114  Bit Score: 86.56  E-value: 2.34e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2006382824  17 AGDREKMPVNHEAFLLMANSQNEMEDWVKAIRRVIWAPFGGG 58
Cdd:cd13379    73 GGDRERMTANHETYLLMASTQNDMEDWVKSIRRVIWAPFGGG 114
PH_RhoGap25-like cd13263
Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain; ...
17-58 8.35e-20

Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain; RhoGAP25 (also called ArhGap25) like other RhoGaps are involved in cell polarity, cell morphology and cytoskeletal organization. They act as GTPase activators for the Rac-type GTPases by converting them to an inactive GDP-bound state and control actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity and are able to suppress RAC1 and CDC42 activity in vitro. Overexpression of these proteins induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. This hierarchy contains RhoGAP22, RhoGAP24, and RhoGAP25. Members here contain an N-terminal PH domain followed by a RhoGAP domain and either a BAR or TATA Binding Protein (TBP) Associated Factor 4 (TAF4) domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 270083  Cd Length: 114  Bit Score: 85.13  E-value: 8.35e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2006382824  17 AGDREKMPVNHEAFLLMANSQNEMEDWVKAIRRVIWAPFGGG 58
Cdd:cd13263    73 GGGGDRMTSNHDSYLLMANSQAEMEEWVKVIRRVIGSPFGGG 114
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
59-223 2.00e-15

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 75.53  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  59 IFGQRLEDTVQyerKYGQRLaPLLVEQCVDFIRERGLTEEGLFRMPGQANLVKDLQDSFDC-GEKPLFDSnTDVHTVASL 137
Cdd:cd04375     4 VFGVPLLVNLQ---RTGQPL-PRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESsTDNVNYDG-QQAYDVADM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 138 LKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEGegTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLAT 217
Cdd:cd04375    79 LKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQR--LEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAV 156

                  ....*.
gi 2006382824 218 VFGPNI 223
Cdd:cd04375   157 CLAPSL 162
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
78-236 8.51e-15

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 73.37  E-value: 8.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  78 LAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVkDLQDSFDCGEKPLFDSNTDVHTVASLLKLYLRELPEPVIPFAKYED 157
Cdd:cd04388    14 VAPPLLIKLVEAIEKKGLESSTLYRTQSSSSLT-ELRQILDCDAASVDLEQFDVAALADALKRYLLDLPNPVIPAPVYSE 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 158 FLSCGQ-LLSKDEGEGTQELVKQVKNLPQANYNLLKYICKFLDEVQAHSSINKMSVQNLATVFGPNILR------PKMED 230
Cdd:cd04388    93 MISRAQeVQSSDEYAQLLRKLIRSPNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFRfqpassDSPEF 172

                  ....*.
gi 2006382824 231 PVTMME 236
Cdd:cd04388   173 HIRIIE 178
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
127-234 6.89e-07

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 50.41  E-value: 6.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 127 SNTDVHTVASLLKLYLRELPEPVIPFAKYEDFLSCGQLLSKDEGEGTQELVKQVKN----LPQANYNLLKYICKFLDEVq 202
Cdd:cd04399    74 KKFEPSTVASVLKLYLLELPDSLIPHDIYDLIRSLYSAYPPSQEDSDTARIQGLQStlsqLPKSHIATLDAIITHFYRL- 152
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2006382824 203 ahSSINKMS------VQNLATVFGPNILRPKMEDPVTM 234
Cdd:cd04399   153 --IEITKMGeseeeyADKLATSLSREILRPIIESLLTI 188
RhoGAP_fMSB1 cd04401
RhoGAP_fMSB1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
82-221 1.37e-03

RhoGAP_fMSB1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal MSB1-like proteins. Msb1 was originally identified as a multicopy suppressor of temperature sensitive cdc42 mutation. Msb1 is a positive regulator of the Pkc1p-MAPK pathway and 1,3-beta-glucan synthesis, both pathways involve Rho1 regulation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239866  Cd Length: 198  Bit Score: 40.41  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  82 LVEQCVDFIRERGLTEEGL---FRmPGQAN-----LVKDLQDSFDC---GEKPLFD--SNTDVHTVASLLKLYLRELPEP 148
Cdd:cd04401     9 LIHNITEELKSRGLDTPLLflpFR-PELSPdkvrsLINSFFPSQNGqlqGTAELLDelRYADPHTLILVLKWIWSRLPGS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 149 VIPFAK-YEDFlscgQLLSKDEGEGTQ---ELVKQVknLPQANYNLLKYicKFLD---EVQAHSSINKMSVQNLATVFGP 221
Cdd:cd04401    88 KVIWWEvYEEF----KARERRSNYPADaflDLLPQC--LSSPAHASILY--DFFDllsSIAAHSSVNGMSGRKLSKMAGP 159
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
511-583 1.46e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2006382824 511 RALQSLVVELKTELSKQRTEY---ETSIKRIEETSADLRNQVVRLEEELDQER--KKYTMLEIKLRNSERAREDAEKR 583
Cdd:COG1579    34 AELEDELAALEARLEAAKTELedlEKEIKRLELEIEEVEARIKKYEEQLGNVRnnKEYEALQKEIESLKRRISDLEDE 111
PH pfam00169
PH domain; PH stands for pleckstrin homology.
26-51 4.69e-03

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 37.16  E-value: 4.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 2006382824  26 NHEAFLLMANSQNEMEDWVKAIRRVI 51
Cdd:pfam00169  79 GKRTYLLQAESEEERKDWIKAIQSAI 104
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
519-594 5.19e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 5.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2006382824 519 ELKTELSKQRTEYETSIKRIEETSAdLRNQVVRLEEELDQERKKYTMLEIKLRNSERAREDAEKRNYLLQKEMEEF 594
Cdd:COG2433   445 RLERELSEARSEERREIRKDREISR-LDREIERLERELEEERERIEELKRKLERLKELWKLEHSGELVPVKVVEKF 519
THOC7 pfam05615
Tho complex subunit 7; The Tho complex is involved in transcription elongation and mRNA export ...
499-583 5.67e-03

Tho complex subunit 7; The Tho complex is involved in transcription elongation and mRNA export from the nucleus.


Pssm-ID: 461692 [Multi-domain]  Cd Length: 135  Bit Score: 37.63  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 499 PAAASRDSVQCSRALQSLVVEL--------KTEL-----SKQRTEYETSIKRIEETSADLRNQVVRLEEELDQE------ 559
Cdd:pfam05615  32 CNSLDSTPEEIQALREDLLLDLaafelsieKSQLlaeanERERENYEAEKEEIEEEIEAVREEIEELKERLEEAkrtrkn 111
                          90       100
                  ....*....|....*....|....
gi 2006382824 560 RKKYTmLEIKLRNSERAREDAEKR 583
Cdd:pfam05615 112 REEYD-ALAEKINENPSREETEKQ 134
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
492-593 5.87e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 5.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  492 SSSEQSDPAAASRDSVQCSRALQSLVVELkTELSKQRTEY-------ETSIKRIEETSADLRNQVVRLEEELDQER---- 560
Cdd:TIGR02168  728 ISALRKDLARLEAEVEQLEERIAQLSKEL-TELEAEIEELeerleeaEEELAEAEAEIEELEAQIEQLKEELKALReald 806
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2006382824  561 ---KKYTMLEIKLRNSERAREDAEKRNYLLQKEMEE 593
Cdd:TIGR02168  807 elrAELTLLNEEAANLRERLESLERRIAATERRLED 842
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
511-584 5.90e-03

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 36.39  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 511 RALQSLVVELKTELSKQRTEyetsIKRIEETSADLRNQVVRLEEELDQERKKYTMLEIKLR-----NSE-------RARE 578
Cdd:cd22887     7 QELEKRLAELEAELASLEEE----IKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRklqeeNDElverwmaKKQQ 82

                  ....*.
gi 2006382824 579 DAEKRN 584
Cdd:cd22887    83 EADKMN 88
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
469-593 6.51e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.55  E-value: 6.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824 469 SLSQSEVKTADLENSMDRFEACSSSS--EQSDPAAASRDSVQCSRALQSLVvelktELSKQRTEYETSIKRIEETSAdlR 546
Cdd:pfam15709 298 SPTQTFVVTGNMESEEERSEEDPSKAllEKREQEKASRDRLRAERAEMRRL-----EVERKRREQEEQRRLQQEQLE--R 370
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2006382824 547 NQVVRLEEELDQERKKYtmlEIKLRNS----ERAREDAEKRNYLLQKEMEE 593
Cdd:pfam15709 371 AEKMREELELEQQRRFE---EIRLRKQrleeERQRQEEEERKQRLQLQAAQ 418
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
523-595 6.82e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 38.74  E-value: 6.82e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2006382824 523 ELSKQRTEYETSIKRIEETSADLRNQVVRLEEELDQERKKYTMLEIKLRNSERAREDAEkrnylLQKEMEEFF 595
Cdd:COG1340   206 ELRKEADELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEE-----LEEKAEEIF 273
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
513-592 9.13e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 39.00  E-value: 9.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006382824  513 LQSLVVELKTELSKQRTEYETSIKRIEETSAD----------LRNQVVRLEEELDQERKkytmleiklrnserAREDAEK 582
Cdd:pfam01576  227 LQAQIAELRAQLAKKEEELQAALARLEEETAQknnalkkireLEAQISELQEDLESERA--------------ARNKAEK 292
                           90
                   ....*....|
gi 2006382824  583 RNYLLQKEME 592
Cdd:pfam01576  293 QRRDLGEELE 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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