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Conserved domains on  [gi|2024354694|ref|XP_040503079|]
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SH3 domain and tetratricopeptide repeat-containing protein 2 isoform X5 [Gallus gallus]

Protein Classification

SH3 domain-containing protein( domain architecture ID 99303)

Src Homology 3 (SH3) domain-containing protein plays versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SH3 super family cl17036
Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction ...
 346-400 6.97e-18

Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. SH3 domain containing proteins play versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others. Many members of this superfamily are adaptor proteins that associate with a number of protein partners, facilitating complex formation and signal transduction.


The actual alignment was detected with superfamily member cd11885:

Pssm-ID: 473055  Cd Length: 55  Bit Score: 78.51  E-value: 6.97e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024354694  346 KCTATADHRGAAWDELSFSKGDSIEVVGFFLPGLPWFVGRSLSSGNIGFVPVRFV 400
Cdd:cd11885      1 SCTAKMDFEGVEPGELSFRQGDSIEIIGDLIPGLQWFVGRSKSSGRVGFVPTNHF 55
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 915-1038 2.04e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024354694  915 AVHNLLAIALKGAGQVQKAAENYLRALHKAKEtgnkrnQAIALANLGQLSQSRGASQLSELYLLQAAQLYAELqgseele 994
Cdd:COG3914    113 EALFNLGNLLLALGRLEEALAALRRALALNPD------FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDN------- 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2024354694  995 lesVHVMLWLAQAMVSRQRMEDGKLCYELALVFALKWHNVRSQL 1038
Cdd:COG3914    180 ---AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
SH3 super family cl17036
Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction ...
 266-312 1.36e-03

Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. SH3 domain containing proteins play versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others. Many members of this superfamily are adaptor proteins that associate with a number of protein partners, facilitating complex formation and signal transduction.


The actual alignment was detected with superfamily member pfam07653:

Pssm-ID: 473055 [Multi-domain]  Cd Length: 54  Bit Score: 37.96  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024354694  266 GEGQEGLQLCRNELVHVKNIGGESKWEGMSllTGQRGLVPVTALEPV 312
Cdd:pfam07653   10 GTDKNGLTLKKGDVVKVLGKDNDGWWEGET--GGRVGLVPSTAVEEI 54
 
Name Accession Description Interval E-value
SH3_SH3TC cd11885
Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins ...
 346-400 6.97e-18

Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains; This subfamily is composed of vertebrate SH3TC proteins and hypothetical fungal proteins containing BAR and SH3 domains. Mammals contain two SH3TC proteins, SH3TC1 and SH3TC2. The function of SH3TC1 is unknown. SH3TC2 is localized in Schwann cells in the peripheral nervous system, where it interacts with Rab11 and plays a role in peripheral nerve myelination. Mutations in SH3TC2 are associated with Charcot-Marie-Tooth disease type 4C, a severe hereditary peripheral neuropathy with symptoms that include progressive scoliosis, delayed age of walking, muscular atrophy, distal weakness, and reduced nerve conduction velocity. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.


Pssm-ID: 212818  Cd Length: 55  Bit Score: 78.51  E-value: 6.97e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024354694  346 KCTATADHRGAAWDELSFSKGDSIEVVGFFLPGLPWFVGRSLSSGNIGFVPVRFV 400
Cdd:cd11885      1 SCTAKMDFEGVEPGELSFRQGDSIEIIGDLIPGLQWFVGRSKSSGRVGFVPTNHF 55
SH3 smart00326
Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences ...
 344-400 6.67e-06

Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences containing proline and hydrophobic amino acids. Pro-containing polypeptides may bind to SH3 domains in 2 different binding orientations.


Pssm-ID: 214620 [Multi-domain]  Cd Length: 56  Bit Score: 44.45  E-value: 6.67e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024354694   344 KGKCTATADHRGAAWDELSFSKGDSIEVVGFFLPGlpWFVGRsLSSGNIGFVPVRFV 400
Cdd:smart00326    2 GPQVRALYDYTAQDPDELSFKKGDIITVLEKSDDG--WWKGR-LGRGKEGLFPSNYV 55
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 915-1038 2.04e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024354694  915 AVHNLLAIALKGAGQVQKAAENYLRALHKAKEtgnkrnQAIALANLGQLSQSRGASQLSELYLLQAAQLYAELqgseele 994
Cdd:COG3914    113 EALFNLGNLLLALGRLEEALAALRRALALNPD------FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDN------- 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2024354694  995 lesVHVMLWLAQAMVSRQRMEDGKLCYELALVFALKWHNVRSQL 1038
Cdd:COG3914    180 ---AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 266-312 1.36e-03

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 37.96  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024354694  266 GEGQEGLQLCRNELVHVKNIGGESKWEGMSllTGQRGLVPVTALEPV 312
Cdd:pfam07653   10 GTDKNGLTLKKGDVVKVLGKDNDGWWEGET--GGRVGLVPSTAVEEI 54
TPR_12 pfam13424
Tetratricopeptide repeat;
915-984 6.58e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.60  E-value: 6.58e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024354694  915 AVHNLLAIALKGAGQVQKAAENYLRAL--HKAKETGNKRNQAIALANLGQLSQSRGASQLSELYLLQAAQLY 984
Cdd:pfam13424    4 TALNNLAAVLRRLGRYDEALELLEKALeiARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
 
Name Accession Description Interval E-value
SH3_SH3TC cd11885
Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins ...
 346-400 6.97e-18

Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains; This subfamily is composed of vertebrate SH3TC proteins and hypothetical fungal proteins containing BAR and SH3 domains. Mammals contain two SH3TC proteins, SH3TC1 and SH3TC2. The function of SH3TC1 is unknown. SH3TC2 is localized in Schwann cells in the peripheral nervous system, where it interacts with Rab11 and plays a role in peripheral nerve myelination. Mutations in SH3TC2 are associated with Charcot-Marie-Tooth disease type 4C, a severe hereditary peripheral neuropathy with symptoms that include progressive scoliosis, delayed age of walking, muscular atrophy, distal weakness, and reduced nerve conduction velocity. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.


Pssm-ID: 212818  Cd Length: 55  Bit Score: 78.51  E-value: 6.97e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024354694  346 KCTATADHRGAAWDELSFSKGDSIEVVGFFLPGLPWFVGRSLSSGNIGFVPVRFV 400
Cdd:cd11885      1 SCTAKMDFEGVEPGELSFRQGDSIEIIGDLIPGLQWFVGRSKSSGRVGFVPTNHF 55
SH3 smart00326
Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences ...
 344-400 6.67e-06

Src homology 3 domains; Src homology 3 (SH3) domains bind to target proteins through sequences containing proline and hydrophobic amino acids. Pro-containing polypeptides may bind to SH3 domains in 2 different binding orientations.


Pssm-ID: 214620 [Multi-domain]  Cd Length: 56  Bit Score: 44.45  E-value: 6.67e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024354694   344 KGKCTATADHRGAAWDELSFSKGDSIEVVGFFLPGlpWFVGRsLSSGNIGFVPVRFV 400
Cdd:smart00326    2 GPQVRALYDYTAQDPDELSFKKGDIITVLEKSDDG--WWKGR-LGRGKEGLFPSNYV 55
SH3 cd00174
Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction ...
 346-396 7.81e-05

Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. SH3 domain containing proteins play versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others. Many members of this superfamily are adaptor proteins that associate with a number of protein partners, facilitating complex formation and signal transduction.


Pssm-ID: 212690 [Multi-domain]  Cd Length: 51  Bit Score: 41.29  E-value: 7.81e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024354694  346 KCTATADHRGAAWDELSFSKGDSIEVVGFFLPGlpWFVGRsLSSGNIGFVP 396
Cdd:cd00174      1 YARALYDYEAQDDDELSFKKGDIITVLEKDDDG--WWEGE-LNGGREGLFP 48
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 915-1038 2.04e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024354694  915 AVHNLLAIALKGAGQVQKAAENYLRALHKAKEtgnkrnQAIALANLGQLSQSRGASQLSELYLLQAAQLYAELqgseele 994
Cdd:COG3914    113 EALFNLGNLLLALGRLEEALAALRRALALNPD------FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDN------- 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2024354694  995 lesVHVMLWLAQAMVSRQRMEDGKLCYELALVFALKWHNVRSQL 1038
Cdd:COG3914    180 ---AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 266-312 1.36e-03

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 37.96  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2024354694  266 GEGQEGLQLCRNELVHVKNIGGESKWEGMSllTGQRGLVPVTALEPV 312
Cdd:pfam07653   10 GTDKNGLTLKKGDVVKVLGKDNDGWWEGET--GGRVGLVPSTAVEEI 54
SH3_BOI cd11886
Src Homology 3 domain of fungal BOI-like proteins; This subfamily includes the Saccharomyces ...
 359-399 1.67e-03

Src Homology 3 domain of fungal BOI-like proteins; This subfamily includes the Saccharomyces cerevisiae proteins BOI1 and BOI2, and similar proteins. They contain an N-terminal SH3 domain, a Sterile alpha motif (SAM), and a Pleckstrin homology (PH) domain at the C-terminus. BOI1 and BOI2 interact with the SH3 domain of Bem1p, a protein involved in bud formation. They promote polarized cell growth and participates in the NoCut signaling pathway, which is involved in the control of cytokinesis. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.


Pssm-ID: 212819  Cd Length: 55  Bit Score: 37.70  E-value: 1.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2024354694  359 DELSFSKGDSIEVV----GFflpGLPWFVGRSLSSGNIGFVPVRF 399
Cdd:cd11886     14 DELTLKPGDKIELIeddeEF---GDGWYLGRNLRTGETGLFPVVF 55
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
916-1025 2.02e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024354694  916 VHNLLAIALKGAGQVQKAAENYLRALHKaketgnKRNQAIALANLGQLSQSRGASQLSELYLLQAAqlyaelqgseELEL 995
Cdd:COG0457     44 ALYNLGLAYLRLGRYEEALADYEQALEL------DPDDAEALNNLGLALQALGRYEEALEDYDKAL----------ELDP 107

                           90       100       110
                   ....*....|....*....|....*....|
gi 2024354694  996 ESVHVMLWLAQAMVSRQRMEDGKLCYELAL 1025
Cdd:COG0457    108 DDAEALYNLGLALLELGRYDEAIEAYERAL 137
SH3_Amphiphysin cd11790
Src Homology 3 domain of Amphiphysin and related domains; Amphiphysins function primarily in ...
 346-399 3.96e-03

Src Homology 3 domain of Amphiphysin and related domains; Amphiphysins function primarily in endocytosis and other membrane remodeling events. They exist in several isoforms and mammals possess two amphiphysin proteins from distinct genes. Amphiphysin I proteins, enriched in the brain and nervous system, contain domains that bind clathrin, Adaptor Protein complex 2 (AP2), dynamin, and synaptojanin. They function in synaptic vesicle endocytosis. Human autoantibodies to amphiphysin I hinder GABAergic signaling and contribute to the pathogenesis of paraneoplastic stiff-person syndrome. Some amphiphysin II isoforms, also called Bridging integrator 1 (Bin1), are localized in many different tissues and may function in intracellular vesicle trafficking. In skeletal muscle, Bin1 plays a role in the organization and maintenance of the T-tubule network. Mutations in Bin1 are associated with autosomal recessive centronuclear myopathy. Amphiphysins contain an N-terminal BAR domain with an additional N-terminal amphipathic helix (an N-BAR), a variable central domain, and a C-terminal SH3 domain. The SH3 domain of amphiphysins bind proline-rich motifs present in binding partners such as dynamin, synaptojanin, and nsP3. It also belongs to a subset of SH3 domains that bind ubiquitin in a site that overlaps with the peptide binding site. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212724 [Multi-domain]  Cd Length: 64  Bit Score: 36.92  E-value: 3.96e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024354694  346 KCTATADHRGAAWDELSFSKGDSIEVVGFFLP-----GlpWFVGRSLSSGNIGFVPVRF 399
Cdd:cd11790      4 KVRATHDYTAEDTDELTFEKGDVILVIPFDDPeeqdeG--WLMGVKESTGCRGVFPENF 60
TPR_12 pfam13424
Tetratricopeptide repeat;
915-984 6.58e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.60  E-value: 6.58e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024354694  915 AVHNLLAIALKGAGQVQKAAENYLRAL--HKAKETGNKRNQAIALANLGQLSQSRGASQLSELYLLQAAQLY 984
Cdd:pfam13424    4 TALNNLAAVLRRLGRYDEALELLEKALeiARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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